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1
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Current status of the research and development of diacylglycerol O-acyltransferase 1 (DGAT1) inhibitors

Devita, Robert J ; Pinto, Shirly

Journal of medicinal chemistry, 27 December 2013, Vol.56(24), pp.9820-5 [Peer Reviewed Journal]

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Identification of neuronal subpopulations that project from hypothalamus to both liver and adipose tissue polysynaptically

Stanley, Sarah ; Pinto, Shirly ; Segal, Jeremy ; Pérez, Cristian A ; Viale, Agnes ; Defalco, Jeff ; Cai, Xiaoli ; Heisler, Lora K ; Friedman, Jeffrey M

Proceedings of the National Academy of Sciences of the United States of America, 13 April 2010, Vol.107(15), pp.7024-9 [Peer Reviewed Journal]

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3
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Rapid rewiring of arcuate nucleus feeding circuits by leptin

Pinto, Shirly ; Roseberry, Aaron G ; Liu, Hongyan ; Diano, Sabrina ; Shanabrough, Marya ; Cai, Xiaoli ; Friedman, Jeffrey M ; Horvath, Tamas L

Science (New York, N.Y.), 02 April 2004, Vol.304(5667), pp.110-5 [Peer Reviewed Journal]

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Identification and Characterization of Sebaceous Gland Atrophy-Sparing DGAT1 Inhibitors

Muise, Eric S ; Zhu, Yonghua ; Verras, Andreas ; Karanam, Bindhu V ; Gorski, Judith ; Weingarth, Drew ; Lin, Hua V ; Hwa, Joyce ; Thompson, John R ; Hu, Guanghui ; Liu, Jian ; He, Shuwen ; Devita, Robert J ; Shen, Dong-Ming ; Pinto, Shirly Slominski, Andrzej T. (editor)

PLoS ONE, 2014, Vol.9(2) [Peer Reviewed Journal]

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5
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Diacylglycerol acyltransferase-1 (DGAT1) inhibition perturbs postprandial gut hormone release

Lin, Hua V ; Chen, Dunlu ; Shen, Zhu ; Zhu, Lei ; Ouyang, Xuesong ; Vongs, Aurawan ; Kan, Yanqing ; Levorse, John M ; Kowalik, Edward J ; Szeto, Daphne M ; Yao, Xiaorui ; Xiao, Jianying ; Chen, Shirley ; Liu, Jinqi ; Garcia-Calvo, Marga ; Shin, Myung K ; Pinto, Shirly

PloS one, 2013, Vol.8(1), pp.e54480 [Peer Reviewed Journal]

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6
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Microscale High-Throughput Experimentation as an Enabling Technology in Drug Discovery: Application in the Discovery of (Piperidinyl)pyridinyl-1H-benzimidazole Diacylglycerol Acyltransferase 1 Inhibitors

Cernak, Tim ; Gesmundo, Nathan J ; Dykstra, Kevin ; Yu, Yang ; Wu, Zhicai ; Shi, Zhi-Cai ; Vachal, Petr ; Sperbeck, Donald ; He, Shuwen ; Murphy, Beth Ann ; Sonatore, Lisa ; Williams, Steven ; Madeira, Maria ; Verras, Andreas ; Reiter, Maud ; Lee, Claire Heechoon ; Cuff, James ; Sherer, Edward C ; Kuethe, Jeffrey ; Goble, Stephen ; Perrotto, Nicholas ; Pinto, Shirly ; Shen, Dong-Ming ; Nargund, Ravi ; Balkovec, James ; Devita, Robert J ; Dreher, Spencer D

Journal of medicinal chemistry, 11 May 2017, Vol.60(9), pp.3594-3605 [Peer Reviewed Journal]

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Discovery and Pharmacology of a Novel Class of Diacylglycerol Acyltransferase 2 Inhibitors

