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1
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Determination of the Disulfide Structure of Murine Meteorin, a Neurotrophic Factor, by LC-MS and Electron Transfer Dissociation-High-Energy Collisional Dissociation Analysis of Proteolytic Fragments

Wen, Dingyi ; Xiao, Yongsheng ; Vecchi, Malgorzata M ; Gong, Bang Jian ; Dolnikova, Jana ; Pepinsky, R Blake

Analytical chemistry, 04 April 2017, Vol.89(7), pp.4021-4030 [Peer Reviewed Journal]

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2
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Efficient on-column conversion of IgG 1 trisulfide linkages to native disulfides in tandem with Protein A affinity chromatography

Aono, Hiromasa ; Wen, Dingy ; Zang, Li ; Houde, Damian ; Pepinsky, R. Blake ; Evans, David R.H

Journal of Chromatography A, 2010, Vol.1217(32), pp.5225-5232 [Peer Reviewed Journal]

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3
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Characterization of trisulfide modification in antibodies

Gu, Sheng ; Wen, Dingyi ; Weinreb, Paul H ; Sun, Yaping ; Zhang, Lihe ; Foley, Susan F ; Kshirsagar, Rashmi ; Evans, David ; Mi, Sha ; Meier, Werner ; Pepinsky, R. Blake

Analytical Biochemistry, 2010, Vol.400(1), pp.89-98 [Peer Reviewed Journal]

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4
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Blocking LINGO-1 as a therapy to promote CNS repair: from concept to the clinic

Mi, Sha ; Pepinsky, R Blake ; Cadavid, Diego

CNS drugs, July 2013, Vol.27(7), pp.493-503 [Peer Reviewed Journal]

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5
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Detection of VAC‐β (annexin‐8) in human placenta

Pepinsky, R. Blake ; Hauptmann, Rudolf

FEBS Letters, 13 July 1992, Vol.306(1), pp.85-89 [Peer Reviewed Journal]

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6
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Constitutive negative regulation in the processing of the anti-Müllerian hormone receptor II

Hirschhorn, Tal ; Di Clemente, Nathalie ; Amsalem, Ayelet R ; Pepinsky, R Blake ; Picard, Jean-Yves ; Smorodinsky, Nechama I ; Cate, Richard L ; Ehrlich, Marcelo

Journal of cell science, 01 April 2015, Vol.128(7), pp.1352-64 [Peer Reviewed Journal]

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7
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Structure of the LINGO-1-anti-LINGO-1 Li81 antibody complex provides insights into the biology of LINGO-1 and the mechanism of action of the antibody therapy

Pepinsky, R Blake ; Arndt, Joseph W ; Quan, Chao ; Gao, Yan ; Quintero-Monzon, Omar ; Lee, Xinhua ; Mi, Sha

The Journal of pharmacology and experimental therapeutics, July 2014, Vol.350(1), pp.110-23 [Peer Reviewed Journal]

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8
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Sphingosine 1-phosphate receptor modulator fingolimod (FTY720) does not promote remyelination in vivo

Hu, Yinghui ; Lee, Xinhua ; Ji, Benxiu ; Guckian, Kevin ; Apicco, Daniel ; Pepinsky, R. Blake ; Miller, Robert H ; Mi, Sha

Molecular and Cellular Neuroscience, September 2011, Vol.48(1), pp.72-81 [Peer Reviewed Journal]

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9
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Dynamic structural changes are observed upon collagen and metal ion binding to the integrin α1 I domain

Weinreb, Paul H ; Li, Sheng ; Gao, Sharon X ; Liu, Tong ; Pepinsky, R Blake ; Caravella, Justin A ; Lee, Jun H ; Woods, Virgil L

The Journal of biological chemistry, 21 September 2012, Vol.287(39), pp.32897-912 [Peer Reviewed Journal]

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10
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Production of a PEGylated Fab' of the anti-LINGO-1 Li33 antibody and assessment of its biochemical and functional properties in vitro and in a rat model of remyelination

