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Farnesoid X receptor (FXR) activation and FXR genetic variation in inflammatory bowel disease

Nijmeijer, Rian M ; Gadaleta, Raffaella M ; Van Mil, Saskia W C ; Van Bodegraven, Adriaan A ; Crusius, J Bart A ; Dijkstra, Gerard ; Hommes, Daan W ; De Jong, Dirk J ; Stokkers, Pieter C F ; Verspaget, Hein W ; Weersma, Rinse K ; Van Der Woude, C Janneke ; Stapelbroek, Janneke M ; Schipper, Marguerite E I ; Wijmenga, Cisca ; Van Erpecum, Karel J ; Oldenburg, Bas

PloS one, 2011, Vol.6(8), pp.e23745 [Peer Reviewed Journal]

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An extract from date palm fruit (Phoenix dactylifera) acts as a co-agonist ligand for the nuclear receptor FXR and differentially modulates FXR target-gene expression in vitro

Alfaro-Viquez, Emilia ; Roling, Brent F ; Krueger, Christian G ; Rainey, Charlene J ; Reed, Jess D ; Ricketts, Marie-Louise

PloS one, 2018, Vol.13(1), pp.e0190210 [Peer Reviewed Journal]

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Pharmacological activation of the bile acid nuclear farnesoid X receptor is feasible in patients with quiescent Crohn's colitis

Van Schaik, Fiona D M ; Gadaleta, Raffaella M ; Schaap, Frank G ; Van Mil, Saskia W C ; Siersema, Peter D ; Oldenburg, Bas ; Van Erpecum, Karel J

PloS one, 2012, Vol.7(11), pp.e49706 [Peer Reviewed Journal]

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Disruption of communication between peripheral and central trigeminovascular neurons mediates the antimigraine action of 5HT 1B/1D receptor agonists

Levy, Dan ; Jakubowski, Moshe ; Burstein, Rami

Proceedings of the National Academy of Sciences of the United States of America, 23 March 2004, Vol.101(12), pp.4274-9 [Peer Reviewed Journal]

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PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines

Jiang, C ; Ting, A T ; Seed, B

Nature, 01 January 1998, Vol.391(6662), pp.82-6 [Peer Reviewed Journal]

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The soluble guanylyl cyclase activator bay 58-2667 selectively limits cardiomyocyte hypertrophy

Irvine, Jennifer C ; Ganthavee, Virat ; Love, Jane E ; Alexander, Amy E ; Horowitz, John D ; Stasch, Johannes-Peter ; Kemp-Harper, Barbara K ; Ritchie, Rebecca H

PloS one, 2012, Vol.7(11), pp.e44481 [Peer Reviewed Journal]

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Effects of bile acids and the bile acid receptor FXR agonist on the respiratory rhythm in the in vitro brainstem medulla slice of neonatal Sprague-Dawley rats

Zhao, Cong ; Wang, Xianbao ; Cong, Yuling ; Deng, Yi ; Xu, Yijun ; Chen, Aihua ; Yin, Yanru

PloS one, 2014, Vol.9(11), pp.e112212 [Peer Reviewed Journal]

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FXR agonist INT-747 upregulates DDAH expression and enhances insulin sensitivity in high-salt fed Dahl rats

Ghebremariam, Yohannes T ; Yamada, Keisuke ; Lee, Jerry C ; Johnson, Christine L C ; Atzler, Dorothee ; Anderssohn, Maike ; Agrawal, Rani ; Higgins, John P ; Patterson, Andrew J ; Böger, Rainer H ; Cooke, John P

PloS one, 2013, Vol.8(4), pp.e60653 [Peer Reviewed Journal]

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Constitutive androstane receptor ligands modulate the anti-tumor efficacy of paclitaxel in non-small cell lung cancer cells

Fukumasu, Heidge ; Rochetti, Arina L ; Pires, Pedro R L ; Silva, Edson R ; Mesquita, Ligia G ; Strefezzi, Ricardo F ; De Carvalho, Daniel D ; Dagli, Maria L

PloS one, 2014, Vol.9(6), pp.e99484 [Peer Reviewed Journal]

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A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport

Oliver, W R ; Shenk, J L ; Snaith, M R ; Russell, C S ; Plunket, K D ; Bodkin, N L ; Lewis, M C ; Winegar, D A ; Sznaidman, M L ; Lambert, M H ; Xu, H E ; Sternbach, D D ; Kliewer, S A ; Hansen, B C ; Willson, T M