Imbriglio, Jason E ; Shen, Dong-Ming ; Liang, Rui ; Marby, Ken ; You, Ming ; Youm, Hye Won ; Feng, Zhe ; London, Clare ; Xiong, Yusheng ; Tata, Jim ; Verras, Andreas ; Garcia-Calvo, Margarita ; Song, Xuelei ; Addona, George H ; Mclaren, Dave G ; He, Timothy ; Murphy, Beth ; Metzger, Dan E ; Salituro, Gino ; Deckman, Diana ; Chen, Qing ; Jin, Xiaoling ; Stout, Steven J ; Wang, Sheng-Ping ; Wilsie, Larissa ; Palyha, Oksana ; Han, Seongah ; Hubbard, Brian K ; Previs, Stephen F ; Pinto, Shirly ; Taggart, Andrew

Journal of medicinal chemistry, 10 December 2015, Vol.58(23), pp.9345-53 [Peer Reviewed Journal]

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Pharmacological inhibition of diacylglycerol acyltransferase 1 reduces body weight and modulates gut peptide release—Potential insight into mechanism of action

Liu, Jinqi ; Gorski, Judith N. ; Gold, Stephen J. ; Chen, Dunlu ; Chen, Shirley ; Forrest, Gail ; Itoh, Yoshiki ; Marsh, Donald J. ; Mclaren, David G. ; Shen, Zhu ; Sonatore, Lisa ; Carballo‐Jane, Ester ; Craw, Stephanie ; Guan, Xiaoming ; Karanam, Bindhu ; Sakaki, Junichi ; Szeto, Daphne ; Tong, Xinchun ; Xiao, Jianying ; Yoshimoto, Ryo ; Yu, Hong ; Roddy, Thomas P. ; Balkovec, James ; Pinto, Shirly

Obesity, July 2013, Vol.21(7), pp.1406-1415 [Peer Reviewed Journal]

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Design and synthesis of prolylcarboxypeptidase (PrCP) inhibitors to validate PrCP as a potential target for obesity

Zhou, Changyou ; Garcia-Calvo, Margareta ; Pinto, Shirly ; Lombardo, Matthew ; Feng, Zhe ; Bender, Kate ; Pryor, Kellyann D ; Bhatt, Urmi R ; Chabin, Renee M ; Geissler, Wayne M ; Shen, Zhu ; Tong, Xinchun ; Zhang, Zhoupeng ; Wong, Kenny K ; Roy, Ranabir Sinha ; Chapman, Kevin T ; Yang, Lihu ; Xiong, Yusheng

Journal of medicinal chemistry, 14 October 2010, Vol.53(19), pp.7251-63 [Peer Reviewed Journal]

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10
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In Vitro Assays for the Discovery of PCSK9 Autoprocessing Inhibitors

Salowe, Scott P ; Zhang, Lei ; Zokian, Hratch J ; Gesell, Jennifer J ; Zink, Deborah L ; Wiltsie, Judyann ; Ai, Xi ; Kavana, Michael ; Pinto, Shirly

Journal of Biomolecular Screening, December 2016, Vol.21(10), pp.1034-1041 [Peer Reviewed Journal]

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11
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Variations in DNA elucidate molecular networks that cause disease

Chen, Yanqing ; Zhu, Jun ; Lum, Pek Yee ; Yang, Xia ; Pinto, Shirly ; Macneil, Douglas J ; Zhang, Chunsheng ; Lamb, John ; Edwards, Stephen ; Sieberts, Solveig K ; Leonardson, Amy ; Castellini, Lawrence W ; Wang, Susanna ; Champy, Marie-France ; Zhang, Bin ; Emilsson, Valur ; Doss, Sudheer ; Ghazalpour, Anatole ; Horvath, Steve ; Drake, Thomas A ; Lusis, Aldons J ; Schadt, Eric E

Nature, 27 March 2008, Vol.452(7186), pp.429-35 [Peer Reviewed Journal]

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12
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Identification and characterization of a novel DGAT1 missense mutation associated with congenital diarrhea[S]

Gluchowski, Nina L. ; Chitraju, Chandramohan ; Picoraro, Joseph A. ; Mejhert, Niklas ; Pinto, Shirly ; Xin, Winnie ; Kamin, Daniel S. ; Winter, Harland S. ; Chung, Wendy K. ; Walther, Tobias C. ; Farese, Robert V.

