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Design and synthesis of de novo cytotoxic alkaloids by mimicking the bioactive conformation of paclitaxel

Sun, Liang ; Veith, Jean M ; Pera, Paula ; Bernacki, Ralph J ; Ojima, Iwao

Bioorganic & Medicinal Chemistry, 2010, Vol.18(19), pp.7101-7112 [Peer Reviewed Journal]

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Highly Effective Dual-Function Near-Infrared (NIR) Photosensitizer for Fluorescence Imaging and Photodynamic Therapy (PDT) of Cancer

Patel, Nayan ; Pera, Paula ; Joshi, Penny ; Dukh, Mykhaylo ; Tabaczynski, Walter A ; Siters, Kevin E ; Kryman, Mark ; Cheruku, Ravindra R ; Durrani, Farukh ; Missert, Joseph R ; Watson, Ramona ; Ohulchanskyy, Tymish Y ; Tracy, Erin C ; Baumann, Heinz ; Pandey, Ravindra K

Journal of medicinal chemistry, 10 November 2016, Vol.59(21), pp.9774-9787 [Peer Reviewed Journal]

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Effect of chirality on cellular uptake, imaging and photodynamic therapy of photosensitizers derived from chlorophyll-a

Srivatsan, Avinash ; Pera, Paula ; Joshi, Penny ; Wang, Yanfang ; Missert, Joseph R ; Tracy, Erin C ; Tabaczynski, Walter A ; Yao, Rutao ; Sajjad, Munawwar ; Baumann, Heinz ; Pandey, Ravindra K

Bioorganic & Medicinal Chemistry, 01 July 2015, Vol.23(13), pp.3603-3617 [Peer Reviewed Journal]

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Photodynamic therapy of human lung cancer xenografts in mice

Nwogu, Chukwumere ; Pera, Paula ; Bshara, Wiam ; Attwood, Kristopher ; Pandey, Ravindra

Journal of Surgical Research, January 2016, Vol.200(1), pp.8-12 [Peer Reviewed Journal]

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Photodynamic therapy does not induce cyclobutane pyrimidine dimers in the presence of melanin

Mudambi, Shaila ; Pera, Paula ; Washington, Deschana ; Remenyik, Eva ; Fidrus, Eszter ; Shafirstein, Gal ; Bellnier, David ; Paragh, Gyorgy

Photodiagnosis and Photodynamic Therapy, June 2018, Vol.22, pp.241-244 [Peer Reviewed Journal]

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Synthesis, Photophysical, Electrochemical, Tumor-Imaging, and Phototherapeutic Properties of Purpurinimide-N-substituted Cyanine Dyes Joined with Variable Lengths of Linkers

Williams, Michael ; Ethirajan, Manivannan ; Ohkubo, Kei ; Chen, Ping ; Pera, Paula ; Morgan, Janet ; White, William ; Shibata, Masayuki ; Fukuzumi, Shunichi ; Kadish, Karl ; Pandey, Ravindra

Bioconjugate Chemistry, Nov 16, 2011, p.2283 [Peer Reviewed Journal]

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Effect of Metalation on Porphyrin-Based Bifunctional Agents in Tumor Imaging and Photodynamic Therapy

Patel, Nayan ; Chen, Yihui ; Joshi, Penny ; Pera, Paula ; Baumann, Heinz ; Missert, Joseph ; Ohkubo, Kei ; Fukuzumi, Shunichi ; Nani, Roger ; Schnermann, Martin ; Chen, Ping ; Zhu, Jialiang ; Kadish, Karl ; Pandey, Ravindra

Bioconjugate Chemistry, Mar 16, 2016, Vol.27(3), p.667 [Peer Reviewed Journal]

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Synthesis, photophysical, electrochemical, tumor-imaging, and phototherapeutic properties of purpurinimide-N-substituted cyanine dyes joined with variable lengths of linkers

