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Using Electron Paramagnetic Resonance Spectroscopy To Facilitate Problem Solving in Pharmaceutical Research and Development

Mangion, Ian ; Liu, Yizhou ; Reibarkh, Mikhail ; Williamson, R Thomas ; Welch, Christopher J

The Journal of organic chemistry, 19 August 2016, Vol.81(16), pp.6937-44 [Peer Reviewed Journal]

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Discovery of a Photoinduced Dark Catalytic Cycle Using in Situ LED-NMR Spectroscopy

Lehnherr, Dan ; Ji, Yining ; Neel, Andrew J ; Cohen, Ryan D ; Brunskill, Andrew P J ; Yang, Junyu ; Reibarkh, Mikhail

Journal of the American Chemical Society, 24 October 2018, Vol.140(42), pp.13843-13853 [Peer Reviewed Journal]

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A multifunctional catalyst that stereoselectively assembles prodrugs

Dirocco, Daniel A ; Ji, Yining ; Sherer, Edward C ; Klapars, Artis ; Reibarkh, Mikhail ; Dropinski, James ; Mathew, Rose ; Maligres, Peter ; Hyde, Alan M ; Limanto, John ; Brunskill, Andrew ; Ruck, Rebecca T ; Campeau, Louis-Charles ; Davies, Ian W

Science (New York, N.Y.), 28 April 2017, Vol.356(6336), pp.426-430 [Peer Reviewed Journal]

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Facile Quantum Yield Determination via NMR Actinometry

Ji, Yining ; Dirocco, Daniel A ; Hong, Cynthia M ; Wismer, Michael K ; Reibarkh, Mikhail

Organic letters, 20 April 2018, Vol.20(8), pp.2156-2159 [Peer Reviewed Journal]

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Promotion of a Ti-Mediated Mannich Reaction by a Proton Source

Limanto, John ; Yoshikawa, Naoki ; Reamer, Robert A ; Tan, Lushi ; Brunskill, Andrew ; Reibarkh, Mikhail

The Journal of organic chemistry, 15 January 2016, Vol.81(2), pp.723-8 [Peer Reviewed Journal]

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6
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Asymmetric synthesis of cyclic indole aminals via 1,3-stereoinduction

Li, Hongmei ; Chen, Cheng-Yi ; Nguyen, Hoa ; Cohen, Ryan ; Maligres, Peter E ; Yasuda, Nobuyoshi ; Mangion, Ian ; Zavialov, Ilia ; Reibarkh, Mikhail ; Chung, John Y L

The Journal of organic chemistry, 19 September 2014, Vol.79(18), pp.8533-40 [Peer Reviewed Journal]

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7
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Visualizing small differences using subtractive chromatographic analysis

Zawatzky, Kerstin ; Reibarkh, Mikhail ; Canfield, Nicole ; Wang, Ting-Chuan ; Li, Shanren ; Du, Liangcheng ; Welch, Christopher J

Journal of Chromatography A, 14 October 2016, Vol.1468, pp.245-249 [Peer Reviewed Journal]

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8
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Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains

Miao, Benchun ; Skidan, Igor ; Yang, Jinsheng ; Lugovskoy, Alexey ; Reibarkh, Mikhail ; Long, Kai ; Brazell, Tres ; Durugkar, Kulbhushan A ; Maki, Jenny ; Ramana, C V ; Schaffhausen, Brian ; Wagner, Gerhard ; Torchilin, Vladimir ; Yuan, Junying ; Degterev, Alexei

Proceedings of the National Academy of Sciences of the United States of America, 16 November 2010, Vol.107(46), pp.20126-31 [Peer Reviewed Journal]

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9
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Band-Selective 2D HSQMBC: A Universal Technique for Detection and Measurement of Cl Isotope Effects for C Nuclei

Saurí, Josep ; Reibarkh, Mikhail ; Zhang, Ting ; Cohen, Ryan D ; Wang, Xiao ; Molinski, Tadeusz F ; Martin, Gary E ; Williamson, R Thomas

Organic letters, 07 October 2016, Vol.18(19), pp.4786-4789 [Peer Reviewed Journal]