Gluchowski, N. L., C. Chitraju, J. A. Picoraro, N. Mejhert, S. Pinto, W. Xin, D. S. Kamin, et al. 2017. “Identification and characterization of a novel DGAT1 missense mutation associated with congenital diarrhea[S].” Journal of Lipid Research 58 (6): 1230-1237. doi:10.1194/jlr.P075119. http://dx.doi.org/10.1194/jlr.P075119. [Peer Reviewed Journal]

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13
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siRNA-mediated inhibition of SREBP cleavage-activating protein reduces dyslipidemia in spontaneously dysmetabolic rhesus monkeys

Murphy, Beth Ann ; Tadin-Strapps, Marija ; Jensen, Kristian ; Mogg, Robin ; Liaw, Andy ; Herath, Kithsiri ; Bhat, Gowri ; Mclaren, David G ; Previs, Stephen F ; Pinto, Shirly

Metabolism, June 2017, Vol.71, pp.202-212 [Peer Reviewed Journal]

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14
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Identification of DGAT2 Inhibitors Using Mass Spectrometry

Song, Xuelei S ; Zhang, Jiaping ; Chen, Xun ; Palyha, Oksana ; Chung, Christine ; Sonatore, Lisa M ; Wilsie, Larissa ; Stout, Steven ; Mclaren, David G ; Taggart, Andrew ; Imbriglio, Jason E ; Pinto, Shirly ; Garcia-Calvo, Margarita ; Addona, George H Wingfield, Jonathan (Editor) ; Wilson, Ian D (Editor)

Journal of Biomolecular Screening, February 2016, Vol.21(2), pp.117-126 [Peer Reviewed Journal]

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15
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Potential mechanism of enhanced postprandial glucagon‐like peptide‐1 release following treatment with a diacylglycerol acyltransferase 1 inhibitor

Liu, Jinqi ; Mclaren, David G. ; Chen, Dunlu ; Kan, Yanqing ; Stout, Steven J. ; Shen, Xiaolan ; Murphy, Beth Ann ; Forrest, Gail ; Karanam, Bindhu ; Sonatore, Lisa ; He, Shuwen ; Roddy, Thomas P. ; Pinto, Shirly

Pharmacology Research & Perspectives, December 2015, Vol.3(6), pp.n/a-n/a [Peer Reviewed Journal]

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16
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The hepatitis C virus core protein inhibits adipose triglyceride lipase (ATGL)-mediated lipid mobilization and enhances the ATGL interaction with comparative gene identification 58 (CGI-58) and lipid droplets

Camus, Gregory ; Schweiger, Martina ; Herker, Eva ; Harris, Charles ; Kondratowicz, Andrew S ; Tsou, Chia-Lin ; Farese, Robert V ; Herath, Kithsiri ; Previs, Stephen F ; Roddy, Thomas P ; Pinto, Shirly ; Zechner, Rudolf ; Ott, Melanie

The Journal of biological chemistry, 26 December 2014, Vol.289(52), pp.35770-80 [Peer Reviewed Journal]

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17
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Pyrazoles as non-classical bioisosteres in prolylcarboxypeptidase (PrCP) inhibitors

Graham, Thomas H ; Shu, Min ; Verras, Andreas ; Chen, Qing ; Garcia-Calvo, Margarita ; Li, Xiaohua ; Lisnock, Jeanmarie ; Tong, Xinchun ; Tung, Elaine C ; Wiltsie, Judyann ; Hale, Jeffrey J ; Pinto, Shirly ; Shen, Dong-Ming

Bioorganic & Medicinal Chemistry Letters, 01 April 2014, Vol.24(7), pp.1657-1660 [Peer Reviewed Journal]

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18
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An integrin antagonist (MK‐0429) decreases proteinuria and renal fibrosis in the ZSF1 rat diabetic nephropathy model

Zhou, Xiaoyan ; Zhang, Ji ; Haimbach, Robin ; Zhu, Wei ; Mayer‐Ezell, Rosemary ; Garcia‐Calvo, Margarita ; Smith, Elizabeth ; Price, Olga ; Kan, Yanqing ; Zycband, Emanuel ; Zhu, Yonghua ; Hoek, Maarten ; Cox, Jason M. ; Ma, Lijun ; Kelley, David E. ; Pinto, Shirly

