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Sphingosine-1-phosphate receptor 1 activation in astrocytes contributes to neuropathic pain

Chen, Zhoumou ; Doyle, Timothy M ; Luongo, Livio ; Largent-Milnes, Tally M ; Giancotti, Luigino Antonio ; Kolar, Grant ; Squillace, Silvia ; Boccella, Serena ; Walker, John K ; Pendleton, Alexander ; Spiegel, Sarah ; Neumann, William L ; Vanderah, Todd W ; Salvemini, Daniela

Proceedings of the National Academy of Sciences of the United States of America, 21 May 2019, Vol.116(21), pp.10557-10562 [Peer Reviewed Journal]

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A novel role of sphingosine kinase‐1 in the invasion and angiogenesis of VHL mutant clear cell renal cell carcinoma

Salama, Mohamed F. ; Carroll, Brittany ; Adada, Mohamad ; Pulkoski‐Gross, Michael ; Hannun, Yusuf A. ; Obeid, Lina M.

FASEB Journal, July 2015, Vol.29(7), pp.2803-2813 [Peer Reviewed Journal]

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Sphingosine‐1‐phosphate receptor type 1 regulates glioma cell proliferation and correlates with patient survival

Yoshida, Yuya ; Nakada, Mitsutoshi ; Sugimoto, Naotoshi ; Harada, Tomoya ; Hayashi, Yasuhiko ; Kita, Daisuke ; Uchiyama, Naoyuki ; Hayashi, Yutaka ; Yachie, Akihiro ; Takuwa, Yoh ; Hamada, Jun‐Ichiro

International Journal of Cancer, 15 May 2010, Vol.126(10), pp.2341-2352 [Peer Reviewed Journal]

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The effect of low levels of lead (Pb) in the blood on levels of sphingosine-1-phosphate (S1P) and expression of S1P receptor 1 in the brain of the rat in the perinatal period

Łukomska, A ; Baranowska-Bosiacka, I ; Budkowska, M ; Pilutin, A ; Tarnowski, M ; Dec, K ; Dołęgowska, B ; Metryka, E ; Chlubek, D ; Gutowska, I

Chemosphere, January 2017, Vol.166, pp.221-229 [Peer Reviewed Journal]

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Expression profile of the sphingosine kinase signalling system in the lung of patients with chronic obstructive pulmonary disease

Cordts, Fabian ; Pitson, Stuart ; Tabeling, Christoph ; Gibbins, Ian ; Moffat, David F ; Jersmann, Hubertus ; Hodge, Sandra ; Haberberger, Rainer V

Life Sciences, 21 November 2011, Vol.89(21-22), pp.806-811 [Peer Reviewed Journal]

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Discovery of BAF312 (Siponimod), a Potent and Selective S1P Receptor Modulator

Pan, Shifeng ; Gray, Nathanael S ; Gao, Wenqi ; Mi, Yuan ; Fan, Yi ; Wang, Xing ; Tuntland, Tove ; Che, Jianwei ; Lefebvre, Sophie ; Chen, Yu ; Chu, Alan ; Hinterding, Klaus ; Gardin, Anne ; End, Peter ; Heining, Peter ; Bruns, Christian ; Cooke, Nigel G ; Nuesslein-Hildesheim, Barbara

ACS medicinal chemistry letters, 14 March 2013, Vol.4(3), pp.333-7 [Peer Reviewed Journal]

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Regulation of synaptic strength by sphingosine 1-phosphate in the hippocampus

Kanno, T ; Nishizaki, T ; Proia, R.L ; Kajimoto, T ; Jahangeer, S ; Okada, T ; Nakamura, S

Neuroscience, 2010, Vol.171(4), pp.973-980 [Peer Reviewed Journal]

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S1P 4 receptor mediates S1P-induced vasoconstriction in normotensive and hypertensive rat lungs

Ota, Hiroki ; Beutz, Michelle ; Ito, Masako ; Abe, Kohtaro ; Oka, Masahiko ; McMurtry, Ivan

Pulmonary Circulation, 2011, Vol.1(3), p.399-404 [Peer Reviewed Journal]

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Modeling clinical efficacy of the S1P receptor modulator ponesimod in psoriasis

Krause, Andreas ; D'Ambrosio, Daniele ; Dingemanse, Jasper

Journal of Dermatological Science, February 2018, Vol.89(2), pp.136-145 [Peer Reviewed Journal]

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Kilogram-Scale Pilot Synthesis of Fingolimod

Balaev, A. ; Busel, A. ; Fedorov, V.

