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Cytokine inhibition. Control of receptor appetite

Whicher, J

Nature, 12 April 1990, Vol.344(6267), pp.584 [Peer Reviewed Journal]

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Combinatorial library of improved peptide aptamers, CLIPs to inhibit RAGE signal transduction in mammalian cells

Reverdatto, Sergey ; Rai, Vivek ; Xue, Jing ; Burz, David S ; Schmidt, Ann Marie ; Shekhtman, Alexander

PloS one, 2013, Vol.8(6), pp.e65180 [Peer Reviewed Journal]

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SIRPα-Antibody Fusion Proteins Selectively Bind and Eliminate Dual Antigen-Expressing Tumor Cells

Piccione, Emily C ; Juarez, Silvia ; Tseng, Serena ; Liu, Jie ; Stafford, Melissa ; Narayanan, Cyndhavi ; Wang, Lijuan ; Weiskopf, Kipp ; Majeti, Ravindra

Clinical cancer research : an official journal of the American Association for Cancer Research, 15 October 2016, Vol.22(20), pp.5109-5119 [Peer Reviewed Journal]

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Purification, cloning, expression and biological characterization of an interleukin-1 receptor antagonist protein

Carter, D B ; Deibel, M R ; Dunn, C J ; Tomich, C S ; Laborde, A L ; Slightom, J L ; Berger, A E ; Bienkowski, M J ; Sun, F F ; Mcewan, R N

Nature, 12 April 1990, Vol.344(6267), pp.633-8 [Peer Reviewed Journal]

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Novel sulfated polysaccharides disrupt cathelicidins, inhibit RAGE and reduce cutaneous inflammation in a mouse model of rosacea

Zhang, Jianxing ; Xu, Xiaoyu ; Rao, Narayanam V ; Argyle, Brian ; Mccoard, Lindsi ; Rusho, William J ; Kennedy, Thomas P ; Prestwich, Glenn D ; Krueger, Gerald

PloS one, 09 February 2011, Vol.6(2), pp.e16658 [Peer Reviewed Journal]

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On the mechanism of an asymmetric alpha,beta-unsaturated carboxylic acid hydrogenation: application to the synthesis of a PGD2 receptor antagonist

Tellers, David M ; Mcwilliams, J Christopher ; Humphrey, Guy ; Journet, Michel ; Dimichele, Lisa ; Hinksmon, Joseph ; Mckeown, Arlene E ; Rosner, Thorsten ; Sun, Yongkui ; Tillyer, Richard D

Journal of the American Chemical Society, 27 December 2006, Vol.128(51), pp.17063-73 [Peer Reviewed Journal]

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S100P-derived RAGE antagonistic peptide reduces tumor growth and metastasis

Arumugam, Thiruvengadam ; Ramachandran, Vijaya ; Gomez, Sobeyda B ; Schmidt, Ann M ; Logsdon, Craig D

Clinical cancer research : an official journal of the American Association for Cancer Research, 15 August 2012, Vol.18(16), pp.4356-64 [Peer Reviewed Journal]

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Dendritic cell immunoreceptor is a new target for anti-AIDS drug development: identification of DCIR/HIV-1 inhibitors

Lambert, Alexandra A ; Azzi, Arezki ; Lin, Sheng-Xiang ; Allaire, Geneviève ; St-Gelais, Karianne P ; Tremblay, Michel J ; Gilbert, Caroline

PloS one, 2013, Vol.8(7), pp.e67873 [Peer Reviewed Journal]

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Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist

Eisenberg, S P ; Evans, R J ; Arend, W P ; Verderber, E ; Brewer, M T ; Hannum, C H ; Thompson, R C

Nature, 25 January 1990, Vol.343(6256), pp.341-6 [Peer Reviewed Journal]

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10
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Antagonism of the prostaglandin D2 receptor 1 suppresses nicotinic acid-induced vasodilation in mice and humans

Cheng, Kang ; Wu, Tsuei-Ju ; Wu, Kenneth K ; Sturino, Claudio ; Metters, Kathleen ; Gottesdiener, Keith ; Wright, Samuel D ; Wang, Zhaoyin ; O'Neill, Gary ; Lai, Eseng ; Waters, M Gerard

Proceedings of the National Academy of Sciences of the United States of America, 25 April 2006, Vol.103(17), pp.6682-7 [Peer Reviewed Journal]

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11
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Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor

Hannum, C H ; Wilcox, C J ; Arend, W P ; Joslin, F G ; Dripps, D J ; Heimdal, P L ; Armes, L G ; Sommer, A ; Eisenberg, S P ; Thompson, R C