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10
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Synthesis of β-carbolines from aldehydes and ketones via the α-siloxy α,β-unsaturated esters

He, Shuwen ; Lai, Zhong ; Yang, David X ; Hong, Qingmei ; Reibarkh, Mikhail ; Nargund, Ravi P ; Hagmann, William K

Tetrahedron Letters, 2010, Vol.51(33), pp.4361-4364 [Peer Reviewed Journal]

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11
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NMR distinction of single- and multiple-mode binding of small-molecule protein ligands

Reibarkh, Mikhail ; Malia, Thomas J ; Wagner, Gerhard

Journal of the American Chemical Society, 22 February 2006, Vol.128(7), pp.2160-1 [Peer Reviewed Journal]

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12
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Oxyfunctionalization of the Remote C−H Bonds of Aliphatic Amines by Decatungstate Photocatalysis

Schultz, Danielle M. ; Lévesque, François ; Dirocco, Daniel A. ; Reibarkh, Mikhail ; Ji, Yining ; Joyce, Leo A. ; Dropinski, James F. ; Sheng, Huaming ; Sherry, Benjamin D. ; Davies, Ian W.

Angewandte Chemie International Edition, 27 November 2017, Vol.56(48), pp.15274-15278 [Peer Reviewed Journal]

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Discovery of N-Bis(4-methoxyphenyl)methyl-4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamide (MK-8617), an Orally Active Pan-Inhibitor of Hypoxia-Inducible Factor Prolyl Hydroxylase 1-3 (HIF PHD1-3) for the Treatment of Anemia

Debenham, John S ; Madsen-Duggan, Christina ; Clements, Matthew J ; Walsh, Thomas F ; Kuethe, Jeffrey T ; Reibarkh, Mikhail ; Salowe, Scott P ; Sonatore, Lisa M ; Hajdu, Richard ; Milligan, James A ; Visco, Denise M ; Zhou, Dan ; Lingham, Russell B ; Stickens, Dominique ; Demartino, Julie A ; Tong, Xinchun ; Wolff, Michael ; Pang, Jianmei ; Miller, Randy R ; Sherer, Edward C ; Hale, Jeffrey J

Journal of medicinal chemistry, 22 December 2016, Vol.59(24), pp.11039-11049 [Peer Reviewed Journal]

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14
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1 J CC ‐edited HSQC‐1, n ‐ADEQUATE: a new paradigm for simultaneous direct and long‐range carbon–carbon correlation

Martin, Gary E. ; Blinov, Kirill A. ; Reibarkh, Mikhail ; Williamson, R. Thomas

Magnetic Resonance in Chemistry, November 2012, Vol.50(11), pp.722-728 [Peer Reviewed Journal]

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15
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Broadband inversion of 1JCC responses in 1,n-ADEQUATE spectra

Reibarkh, Mikhail ; Williamson, R. Thomas ; Martin, Gary E ; Bermel, Wolfgang

Journal of Magnetic Resonance, November 2013, Vol.236, pp.126-133 [Peer Reviewed Journal]

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16
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Structure elucidation of uniformly 13C labeled small molecule natural products

Reibarkh, Mikhail ; Wyche, Thomas P. ; Saurí, Josep ; Bugni, Tim S. ; Martin, Gary E. ; Thomas Williamson, R.

Magnetic Resonance in Chemistry, December 2015, Vol.53(12), pp.996-1002 [Peer Reviewed Journal]

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17
NMR Study of Monomer−Dimer Equilibrium of Barstar in Solution
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NMR Study of Monomer−Dimer Equilibrium of Barstar in Solution

Korchuganov, Denis S. ; Nolde, Svetlana B. ; Reibarkh, Mikhail Ya. ; Orekhov, Vladislav Yu. ; Schulga, Alexey A. ; Ermolyuk, Yaroslav S. ; Kirpichnikov, Mikhail P. ; Arseniev, Alexander S.