Pepinsky, R Blake ; Walus, Lee ; Shao, Zhaohui ; Ji, Benxiu ; Gu, Sheng ; Sun, Yaping ; Wen, Dingyi ; Lee, Xinhua ; Wang, Qin ; Garber, Ellen ; Mi, Sha

Bioconjugate chemistry, 16 February 2011, Vol.22(2), pp.200-10 [Peer Reviewed Journal]

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11
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Processing of anti-mullerian hormone regulates receptor activation by a mechanism distinct from TGF-beta

Di Clemente, Nathalie ; Jamin, Soazik P ; Lugovskoy, Alexey ; Carmillo, Paul ; Ehrenfels, Christian ; Picard, Jean-Yves ; Whitty, Adrian ; Josso, Nathalie ; Pepinsky, R Blake ; Cate, Richard L Jonchère, Laurent (Editor)

Molecular Endocrinology -Baltimore, 31 October 2010, Vol.24(11), pp.2193-206 [Peer Reviewed Journal]

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12
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Improving the solubility of anti‐LINGO‐1 monoclonal antibody Li33 by isotype switching and targeted mutagenesis

Pepinsky, R. Blake ; Silvian, Laura ; Berkowitz, Steven A. ; Farrington, Graham ; Lugovskoy, Alexey ; Walus, Lee ; Eldredge, John ; Capili, Allan ; Mi, Sha ; Graff, Christilyn ; Garber, Ellen

Protein Science, May 2010, Vol.19(5), pp.954-966 [Peer Reviewed Journal]

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13
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Death receptor 6 negatively regulates oligodendrocyte survival, maturation and myelination

Mi, Sha ; Lee, Xinhua ; Hu, Yinghui ; Ji, Benxiu ; Shao, Zhaohui ; Yang, Weixing ; Huang, Guanrong ; Walus, Lee ; Rhodes, Kenneth ; Gong, Bang Jian ; Miller, Robert H ; Pepinsky, R Blake

Nature medicine, 03 July 2011, Vol.17(7), pp.816-21 [Peer Reviewed Journal]

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14
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Exposure levels of anti-LINGO-1 Li81 antibody in the central nervous system and dose-efficacy relationships in rat spinal cord remyelination models after systemic administration

Pepinsky, R Blake ; Shao, Zhaohui ; Ji, Benxiu ; Wang, Qin ; Meng, Gym ; Walus, Lee ; Lee, Xinhua ; Hu, Yinghui ; Graff, Christilyn ; Garber, Ellen ; Meier, Werner ; Mi, Sha

The Journal of pharmacology and experimental therapeutics, November 2011, Vol.339(2), pp.519-29 [Peer Reviewed Journal]

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15
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Antibody humanization by redesign of complementarity-determining region residues proximate to the acceptor framework

Hanf, Karl J.M ; Arndt, Joseph W ; Chen, Ling Ling ; Jarpe, Matthew ; Boriack-Sjodin, P. Ann ; Li, You ; van Vlijmen, Herman W.T ; Pepinsky, R. Blake ; Simon, Kenneth J ; Lugovskoy, Alexey

Methods, 01 January 2014, Vol.65(1), pp.68-76 [Peer Reviewed Journal]

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16
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Development and validation of immunoassays to quantify the half-antibody exchange of an IgG4 antibody, natalizumab (Tysabri ®) with endogenous IgG4

Shapiro, Renée I ; Plavina, Tatiana ; Schlain, Brian R ; Pepinsky, R. Blake ; Garber, Ellen A ; Jarpe, Matthew ; Hochman, Paula S ; Wehner, Nancy G ; Bard, Frederique ; Motter, Ruth ; Yednock, Ted A ; Taylor, Frederick R

Journal of Pharmaceutical and Biomedical Analysis, 2011, Vol.55(1), pp.168-175 [Peer Reviewed Journal]

