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The study of a novel sorafenib derivative HLC-080 as an antitumor agent

Tang, Ke ; Luo, Can ; Li, Yan ; Lu, Chenshu ; Zhou, Wanqi ; Huang, Haihong ; Chen, Xiaoguang

PloS one, 2014, Vol.9(7), pp.e101889 [Peer Reviewed Journal]

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Physiological and morphological aspects of Aedes aegypti developing larvae: effects of the chitin synthesis inhibitor novaluron

Farnesi, Luana C ; Brito, José M ; Linss, Jutta G ; Pelajo-Machado, Marcelo ; Valle, Denise ; Rezende, Gustavo L

PloS one, 2012, Vol.7(1), pp.e30363 [Peer Reviewed Journal]

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Pharmacological inhibition of CXCR2 chemokine receptors modulates paraquat-induced intoxication in rats

Costa, Kesiane M ; Maciel, Izaque S ; Kist, Luiza W ; Campos, Maria M ; Bogo, Maurício R

PloS one, 2014, Vol.9(8), pp.e105740 [Peer Reviewed Journal]

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The Enhanced metastatic potential of hepatocellular carcinoma (HCC) cells with sorafenib resistance

Chow, Ariel Ka-Man ; Ng, Lui ; Lam, Colin Siu-Chi ; Wong, Sunny Kit-Man ; Wan, Timothy Ming-Hun ; Cheng, Nathan Shiu-Man ; Yau, Thomas Chung-Cheung ; Poon, Ronnie Tung-Ping ; Pang, Roberta Wen-Chi

PloS one, 2013, Vol.8(11), pp.e78675 [Peer Reviewed Journal]

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Inhibition of Cell Proliferation in an NRAS Mutant Melanoma Cell Line by Combining Sorafenib and α-Mangostin

Xia, Yun ; Li, Ying ; Westover, Kenneth D ; Sun, Jiaming ; Chen, Hongxiang ; Zhang, Jianming ; Fisher, David E

PloS one, 2016, Vol.11(5), pp.e0155217 [Peer Reviewed Journal]

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SB225002 promotes mitotic catastrophe in chemo-sensitive and -resistant ovarian cancer cells independent of p53 status in vitro

Du, Meirong ; Qiu, Qing ; Gruslin, Andree ; Gordon, John ; He, Miao ; Chan, Chi Chung ; Li, Dajin ; Tsang, Benjamin K

PloS one, 2013, Vol.8(1), pp.e54572 [Peer Reviewed Journal]

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Somatic integration of single ion channel responses of α7 nicotinic acetylcholine receptors enhanced by PNU-120596

Uteshev, Victor V

PloS one, 2012, Vol.7(3), pp.e32951 [Peer Reviewed Journal]

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8
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Synergistic inhibitory effect of hyperbaric oxygen combined with sorafenib on hepatoma cells

Peng, Hai-Shan ; Liao, Ming-Bin ; Zhang, Mei-Yin ; Xie, Yin ; Xu, Li ; Zhang, Yao-Jun ; Zheng, X F Steven ; Wang, Hui-Yun ; Chen, Yi-Fei

PloS one, 2014, Vol.9(6), pp.e100814 [Peer Reviewed Journal]

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Forchlorfenuron disrupts SEPT9_i1 filaments and inhibits HIF-1

Vardi-Oknin, Dikla ; Golan, Maya ; Mabjeesh, Nicola J

PloS one, 2013, Vol.8(8), pp.e73179 [Peer Reviewed Journal]

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10
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Olmesartan potentiates the anti-angiogenic effect of sorafenib in mice bearing Ehrlich's ascites carcinoma: role of angiotensin (1-7)

Abd-Alhaseeb, Mohammad M ; Zaitone, Sawsan A ; Abou-El-Ela, Soad H ; Moustafa, Yasser M

PloS one, 2014, Vol.9(1), pp.e85891 [Peer Reviewed Journal]

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XZH-5 inhibits STAT3 phosphorylation and enhances the cytotoxicity of chemotherapeutic drugs in human breast and pancreatic cancer cells

Liu, Aiguo ; Liu, Yan ; Jin, Zhigang ; Hu, Qun ; Lin, Li ; Jou, David ; Yang, Jing ; Xu, Zhenghu ; Wang, Hong ; Li, Chenglong ; Lin, Jiayuh

