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22 Results  for Everything (Includes Articles)

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1
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Antifungal spectrum, in vivo efficacy, and structure-activity relationship of ilicicolin h

Singh, Sheo B ; Liu, Weiguo ; Li, Xiaohua ; Chen, Tom ; Shafiee, Ali ; Card, Deborah ; Abruzzo, George ; Flattery, Amy ; Gill, Charles ; Thompson, John R ; Rosenbach, Mark ; Dreikorn, Sarah ; Hornak, Viktor ; Meinz, Maria ; Kurtz, Myra ; Kelly, Rosemarie ; Onishi, Janet C

ACS medicinal chemistry letters, 11 October 2012, Vol.3(10), pp.814-7 [Peer Reviewed Journal]

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2
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Mice deficient in sphingosine kinase 1 are rendered lymphopenic by FTY720

Allende, Maria L ; Sasaki, Teiji ; Kawai, Hiromichi ; Olivera, Ana ; Mi, Yide ; Van Echten-Deckert, Gerhild ; Hajdu, Richard ; Rosenbach, Mark ; Keohane, Carol Ann ; Mandala, Suzanne ; Spiegel, Sarah ; Proia, Richard L

The Journal of biological chemistry, 10 December 2004, Vol.279(50), pp.52487-92 [Peer Reviewed Journal]

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A rational utilization of high-throughput screening affords selective, orally bioavailable 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 receptor agonists

Hale, Jeffrey J ; Lynch, Christopher L ; Neway, William ; Mills, Sander G ; Hajdu, Richard ; Keohane, Carol Ann ; Rosenbach, Mark J ; Milligan, James A ; Shei, Gan-Ju ; Parent, Stephen A ; Chrebet, Gary ; Bergstrom, James ; Card, Deborah ; Ferrer, Marc ; Hodder, Peter ; Strulovici, Berta ; Rosen, Hugh ; Mandala, Suzanne

Journal of medicinal chemistry, 30 December 2004, Vol.47(27), pp.6662-5 [Peer Reviewed Journal]

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4
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Discovery of MK-4409, a Novel Oxazole FAAH Inhibitor for the Treatment of Inflammatory and Neuropathic Pain

Chobanian, Harry R ; Guo, Yan ; Liu, Ping ; Chioda, Marc D ; Fung, Selena ; Lanza, Thomas J ; Chang, Linda ; Bakshi, Raman K ; Dellureficio, James P ; Hong, Qingmei ; Mclaughlin, Mark ; Belyk, Kevin M ; Krska, Shane W ; Makarewicz, Amanda K ; Martel, Elliot J ; Leone, Joseph F ; Frey, Lisa ; Karanam, Bindhu ; Madeira, Maria ; Alvaro

ACS medicinal chemistry letters, 12 June 2014, Vol.5(6), pp.717-21 [Peer Reviewed Journal]

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5
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Discovery of Triazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys

Hoyt, Scott B ; Petrilli, Whitney ; London, Clare ; Liang, Gui-Bai ; Tata, Jim ; Hu, Qingzhong ; Yin, Lina ; Van Koppen, Chris J ; Hartmann, Rolf W ; Struthers, Mary ; Wisniewski, Tom ; Ren, Ning ; Bopp, Charlene ; Sok, Andrea ; Cai, Tian-Quan ; Stribling, Sloan ; Pai, Lee-Yuh ; Ma, Xiuying ; Metzger, Joe ; Verras

ACS medicinal chemistry letters, 13 August 2015, Vol.6(8), pp.861-5 [Peer Reviewed Journal]

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6
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Synthesis, stereochemical determination and biochemical characterization of the enantiomeric phosphate esters of the novel immunosuppressive agent FTY720

Hale, Jeffrey J ; Yan, Lin ; Neway, William E ; Hajdu, Richard ; Bergstrom, James D ; Milligan, James A ; Shei, Gan-Ju ; Chrebet, Gary L ; Thornton, Rosemary A ; Card, Deborah ; Rosenbach, Mark ; Hughrosen ; Mandala, Suzanne