Pharmacology Research & Perspectives, October 2017, Vol.5(5), pp.n/a-n/a [Peer Reviewed Journal]

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19
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Discovery of benzimidazole pyrrolidinyl amides as prolylcarboxypeptidase inhibitors

Shen, Hong C ; Ding, Fa-Xiang ; Zhou, Changyou ; Xiong, Yusheng ; Verras, Andreas ; Chabin, Renee M ; Xu, Suoyu ; Tong, Xinchun ; Xie, Dan ; Lassman, Michael E ; Bhatt, Urmi R ; Garcia-Calvo, Margarita M ; Geissler, Wayne ; Shen, Zhu ; Chen, Dunlu ; Sinharoy, Ranabir ; Hale, Jeffery J ; Tata, James R ; Pinto, Shirly ; Shen, Dong-Ming ; Colletti, Steven L

Bioorganic & Medicinal Chemistry Letters, 2011, Vol.21(5), pp.1299-1305 [Peer Reviewed Journal]

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20
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Effects of small interfering RNA-mediated hepatic glucagon receptor inhibition on lipid metabolism in db/db mice

Han, Seongah ; Akiyama, Taro E ; Previs, Stephen F ; Herath, Kithsiri ; Roddy, Thomas P ; Jensen, Kristian K ; Guan, Hong-Ping ; Murphy, Beth A ; Mcnamara, Lesley A ; Shen, Xun ; Strapps, Walter ; Hubbard, Brian K ; Pinto, Shirly ; Li, Cai ; Li, Jing

Journal of lipid research, October 2013, Vol.54(10), pp.2615-22 [Peer Reviewed Journal]

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21
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Discovery of benzodihydroisofurans as novel, potent, bioavailable and brain-penetrant prolylcarboxypeptidase inhibitors

Shen, Hong C ; Ding, Fa-Xiang ; Jiang, Jinlong ; Verras, Andreas ; Chabin, Renee M ; Xu, Suoyu ; Tong, Xinchun ; Chen, Qing ; Xie, Dan ; Lassman, Mike E ; Bhatt, Urmi R ; Garcia-Calvo, Margarita M ; Geissler, Wayne ; Shen, Zhu ; Murphy, Beth Ann ; Gorski, Judith N ; Wiltsie, Judyann ; Sinharoy, Ranabir ; Hale, Jeffrey J ; Pinto, Shirly ; Shen, Dong-Ming

Bioorganic & Medicinal Chemistry Letters, 15 February 2012, Vol.22(4), pp.1550-1556 [Peer Reviewed Journal]

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22
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Discovery of aminoheterocycles as potent and brain penetrant prolylcarboxypeptidase inhibitors

Wu, Zhicai ; Yang, Cangming ; Graham, Thomas H ; Verras, Andreas ; Chabin, Renee M ; Xu, Suoyu ; Tong, Xinchun ; Xie, Dan ; Lassman, Mike E ; Bhatt, Urmi R ; Garcia-Calvo, Margarita M ; Shen, Zhu ; Chen, Qing ; Bleasby, Kelly ; Sinharoy, Ranabir ; Hale, Jeffrey J ; Tata, James R ; Pinto, Shirly ; Colletti, Steven L ; Shen, Dong-Ming

Bioorganic & Medicinal Chemistry Letters, 15 February 2012, Vol.22(4), pp.1727-1730 [Peer Reviewed Journal]

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23
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Discovery of a new class of potent prolylcarboxypeptidase inhibitors derived from alanine

Wu, Zhicai ; Yang, Cangming ; Xiong, Yusheng ; Feng, Zhe ; Lombardo, Matthew ; Verras, Andreas ; Chabin, Renee M ; Xu, Suoyu ; Tong, Xinchun ; Xie, Dan ; Lassman, Mike E ; Bhatt, Urmi R ; Garcia-Calvo, Margarita M ; Geissler, Wayne ; Shen, Zhu ; Chen, Qing ; Sinharoy, Ranabir ; Hale, Jeffrey J ; Tata, James R ; Pinto, Shirly ; Shen, Dong-Ming ; Colletti, Steven L

Bioorganic & Medicinal Chemistry Letters, 15 February 2012, Vol.22(4), pp.1774-1778 [Peer Reviewed Journal]