Williams, Michael P A ; Ethirajan, Manivannan ; Ohkubo, Kei ; Chen, Ping ; Pera, Paula ; Morgan, Janet ; White, William H ; Shibata, Masayuki ; Fukuzumi, Shunichi ; Kadish, Karl M ; Pandey, Ravindra K

Bioconjugate chemistry, 16 November 2011, Vol.22(11), pp.2283-95 [Peer Reviewed Journal]

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Synthesis and biological evaluation of novel 3′-difluorovinyl taxoids

Kuznetsova, Larissa ; Sun, Liang ; Chen, Jin ; Zhao, Xianrui ; Seitz, Joshua ; Das, Manisha ; Li, Yuan ; Veith, Jean M ; Pera, Paula ; Bernacki, Ralph J ; Xia, Shujun ; Horwitz, Susan B ; Ojima, Iwao

Journal of Fluorine Chemistry, November 2012, Vol.143, pp.177-188 [Peer Reviewed Journal]

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Multifunctional nanoplatforms for fluorescence imaging and photodynamic therapy developed by post-loading photosensitizer and fluorophore to polyacrylamide nanoparticles

Gupta, Anurag ; Wang, Shouyan ; Pera, Paula ; Rao, K.V.R ; Patel, Nayan ; Ohulchanskyy, Tymish Y ; Missert, Joseph ; Morgan, Janet ; Koo-Lee, Yong-Eun ; Kopelman, Raoul ; Pandey, Ravindra K

Nanomedicine: Nanotechnology, Biology, and Medicine, August 2012, Vol.8(6), pp.941-950 [Peer Reviewed Journal]

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11
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Novel methods to incorporate photosensitizers into nanocarriers for cancer treatment by photodynamic therapy

Wang, Shouyan ; Fan, Wenzhe ; Kim, Gwangseong ; Hah, Hoe Jin ; Lee, Yong‐Eun Koo ; Kopelman, Raoul ; Ethirajan, Manivannan ; Gupta, Anurag ; Goswami, Lalit N. ; Pera, Paula ; Morgan, Janet ; Pandey, Ravindra K.

Lasers in Surgery and Medicine, September 2011, Vol.43(7), pp.686-695 [Peer Reviewed Journal]

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12
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Structural and Epimeric Isomers of HPPH 3-Devinyl 3-{1-(1-hexyloxy) ethyl}pyropheophorbide-a: Effects on Uptake and Photodynamic Therapy of Cancer

Saenz, Courtney ; Cheruku, Ravindra R ; Ohulchanskyy, Tymish Y ; Joshi, Penny ; Tabaczynski, Walter A ; Missert, Joseph R ; Chen, Yihui ; Pera, Paula ; Tracy, Erin ; Marko, Aimee ; Rohrbach, Daniel ; Sunar, Ulas ; Baumann, Heinz ; Pandey, Ravindra K

ACS chemical biology, 21 April 2017, Vol.12(4), pp.933-946 [Peer Reviewed Journal]

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Synthesis and Biological Evaluation of Novel 3'-Difluorovinyl Taxoids

Kuznetsova, Larissa ; Sun, Liang ; Chen, Jin ; Zhao, Xianrui ; Seitz, Joshua ; Das, Manisha ; Li, Yuan ; Veith, Jean M ; Pera, Paula ; Bernacki, Ralph J ; Xia, Shujun ; Horwitz, Susan B ; Ojima, Iwao

Journal of fluorine chemistry, 01 November 2012, Vol.143, pp.177-188 [Peer Reviewed Journal]

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14
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Synthesis, molecular modeling, and evaluation of nonphenolic indole analogs of mycophenolic acid

El-Araby, Moustafa E ; Bernacki, Ralph J ; Makara, Gergely M ; Pera, Paula J ; Anderson, Wayne K

Bioorganic & Medicinal Chemistry, 2004, Vol.12(11), pp.2867-2879 [Peer Reviewed Journal]

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15
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In Vitro Antitumor Activity of 9‐Nitro‐Camptothecin as a Single Agent and in Combination with other Antitumor Drugs

Bernacki, Ralph J. ; Pera, Paula ; Gambacorta, Peter ; Brun, Yseult ; Greco, William R.