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17
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Structural and kinetic basis for the selectivity of aducanumab for aggregated forms of amyloid-β

Arndt, Joseph W ; Qian, Fang ; Smith, Benjamin A ; Quan, Chao ; Kilambi, Krishna Praneeth ; Bush, Martin W ; Walz, Thomas ; Pepinsky, R. Blake ; Bussière, Thierry ; Hamann, Stefan ; Cameron, Thomas O ; Weinreb, Paul H Argonne National Lab. (Anl), Argonne, Il (United States). Advanced Photon Source (APS) (Corporate Author)

Scientific Reports, 23 April 2018, Vol.8(1) [Peer Reviewed Journal]

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18
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GFRalpha3 is expressed predominantly in nociceptive sensory neurons

Orozco, Olivia E. ; Walus, Lee ; Sah, Dinah W. Y. ; Pepinsky, R. Blake ; Sanicola, Michele

European Journal of Neuroscience, June 2001, Vol.13(11), pp.2177-2182 [Peer Reviewed Journal]

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19
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Disulfide structure of the leucine-rich repeat C-terminal cap and C-terminal stalk region of Nogo-66 receptor

Wen, Dingyi ; Wildes, Craig P ; Silvian, Laura ; Walus, Lee ; Mi, Sha ; Lee, Daniel H S ; Meier, Werner ; Pepinsky, R Blake

Biochemistry, 20 December 2005, Vol.44(50), pp.16491-501 [Peer Reviewed Journal]

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20
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Effect of combined treatment with methylprednisolone and soluble Nogo‐66 receptor after rat spinal cord injury

Ji, Benxiu ; Li, Mingwei ; Budel, Stephane ; Pepinsky, R. Blake ; Walus, Lee ; Engber, Thomas M. ; Strittmatter, Stephen M. ; Relton, Jane K.

European Journal of Neuroscience, August 2005, Vol.22(3), pp.587-594 [Peer Reviewed Journal]

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21
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Development of an aggregate-selective, human-derived α-synuclein antibody BIIB054 that ameliorates disease phenotypes in Parkinson's disease models

Weihofen, Andreas ; Liu, Yuting ; Arndt, Joseph W ; Huy, Christian ; Quan, Chao ; Smith, Benjamin A ; Baeriswyl, Jean-Luc ; Cavegn, Nicole ; Senn, Luzia ; Su, Lihe ; Marsh, Galina ; Auluck, Pavan K ; Montrasio, Fabio ; Nitsch, Roger M ; Hirst, Warren D ; Cedarbaum, Jesse M ; Pepinsky, R. Blake ; Grimm, Jan ; Weinreb, Paul H

Neurobiology of Disease, April 2019, Vol.124, pp.276-288 [Peer Reviewed Journal]

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22
The Plasma and Cytoplasmic Forms of Human Gelsolin Differ in Disulfide Structure †
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The Plasma and Cytoplasmic Forms of Human Gelsolin Differ in Disulfide Structure †

Wen, Dingyi ; Corina, Karen ; Chow, E. Pingchang ; Miller, Stephan ; Janmey, Paul A. ; Pepinsky, R. Blake

Biochemistry, 01/1996, Vol.35(30), pp.9700-9709 [Peer Reviewed Journal]

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23
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A cell-free electrochemiluminescence assay for measuring beta1-integrin-ligand interactions

Weinreb, Paul H ; Yang, William J ; Violette, Shelia M ; Couture, Megan ; Kimball, Kathleen ; Pepinsky, R Blake ; Lobb, Roy R ; Josiah, Serene

Analytical biochemistry, 15 July 2002, Vol.306(2), pp.305-13 [Peer Reviewed Journal]

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24
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IGF-1:Tetanus toxin fragment C fusion protein improves delivery of IGF-1 to spinal cord but fails to prolong survival of ALS mice