PloS one, 2012, Vol.7(10), pp.e46624 [Peer Reviewed Journal]

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12
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Why CCR2 and CCR5 blockade failed and why CCR1 blockade might still be effective in the treatment of rheumatoid arthritis

Lebre, Maria C ; Vergunst, Clarissa E ; Choi, Ivy Y K ; Aarrass, Saïda ; Oliveira, Ana S F ; Wyant, Tim ; Horuk, Richard ; Reedquist, Kris A ; Tak, Paul P

PloS one, 2011, Vol.6(7), pp.e21772 [Peer Reviewed Journal]

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13
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Effects of the small molecule HERG activator NS1643 on Kv11.3 channels

Bilet, Arne ; Bauer, Christiane K

PloS one, 2012, Vol.7(11), pp.e50886 [Peer Reviewed Journal]

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DOT1L inhibitor improves early development of porcine somatic cell nuclear transfer embryos

Tao, Jia ; Zhang, Yu ; Zuo, Xiaoyuan ; Hong, Renyun ; Li, Hui ; Liu, Xing ; Huang, Weiping ; Cao, Zubing ; Zhang, Yunhai

PloS one, 2017, Vol.12(6), pp.e0179436 [Peer Reviewed Journal]

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15
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Activation of functional α7-containing nAChRs in hippocampal CA1 pyramidal neurons by physiological levels of choline in the presence of PNU-120596

Kalappa, Bopanna I ; Gusev, Alexander G ; Uteshev, Victor V

PloS one, 12 November 2010, Vol.5(11), pp.e13964 [Peer Reviewed Journal]

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Suppression of natural killer cells by sorafenib contributes to prometastatic effects in hepatocellular carcinoma

Zhang, Qiang-Bo ; Sun, Hui-Chuan ; Zhang, Ke-Zhi ; Jia, Qing-An ; Bu, Yang ; Wang, Miao ; Chai, Zong-Tao ; Zhang, Quan-Bao ; Wang, Wen-Quan ; Kong, Ling-Qun ; Zhu, Xiao-Dong ; Lu, Lu ; Wu, Wei-Zhong ; Wang, Lu ; Tang, Zhao-You

PloS one, 2013, Vol.8(2), pp.e55945 [Peer Reviewed Journal]

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17
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Sorafenib inhibits epithelial-mesenchymal transition through an epigenetic-based mechanism in human lung epithelial cells

Zhang, Juyong ; Chen, Yue-Lei ; Ji, Guanyu ; Fang, Weiying ; Gao, Zhaowei ; Liu, Yi ; Wang, Jun ; Ding, Xiaoyan ; Gao, Fei

PloS one, 2013, Vol.8(5), pp.e64954 [Peer Reviewed Journal]

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18
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The Sulfamate Small Molecule CAIX Inhibitor S4 Modulates Doxorubicin Efficacy

Van Kuijk, Simon J A ; Gieling, Roben G ; Niemans, Raymon ; Lieuwes, Natasja G ; Biemans, Rianne ; Telfer, Brian A ; Haenen, Guido R M M ; Yaromina, Ala ; Lambin, Philippe ; Dubois, Ludwig J ; Williams, Kaye J

PloS one, 2016, Vol.11(8), pp.e0161040 [Peer Reviewed Journal]

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19
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Regorafenib effects on human colon carcinoma xenografts monitored by dynamic contrast-enhanced computed tomography with immunohistochemical validation

Cyran, Clemens C ; Kazmierczak, Philipp M ; Hirner, Heidrun ; Moser, Matthias ; Ingrisch, Michael ; Havla, Lukas ; Michels, Alexandra ; Eschbach, Ralf ; Schwarz, Bettina ; Reiser, Maximilian F ; Bruns, Christiane J ; Nikolaou, Konstantin

PloS one, 2013, Vol.8(9), pp.e76009 [Peer Reviewed Journal]

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20
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Activation of phosphatidylinositol 3-kinase/AKT/snail signaling pathway contributes to epithelial-mesenchymal transition-induced multi-drug resistance to sorafenib in hepatocellular carcinoma cells

Dong, Jiejie ; Zhai, Bo ; Sun, Weihua ; Hu, Fengli ; Cheng, Hao ; Xu, Jun

PloS one, 2017, Vol.12(9), pp.e0185088 [Peer Reviewed Journal]