Annals of the New York Academy of Sciences, December 2000, Vol.922(1), pp.293-297 [Peer Reviewed Journal]

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16
Synthesis and Structure−Activity Relationships of Nonaromatic Taxoids:  Effects of Alkyl and Alkenyl Ester Groups on Cytotoxicity
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Synthesis and Structure−Activity Relationships of Nonaromatic Taxoids:  Effects of Alkyl and Alkenyl Ester Groups on Cytotoxicity

Ojima, Iwao ; Kuduk, Scott D. ; Pera, Paula ; Veith, Jean M. ; Bernacki, Ralph J.

Journal of Medicinal Chemistry, 01/1997, Vol.40(3), pp.279-285 [Peer Reviewed Journal]

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17
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The tyrosine kinase inhibitor imatinib mesylate enhances the efficacy of photodynamic therapy by inhibiting ABCG2

Liu, Weiguo ; Baer, Maria R ; Bowman, Mary Jo ; Pera, Paula ; Zheng, Xiang ; Morgan, Janet ; Pandey, Ravindra A ; Oseroff, Allan R

Clinical cancer research : an official journal of the American Association for Cancer Research, 15 April 2007, Vol.13(8), pp.2463-70 [Peer Reviewed Journal]

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18
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High-resolution magnetic resonance imaging of the efficacy of the cytosine analogue 1-2-C-cyano-2-deoxy-beta-D-arabino-pentofuranosyl-N(4)-palmitoyl cytosine (CS-682) in a liver-metastasis athymic nude mouse model

Wu, Ming ; Mazurchuk, Richard ; Chaudhary, Neeta D ; Spernyak, Joseph ; Veith, Jean ; Pera, Paula ; Greco, William ; Hoffman, Robert M ; Kobayashi, Tomowo ; Bernacki, Ralph J

Cancer research, 15 May 2003, Vol.63(10), pp.2477-82 [Peer Reviewed Journal]

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19
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Design, synthesis, and biological evaluation of novel C14-C3'BzN-linked macrocyclic taxoids

Sun, Liang ; Geng, Xudong ; Geney, Raphaël ; Li, Yuan ; Simmerling, Carlos ; Li, Zhong ; Lauher, Joseph W ; Xia, Shujun ; Horwitz, Susan B ; Veith, Jean M ; Pera, Paula ; Bernacki, Ralph J ; Ojima, Iwao

The Journal of organic chemistry, 19 December 2008, Vol.73(24), pp.9584-93 [Peer Reviewed Journal]

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20
Syntheses and Structure−Activity Relationships of Novel Nor-seco Taxoids
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Syntheses and Structure−Activity Relationships of Novel Nor-seco Taxoids

Ojima, Iwao ; Lin, Songnian ; Chakravarty, Subrata ; Fenoglio, Ivana ; Park, Young Hoon ; Sun, Chung-Ming ; Appendino, Giovanni ; Pera, Paula ; Veith, Jean M. ; Bernacki, Ralph J.

The Journal of Organic Chemistry, 03/1998, Vol.63(5), pp.1637-1645 [Peer Reviewed Journal]

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21
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Syntheses and biological activity of C-3′-difluoromethyl-taxoids

Ojima, Iwao ; Lin, Songnian ; Slater, John C ; Wang, Tao ; Pera, Paula ; Bernacki, Ralph J ; Ferlini, Cristiano ; Scambia, Giovanni

Bioorganic & Medicinal Chemistry, July 2000, Vol.8(7), pp.1619-1628 [Peer Reviewed Journal]

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22
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Synthesis and evaluation of analogues of 5'-((Z)-4-amino-2-butenylmethylamino)-5'-deoxyadenosine as inhibitors of tumor cell growth, trypanosomal growth, and HIV-1 infectivity