Proceedings of the National Academy of Sciences of the United States of America, 24 April 2001, Vol.98(9), pp.5306-11 [Peer Reviewed Journal]

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FXR controls the tumor suppressor NDRG2 and FXR agonists reduce liver tumor growth and metastasis in an orthotopic mouse xenograft model

Deuschle, Ulrich ; Schüler, Julia ; Schulz, Andreas ; Schlüter, Thomas ; Kinzel, Olaf ; Abel, Ulrich ; Kremoser, Claus

PloS one, 2012, Vol.7(10), pp.e43044 [Peer Reviewed Journal]

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A novel principle for partial agonism of liver X receptor ligands. Competitive recruitment of activators and repressors

Albers, Michael ; Blume, Beatrix ; Schlueter, Thomas ; Wright, Matthew B ; Kober, Ingo ; Kremoser, Claus ; Deuschle, Ulrich ; Koegl, Manfred

The Journal of biological chemistry, 24 February 2006, Vol.281(8), pp.4920-30 [Peer Reviewed Journal]

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St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor

Moore, L B ; Goodwin, B ; Jones, S A ; Wisely, G B ; Serabjit-Singh, C J ; Willson, T M ; Collins, J L ; Kliewer, S A

Proceedings of the National Academy of Sciences of the United States of America, 20 June 2000, Vol.97(13), pp.7500-2 [Peer Reviewed Journal]

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Garlic extract diallyl sulfide (DAS) activates nuclear receptor CAR to induce the Sult1e1 gene in mouse liver

Sueyoshi, Tatsuya ; Green, William D ; Vinal, Kellie ; Woodrum, Tyler S ; Moore, Rick ; Negishi, Masahiko

PloS one, 2011, Vol.6(6), pp.e21229 [Peer Reviewed Journal]

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Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome

Tanaka, Toshiya ; Yamamoto, Joji ; Iwasaki, Satoshi ; Asaba, Hiroshi ; Hamura, Hiroki ; Ikeda, Yukio ; Watanabe, Mitsuhiro ; Magoori, Kenta ; Ioka, Ryoichi X ; Tachibana, Keisuke ; Watanabe, Yuichiro ; Uchiyama, Yasutoshi ; Sumi, Koichi ; Iguchi, Haruhisa ; Ito, Sadayoshi ; Doi, Takefumi ; Hamakubo, Takao ; Naito, Makoto ; Auwerx, Johan ; Yanagisawa

Proceedings of the National Academy of Sciences of the United States of America, 23 December 2003, Vol.100(26), pp.15924-9 [Peer Reviewed Journal]

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16
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Inhibition of endothelin-1-mediated contraction of hepatic stellate cells by FXR ligand

Li, Jiang ; Kuruba, Ramalinga ; Wilson, Annette ; Gao, Xiang ; Zhang, Yifei ; Li, Song

PloS one, 11 November 2010, Vol.5(11), pp.e13955 [Peer Reviewed Journal]

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17
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Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARgamma agonist

Mcintyre, Thomas M ; Pontsler, Aaron V ; Silva, Adriana R ; St Hilaire, Andy ; Xu, Yong ; Hinshaw, Jerald C ; Zimmerman, Guy A ; Hama, Kotaro ; Aoki, Junken ; Arai, Hiroyuki ; Prestwich, Glenn D

Proceedings of the National Academy of Sciences of the United States of America, 07 January 2003, Vol.100(1), pp.131-6 [Peer Reviewed Journal]

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18
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Pharmacological and Genetic Modulation of REV-ERB Activity and Expression Affects Orexigenic Gene Expression

Amador, Ariadna ; Wang, Yongjun ; Banerjee, Subhashis ; Kameneka, Theodore M ; Solt, Laura A ; Burris, Thomas P

PloS one, 2016, Vol.11(3), pp.e0151014 [Peer Reviewed Journal]

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19
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Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes

Maglich, Jodi M ; Parks, Derek J ; Moore, Linda B ; Collins, Jon L ; Goodwin, Bryan ; Billin, Andrew N ; Stoltz, Catherine A ; Kliewer, Steven A ; Lambert, Millard H ; Willson, Timothy M ; Moore, John T

The Journal of biological chemistry, 09 May 2003, Vol.278(19), pp.17277-83 [Peer Reviewed Journal]