Bioorganic & Medicinal Chemistry, 15 September 2004, Vol.12(18), pp.4803-4807 [Peer Reviewed Journal]

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7
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Discovery of potent 3,5-diphenyl-1,2,4-oxadiazole sphingosine-1-phosphate-1 (S1P1) receptor agonists with exceptional selectivity against S1P2 and S1P3

Li, Zhen ; Chen, Weirong ; Hale, Jeffrey J ; Lynch, Christopher L ; Mills, Sander G ; Hajdu, Richard ; Keohane, Carol Ann ; Rosenbach, Mark J ; Milligan, James A ; Shei, Gan-Ju ; Chrebet, Gary ; Parent, Stephen A ; Bergstrom, James ; Card, Deborah ; Forrest, Michael ; Quackenbush, Elizabeth J ; Wickham, L Alexandra ; Vargas, Hugo ; Evans, Rose M ; Rosen

Journal of medicinal chemistry, 06 October 2005, Vol.48(20), pp.6169-73 [Peer Reviewed Journal]

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8
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Discovery of MK-3168: A PET Tracer for Imaging Brain Fatty Acid Amide Hydrolase

Liu, Ping ; Hamill, Terence G ; Chioda, Marc ; Chobanian, Harry ; Fung, Selena ; Guo, Yan ; Chang, Linda ; Bakshi, Raman ; Hong, Qingmei ; Dellureficio, James ; Lin, Linus S ; Abbadie, Catherine ; Alexander, Jessica ; Jin, Hong ; Mandala, Suzanne ; Shiao, Lin-Lin ; Li, Wenping ; Sanabria, Sandra ; Williams, David ; Zeng

ACS medicinal chemistry letters, 13 June 2013, Vol.4(6), pp.509-13 [Peer Reviewed Journal]

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9
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Discovery of Benzimidazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys

Hoyt, Scott B ; Park, Min K ; London, Clare ; Xiong, Yusheng ; Tata, Jim ; Bennett, D Jonathan ; Cooke, Andrew ; Cai, Jiaqiang ; Carswell, Emma ; Robinson, John ; Maclean, John ; Brown, Lindsay ; Belshaw, Simone ; Clarkson, Thomas R ; Liu, Kun ; Liang, Gui-Bai ; Struthers, Mary ; Cully, Doris ; Wisniewski, Tom ; Ren

ACS medicinal chemistry letters, 14 May 2015, Vol.6(5), pp.573-8 [Peer Reviewed Journal]

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10
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Pharmacological AMPK activation induces transcriptional responses congruent to exercise in skeletal and cardiac muscle, adipose tissues and liver

Muise, Eric S ; Guan, Hong-Ping ; Liu, Jinqi ; Nawrocki, Andrea R ; Yang, Xiaodong ; Wang, Chuanlin ; Rodríguez, Carlos G ; Zhou, Dan ; Gorski, Judith N ; Kurtz, Marc M ; Feng, Danqing ; Leavitt, Kenneth J ; Wei, Lan ; Wilkening, Robert R ; Apgar, James M ; Xu, Shiyao ; Lu, Ku ; Feng, Wen ; Li

PloS one, 2019, Vol.14(2), pp.e0211568 [Peer Reviewed Journal]

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11
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SAR studies of 3-arylpropionic acids as potent and selective agonists of sphingosine-1-phosphate receptor-1 (S1P 1) with enhanced pharmacokinetic properties

Yan, Lin ; Huo, Pei ; Hale, Jeffrey J ; Mills, Sander G ; Hajdu, Richard ; Keohane, Carol A ; Rosenbach, Mark J ; Milligan, James A ; Shei, Gan-Ju ; Chrebet, Gary ; Bergstrom, James ; Card, Deborah ; Mandala, Suzanne M