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24
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CM-101: Type I Collagen-targeted MR Imaging Probe for Detection of Liver Fibrosis

Farrar, Christian T ; Gale, Eric M ; Kennan, Richard ; Ramsay, Ian ; Masia, Ricard ; Arora, Gunisha ; Looby, Kailyn ; Wei, Lan ; Kalpathy-Cramer, Jayashree ; Bunzel, Michelle M ; Zhang, Chunlian ; Zhu, Yonghua ; Akiyama, Taro E ; Klimas, Michael ; Pinto, Shirly ; Diyabalanage, Himashinie ; Tanabe, Kenneth K ; Humblet, Valerie ; Fuchs, Bryan C ; Caravan, Peter

Radiology, May 2018, Vol.287(2), pp.581-589 [Peer Reviewed Journal]

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25
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A new class of prolylcarboxypeptidase inhibitors, Part 2: The aminocyclopentanes

Graham, Thomas H ; Liu, Wensheng ; Verras, Andreas ; Reibarkh, Mikhail ; Bleasby, Kelly ; Bhatt, Urmi R ; Chen, Qing ; Garcia-Calvo, Margarita ; Geissler, Wayne M ; Gorski, Judith N ; He, Huaibing ; Lassman, Michael E ; Lisnock, Jeanmarie ; Li, Xiaohua ; Shen, Zhu ; Tong, Xinchun ; Tung, Elaine C ; Wiltsie, Judyann ; Xie, Dan ; Xu, Suoyu ; Xiao, Jianying ; Hale, Jeffrey J ; Pinto, Shirly ; Shen, Dong-Ming

Bioorganic & Medicinal Chemistry Letters, 15 April 2012, Vol.22(8), pp.2818-2822 [Peer Reviewed Journal]

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26
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Ghrelin controls hippocampal spine synapse density and memory performance

Diano, Sabrina ; Farr, Susan A ; Benoit, Stephen C ; Mcnay, Ewan C ; Da Silva, Ivaldo ; Horvath, Balazs ; Gaskin, F Spencer ; Nonaka, Naoko ; Jaeger, Laura B ; Banks, William A ; Morley, John E ; Pinto, Shirly ; Sherwin, Robert S ; Xu, Lin ; Yamada, Kelvin A ; Sleeman, Mark W ; Tschöp, Matthias H ; Horvath, Tamas L

Nature neuroscience, March 2006, Vol.9(3), pp.381-8 [Peer Reviewed Journal]

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27
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Dose-dependent effects of siRNA-mediated inhibition of SCAP on PCSK9, LDLR, and plasma lipids in mouse and rhesus monkey

Jensen, Kristian K ; Tadin-Strapps, Marija ; Wang, Sheng-Ping ; Hubert, James ; Kan, Yanqing ; Ma, Yong ; Mclaren, David G ; Previs, Stephen F ; Herath, Kithsiri B ; Mahsut, Ablatt ; Liaw, Andy ; Wang, Shubing ; Stout, Steven J ; Keohan, Carolann ; Forrest, Gail ; Coelho, David ; Yendluri, Satya ; Williams, Stephanie ; Koser, Martin ; Bartz, Steven ; Akinsanya, Karen O ; Pinto, Shirly

Journal of lipid research, December 2016, Vol.57(12), pp.2150-2162 [Peer Reviewed Journal]

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28
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Discovery and optimization of orally active cyclohexane-based prolylcarboxypeptidase (PrCP) inhibitors

Debenham, John S ; Graham, Thomas H ; Verras, Andreas ; Zhang, Yong ; Clements, Matthew J ; Kuethe, Jeffrey T ; Madsen-Duggan, Christina ; Liu, Wensheng ; Bhatt, Urmi R ; Chen, Dunlu ; Chen, Qing ; Garcia-Calvo, Margarita ; Geissler, Wayne M ; He, Huaibing ; Li, Xiaohua ; Lisnock, Jeanmarie ; Shen, Zhu ; Tong, Xinchun ; Tung, Elaine C ; Wiltsie, Judyann ; Xu, Suoyu ; Hale, Jeffrey J ; Pinto, Shirly ; Shen, Dong-Ming