Marasco, Canio J ; Kramer, Debora L ; Miller, John ; Porter, Carl W ; Bacchi, Cyrus J ; Rattendi, Donna ; Kucera, Louis ; Iyer, Nathan ; Bernacki, Ralph ; Pera, Paula ; Sufrin, Janice R

Journal of medicinal chemistry, 07 November 2002, Vol.45(23), pp.5112-22 [Peer Reviewed Journal]

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23
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Modeling the combination of amphotericin B, micafungin, and nikkomycin Z against Aspergillus fumigatus in vitro using a novel response surface paradigm

Brun, Yseult F ; Dennis, Carly G ; Greco, William R ; Bernacki, Ralph J ; Pera, Paula J ; Bushey, Jennifer J ; Youn, Richard C ; White, Donald B ; Segal, Brahm H

Antimicrobial agents and chemotherapy, May 2007, Vol.51(5), pp.1804-12 [Peer Reviewed Journal]

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24
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Design, synthesis, and biological evaluation of new-generation taxoids

Ojima, Iwao ; Chen, Jin ; Sun, Liang ; Borella, Christopher P ; Wang, Tao ; Miller, Michael L ; Lin, Songnian ; Geng, Xudong ; Kuznetsova, Larisa ; Qu, Chuanxing ; Gallager, David ; Zhao, Xianrui ; Zanardi, Ilaria ; Xia, Shujun ; Horwitz, Susan B ; Mallen-St Clair, Jon ; Guerriero, Jennifer L ; Bar-Sagi, Dafna ; Veith, Jean M ; Pera, Paula ; Bernacki, Ralph J

Journal of medicinal chemistry, 12 June 2008, Vol.51(11), pp.3203-21 [Peer Reviewed Journal]

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25
Syntheses and Structure−Activity Relationships of Taxoids Derived from 14β-Hydroxy-10-deacetylbaccatin III
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Syntheses and Structure−Activity Relationships of Taxoids Derived from 14β-Hydroxy-10-deacetylbaccatin III

Ojima, Iwao ; Slater, John C. ; Kuduk, Scott D. ; Takeuchi, Craig S. ; Gimi, Rayomand H. ; Sun, Chung-Ming ; Park, Young Hoon ; Pera, Paula ; Veith, Jean M. ; Bernacki, Ralph J.

Journal of Medicinal Chemistry, 01/1997, Vol.40(3), pp.267-278 [Peer Reviewed Journal]

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26
Syntheses and Structure−Activity Relationships of the Second-Generation Antitumor Taxoids:  Exceptional Activity against Drug-Resistant Cancer Cells
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Syntheses and Structure−Activity Relationships of the Second-Generation Antitumor Taxoids:  Exceptional Activity against Drug-Resistant Cancer Cells

Ojima, Iwao ; Slater, John C. ; Michaud, Evelyne ; Kuduk, Scott D. ; Bounaud, Pierre-Yves ; Vrignaud, Patricia ; Bissery, Marie-Christine ; Veith, Jean M. ; Pera, Paula ; Bernacki, Ralph J.

Journal of Medicinal Chemistry, 01/1996, Vol.39(20), pp.3889-3896 [Peer Reviewed Journal]

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27
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Design, synthesis and structure-activity relationships of novel taxane-based multidrug resistance reversal agents

Ojima, Iwao ; Borella, Christopher P ; Wu, Xinyuan ; Bounaud, Pierre-Yves ; Oderda, Cecilia Fumero ; Sturm, Matthew ; Miller, Michael L ; Chakravarty, Subrata ; Chen, Jin ; Huang, Qing ; Pera, Paula ; Brooks, Tracy A ; Baer, Maria R ; Bernacki, Ralph J

Journal of medicinal chemistry, 24 March 2005, Vol.48(6), pp.2218-28 [Peer Reviewed Journal]