Chian, Ru-Ju ; Li, Jianhong ; Ay, Ilknur ; Celia, Samuel A ; Kashi, Brenda B ; Tamrazian, Eric ; Matthews, Jonathan C ; Bronson, Roderick T ; Rossomando, Anthony ; Pepinsky, R. Blake ; Fishman, Paul S ; Brown, Robert H ; Francis, Jonathan W

Brain Research, 2009, Vol.1287, pp.1-19 [Peer Reviewed Journal]

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25
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Crystal structure of the α1β1 integrin I‐domain: insights into integrin I‐domain function

Nolte, Matthias ; Pepinsky, R. Blake ; Venyaminov, Sergei Yu. ; Koteliansky, Victor ; Gotwals, Philip J. ; Karpusas, Michael

FEBS Letters, 11 June 1999, Vol.452(3), pp.379-385 [Peer Reviewed Journal]

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26
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TAJ/TROY, an Orphan TNF Receptor Family Member, Binds Nogo-66 Receptor 1 and Regulates Axonal Regeneration

Shao, Zhaohui ; Browning, Jeffrey L ; Lee, Xinhua ; Scott, Martin L ; Shulga-Morskaya, Sveltlana ; Allaire, Norm ; Thill, Greg ; Levesque, Melissa ; Sah, Dinah ; Mccoy, John M ; Murray, Beth ; Jung, Vincent ; Pepinsky, R. Blake ; Mi, Sha

Neuron, 2005, Vol.45(3), pp.353-359 [Peer Reviewed Journal]

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27
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LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex

Mi, Sha ; Lee, Xinhua ; Shao, Zhaohui ; Thill, Greg ; Ji, Benxiu ; Relton, Jane ; Levesque, Melissa ; Allaire, Norm ; Perrin, Steve ; Sands, Bryan ; Crowell, Thomas ; Cate, Richard L ; Mccoy, John M ; Pepinsky, R Blake

Nature neuroscience, March 2004, Vol.7(3), pp.221-8 [Peer Reviewed Journal]

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28
Identification of Ligand Binding Sites on Integrin α4β1 through Chemical Cross-Linking
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Identification of Ligand Binding Sites on Integrin α4β1 through Chemical Cross-Linking

Chen, Ling Ling ; Lobb, Roy R. ; Cuervo, Julio H. ; Lin, Ko-Chung ; Adams, Steven P. ; Pepinsky, R. Blake

Biochemistry, 06/1998, Vol.37(24), pp.8743-8753 [Peer Reviewed Journal]

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29
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Tetanus toxin fragment C fusion facilitates protein delivery to CNS neurons from cerebrospinal fluid in mice

Benn, Susanna C. ; Ay, Ilknur ; Bastia, Elena ; Chian, Ru‐Ju ; Celia, Samuel A. ; Pepinsky, R. Blake ; Fishman, Paul S. ; Brown, Robert H. ; Francis, Jonathan W.

Journal of Neurochemistry, November 2005, Vol.95(4), pp.1118-1131 [Peer Reviewed Journal]

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30
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Pathophysiologic Role of α4 Integrins in the Lung

Lobb, Roy R. ; Abraham, William M. ; Burkly, Linda C. ; Gill, Alan ; Ma, Weining ; Knight, James A. ; Leone, Diane R. ; Antognetti, Giovanna ; Pepinsky, R. Blake

Annals of the New York Academy of Sciences, October 1996, Vol.796(1), pp.113-123 [Peer Reviewed Journal]

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31
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Resolution of disulfide heterogeneity in Nogo receptor 1 fusion proteins by molecular engineering

Weinreb, Paul H. ; Wen, Dingyi ; Qian, Fang ; Wildes, Craig P. ; Garber, Ellen A. ; Walus, Lee ; Jung, Mi‐Young ; Wang, Joy ; Relton, Jane K. ; Amatucci, Joseph ; Wang, Ruizhong ; Porreca, Frank ; Silvian, Laura ; Meier, Werner ; Pepinsky, R. Blake ; Lee, Daniel H. S.

