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A targeted library screen reveals a new inhibitor scaffold for protein kinase D

Tandon, Manuj ; Wang, Lirong ; Xu, Qi ; Xie, Xiangqun ; Wipf, Peter ; Wang, Qiming Jane

PloS one, 2012, Vol.7(9), pp.e44653 [Peer Reviewed Journal]

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2
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Lysosphingolipids inhibit protein kinase C: implications for the sphingolipidoses

Hannun, Y A ; Bell, R M

Science (New York, N.Y.), 06 February 1987, Vol.235(4789), pp.670-4 [Peer Reviewed Journal]

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ATP competitive protein kinase C inhibitors demonstrate distinct state-dependent inhibition

Smith, Ida M ; Hoshi, Naoto

PloS one, 2011, Vol.6(10), pp.e26338 [Peer Reviewed Journal]

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4
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PKC-Dependent GlyT1 Ubiquitination Occurs Independent of Phosphorylation: Inespecificity in Lysine Selection for Ubiquitination

Barrera, Susana P ; Castrejon-Tellez, Vicente ; Trinidad, Margarita ; Robles-Escajeda, Elisa ; Vargas-Medrano, Javier ; Varela-Ramirez, Armando ; Miranda, Manuel

PloS one, 2015, Vol.10(9), pp.e0138897 [Peer Reviewed Journal]

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5
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Protein quality control disruption by PKCβII in heart failure; rescue by the selective PKCβII inhibitor, βIIV5-3

Ferreira, Julio C B ; Boer, Berta Napchan ; Grinberg, Max ; Brum, Patricia Chakur ; Mochly-Rosen, Daria

PloS one, 2012, Vol.7(3), pp.e33175 [Peer Reviewed Journal]

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A highly potent and selective PKCalpha inhibitor generated via combinatorial modification of a peptide scaffold

Lee, Jung Hwan ; Nandy, Sandip K ; Lawrence, David S

Journal of the American Chemical Society, 24 March 2004, Vol.126(11), pp.3394-5 [Peer Reviewed Journal]

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Dramatic switching of protein kinase C agonist/antagonist activity by modifying the 12-ester side chain of phorbol esters

Wada, Reiko ; Suto, Yutaka ; Kanai, Motomu ; Shibasaki, Masakatsu

Journal of the American Chemical Society, 11 September 2002, Vol.124(36), pp.10658-9 [Peer Reviewed Journal]

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8
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Protein Kinase C-Independent Inhibition of Organic Cation Transporter 1 Activity by the Bisindolylmaleimide Ro 31-8220

Mayati, Abdullah ; Bruyere, Arnaud ; Moreau, Amélie ; Jouan, Elodie ; Denizot, Claire ; Parmentier, Yannick ; Fardel, Olivier

PloS one, 2015, Vol.10(12), pp.e0144667 [Peer Reviewed Journal]

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Diabetes complications: why is glucose potentially toxic?

Porte, D ; Schwartz, M W

Science (New York, N.Y.), 03 May 1996, Vol.272(5262), pp.699-700 [Peer Reviewed Journal]

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10
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Relationship of FKBP to PKCI-2

Albers, M W ; Liu, J ; Schreiber, S L

Nature, 13 June 1991, Vol.351(6327), pp.527 [Peer Reviewed Journal]

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11
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The protein kinase C inhibitor enzastaurin exhibits antitumor activity against uveal melanoma

Wu, Xinqi ; Zhu, Meijun ; Fletcher, Jonathan A ; Giobbie-Hurder, Anita ; Hodi, F Stephen

PloS one, 2012, Vol.7(1), pp.e29622 [Peer Reviewed Journal]

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12
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Discovery of diverse small molecule chemotypes with cell-based PKD1 inhibitory activity

Sharlow, Elizabeth R ; Mustata Wilson, Gabriela ; Close, David ; Leimgruber, Stephanie ; Tandon, Manuj ; Reed, Robyn B ; Shun, Tong Ying ; Wang, Q Jane ; Wipf, Peter ; Lazo, John S

PloS one, 2011, Vol.6(10), pp.e25134 [Peer Reviewed Journal]

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13
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Inhibition of protein kinase C by alcohols and anaesthetics

Slater, S J ; Cox, K J ; Lombardi, J V ; Ho, C ; Kelly, M B ; Rubin, E ; Stubbs, C D

Nature, 01 July 1993, Vol.364(6432), pp.82-4 [Peer Reviewed Journal]

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A dimeric 14-3-3 protein is an essential cofactor for Raf kinase activity