Nature, 25 January 1990, Vol.343(6256), pp.336-40 [Peer Reviewed Journal]

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12
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Interleukin 1 receptor antagonist is a member of the interleukin 1 gene family: evolution of a cytokine control mechanism

Eisenberg, S P ; Brewer, M T ; Verderber, E ; Heimdal, P ; Brandhuber, B J ; Thompson, R C

Proceedings of the National Academy of Sciences of the United States of America, 15 June 1991, Vol.88(12), pp.5232-6 [Peer Reviewed Journal]

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13
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cDNA cloning of an intracellular form of the human interleukin 1 receptor antagonist associated with epithelium

Haskill, S ; Martin, G ; Van Le, L ; Morris, J ; Peace, A ; Bigler, C F ; Jaffe, G J ; Hammerberg, C ; Sporn, S A ; Fong, S

Proceedings of the National Academy of Sciences of the United States of America, 01 May 1991, Vol.88(9), pp.3681-5 [Peer Reviewed Journal]

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14
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2,4-Bis(octadecanoylamino)benzenesulfonic acid sodium salt as a novel scavenger receptor inhibitor with low molecular weight

Yoshiizumi, Kazuya ; Nakajima, Fumio ; Dobashi, Rika ; Nishimura, Noriyasu ; Ikeda, Shoji

Bioorganic & medicinal chemistry letters, 07 June 2004, Vol.14(11), pp.2791-5 [Peer Reviewed Journal]

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Characterization and crystal structure of a high-affinity pentavalent receptor-binding inhibitor for cholera toxin and E. coli heat-labile enterotoxin

Merritt, Ethan A ; Zhang, Zhongsheng ; Pickens, Jason C ; Ahn, Misol ; Hol, Wim G J ; Fan, Erkang

Journal of the American Chemical Society, 31 July 2002, Vol.124(30), pp.8818-24 [Peer Reviewed Journal]

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16
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Coordinated antiinflammatory effects of interleukin 4: interleukin 4 suppresses interleukin 1 production but up-regulates gene expression and synthesis of interleukin 1 receptor antagonist

Vannier, E ; Miller, L C ; Dinarello, C A

Proceedings of the National Academy of Sciences of the United States of America, 01 May 1992, Vol.89(9), pp.4076-80 [Peer Reviewed Journal]

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17
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Interleukin 1 receptor antagonist blocks somnogenic and pyrogenic responses to an interleukin 1 fragment

Opp, M R ; Postlethwaite, A E ; Seyer, J M ; Krueger, J M

Proceedings of the National Academy of Sciences of the United States of America, 01 May 1992, Vol.89(9), pp.3726-30 [Peer Reviewed Journal]

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18
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Interleukin-1 receptor antagonist competitively inhibits the binding of interleukin-1 to the type II interleukin-1 receptor

Granowitz, E V ; Clark, B D ; Mancilla, J ; Dinarello, C A

The Journal of biological chemistry, 05 August 1991, Vol.266(22), pp.14147-50 [Peer Reviewed Journal]

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19
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Discovery of new chemical leads for prostaglandin D2 receptor antagonists

Torisu, Kazuhiko ; Kobayashi, Kaoru ; Iwahashi, Maki ; Egashira, Hiromu ; Nakai, Yoshihiko ; Okada, Yutaka ; Nanbu, Fumio ; Ohuchida, Shuichi ; Nakai, Hisao ; Toda, Masaaki

Bioorganic & medicinal chemistry letters, 06 September 2004, Vol.14(17), pp.4557-62 [Peer Reviewed Journal]

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20
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2-Cycloalkyl phenoxyacetic acid CRTh2 receptor antagonists

Sandham, David A ; Aldcroft, Clive ; Baettig, Urs ; Barker, Lucy ; Beer, David ; Bhalay, Gurdip ; Brown, Zarin ; Dubois, Gerald ; Budd, David ; Bidlake, Louise ; Campbell, Emma ; Cox, Brian ; Everatt, Brian ; Harrison, David ; Leblanc, Catherine J ; Manini, Jodie ; Profit, Rachael ; Stringer, Rowan ; Thompson, Katy S ; Turner

Bioorganic & medicinal chemistry letters, 01 August 2007, Vol.17(15), pp.4347-50 [Peer Reviewed Journal]

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21
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Discovery of a potent and selective prostaglandin D2 receptor antagonist, (3R)-4-(4-chloro-benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopentabindol-3-yl-acetic acid (MK-0524)