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20
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A new class of peroxisome proliferator-activated receptor agonists with a novel binding epitope shows antidiabetic effects

Ostberg, Tove ; Svensson, Stefan ; Selén, Göran ; Uppenberg, Jonas ; Thor, Markus ; Sundbom, Maj ; Sydow-Bäckman, Mona ; Gustavsson, Anna-Lena ; Jendeberg, Lena

The Journal of biological chemistry, 24 September 2004, Vol.279(39), pp.41124-30 [Peer Reviewed Journal]

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21
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Effects of ligand activation of peroxisome proliferator-activated receptor gamma in human prostate cancer

Mueller, E ; Smith, M ; Sarraf, P ; Kroll, T ; Aiyer, A ; Kaufman, D S ; Oh, W ; Demetri, G ; Figg, W D ; Zhou, X P ; Eng, C ; Spiegelman, B M ; Kantoff, P W

Proceedings of the National Academy of Sciences of the United States of America, 26 September 2000, Vol.97(20), pp.10990-5 [Peer Reviewed Journal]

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22
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Adipose tissue resistin expression is severely suppressed in obesity and stimulated by peroxisome proliferator-activated receptor gamma agonists

Way, J M ; Görgün, C Z ; Tong, Q ; Uysal, K T ; Brown, K K ; Harrington, W W ; Oliver, W R ; Willson, T M ; Kliewer, S A ; Hotamisligil, G S

The Journal of biological chemistry, 13 July 2001, Vol.276(28), pp.25651-3 [Peer Reviewed Journal]

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23
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Antidiabetic action of a liver x receptor agonist mediated by inhibition of hepatic gluconeogenesis

Cao, Guoqing ; Liang, Yu ; Broderick, Carol L ; Oldham, Brian A ; Beyer, Thomas P ; Schmidt, Robert J ; Zhang, Youyan ; Stayrook, Keith R ; Suen, Chen ; Otto, Keith A ; Miller, Anne R ; Dai, Jiannong ; Foxworthy, Patricia ; Gao, Hong ; Ryan, Timothy P ; Jiang, Xian-Cheng ; Burris, Thomas P ; Eacho, Patrick I ; Etgen, Garret J

The Journal of biological chemistry, 10 January 2003, Vol.278(2), pp.1131-6 [Peer Reviewed Journal]

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24
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Identification of a series of oxadiazole-substituted alpha-isopropoxy phenylpropanoic acids with activity on PPARalpha, PPARgamma, and PPARdelta

Liu, K G ; Smith, J S ; Ayscue, A H ; Henke, B R ; Lambert, M H ; Leesnitzer, L M ; Plunket, K D ; Willson, T M ; Sternbach, D D

Bioorganic & medicinal chemistry letters, 03 September 2001, Vol.11(17), pp.2385-8 [Peer Reviewed Journal]

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25
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Reduction of atherosclerosis by the peroxisome proliferator-activated receptor alpha agonist fenofibrate in mice

Duez, Hélène ; Chao, Yu-Sheng ; Hernandez, Melba ; Torpier, Gérard ; Poulain, Philippe ; Mundt, Steven ; Mallat, Ziad ; Teissier, Elisabeth ; Burton, Charlotte A ; Tedgui, Alain ; Fruchart, Jean-Charles ; Fiévet, Catherine ; Wright, Sam D ; Staels, Bart

The Journal of biological chemistry, 13 December 2002, Vol.277(50), pp.48051-7 [Peer Reviewed Journal]

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26
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Packed column supercritical fluid chromatography of a peroxysome proliferator-activating receptor agonist drug. Achiral and chiral purity of substance, formulation assay and its enantiomeric purity

Gyllenhaal, Olle

Journal of chromatography. A, 09 July 2004, Vol.1042(1-2), pp.173-80 [Peer Reviewed Journal]

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27
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15-Lipoxygenase metabolism of 2-arachidonylglycerol. Generation of a peroxisome proliferator-activated receptor alpha agonist

Kozak, Kevin R ; Gupta, Rajnish A ; Moody, John S ; Ji, Chuan ; Boeglin, William E ; Dubois, Raymond N ; Brash, Alan R ; Marnett, Lawrence J

The Journal of biological chemistry, 28 June 2002, Vol.277(26), pp.23278-86 [Peer Reviewed Journal]

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28
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Influence of peroxisome proliferator-activated receptor alpha agonists on the intracellular turnover and secretion of apolipoprotein (Apo) B-100 and ApoB-48