Journal of the American Chemical Society, 03/2001, Vol.123(9), pp.2068-2069 [Peer Reviewed Journal]

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18
Enabling Efficient Late-Stage Functionalization of Drug-Like Molecules with LC-MS and Reaction-Driven Data Processing: Enabling Efficient Late-Stage Functionalization of Drug-Like Molecules with LC-MS and Reaction-Driven Data Processing
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Enabling Efficient Late-Stage Functionalization of Drug-Like Molecules with LC-MS and Reaction-Driven Data Processing: Enabling Efficient Late-Stage Functionalization of Drug-Like Molecules with LC-MS and Reaction-Driven Data Processing

Yao, Huifang ; Liu, Yong ; Tyagarajan, Sriram ; Streckfuss, Eric ; Reibarkh, Mikhail ; Chen, Kuanchang ; Zamora, Ismael ; Fontaine, Fabien ; Goracci, Laura ; Helmy, Roy ; Bateman, Kevin P. ; Krska, Shane W.

European Journal of Organic Chemistry, 12/22/2017, Vol.2017(47), pp.7122-7126 [Peer Reviewed Journal]

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19
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Coniothyrione: anatomy of a structure revision

Martin, Gary E. ; Buevich, Alexei V. ; Reibarkh, Mikhail ; Singh, Sheo B. ; Ondeyka, John G. ; Williamson, R. Thomas

Magnetic Resonance in Chemistry, July 2013, Vol.51(7), pp.383-390 [Peer Reviewed Journal]

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20
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The protecting-group free selective 3'-functionalization of nucleosides

Mccabe Dunn, Jamie M ; Reibarkh, Mikhail ; Sherer, Edward C ; Orr, Robert K ; Ruck, Rebecca T ; Simmons, Bryon ; Bellomo, Ana

Chemical science, 01 April 2017, Vol.8(4), pp.2804-2810 [Peer Reviewed Journal]

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21
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Eukaryotic initiation factor (eIF) 1 carries two distinct eIF5-binding faces important for multifactor assembly and AUG selection

Reibarkh, Mikhail ; Yamamoto, Yasufumi ; Singh, Chingakham Ranjit ; Del Rio, Federico ; Fahmy, Amr ; Lee, Bumjun ; Luna, Rafael E ; Ii, Miki ; Wagner, Gerhard ; Asano, Katsura

The Journal of biological chemistry, 11 January 2008, Vol.283(2), pp.1094-103 [Peer Reviewed Journal]

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22
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Selective Pharmacological Targeting of a DEAD Box RNA Helicase

Lindqvist, Lisa ; Oberer, Monika ; Reibarkh, Mikhail ; Cencic, Regina ; Bordeleau, Marie-Eve ; Vogt, Emily ; Marintchev, Assen ; Tanaka, Junichi ; Fagotto, Francois ; Altmann, Michael ; Pelletier, Jerry ; Wagner, Gerhard

Lindqvist, Lisa, Monika Oberer, Mikhail Reibarkh, Regina Cencic, Marie-Eve Bordeleau, Emily Vogt, Assen Marintchev, et al. 2008. Selective pharmacological targeting of a DEAD box RNA helicase. PLoS ONE 3(2): e1583. [Peer Reviewed Journal]

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23
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C NMR-Based Approaches for Solving Challenging Stereochemical Problems

Ndukwe, Ikenna E ; Brunskill, Andrew ; Gauthier, Donald R ; Zhong, Yong-Li ; Martin, Gary E ; Williamson, R Thomas ; Reibarkh, Mikhail ; Liu, Yizhou

Organic letters, 22 May 2019 [Peer Reviewed Journal]

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24
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Oxyfunctionalization of the Remote C−H Bonds of Aliphatic Amines by Decatungstate Photocatalysis

Schultz, Danielle M. ; Lévesque, François ; Dirocco, Daniel A. ; Reibarkh, Mikhail ; Ji, Yining ; Joyce, Leo A. ; Dropinski, James F. ; Sheng, Huaming ; Sherry, Benjamin D. ; Davies, Ian W.

Angewandte Chemie, 27 November 2017, Vol.129(48), pp.15476-15480 [Peer Reviewed Journal]

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25
Mechanistic Study of a Re-Catalyzed Monoalkylation of Phenols
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Mechanistic Study of a Re-Catalyzed Monoalkylation of Phenols

Lehnherr, Dan ; Wang, Xiao ; Peng, Feng ; Reibarkh, Mikhail ; Weisel, Mark ; Maloney, Kevin M.