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21
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2-Deoxy-d-Glucose Can Complement Doxorubicin and Sorafenib to Suppress the Growth of Papillary Thyroid Carcinoma Cells

Wang, Shuo-Yu ; Wei, Yau-Huei ; Shieh, Dar-Bin ; Lin, Li-Ling ; Cheng, Shih-Ping ; Wang, Pei-Wen ; Chuang, Jiin-Haur

PloS one, 2015, Vol.10(7), pp.e0130959 [Peer Reviewed Journal]

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22
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Sorafenib ameliorates renal fibrosis through inhibition of TGF-β-induced epithelial-mesenchymal transition

Jia, Lining ; Ma, Xiaotao ; Gui, Baosong ; Ge, Heng ; Wang, Li ; Ou, Yan ; Tian, Lifang ; Chen, Zhao ; Duan, Zhaoyang ; Han, Jin ; Fu, Rongguo

PloS one, 2015, Vol.10(2), pp.e0117757 [Peer Reviewed Journal]

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23
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Metabolic Profiling of Chicken Embryos Exposed to Perfluorooctanoic Acid (PFOA) and Agonists to Peroxisome Proliferator-Activated Receptors

Mattsson, Anna ; Kärrman, Anna ; Pinto, Rui ; Brunström, Björn

PloS one, 2015, Vol.10(12), pp.e0143780 [Peer Reviewed Journal]

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24
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A type-II positive allosteric modulator of α7 nAChRs reduces brain injury and improves neurological function after focal cerebral ischemia in rats

Sun, Fen ; Jin, Kunlin ; Uteshev, Victor V

PloS one, 2013, Vol.8(8), pp.e73581 [Peer Reviewed Journal]

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25
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Development of a Drug-Response Modeling Framework to Identify Cell Line Derived Translational Biomarkers That Can Predict Treatment Outcome to Erlotinib or Sorafenib

Li, Bin ; Shin, Hyunjin ; Gulbekyan, Georgy ; Pustovalova, Olga ; Nikolsky, Yuri ; Hope, Andrew ; Bessarabova, Marina ; Schu, Matthew ; Kolpakova-Hart, Elona ; Merberg, David ; Dorner, Andrew ; Trepicchio, William L

PloS one, 2015, Vol.10(6), pp.e0130700 [Peer Reviewed Journal]

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26
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BCRP/ABCG2 inhibition sensitizes hepatocellular carcinoma cells to sorafenib

Huang, Wei-Chien ; Hsieh, Yi-Ling ; Hung, Chao-Ming ; Chien, Pei-Hsuan ; Chien, Yu-Fong ; Chen, Lei-Chin ; Tu, Chih-Yen ; Chen, Chia-Hung ; Hsu, Sheng-Chieh ; Lin, Yueh-Ming ; Chen, Yun-Ju

PloS one, 2013, Vol.8(12), pp.e83627 [Peer Reviewed Journal]

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27
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Regorafenib inhibited gastric cancer cells growth and invasion via CXCR4 activated Wnt pathway

Lin, Xiao-Lin ; Xu, Qi ; Tang, Lei ; Sun, Li ; Han, Ting ; Wang, Li-Wei ; Xiao, Xiu-Ying

PloS one, 2017, Vol.12(5), pp.e0177335 [Peer Reviewed Journal]

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28
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Model Matters: Differences in Orthotopic Rat Hepatocellular Carcinoma Physiology Determine Therapy Response to Sorafenib

Groß, Claudia ; Steiger, Katja ; Sayyed, Sufyan ; Heid, Irina ; Feuchtinger, Annette ; Walch, Axel ; Heß, Julia ; Unger, Kristian ; Zitzelsberger, Horst ; Settles, Marcus ; Schlitter, Anna Melissa ; Dworniczak, Juliane ; Altomonte, Jennifer ; Ebert, Oliver ; Schwaiger, Markus ; Rummeny, Ernst ; Steingötter, Andreas ; Esposito, Irene ; Braren, Rickmer

Clinical cancer research : an official journal of the American Association for Cancer Research, 01 October 2015, Vol.21(19), pp.4440-50 [Peer Reviewed Journal]

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29
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Regorafenib inhibits colorectal tumor growth through PUMA-mediated apoptosis