Biotechnology and Applied Biochemistry, September 2010, Vol.57(1), pp.31-45 [Peer Reviewed Journal]

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32
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Long‐acting forms of Sonic hedgehog with improved pharmacokinetic and pharmacodynamic properties are efficacious in a nerve injury model

Pepinsky, R. Blake ; Shapiro, Renee I. ; Wang, Shaoshan ; Chakraborty, Abhijit ; Gill, Alan ; Lepage, Doreen J. ; Wen, Dingyi ; Rayhorn, Paul ; Horan, Gerald S. B. ; Taylor, Frederick R. ; Garber, Ellen A. ; Galdes, Alphonse ; Engber, Thomas M.

Journal of Pharmaceutical Sciences, February 2002, Vol.91(2), pp.371-387 [Peer Reviewed Journal]

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33
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Monoclonal antibodies to lipocortin‐1 as probes for biological function

Pepinsky, R. Blake ; Sinclair, Lesley K. ; Dougas, Irene ; Liang, Chi - Ming ; Lawton, Pornsri ; Browning, Jeffrey L.

FEBS Letters, 26 February 1990, Vol.261(2), pp.247-252 [Peer Reviewed Journal]

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34
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A glial cell line-derived neurotrophic factor (GDNF):tetanus toxin fragment C protein conjugate improves delivery of GDNF to spinal cord motor neurons in mice

Larsen, Kristin E ; Benn, Susanna C ; Ay, Ilknur ; Chian, Ru-Ju ; Celia, Samuel A ; Remington, Mary P ; Bejarano, Michelle ; Liu, Meiqin ; Ross, Joshua ; Carmillo, Paul ; Sah, Dinah ; Phillips, Kester A ; Sulzer, David ; Pepinsky, R. Blake ; Fishman, Paul S ; Brown, Robert H ; Francis, Jonathan W

Brain Research, 2006, Vol.1120(1), pp.1-12 [Peer Reviewed Journal]

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35
Enhanced Potency of Human Sonic Hedgehog by Hydrophobic Modification
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Enhanced Potency of Human Sonic Hedgehog by Hydrophobic Modification

Taylor, Frederick R. ; Wen, Dingyi ; Garber, Ellen A. ; Carmillo, Amie N. ; Baker, Darren P. ; Arduini, Robert M. ; Williams, Kevin P. ; Weinreb, Paul H. ; Rayhorn, Paul ; Hronowski, Xiaoping ; Whitty, Adrian ; Day, Eric S. ; Boriack-Sjodin, Ann ; Shapiro, Renee I. ; Galdes, Alphonse ; Pepinsky, R. Blake

Biochemistry, 04/2001, Vol.40(14), pp.4359-4371 [Peer Reviewed Journal]

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36
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Comparative assessment of the ligand and metal ion binding properties of integrins alpha9beta1 and alpha4beta1

Pepinsky, R Blake ; Mumford, Richard A ; Chen, Ling Ling ; Leone, Diane ; Amo, Suzanne E ; Riper, Gail Van ; Whitty, Adrian ; Dolinski, Brian ; Lobb, Roy R ; Dean, Dennis C ; Chang, Linda L ; Raab, Conrad E ; Si, Qian ; Hagmann, William K ; Lingham, Russell B

Biochemistry, 04 June 2002, Vol.41(22), pp.7125-41 [Peer Reviewed Journal]

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37
Divalent Cations Stabilize the α1β1 Integrin I Domain †
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Divalent Cations Stabilize the α1β1 Integrin I Domain †

Gotwals, Philip J. ; Chi-Rosso, Gloria ; Ryan, Sarah T. ; Sizing, Irene ; Zafari, Mohammad ; Benjamin, Chris ; Singh, Jus ; Venyaminov, Sergei Yu. ; Pepinsky, R. Blake ; Koteliansky, Victor

Biochemistry, 06/1999, Vol.38(26), pp.8280-8288 [Peer Reviewed Journal]

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