Pharmaceutical Chemistry Journal, 2017, Vol.51(6), pp.476-479 [Peer Reviewed Journal]

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Decreased Expression of Sphingosine-1-Phosphate Receptor 1 in the Blood Leukocyte of Rheumatoid Arthritis Patients

Choi, Hyun Suk ; Kim, Kyong Hoon ; Jin, Seohoon ; Kim, Jinhyun ; Yoo, Inseol ; Pack, Seung Pil ; Ha, Un-Hwan ; Park, Tae Won ; Choi, Soo An ; Yuk, Soon Hong ; Kang, Seong Wook ; Jung, Yong Woo

Immune Network, 2018, Vol.18(5) [Peer Reviewed Journal]

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Sphingosine 1-phosphate (S1P) signaling in glioblastoma multiforme-A systematic review

Mahajan-Thakur, Shailaja ; Bien-Möller, Sandra ; Marx, Sascha ; Schroeder, Henry ; Rauch, Bernhard H

International journal of molecular sciences, 17 November 2017, Vol.18(11) [Peer Reviewed Journal]

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Multiple‐dose tolerability, pharmacokinetics, and pharmacodynamics of ponesimod, an S1P 1 receptor modulator: Favorable impact of dose up‐titration

Brossard, P. ; Scherz, M. ; Halabi, A. ; Maatouk, H. ; Krause, A. ; Dingemanse, J.

Journal of Clinical Pharmacology, February 2014, Vol.54(2), pp.179-188 [Peer Reviewed Journal]

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FTY720 attenuates hypoxia–reoxygenation-induced apoptosis in cardiomyocytes

Wang, Min ; Lu, Lin ; Liu, Yehong ; Gu, Gang ; Tao, Rong

Experimental and Molecular Pathology, October 2014, Vol.97(2), pp.218-224 [Peer Reviewed Journal]

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Correlations Between Plasma Sphingosine-1-phosphate (S1P) and Gene Expression of S1P Receptors with Mogenic Regulatory Factors Following Resistance Training

Ebrahim Banitalebi ; Reza Gharakhanlou

Research in Molecular Medicine, 01 April 2016, Vol.4(2), pp.30-35 [Peer Reviewed Journal]

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16
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Dissecting influenza virus pathogenesis uncovers a novel chemical approach to combat the infection

Oldstone, Michael B.A ; Teijaro, John R ; Walsh, Kevin B ; Rosen, Hugh

Virology, 05 January 2013, Vol.435(1), pp.92-101 [Peer Reviewed Journal]

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Oncogenic S1P signalling in EBV‐associated nasopharyngeal carcinoma activates AKT and promotes cell migration through S1P receptor 3

Lee, Hui Min ; Lo, Kwok‐Wai ; Wei, Wenbin ; Tsao, Sai Wah ; Chung, Grace Tin Yun ; Ibrahim, Maha Hafez ; Dawson, Christopher W ; Murray, Paul G ; Paterson, Ian C ; Yap, Lee Fah

Journal of Pathology, May 2017, Vol.242(1), pp.62-72 [Peer Reviewed Journal]

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Ablation of Sphingosine 1-Phosphate Receptor Subtype 3 Impairs Hippocampal Neuron Excitability and Spatial Working Memory

Weth-Malsch, Daniela ; Langeslag, Michiel ; Beroukas, Dimitra ; Zangrandi, Luca ; Kastenberger, Iris ; Quarta, Serena ; Malsch, Philipp ; Kalpachidou, Theodora ; Schwarzer, Christoph ; Proia, Richard L ; Haberberger, Rainer V ; Kress, Michaela

Frontiers in cellular neuroscience, 2016, Vol.10, pp.258 [Peer Reviewed Journal]