Chen, Dongshi ; Wei, Liang ; Yu, Jian ; Zhang, Lin

Clinical cancer research : an official journal of the American Association for Cancer Research, 01 July 2014, Vol.20(13), pp.3472-84 [Peer Reviewed Journal]

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30
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STAT3 mediates regorafenib-induced apoptosis in hepatocellular carcinoma

Tai, Wei-Tien ; Chu, Pei-Yi ; Shiau, Chung-Wai ; Chen, Yao-Li ; Li, Yong-Shi ; Hung, Man-Hsin ; Chen, Li-Ju ; Chen, Pei-Lung ; Su, Jung-Chen ; Lin, Ping-Yi ; Yu, Hui-Chuan ; Chen, Kuen-Feng

Clinical cancer research : an official journal of the American Association for Cancer Research, 15 November 2014, Vol.20(22), pp.5768-76 [Peer Reviewed Journal]

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31
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Identification of a series of CCK-2 receptor nonpeptide agonists: sensitivity to stereochemistry and a receptor point mutation

Kopin, Alan S ; Mcbride, Edward W ; Chen, Ci ; Freidinger, Roger M ; Chen, Duan ; Zhao, Chun-Mei ; Beinborn, Martin

Proceedings of the National Academy of Sciences of the United States of America, 29 April 2003, Vol.100(9), pp.5525-30 [Peer Reviewed Journal]

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32
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Investigation of the DNA damage response to SFOM-0046, a new small-molecule drug inducing DNA double-strand breaks

Pauty, Joris ; Côté, Marie-France ; Rodrigue, Amélie ; Velic, Denis ; Masson, Jean-Yves ; Fortin, Sébastien

Scientific reports, 22 March 2016, Vol.6, pp.23302 [Peer Reviewed Journal]

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33
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Activities of N,N'-Diarylurea MMV665852 analogs against Schistosoma mansoni

Cowan, Noemi ; Dätwyler, Philipp ; Ernst, Beat ; Wang, Chunkai ; Vennerstrom, Jonathan L ; Spangenberg, Thomas ; Keiser, Jennifer

Antimicrobial agents and chemotherapy, April 2015, Vol.59(4), pp.1935-41 [Peer Reviewed Journal]

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34
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Effect of summer pruning and CPPU on yield and quality of kiwi fruit (Actinidia deliciosa)

Pramanick, K K ; Kashyap, Poonam ; Kishore, D K ; Sharma, Y P

Journal of environmental biology, March 2015, Vol.36(2), pp.351-6 [Peer Reviewed Journal]

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35
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Investigation of the molecular mechanism of the α7 nicotinic acetylcholine receptor positive allosteric modulator PNU-120596 provides evidence for two distinct desensitized states

Williams, Dustin K ; Wang, Jingyi ; Papke, Roger L

Molecular pharmacology, December 2011, Vol.80(6), pp.1013-32 [Peer Reviewed Journal]

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36
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SB225002 Induces Cell Death and Cell Cycle Arrest in Acute Lymphoblastic Leukemia Cells through the Activation of GLIPR1

De Vasconcellos, Jaíra Ferreira ; Laranjeira, Angelo Brunelli Albertoni ; Leal, Paulo C ; Bhasin, Manoj K ; Zenatti, Priscila Pini ; Nunes, Ricardo J ; Yunes, Rosendo A ; Nowill, Alexandre E ; Libermann, Towia A ; Zerbini, Luiz Fernando ; Yunes, José Andrés

PloS one, 2015, Vol.10(8), pp.e0134783 [Peer Reviewed Journal]

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37
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Aspirin minimized the pro-metastasis effect of sorafenib and improved survival by up-regulating HTATIP2 in hepatocellular carcinoma

Lu, Lu ; Sun, Hui-Chuan ; Zhang, Wei ; Chai, Zong-Tao ; Zhu, Xiao-Dong ; Kong, Ling-Qun ; Wang, Wen-Quan ; Zhang, Ke-Zhi ; Zhang, Yuan-Yuan ; Zhang, Qiang-Bo ; Ao, Jian-Yang ; Li, Jia-Qi ; Wang, Lu ; Wu, Wei-Zhong ; Tang, Zhao-You

PloS one, 2013, Vol.8(5), pp.e65023 [Peer Reviewed Journal]

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