Bioorganic & Medicinal Chemistry Letters, 01 December 2013, Vol.23(23), pp.6228-6233 [Peer Reviewed Journal]

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29
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A new class of prolylcarboxypeptidase inhibitors, Part 1: Discovery and evaluation

Graham, Thomas H ; Liu, Wensheng ; Verras, Andreas ; Sebhat, Iyassu K ; Xiong, Yusheng ; Bleasby, Kelly ; Bhatt, Urmi R ; Chen, Qing ; Garcia-Calvo, Margarita ; Geissler, Wayne M ; Gorski, Judith N ; He, Huaibing ; Lassman, Michael E ; Lisnock, Jeanmarie ; Li, Xiaohua ; Shen, Zhu ; Tong, Xinchun ; Tung, Elaine C ; Wiltsie, Judyann ; Xiao, Jianying ; Xie, Dan ; Xu, Suoyu ; Hale, Jeffrey J ; Pinto, Shirly ; Shen, Dong-Ming

Bioorganic & Medicinal Chemistry Letters, 15 April 2012, Vol.22(8), pp.2811-2817 [Peer Reviewed Journal]

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30
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The discovery of non-benzimidazole and brain-penetrant prolylcarboxypeptidase inhibitors

Graham, Thomas H ; Shen, Hong C ; Liu, Wensheng ; Xiong, Yusheng ; Verras, Andreas ; Bleasby, Kelly ; Bhatt, Urmi R ; Chabin, Renee M ; Chen, Dunlu ; Chen, Qing ; Garcia-Calvo, Margarita ; Geissler, Wayne M ; He, Huaibing ; Lassman, Michael E ; Shen, Zhu ; Tong, Xinchun ; Tung, Elaine C ; Xie, Dan ; Xu, Suoyu ; Colletti, Steven L ; Tata, James R ; Hale, Jeffrey J ; Pinto, Shirly ; Shen, Dong-Ming

Bioorganic & Medicinal Chemistry Letters, 01 January 2012, Vol.22(1), pp.658-665 [Peer Reviewed Journal]

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31
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The use of stable-isotopically labeled oleic acid to interrogate lipid assembly in vivo: assessing pharmacological effects in preclinical species

Mclaren, David G ; He, Timothy ; Wang, Sheng-Ping ; Mendoza, Vivienne ; Rosa, Raymond ; Gagen, Karen ; Bhat, Gowri ; Herath, Kithsiri ; Miller, Paul L ; Stribling, Sloan ; Taggart, Andrew ; Imbriglio, Jason ; Liu, Jinqi ; Chen, Dunlu ; Pinto, Shirly ; Balkovec, James M ; Devita, Robert J ; Marsh, Donald J ; Castro-Perez, Jose M ; Strack, Alison ; Johns, Douglas G ; Previs, Stephen F ; Hubbard, Brian K ; Roddy, Thomas P

Journal of lipid research, June 2011, Vol.52(6), pp.1150-61 [Peer Reviewed Journal]

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32
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Peptidomic profiling of human cerebrospinal fluid identifies YPRPIHPA as a novel substrate for prolylcarboxypeptidase

Zhao, Xuemei ; Southwick, Katie ; Cardasis, Helene L. ; Du, Yi ; Lassman, Michael E. ; Xie, Dan ; El‐Sherbeini, Mohamed ; Geissler, Wayne M. ; Pryor, Kellyann D. ; Verras, Andreas ; Garcia‐Calvo, Margarita ; Shen, Dong‐Ming ; Yates, Nathan A. ; Pinto, Shirly ; Hendrickon, Ronald C.

PROTEOMICS, August 2010, Vol.10(15), pp.2882-2886 [Peer Reviewed Journal]

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33
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Peptidomic profiling of human cerebrospinal fluid identifies YPRPIHPA as a novel substrate for prolylcarboxypeptidase

Zhao, Xuemei ; Southwick, Katie ; Cardasis, Helene L. ; Du, Yi ; Lassman, Michael E. ; Xie, Dan ; El‐Sherbeini, Mohamed ; Geissler, Wayne M. ; Pryor, Kellyann D. ; Verras, Andreas ; Garcia‐Calvo, Margarita ; Shen, Dong‐Ming ; Yates, Nathan A. ; Pinto, Shirly ; Hendrickon, Ronald C.