Bioorganic & Medicinal Chemistry Letters, 2007, Vol.17(3), pp.828-831 [Peer Reviewed Journal]

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12
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Highly selective and potent agonists of sphingosine-1-phosphate 1 (S1P 1) receptor

Vachal, Petr ; Toth, Leslie M ; Hale, Jeffrey J ; Yan, Lin ; Mills, Sander G ; Chrebet, Gary L ; Koehane, Carol A ; Hajdu, Richard ; Milligan, James A ; Rosenbach, Mark J ; Mandala, Suzanne

Bioorganic & Medicinal Chemistry Letters, 2006, Vol.16(14), pp.3684-3687 [Peer Reviewed Journal]

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13
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The discovery of 3-(N-alkyl)aminopropylphosphonic acids as potent S1P receptor agonists

Hale, Jeffrey J ; Doherty, George ; Toth, Leslie ; Li, Zhen ; Mills, Sander G ; Hajdu, Richard ; Ann Keohane, Carol ; Rosenbach, Mark ; Milligan, James ; Shei, Gan-Ju ; Chrebet, Gary ; Bergstrom, James ; Card, Deborah ; Rosen, Hugh ; Mandala, Suzanne

Bioorganic & Medicinal Chemistry Letters, 2004, Vol.14(13), pp.3495-3499 [Peer Reviewed Journal]

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14
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Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists

Mandala, Suzanne ; Hajdu, Richard ; Bergstrom, James ; Quackenbush, Elizabeth ; Xie, Jenny ; Milligan, James ; Thornton, Rosemary ; Shei, Gan-Ju ; Card, Deborah ; Keohane, Carolann ; Rosenbach, Mark ; Hale, Jeffrey ; Lynch, Christopher L ; Rupprecht, Kathleen ; Parsons, William ; Rosen, Hugh

Science (New York, N.Y.), 12 April 2002, Vol.296(5566), pp.346-9 [Peer Reviewed Journal]

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15
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2-Aryl(pyrrolidin-4-yl)acetic acids are potent agonists of sphingosine-1-phosphate (S1P) receptors

Yan, Lin ; Budhu, Richard ; Huo, Pei ; Lynch, Christopher L ; Hale, Jeffrey J ; Mills, Sander G ; Hajdu, Richard ; Keohane, Carol A ; Rosenbach, Mark J ; Milligan, James A ; Shei, Gan-Ju ; Chrebet, Gary ; Bergstrom, James ; Card, Deborah ; Mandala, Suzanne M

Bioorganic & Medicinal Chemistry Letters, 01 July 2006, Vol.16(13), pp.3564-3568 [Peer Reviewed Journal]

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16
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2,5-Disubstituted pyrrolidine carboxylates as potent, orally active sphingosine-1-phosphate (S1P) receptor agonists

Colandrea, Vincent J ; Legiec, Irene E ; Huo, Pei ; Yan, Lin ; Hale, Jeffrey J ; Mills, Sander G ; Bergstrom, James ; Card, Deborah ; Chebret, Gary ; Hajdu, Richard ; Keohane, Carol Ann ; Milligan, James A ; Rosenbach, Mark J ; Shei, Gan-Ju ; Mandala, Suzanne M

Bioorganic & Medicinal Chemistry Letters, 2006, Vol.16(11), pp.2905-2908 [Peer Reviewed Journal]

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17
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Discovery of 3-arylpropionic acids as potent agonists of sphingosine-1-phosphate receptor-1 (S1P 1) with high selectivity against all other known S1P receptor subtypes

Yan, Lin ; Huo, Pei ; Doherty, George ; Toth, Lesile ; Hale, Jeffrey J ; Mills, Sander G ; Hajdu, Richard ; Keohane, Carol A ; Rosenbach, Mark J ; Milligan, James A ; Shei, Gan-Ju ; Chrebet, Gary ; Bergstrom, James ; Card, Deborah ; Quackenbush, Elizabeth ; Wickham, Alexandra ; Mandala, Suzanne M