Tzivion, G ; Luo, Z ; Avruch, J

Nature, 02 July 1998, Vol.394(6688), pp.88-92 [Peer Reviewed Journal]

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15
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Lestaurtinib inhibits histone phosphorylation and androgen-dependent gene expression in prostate cancer cells

Köhler, Jens ; Erlenkamp, German ; Eberlin, Adrien ; Rumpf, Tobias ; Slynko, Inna ; Metzger, Eric ; Schüle, Roland ; Sippl, Wolfgang ; Jung, Manfred

PloS one, 2012, Vol.7(4), pp.e34973 [Peer Reviewed Journal]

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16
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Erasing sensorimotor memories via PKMzeta inhibition

Von Kraus, Lee Michael ; Sacktor, Todd Charlton ; Francis, Joseph Thachil

PloS one, 15 June 2010, Vol.5(6), pp.e11125 [Peer Reviewed Journal]

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17
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PKMzeta inhibition reverses learning-induced increases in hippocampal synaptic strength and memory during trace eyeblink conditioning

Madroñal, Noelia ; Gruart, Agnès ; Sacktor, Todd C ; Delgado-García, José M

PloS one, 29 April 2010, Vol.5(4), pp.e10400 [Peer Reviewed Journal]

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18
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Amelioration of vascular dysfunctions in diabetic rats by an oral PKC beta inhibitor

Ishii, H ; Jirousek, M R ; Koya, D ; Takagi, C ; Xia, P ; Clermont, A ; Bursell, S E ; Kern, T S ; Ballas, L M ; Heath, W F ; Stramm, L E ; Feener, E P ; King, G L

Science (New York, N.Y.), 03 May 1996, Vol.272(5262), pp.728-31 [Peer Reviewed Journal]

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19
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New pyrazolopyrimidine inhibitors of protein kinase d as potent anticancer agents for prostate cancer cells

Tandon, Manuj ; Johnson, James ; Li, Zhihong ; Xu, Shuping ; Wipf, Peter ; Wang, Qiming Jane

PloS one, 2013, Vol.8(9), pp.e75601 [Peer Reviewed Journal]

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20
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The PKD inhibitor CID755673 enhances cardiac function in diabetic db/db mice

Venardos, Kylie ; De Jong, Kirstie A ; Elkamie, Mansour ; Connor, Timothy ; Mcgee, Sean L

PloS one, 2015, Vol.10(3), pp.e0120934 [Peer Reviewed Journal]

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21
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SD-208, a novel protein kinase D inhibitor, blocks prostate cancer cell proliferation and tumor growth in vivo by inducing G2/M cell cycle arrest

Tandon, Manuj ; Salamoun, Joseph M ; Carder, Evan J ; Farber, Elisa ; Xu, Shuping ; Deng, Fan ; Tang, Hua ; Wipf, Peter ; Wang, Q Jane

PloS one, 2015, Vol.10(3), pp.e0119346 [Peer Reviewed Journal]

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22
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Inhibition of protein kinase C/Twist1 signaling augments anticancer effects of androgen deprivation and enzalutamide in prostate cancer

Shiota, Masaki ; Yokomizo, Akira ; Takeuchi, Ario ; Imada, Kenjiro ; Kashiwagi, Eiji ; Song, Yoohyun ; Inokuchi, Junichi ; Tatsugami, Katsunori ; Uchiumi, Takeshi ; Naito, Seiji

Clinical cancer research : an official journal of the American Association for Cancer Research, 15 February 2014, Vol.20(4), pp.951-61 [Peer Reviewed Journal]

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23
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The novel immunosuppressive protein kinase C inhibitor sotrastaurin has no pro-viral effects on the replication cycle of hepatitis B or C virus

Von Hahn, Thomas ; Schulze, Andreas ; Chicano Wust, Ivan ; Heidrich, Benjamin ; Becker, Thomas ; Steinmann, Eike ; Helfritz, Fabian A ; Rohrmann, Katrin ; Urban, Stephan ; Manns, Michael P ; Pietschmann, Thomas ; Ciesek, Sandra

PloS one, 2011, Vol.6(9), pp.e24142 [Peer Reviewed Journal]

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24
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Kinase and neurotransmitters

Aitken, A ; Ellis, C A ; Harris, A ; Sellers, L A ; Toker, A

Nature, 12 April 1990, Vol.344(6267), pp.594 [Peer Reviewed Journal]

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25
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A self-assembling protein kinase C inhibitor

Rotenberg, S A ; Calogeropoulou, T ; Jaworski, J S ; Weinstein, I B ; Rideout, D

Proceedings of the National Academy of Sciences of the United States of America, 15 March 1991, Vol.88(6), pp.2490-4 [Peer Reviewed Journal]

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26
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Tandem inhibition of PKC in Diαβetic nephropathy: it takes two to tango?