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Pharmacokinetics, Pharmacodynamics, Tolerability, and Food Effect of Cenerimod, a Selective S1P 1 Receptor Modulator in Healthy Subjects

Juif, Pierre-Eric ; Baldoni, Daniela ; Reyes, Maribel ; Wilbraham, Darren ; Febbraro, Salvatore ; Vaclavkova, Andrea ; Hoch, Matthias ; Dingemanse, Jasper

International Journal of Molecular Sciences, 2017, Vol.18(12) [Peer Reviewed Journal]

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20
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The sphingosine 1-phosphate receptor modulator fingolimod as a therapeutic agent: Recent findings and new perspectives

Huwiler, Andrea ; Zangemeister-Wittke, Uwe

Pharmacology and Therapeutics, May 2018, Vol.185, pp.34-49 [Peer Reviewed Journal]

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21
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A benzo[b]thiophene-based selective type 4 S1P receptor agonist

Hur, Wooyoung ; Rosen, Hugh ; Gray, Nathanael S

Bioorganic & Medicinal Chemistry Letters, 01 January 2017, Vol.27(1), pp.1-5 [Peer Reviewed Journal]

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22
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3D-QSAR Studies on Thiazolidin-4-one S1P 1 Receptor Agonists by CoMFA and CoMSIA

Qian, Chuiwen ; Zheng, Junxia ; Xiao, Gaokeng ; Guo, Jialiang ; Yang, Zhaoqi ; Huang, Li ; Chao, Wei ; Rao, Longyi ; Sun, Pinghua

International Journal of Molecular Sciences, 2011, Vol.12(10), p.6502-6516 [Peer Reviewed Journal]

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23
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Targeting S1PR1/STAT3 loop abrogates desmoplasia and chemosensitizes pancreatic cancer to gemcitabine

Lankadasari, Manendra Babu ; Aparna, Jayasekharan S ; Mohammed, Sabira ; James, Shirley ; Aoki, Kazunori ; Binu, Valsalakumari S ; Nair, Sindhu ; Harikumar, Kuzhuvelil B

Theranostics, 2018, Vol.8(14), pp.3824-3840 [Peer Reviewed Journal]

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24
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Ablation of Sphingosine 1-Phosphate Receptor Subtype 3 Impairs Hippocampal Neuron Excitability In vitro and Spatial Working Memory In vivo

Weth-Malsch, Daniela ; Langeslag, Michiel ; Beroukas, Dimitra ; Zangrandi, Luca ; Kastenberger, Iris ; Quarta, Serena ; Malsch, Philipp ; Kalpachidou, Theodora ; Schwarzer, Christoph ; Proia, Richard ; Haberberger, Rainer ; Kress, Michaela

Frontiers in Cellular Neuroscience, Nov 7, 2016 [Peer Reviewed Journal]

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25
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Sphingosine kinase 1/sphingosine-1-phosphate (S1P)/S1P receptor axis is involved in ovarian cancer angiogenesis

Dai, Lan ; Liu, Yixuan ; Xie, Lei ; Wu, Xia ; Qiu, Lihua ; Di, Wen

Oncotarget, 26 September 2017, Vol.8(43), pp.74947-74961 [Peer Reviewed Journal]

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26
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Therapeutic Strategies and Pharmacological Tools Influencing S1P Signaling and Metabolism

Vogt, Dominik ; Stark, Holger

Medicinal Research Reviews, January 2017, Vol.37(1), pp.3-51 [Peer Reviewed Journal]

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27
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Regulation of endothelial nitric oxide synthase activation in endothelial cells by S1P1 and S1P3

Tölle, M ; Klöckl, L ; Wiedon, A ; Zidek, W ; van Der Giet, M ; Schuchardt, M

Biochemical and Biophysical Research Communications, 05 August 2016, Vol.476(4), pp.627-634 [Peer Reviewed Journal]

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Sphingosine 1-phosphate receptor 5 mediates the immune quiescence of the human brain endothelial barrier

van Doorn Ruben ; Lopes Pinheiro Melissa A ; Kooij Gijs ; Lakeman Kim ; van Het Hof Bert ; van Der Pol Susanne MA ; Geerts Dirk ; van Horssen Jack ; van Der Valk Paul ; van Der Kam Elizabeth ; Ronken Eric ; Reijerkerk Arie ; de Vries Helga E