Bioorganic & Medicinal Chemistry Letters, 2006, Vol.16(14), pp.3679-3683 [Peer Reviewed Journal]

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18
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Selecting against S1P 3 enhances the acute cardiovascular tolerability of 3-(N-benzyl)aminopropylphosphonic acid S1P receptor agonists

Hale, Jeffrey J ; Doherty, George ; Toth, Leslie ; Mills, Sander G ; Hajdu, Richard ; Ann Keohane, Carol ; Rosenbach, Mark ; Milligan, James ; Shei, Gan-Ju ; Chrebet, Gary ; Bergstrom, James ; Card, Deborah ; Forrest, Michael ; Sun, Shu-Yu ; West, Sarah ; Xie, Huijuan ; Nomura, Naomi ; Rosen, Hugh ; Mandala, Suzanne

Bioorganic & Medicinal Chemistry Letters, 2004, Vol.14(13), pp.3501-3505 [Peer Reviewed Journal]

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19
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Design and synthesis of conformationally constrained 3-(N-alkylamino)propylphosphonic acids as potent agonists of sphingosine-1-phosphate (S1P) receptors

Yan, Lin ; Hale, Jeffrey J ; Lynch, Christopher L ; Budhu, Richard ; Gentry, Amy ; Mills, Sander G ; Hajdu, Richard ; Keohane, Carol Ann ; Rosenbach, Mark J ; Milligan, James A ; Shei, Gan-Ju ; Chrebet, Gary ; Bergstrom, James ; Card, Deborah ; Rosen, Hugh ; Mandala, Suzanne M

Bioorganic & medicinal chemistry letters, 04 October 2004, Vol.14(19), pp.4861-6 [Peer Reviewed Journal]

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Potent S1P receptor agonists replicate the pharmacologic actions of the novel immune modulator FTY720

Hale, Jeffrey J ; Neway, William ; Mills, Sander G ; Hajdu, Richard ; Ann Keohane, Carol ; Rosenbach, Mark ; Milligan, James ; Shei, Gan-Ju ; Chrebet, Gary ; Bergstrom, James ; Card, Deborah ; Koo, Gloria C ; Koprak, Sam L ; Jackson, Jesse J ; Rosen, Hugh ; Mandala, Suzanne

Bioorganic & Medicinal Chemistry Letters, 2004, Vol.14(12), pp.3351-3355 [Peer Reviewed Journal]

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21
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Design and synthesis of conformationally constrained 3-( N-alkylamino)propylphosphonic acids as potent agonists of sphingosine-1-phosphate (S1P) receptors

Yan, Lin ; Hale, Jeffrey J ; Lynch, Christopher L ; Budhu, Richard ; Gentry, Amy ; Mills, Sander G ; Hajdu, Richard ; Keohane, Carol Ann ; Rosenbach, Mark J ; Milligan, James A ; Shei, Gan-Ju ; Chrebet, Gary ; Bergstrom, James ; Card, Deborah ; Rosen, Hugh ; Mandala, Suzanne M

Bioorganic & Medicinal Chemistry Letters, 2004, Vol.14(19), pp.4861-4866 [Peer Reviewed Journal]

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22
Hyalodendrosides A and B, Antifungal Triterpenoid Glycosides from a Lignicolous Hyphomycete, Hyalodendron Species
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Hyalodendrosides A and B, Antifungal Triterpenoid Glycosides from a Lignicolous Hyphomycete, Hyalodendron Species

Bills, Gerald ; Dombrowski, Anne ; Morris, Sandra A. ; Hensens, Otto ; Liesch, Jerrold M. ; Zink, Deborah L. ; Onishi, Jan ; Meinz, Maria S. ; Rosenbach, Mark ; Thompson, John R. ; Schwartz, Robert E.

Journal of Natural Products, 01/2000, Vol.63(1), pp.90-94 [Peer Reviewed Journal]

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