Sturino, Claudio F ; O'Neill, Gary ; Lachance, Nicolas ; Boyd, Michael ; Berthelette, Carl ; Labelle, Marc ; Li, Lianhai ; Roy, Bruno ; Scheigetz, John ; Tsou, Nancy ; Aubin, Yves ; Bateman, Kevin P ; Chauret, Nathalie ; Day, Stephen H ; Lévesque, Jean-François ; Seto, Carmai ; Silva

Journal of medicinal chemistry, 22 February 2007, Vol.50(4), pp.794-806 [Peer Reviewed Journal]

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22
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C- and N-terminal residue effect on peptide derivatives' antagonism toward the formyl-peptide receptor

Dalpiaz, Alessandro ; Ferretti, Maria E ; Vertuani, Gianni ; Traniello, Serena ; Scatturin, Angelo ; Spisani, Susanna

European journal of pharmacology, 02 February 2002, Vol.436(3), pp.187-96 [Peer Reviewed Journal]

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23
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The inhibitory receptor LILRB1 modulates the differentiation and regulatory potential of human dendritic cells

Young, Neil T ; Waller, Edward C P ; Patel, Rashmi ; Roghanian, Ali ; Austyn, Jonathan M ; Trowsdale, John

Blood, 15 March 2008, Vol.111(6), pp.3090-6 [Peer Reviewed Journal]

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24
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Isosteric ramatroban analogs: selective and potent CRTH-2 antagonists

Robarge, Michael J ; Bom, David C ; Tumey, L Nathan ; Varga, Norbert ; Gleason, Elizabeth ; Silver, Daniel ; Song, Jianping ; Murphy, Steven M ; Ekema, George ; Doucette, Chris ; Hanniford, Doug ; Palmer, Marc ; Pawlowski, Gary ; Danzig, Joel ; Loftus, Margaret ; Hunady, Karen ; Sherf, Bruce A ; Mays, Robert W ; Stricker-Krongrad, Alain ; Brunden

Bioorganic & medicinal chemistry letters, 15 March 2005, Vol.15(6), pp.1749-53 [Peer Reviewed Journal]

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25
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Identification of an indole series of prostaglandin D2 receptor antagonists

Sturino, Claudio F ; Lachance, Nicolas ; Boyd, Michael ; Berthelette, Carl ; Labelle, Marc ; Li, Lianhai ; Roy, Bruno ; Scheigetz, John ; Tsou, Nancy ; Brideau, Christine ; Cauchon, Elizabeth ; Carriere, Marie-Claude ; Denis, Danielle ; Greig, Gillian ; Kargman, Stacia ; Lamontagne, Sonia ; Mathieu, Marie-Claude ; Sawyer, Nicole ; Slipetz, Deborah ; O'Neill

Bioorganic & medicinal chemistry letters, 01 June 2006, Vol.16(11), pp.3043-8 [Peer Reviewed Journal]

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26
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Blockade of late stages of autoimmune diabetes by inhibition of the receptor for advanced glycation end products

Chen, Yali ; Yan, Shirley Shidu ; Colgan, John ; Zhang, Hui-Ping ; Luban, Jeremy ; Schmidt, Ann Marie ; Stern, David ; Herold, Kevan C

Journal of immunology (Baltimore, Md. : 1950), 15 July 2004, Vol.173(2), pp.1399-405 [Peer Reviewed Journal]

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27
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Synthesis and in vitro evaluation of a selective antagonist and the corresponding radioligand for the prostaglandin D2 receptor CRTH2

Ulven, Trond ; Gallen, Michael J ; Nielsen, Mads C ; Merten, Nicole ; Schmidt, Carola ; Mohr, Klaus ; Tränkle, Christian ; Kostenis, Evi

Bioorganic & medicinal chemistry letters, 01 November 2007, Vol.17(21), pp.5924-7 [Peer Reviewed Journal]

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28
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Induction of β-catenin by the suppression of signal regulatory protein α1 in K562 cells

Maekawa, Tomohiro ; Imoto, Akemi ; Satoh, Takashi ; Okazaki, Toshio ; Takahashi, Shinichiro

International journal of molecular medicine, June 2011, Vol.27(6), pp.865-72 [Peer Reviewed Journal]

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29
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Studies on scavenger receptor inhibitors. Part 1: synthesis and structure-activity relationships of novel derivatives of sulfatides