Journal of Neuroinflammation, 01 June 2012, Vol.9(1), p.133 [Peer Reviewed Journal]

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29
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Pharmacological Modulation of Peripheral T and B Lymphocytes by a Selective Sphingosine 1‐Phosphate Receptor‐1 Modulator

Moberly, James B. ; Rohatagi, Shashank ; Zahir, Hamim ; Hsu, Ching ; Noveck, Robert J. ; Truitt, Kenneth E.

Journal of Clinical Pharmacology, July 2012, Vol.52(7), pp.996-1006 [Peer Reviewed Journal]

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30
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Sphingosine kinase 1/S1P pathway involvement in the GDNF‐induced GAP43 transcription

Murakami, Masashi ; Ito, Hiromi ; Hagiwara, Kazumi ; Kobayashi, Misa ; Hoshikawa, Asuka ; Takagi, Akira ; Kojima, Tetsuhito ; Tamiya‐Koizumi, Keiko ; Sobue, Sayaka ; Ichihara, Masatoshi ; Suzuki, Motoshi ; Banno, Yoshiko ; Nozawa, Yoshinori ; Murate, Takashi

Journal of Cellular Biochemistry, November 2011, Vol.112(11), pp.3449-3458 [Peer Reviewed Journal]

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31
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Immunohistochemical detection of sphingosine-1-phosphate receptor 1 and 5 in human multiple sclerosis lesions

Brana, Corinne ; Frossard, Marie José ; Pescini Gobert, Rosanna ; Martinier, Nicolas ; Boschert, Ursula ; Seabrook, Timothy J

Neuropathology and applied neurobiology, August 2014, Vol.40(5), pp.564-78 [Peer Reviewed Journal]

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32
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S1P receptor mediated activity of FTY720 phosphate mimics

Högenauer, Klemens ; Hinterding, Klaus ; Nussbaumer, Peter

Bioorganic & Medicinal Chemistry Letters, 2010, Vol.20(5), pp.1485-1487 [Peer Reviewed Journal]

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33
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Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P

Xu, Ruijuan ; Jin, Junfei ; Hu, Wei ; Sun, Wei ; Bielawski, Jacek ; Szulc, Zdzislaw ; Taha, Tarek ; Obeid, Lina M. ; Mao, Cungui

FASEB Journal, September 2006, Vol.20(11), pp.1813-1825 [Peer Reviewed Journal]

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Sphingosine 1-Phosphate Receptor 1 as a Useful Target for Treatment of Multiple Sclerosis

Kunitomo Adachi ; Kenji Chiba

Pharmaceuticals, 01 May 2012, Vol.5(5), pp.514-528 [Peer Reviewed Journal]

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Emerging role of sphingosine-1-phosphate signaling in head and neck squamous cell carcinoma

Nema, Rajeev ; Vishwakarma, Supriya ; Agarwal, Rahul ; Panday, Rajendra ; Kumar, Ashok

OncoTargets and Therapy, 2016, Vol.9, pp.3269-3280 [Peer Reviewed Journal]

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Pharmacokinetics of H002, a novel S1PR1 modulator, and its metabolites in rat blood using liquid chromatography–tandem mass spectrometry

Jiaqi Mi ; Manman Zhao ; Shu Yang ; Shuang Yang ; Jing Jin ; Xiaojian Wang ; Qiong Xiao ; Jinping Hu ; Yan Li

Acta Pharmaceutica Sinica B, 01 October 2016, Vol.6(6), pp.576-583 [Peer Reviewed Journal]

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A polysaccharides MDG-1 augments survival in the ischemic heart by inducing S1P release and S1P1 expression

Wang, Shuo ; Lin, Xiao ; Wang, Ling-Yi ; Ruan, Ke-Feng ; Feng, Yi ; Li, Xiao-Yan

International Journal of Biological Macromolecules, 01 April 2012, Vol.50(3), pp.734-740 [Peer Reviewed Journal]

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