Organometallics, 01/14/2019, Vol.38(1), pp.103-118 [Peer Reviewed Journal]

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26
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Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G

Moerke, Nathan J ; Aktas, Huseyin ; Chen, Han ; Cantel, Sonia ; Reibarkh, Mikhail Y ; Fahmy, Amr ; Gross, John D ; Degterev, Alexei ; Yuan, Junying ; Chorev, Michael ; Halperin, Jose A ; Wagner, Gerhard Cantel, Sonia (Editor)

Cell, 26 January 2007, Vol.128(2), pp.257-67 [Peer Reviewed Journal]

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27
Process Development of the HCV NS5B Site D Inhibitor MK-8876
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Process Development of the HCV NS5B Site D Inhibitor MK-8876

Williams, Michael J. ; Chen, Qinghao ; Codan, Lorenzo ; Dermenjian, Renee K. ; Dreher, Spencer ; Gibson, Andrew W. ; He, Xianliang ; Jin, Yan ; Keen, Stephen P. ; Lee, Alfred Y. ; Lieberman, David R. ; Lin, Wei ; Liu, Guiquan ; Mclaughlin, Mark ; Reibarkh, Mikhail ; Scott, Jeremy P. ; Strickfuss, Sophie ; Tan, Lushi ; Varsolona, Richard J. ; Wen, Feng

Organic Process Research & Development, 07/15/2016, Vol.20(7), pp.1227-1238 [Peer Reviewed Journal]

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28
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Discovery of Novel Indoline Cholesterol Ester Transfer Protein Inhibitors (CETP) through a Structure-Guided Approach

Wilson, Jonathan E ; Kurukulasuriya, Ravi ; Reibarkh, Mikhail ; Reiter, Maud ; Zwicker, Aaron ; Zhao, Kake ; Zhang, Fengqi ; Anand, Rajan ; Colandrea, Vincent J ; Cumiskey, Anne-Marie ; Crespo, Alejandro ; Duffy, Ruth A ; Murphy, Beth Ann ; Mitra, Kaushik ; Johns, Douglas G ; Duffy, Joseph L ; Vachal, Petr

ACS medicinal chemistry letters, 10 March 2016, Vol.7(3), pp.261-5 [Peer Reviewed Journal]

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29
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A new class of prolylcarboxypeptidase inhibitors, Part 2: The aminocyclopentanes

Graham, Thomas H ; Liu, Wensheng ; Verras, Andreas ; Reibarkh, Mikhail ; Bleasby, Kelly ; Bhatt, Urmi R ; Chen, Qing ; Garcia-Calvo, Margarita ; Geissler, Wayne M ; Gorski, Judith N ; He, Huaibing ; Lassman, Michael E ; Lisnock, Jeanmarie ; Li, Xiaohua ; Shen, Zhu ; Tong, Xinchun ; Tung, Elaine C ; Wiltsie, Judyann ; Xie, Dan ; Xu, Suoyu ; Xiao, Jianying ; Hale, Jeffrey J ; Pinto, Shirly ; Shen, Dong-Ming

Bioorganic & Medicinal Chemistry Letters, 15 April 2012, Vol.22(8), pp.2818-2822 [Peer Reviewed Journal]

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30
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Enabling Efficient Late‐Stage Functionalization of Drug‐Like Molecules with LC‐MS and Reaction‐Driven Data Processing

Yao, Huifang ; Liu, Yong ; Tyagarajan, Sriram ; Streckfuss, Eric ; Reibarkh, Mikhail ; Chen, Kuanchang ; Zamora, Ismael ; Fontaine, Fabien ; Goracci, Laura ; Helmy, Roy ; Bateman, Kevin P. ; Krska, Shane W.