Lindén, Daniel ; Lindberg, Karin ; Oscarsson, Jan ; Claesson, Catharina ; Asp, Lennart ; Li, Lu ; Gustafsson, Maria ; Borén, Jan ; Olofsson, Sven-Olof

The Journal of biological chemistry, 21 June 2002, Vol.277(25), pp.23044-53 [Peer Reviewed Journal]

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29
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The mechanisms by which both heterozygous peroxisome proliferator-activated receptor gamma (PPARgamma) deficiency and PPARgamma agonist improve insulin resistance

Yamauchi, T ; Kamon, J ; Waki, H ; Murakami, K ; Motojima, K ; Komeda, K ; Ide, T ; Kubota, N ; Terauchi, Y ; Tobe, K ; Miki, H ; Tsuchida, A ; Akanuma, Y ; Nagai, R ; Kimura, S ; Kadowaki, T

The Journal of biological chemistry, 02 November 2001, Vol.276(44), pp.41245-54 [Peer Reviewed Journal]

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30
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Agonist-dependent and agonist-independent transactivations of the human constitutive androstane receptor are modulated by specific amino acid pairs

Frank, Christian ; Molnár, Ferdinand ; Matilainen, Merja ; Lempiäinen, Harri ; Carlberg, Carsten

The Journal of biological chemistry, 06 August 2004, Vol.279(32), pp.33558-66 [Peer Reviewed Journal]

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31
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Application of the Dakin-West reaction for the synthesis of oxazole-containing dual PPARalpha/gamma agonists

Godfrey, Alexander G ; Brooks, Dawn A ; Hay, Lynne A ; Peters, Mary ; Mccarthy, James R ; Mitchell, David

The Journal of organic chemistry, 04 April 2003, Vol.68(7), pp.2623-32 [Peer Reviewed Journal]

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32
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Stabilization of peroxisome proliferator-activated receptor alpha by the ligand

Hirotani, M ; Tsukamoto, T ; Bourdeaux, J ; Sadano, H ; Osumi, T

Biochemical and biophysical research communications, 19 October 2001, Vol.288(1), pp.106-10 [Peer Reviewed Journal]

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33
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A short and efficient synthesis of the pharmacological research tool GW501516 for the peroxisome proliferator-activated receptor delta

Wei, Zhi-Liang ; Kozikowski, Alan P

The Journal of organic chemistry, 14 November 2003, Vol.68(23), pp.9116-8 [Peer Reviewed Journal]

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34
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Enantio-dependent binding and transactivation of optically active phenylpropanoic acid derivatives at human peroxisome proliferator-activated receptor alpha

Miyachi, Hiroyuki ; Nomura, Masahiro ; Tanase, Takahiro ; Suzuki, Masahiro ; Murakami, Koji ; Awano, Katsuya

Bioorganic & medicinal chemistry letters, 11 February 2002, Vol.12(3), pp.333-5 [Peer Reviewed Journal]

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35
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Farnesoid X receptor agonist reduces serum asymmetric dimethylarginine levels through hepatic dimethylarginine dimethylaminohydrolase-1 gene regulation

Hu, Tonghuan ; Chouinard, Michael ; Cox, Amy L ; Sipes, Philip ; Marcelo, Marialuisa ; Ficorilli, James ; Li, Shuyu ; Gao, Hong ; Ryan, Timothy P ; Michael, M Dodson ; Michael, Laura F

The Journal of biological chemistry, 29 December 2006, Vol.281(52), pp.39831-8 [Peer Reviewed Journal]

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36
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Benzoxazinones as PPARgamma agonists. part 1: SAR of three aromatic regions

Rybczynski, Philip J ; Zeck, Roxanne E ; Combs, Donald W ; Turchi, Ignatius ; Burris, Thomas P ; Xu, Jun Z ; Yang, Maria ; Demarest, Keith T

Bioorganic & medicinal chemistry letters, 21 July 2003, Vol.13(14), pp.2359-62 [Peer Reviewed Journal]

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Therapeutic potential of Liver Receptor Homolog-1 modulators

Lazarus, Kyren A ; Wijayakumara, Dhilushi ; Chand, Ashwini L ; Simpson, Evan R ; Clyne, Colin D

The Journal of steroid biochemistry and molecular biology, July 2012, Vol.130(3-5), pp.138-46 [Peer Reviewed Journal]

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