Yoshiizumi, Kazuya ; Nakajima, Fumio ; Dobashi, Rika ; Nishimura, Noriyasu ; Ikeda, Shoji

Bioorganic & medicinal chemistry, August 2002, Vol.10(8), pp.2445-60 [Peer Reviewed Journal]

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30
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Asymmetric synthesis of a prostaglandin D2 receptor antagonist

Campos, Kevin R ; Journet, Michel ; Lee, Sandra ; Grabowski, Edward J J ; Tillyer, Richard D

The Journal of organic chemistry, 07 January 2005, Vol.70(1), pp.268-74 [Peer Reviewed Journal]

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31
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Metabolic activation of indole-containing prostaglandin D2 receptor 1 antagonists: impacts of glutathione trapping and glucuronide conjugation on covalent binding

Lévesque, Jean-François ; Day, Stephen H ; Chauret, Nathalie ; Seto, Carmai ; Trimble, Laird ; Bateman, Kevin P ; Silva, José M ; Berthelette, Carl ; Lachance, Nicolas ; Boyd, Michael ; Li, Lianhai ; Sturino, Claudio F ; Wang, Zhaoyin ; Zamboni, Robert ; Young, Robert N ; Nicoll-Griffith, Deborah A

Bioorganic & medicinal chemistry letters, 01 June 2007, Vol.17(11), pp.3038-43 [Peer Reviewed Journal]

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32
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Transforming growth factor-beta differentially inhibits MyD88-dependent, but not TRAM- and TRIF-dependent, lipopolysaccharide-induced TLR4 signaling

Naiki, Yoshikazu ; Michelsen, Kathrin S ; Zhang, Wenxuang ; Chen, Shuang ; Doherty, Terence M ; Arditi, Moshe

The Journal of biological chemistry, 18 February 2005, Vol.280(7), pp.5491-5 [Peer Reviewed Journal]

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33
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Inhibition of NK cell activity through TGF-beta 1 by down-regulation of NKG2D in a murine model of head and neck cancer

Dasgupta, Santanu ; Bhattacharya-Chatterjee, Malaya ; O'Malley, Bert W ; Chatterjee, Sunil K

Journal of immunology (Baltimore, Md. : 1950), 15 October 2005, Vol.175(8), pp.5541-50 [Peer Reviewed Journal]

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34
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Selective inhibition of engineered receptors via proximity-accelerated alkylation

Levitsky, Konstantin ; Ciolli, Christopher J ; Belshaw, Peter J

Organic letters, 06 March 2003, Vol.5(5), pp.693-6 [Peer Reviewed Journal]

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35
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Discovery of potent CRTh2 (DP2) receptor antagonists

Birkinshaw, Timothy N ; Teague, Simon J ; Beech, Claire ; Bonnert, Roger V ; Hill, Stephen ; Patel, Anil ; Reakes, Sara ; Sanganee, Hitesh ; Dougall, Iain G ; Phillips, Tim T ; Salter, Sylvia ; Schmidt, Jerzy ; Arrowsmith, Elizabeth C ; Carrillo, Juan J ; Bell, Fiona M ; Paine, Stuart W ; Weaver, Richard

Bioorganic & medicinal chemistry letters, 15 August 2006, Vol.16(16), pp.4287-90 [Peer Reviewed Journal]

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36
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Discovery of orally active prostaglandin D2 receptor antagonists

Torisu, Kazuhiko ; Kobayashi, Kaoru ; Iwahashi, Maki ; Nakai, Yoshihiko ; Onoda, Takahiro ; Nagase, Toshihiko ; Sugimoto, Isamu ; Okada, Yutaka ; Matsumoto, Ryoji ; Nanbu, Fumio ; Ohuchida, Shuichi ; Nakai, Hisao ; Toda, Masaaki

Bioorganic & medicinal chemistry letters, 04 October 2004, Vol.14(19), pp.4891-5 [Peer Reviewed Journal]

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Discovery of a new class of potent, selective, and orally active prostaglandin D2 receptor antagonists

Torisu, Kazuhiko ; Kobayashi, Kaoru ; Iwahashi, Maki ; Nakai, Yoshihiko ; Onoda, Takahiro ; Nagase, Toshihiko ; Sugimoto, Isamu ; Okada, Yutaka ; Matsumoto, Ryoji ; Nanbu, Fumio ; Ohuchida, Shuichi ; Nakai, Hisao ; Toda, Masaaki

Bioorganic & medicinal chemistry, 15 October 2004, Vol.12(20), pp.5361-78 [Peer Reviewed Journal]

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