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28
Design, Synthesis and Structure−Activity Relationships of Novel Taxane-Based Multidrug Resistance Reversal Agents
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Design, Synthesis and Structure−Activity Relationships of Novel Taxane-Based Multidrug Resistance Reversal Agents

Ojima, Iwao ; Borella, Christopher P. ; Wu, Xinyuan ; Bounaud, Pierre-Yves ; Oderda, Cecilia Fumero ; Sturm, Matthew ; Miller, Michael L. ; Chakravarty, Subrata ; Chen, Jin ; Huang, Qing ; Pera, Paula ; Brooks, Tracy A. ; Baer, Maria R. ; Bernacki, Ralph J.

Journal of Medicinal Chemistry, 03/2005, Vol.48(6), pp.2218-2228 [Peer Reviewed Journal]

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29
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Synthesis and biological evaluation of new taxoids derived from 2-deacetoxytaxinine J

Botta, Maurizio ; Armaroli, Silvia ; Castagnolo, Daniele ; Fontana, Gabriele ; Pera, Paula ; Bombardelli, Ezio

Bioorganic & Medicinal Chemistry Letters, 2007, Vol.17(6), pp.1579-1583 [Peer Reviewed Journal]

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30
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Design and synthesis of de novo cytotoxic alkaloids through mimicking taxoid skeleton

Geng, Xudong ; Geney, Raphaël ; Pera, Paula ; Bernacki, Ralph J ; Ojima, Iwao

Bioorganic & Medicinal Chemistry Letters, 2004, Vol.14(13), pp.3491-3494 [Peer Reviewed Journal]

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31
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Design, synthesis and biological activity of novel C2-C3′ N-Linked macrocyclic taxoids

Ojima, Iwao ; Geng, Xudong ; Lin, Songnian ; Pera, Paula ; Bernacki, Ralph J

Bioorganic & Medicinal Chemistry Letters, 2002, Vol.12(3), pp.349-352 [Peer Reviewed Journal]

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32
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Polyamine biosynthetic activity in normal and neoplastic human colorectal tissues

Porter, Carl W. ; Herrera‐Ornelas, Lemuel ; Pera, Paula ; Petrelli, Nicholas F. ; Mittelman, Arnold

Cancer, 15 September 1987, Vol.60(6), pp.1275-1281 [Peer Reviewed Journal]

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33
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Syntheses and structure–activity relationships of novel 3′-difluoromethyl and 3′-trifluoromethyl-taxoids

Kuznetsova, Larissa V ; Pepe, Antonella ; Ungureanu, Ioana M ; Pera, Paula ; Bernacki, Ralph J ; Ojima, Iwao

Journal of Fluorine Chemistry, 2008, Vol.129(9), pp.817-828 [Peer Reviewed Journal]

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34
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Improved Synthesis of β-D-6-Methylpurine Riboside and Antitumor Effects of the β-D- and α-D-Anomers

Marasco, Canio J ; Pera, Paula J ; Spiess, Arthur J ; Bernacki, Ralph ; Sufrin, Janice R

Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry, 2005, Vol.10(8), p.1015-1020 [Peer Reviewed Journal]

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35
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Improved synthesis of beta-D-6-methylpurine riboside and antitumor effects of the beta-D- and alpha-D-anomers

Marasco, Canio J ; Pera, Paula J ; Spiess, Arthur J ; Bernacki, Ralph ; Sufrin, Janice R

Molecules (Basel, Switzerland), 31 August 2005, Vol.10(8), pp.1015-20 [Peer Reviewed Journal]

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36
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Structure-activity relationships of ring C-secotaxoids. 1. Acylative modifications

Appendino, Giovanni ; Bettoni, Piergiorgio ; Noncovich, Alain ; Sterner, Olov ; Fontana, Gabriele ; Bombardelli, Ezio ; Pera, Paula ; Bernacki, Ralph J

Journal of natural products, February 2004, Vol.67(2), pp.184-8 [Peer Reviewed Journal]

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