European Journal of Organic Chemistry, 22 December 2017, Vol.2017(47), pp.7122-7126 [Peer Reviewed Journal]

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31
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CCDC 1432358: Experimental Crystal Structure Determination

Limanto, John ; Yoshikawa, Naoki ; Reamer, Robert A. ; Tan, Lushi ; Brunskill, Andrew ; Reibarkh, Mikhail

2016

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32
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CCDC 1432359: Experimental Crystal Structure Determination

Limanto, John ; Yoshikawa, Naoki ; Reamer, Robert A. ; Tan, Lushi ; Brunskill, Andrew ; Reibarkh, Mikhail

2016

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33
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The C-Terminal Domain of Eukaryotic Initiation Factor 5 Promotes Start Codon Recognition by Its Dynamic Interplay with eIF1 and eIF2β

Luna, Rafael e ; Arthanari, Haribabu ; Hiraishi, Hiroyuki ; Nanda, Jagpreet ; Martin-Marcos, Pilar ; Markus, Michelle a ; Akabayov, Barak ; Milbradt, Alexander g ; Luna, Lunet e ; Seo, Hee-Chan ; Hyberts, Sven g ; Fahmy, Amr ; Reibarkh, Mikhail ; Miles, David ; Hagner, Patrick r ; O'Day, Elizabeth m ; Yi, Tingfang ; Marintchev, Assen ; Hinnebusch, Alan G ; Lorsch, Jon R ; Asano, Katsura ; Wagner, Gerhard

Cell Reports, 28 June 2012, Vol.1(6), pp.689-702 [Peer Reviewed Journal]

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34
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The C-terminal domain of eukaryotic initiation factor 5 promotes start codon recognition by its dynamic interplay with eIF1 and eIF2 beta

Luna, Rafael E. ; Arthanari, Haribabu ; Hiraishi, Hiroyuki ; Nanda, Jagpreed ; Martin - Marcos, Pilar ; Markus, Michelle A. ; Akabayov, Barak ; Milbradt, Alexander G. ; Luna, Lunet E. ; Seo, Hee - Chan ; Hyberts, Sven G. ; Fahmy, Amr ; Reibarkh, Mikhail ; Miles, David ; Hagner, Patrick R. ; O'Day, Elizabeth M. ; Yi, Tingfang ; Marintchev, Assen ; Hinnebusch, Alan G. ; Lorsch, John R. ; Asano, Katsura ; Wagner, Gerhard

2012-06-28

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35
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Substituted fused bicyclic pyrrolizinones as potent, orally bioavailable hNK 1 antagonists

Morriello, Gregori J ; Mills, Sander G ; Johnson, Tricia ; Reibarkh, Mikhail ; Chicchi, Gary ; Demartino, Julie ; Kurtz, Marc ; Davies, P ; Tsao, K.L.C ; Zheng, Song ; Tong, Xinchun ; Carlson, Emma ; Townson, Karen ; Tattersall, F.D ; Wheeldon, Alan ; Boyce, Susan ; Collinson, Neil ; Rupniak, Nadia ; Moore, Stephen ; Devita, Robert J

Bioorganic & Medicinal Chemistry Letters, 2010, Vol.20(6), pp.2007-2012 [Peer Reviewed Journal]

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36
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Interatomic potentials and solvation parameters from protein engineering data for buried residues

Lomize, Andrei L. ; Reibarkh, Mikhail Y. ; Pogozheva, Irina D.

Protein Science, August 2002, Vol.11(8), pp.1984-2000 [Peer Reviewed Journal]

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37
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CCDC 1852119: Experimental Crystal Structure Determination

Lehnherr, Dan ; Ji, Yining ; Neel, Andrew J. ; Cohen, Ryan D. ; Brunskill, Andrew P. J. ; Yang, Junyu ; Reibarkh, Mikhail

2018

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38
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CCDC 1525737: Experimental Crystal Structure Determination

Dunn, Jamie M. McCabe ; Reibarkh, Mikhail ; Sherer, Edward C. ; Orr, Robert K. ; Ruck, Rebecca T. ; Simmons, Bryon ; Bellomo, Ana

2017

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39
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CCDC 1525736: Experimental Crystal Structure Determination

Dunn, Jamie M. McCabe ; Reibarkh, Mikhail ; Sherer, Edward C. ; Orr, Robert K. ; Ruck, Rebecca T. ; Simmons, Bryon ; Bellomo, Ana

2017

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