PROTEOMICS – Clinical Applications, November 2010, Vol.4(10‐11), pp.865-865 [Peer Reviewed Journal]

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34
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The Distribution and Mechanism of Action of Ghrelin in the CNS Demonstrates a Novel Hypothalamic Circuit Regulating Energy Homeostasis

Cowley, Michael A ; Smith, Roy G ; Diano, Sabrina ; Tschöp, Matthias ; Pronchuk, Nina ; Grove, Kevin L ; Strasburger, Christian J ; Bidlingmaier, Martin ; Esterman, Michael ; Heiman, Mark L ; Garcia-Segura, Luis Miguel ; Nillni, Eduardo A ; Mendez, Pablo ; Low, Malcolm J ; Sotonyi, Peter ; Friedman, Jeffrey M ; Liu, Hongyan ; Pinto, Shirly ; Colmers, William F ; Cone, Roger D ; Horvath, Tamas L

Neuron, 2003, Vol.37(4), pp.649-661 [Peer Reviewed Journal]

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35
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Potent DGAT1 Inhibitors in the Benzimidazole Class with a Pyridyl-oxy-cyclohexanecarboxylic Acid Moiety

He, Shuwen ; Hong, Qingmei ; Lai, Zhong ; Wu, Zhicai ; Yu, Yang ; Kim, David W ; Ting, Pauline C ; Kuethe, Jeffrey T ; Yang, Ginger X ; Jian, Tianying ; Liu, Jian ; Guiadeen, Deodial ; Krikorian, Arto D ; Sperbeck, Donald M ; Sonatore, Lisa M ; Wiltsie, Judyann ; Chung, Christine C ; Gibson, Jack T ; Lisnock, Jeanmarie ; Murphy, Beth A ; Gorski, Judith N ; Liu, Jinqi ; Chen, Dunlu ; Chen, Xiaoli ; Wolff, Michael ; Tong, Sharon X ; Madeira, Maria ; Karanam, Bindhu V ; Shen, Dong-Ming ; Balkovec, James M ; Pinto, Shirly ; Nargund, Ravi P ; Devita, Robert J

ACS medicinal chemistry letters, 08 August 2013, Vol.4(8), pp.773-8 [Peer Reviewed Journal]

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36
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Discovery of a Potent and Selective DGAT1 Inhibitor with a Piperidinyl-oxy-cyclohexanecarboxylic Acid Moiety

He, Shuwen ; Hong, Qingmei ; Lai, Zhong ; Yang, David X ; Ting, Pauline C ; Kuethe, Jeffrey T ; Cernak, Timothy A ; Dykstra, Kevin D ; Sperbeck, Donald M ; Wu, Zhicai ; Yu, Yang ; Yang, Ginger X ; Jian, Tianying ; Liu, Jian ; Guiadeen, Deodial ; Krikorian, Arto D ; Sonatore, Lisa M ; Wiltsie, Judyann ; Liu, Jinqi ; Gorski, Judith N ; Chung, Christine C ; Gibson, Jack T ; Lisnock, Jeanmarie ; Xiao, Jianying ; Wolff, Michael ; Tong, Sharon X ; Madeira, Maria ; Karanam, Bindhu V ; Shen, Dong-Ming ; Balkovec, James M ; Pinto, Shirly ; Nargund, Ravi P ; Devita, Robert J

ACS medicinal chemistry letters, 09 October 2014, Vol.5(10), pp.1082-7 [Peer Reviewed Journal]

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PAN-AMPK ACTIVATION IMPROVES RENAL FUNCTION IN A RAT MODEL OF PROGRESSIVE DIABETIC NEPHROPATHY

Zhou, Xiaoyan ; Muise, Eric S ; Haimbach, Robin ; Sebhat, Iyassu K ; Zhu, Yonghua ; Liu, Franklin ; Souza, Sandra ; Kan, Yanqing ; Pinto, Shirly ; Kelley, David E ; Hoek, Maarten

The Journal of pharmacology and experimental therapeutics, 12 July 2019 [Peer Reviewed Journal]

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