Thallas-Bonke, Vicki ; Cooper, Mark E

Diabetes, April 2013, Vol.62(4), pp.1010-1 [Peer Reviewed Journal]

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27
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Specificity of protein kinase inhibitor peptides and induction of long-term potentiation

Hvalby, O ; Hemmings, H C ; Paulsen, O ; Czernik, A J ; Nairn, A C ; Godfraind, J M ; Jensen, V ; Raastad, M ; Storm, J F ; Andersen, P

Proceedings of the National Academy of Sciences of the United States of America, 24 May 1994, Vol.91(11), pp.4761-5 [Peer Reviewed Journal]

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28
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Inhibitors of protein kinase C (PKC) prevent activated transcription: role of events downstream of NF-kappaB DNA binding

Catley, Matthew C ; Cambridge, Lisa M ; Nasuhara, Yasuyuki ; Ito, Kazuhiro ; Chivers, Joanna E ; Beaton, Andrew ; Holden, Neil S ; Bergmann, Martin W ; Barnes, Peter J ; Newton, Robert

The Journal of biological chemistry, 30 April 2004, Vol.279(18), pp.18457-66 [Peer Reviewed Journal]

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29
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Depletion-activated calcium current is inhibited by protein kinase in RBL-2H3 cells

Parekh, A B ; Penner, R

Proceedings of the National Academy of Sciences of the United States of America, 15 August 1995, Vol.92(17), pp.7907-11 [Peer Reviewed Journal]

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30
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Irreversible inactivation of protein kinase C by a peptide-substrate analog

Ward, N E ; Gravitt, K R ; O'Brian, C A

The Journal of biological chemistry, 07 April 1995, Vol.270(14), pp.8056-60 [Peer Reviewed Journal]

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31
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Inhibition of protein kinase C induces differentiation in Neuro-2a cells

Miñana, M D ; Felipo, V ; Grisolía, S

Proceedings of the National Academy of Sciences of the United States of America, June 1990, Vol.87(11), pp.4335-9 [Peer Reviewed Journal]

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32
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Gö 6976, a selective inhibitor of protein kinase C, is a potent antagonist of human immunodeficiency virus 1 induction from latent/low-level-producing reservoir cells in vitro

Qatsha, K A ; Rudolph, C ; Marmé, D ; Schächtele, C ; May, W S

Proceedings of the National Academy of Sciences of the United States of America, 15 May 1993, Vol.90(10), pp.4674-8 [Peer Reviewed Journal]

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33
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Tracing the footsteps of glomerular insulin signaling in diabetic kidney disease

Chang, Gene-Yuan ; Park, Ae Seo ; Susztak, Katalin

Kidney International, Apr 2011, Vol.79(8), pp.802-4 [Peer Reviewed Journal]

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34
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HSP25 inhibits protein kinase C delta-mediated cell death through direct interaction

Lee, Yoon-Jin ; Lee, Dae-Hoon ; Cho, Chul-Koo ; Bae, Sangwoo ; Jhon, Gil-Ja ; Lee, Su-Jae ; Soh, Jae-Won ; Lee, Yun-Sil

The Journal of biological chemistry, 06 May 2005, Vol.280(18), pp.18108-19 [Peer Reviewed Journal]

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35
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Selective inhibition of juxtanuclear translocation of protein kinase C betaII by a negative feedback mechanism involving ceramide formed from the salvage pathway

Becker, Kevin P ; Kitatani, Kazuyuki ; Idkowiak-Baldys, Jolanta ; Bielawski, Jacek ; Hannun, Yusuf A

The Journal of biological chemistry, 28 January 2005, Vol.280(4), pp.2606-12 [Peer Reviewed Journal]

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36
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Ceramide inactivates cellular protein kinase Calpha

Lee, J Y ; Hannun, Y A ; Obeid, L M

The Journal of biological chemistry, 31 May 1996, Vol.271(22), pp.13169-74 [Peer Reviewed Journal]

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37
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Transformed mammalian cells are deficient in kinase-mediated control of progression through the G1 phase of the cell cycle

Crissman, H A ; Gadbois, D M ; Tobey, R A ; Bradbury, E M

Proceedings of the National Academy of Sciences of the United States of America, 01 September 1991, Vol.88(17), pp.7580-4 [Peer Reviewed Journal]

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