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Maleimide conjugates of saxitoxin as covalent inhibitors of voltage-gated sodium channels

Parsons, William H ; Du Bois, J

Journal of the American Chemical Society, 24 July 2013, Vol.135(29), pp.10582-5 [Peer Reviewed Journal]

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A 18F-labeled saxitoxin derivative for in vivo PET-MR imaging of voltage-gated sodium channel expression following nerve injury

Hoehne, Aileen ; Behera, Deepak ; Parsons, William H ; James, Michelle L ; Shen, Bin ; Borgohain, Preeti ; Bodapati, Deepika ; Prabhakar, Archana ; Gambhir, Sanjiv S ; Yeomans, David C ; Biswal, Sandip ; Chin, Frederick T ; Du Bois, J

Journal of the American Chemical Society, 04 December 2013, Vol.135(48), pp.18012-5 [Peer Reviewed Journal]

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Branched Fatty Acid Esters of Hydroxy Fatty Acids Are Preferred Substrates of the MODY8 Protein Carboxyl Ester Lipase

Kolar, Matthew J ; Kamat, Siddhesh S ; Parsons, William H ; Homan, Edwin A ; Maher, Tim ; Peroni, Odile D ; Syed, Ismail ; Fjeld, Karianne ; Molven, Anders ; Kahn, Barbara B ; Cravatt, Benjamin F ; Saghatelian, Alan

Biochemistry, 23 August 2016, Vol.55(33), pp.4636-41 [Peer Reviewed Journal]

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Saxitoxin

Thottumkara, Arun P. ; Parsons, William H. ; Du Bois, J.

Angewandte Chemie, 02 June 2014, Vol.126(23), pp.5868-5894 [Peer Reviewed Journal]

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Benzodimidazole Transient Receptor Potential Vanilloid 1 Antagonists for the Treatment of Pain: Discovery of trans-2-(2-{2-2-(4-Trifluoromethyl-phenyl)-vinyl-1H-benzimidazol-5-yl}-phenyl)-propan-2-ol (Mavatrep)

Parsons, William H ; Calvo, Raul R ; Cheung, Wing ; Lee, Yu-Kai ; Patel, Sharmila ; Liu, Jian ; Youngman, Mark A ; Dax, Scott L ; Stone, Dennis ; Qin, Ning ; Hutchinson, Tasha ; Lubin, Mary Lou ; Zhang, Sui-Po ; Finley, Michael ; Liu, Yi ; Brandt, Michael R ; Flores, Christopher M ; Player, Mark R

Journal of medicinal chemistry, 14 May 2015, Vol.58(9), pp.3859-74 [Peer Reviewed Journal]

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Design and optimization of benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonists

Parks, Daniel J ; Parsons, William H ; Colburn, Raymond W ; Meegalla, Sanath K ; Ballentine, Shelley K ; Illig, Carl R ; Qin, Ning ; Liu, Yi ; Hutchinson, Tasha L ; Lubin, Mary Lou ; Stone, Dennis J ; Baker, Judith F ; Schneider, Craig R ; Ma, Jianya ; Damiano, Bruce P ; Flores, Christopher M ; Player, Mark R

Journal of medicinal chemistry, 13 January 2011, Vol.54(1), pp.233-47 [Peer Reviewed Journal]

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Marked difference in saxitoxin and tetrodotoxin affinity for the human nociceptive voltage-gated sodium channel (Nav1.7) corrected

Walker, James R ; Novick, Paul A ; Parsons, William H ; Mcgregor, Malcolm ; Zablocki, Jeff ; Pande, Vijay S ; Du Bois, J

Proceedings of the National Academy of Sciences of the United States of America, 30 October 2012, Vol.109(44), pp.18102-7 [Peer Reviewed Journal]

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Pyrido2,3-dpyrimidin-5-ones: a novel class of antiinflammatory macrophage colony-stimulating factor-1 receptor inhibitors

Huang, Hui ; Hutta, Daniel A ; Rinker, James M ; Hu, Huaping ; Parsons, William H ; Schubert, Carsten ; Desjarlais, Renee L ; Crysler, Carl S ; Chaikin, Margery A ; Donatelli, Robert R ; Chen, Yanmin ; Cheng, Deping ; Zhou, Zhao ; Yurkow, Edward ; Manthey, Carl L ; Player, Mark R

Journal of medicinal chemistry, 26 February 2009, Vol.52(4), pp.1081-99 [Peer Reviewed Journal]

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Synthesis and reactions of 3-substituted-2-phosphomethyl acrylates

Schoen, William R ; Parsons, William H

Tetrahedron Letters, 1988, Vol.29(41), pp.5201-5204 [Peer Reviewed Journal]

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Novel fragmentation reaction of correolide

Bao, Jianming ; Baker, Robert K ; Doss, George A ; Kayser, Frank ; Kotliar, Andrew ; Miao, Shouwu ; Parsons, William H ; Rupprecht, Kathleen M

Organic letters, 30 May 2002, Vol.4(11), pp.1871-3 [Peer Reviewed Journal]

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FK‐506–A Novel Immunosuppressant

Parsons, William H. ; Sigal, Nolan H. ; Wyvratt, Matthew J.

Annals of the New York Academy of Sciences, June 1993, Vol.685(1), pp.22-36 [Peer Reviewed Journal]

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12
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Discovery of vinylcycloalkyl-substituted benzimidazole TRPM8 antagonists effective in the treatment of cold allodynia

Calvo, Raul R ; Meegalla, Sanath K ; Parks, Daniel J ; Parsons, William H ; Ballentine, Shelley K ; Lubin, Mary Lou ; Schneider, Craig ; Colburn, Raymond W ; Flores, Christopher M ; Player, Mark R

Bioorganic & Medicinal Chemistry Letters, 01 March 2012, Vol.22(5), pp.1903-1907 [Peer Reviewed Journal]

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AIG1 and ADTRP are Atypical Integral Membrane Hydrolases that Degrade Bioactive FAHFAs

Parsons, William H ; Kolar, Matthew J ; Kamat, Siddhesh S ; Cognetta, Armand B ; Hulce, Jonathan J ; Saez, Enrique ; Kahn, Barbara B ; Saghatelian, Alan ; Cravatt, Benjamin F

Parsons, William H, Matthew J Kolar, Siddhesh S Kamat, Armand B Cognetta, Jonathan J Hulce, Enrique Saez, Barbara B Kahn, Alan Saghatelian, and Benjamin F Cravatt. 2016. “AIG1 and ADTRP are Atypical Integral Membrane Hydrolases that Degrade Bioactive FAHFAs.” Nature chemical biology 12 (5): 367-372. doi:10.1038/nchembio.2051. http://dx.doi.org/10.1038/nchembio.2051. [Peer Reviewed Journal]

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Antiradiation Compounds XVII: Binding Ability of Radiation-Protective N-heterocyclic Aminoethyl Disulfides and Thiosulfates to DNA

Foye, William O ; Karkaria, Mahrukh M ; Parsons, William H

Journal of Pharmaceutical Sciences, January 1980, Vol.69(1), pp.84-87 [Peer Reviewed Journal]

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15
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The synthesis of potent marcocyclic renin inhibitors

Dhanoa, Daljit S ; Parsons, William H ; Greenlee, William J ; Patchett, Arthur A

Tetrahedron Letters, 1992, Vol.33(13), pp.1725-1728 [Peer Reviewed Journal]

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16
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Degradation of the C1 side chain of zaragozic acid A

Marquis, Robert W ; Plevyak, Sandra P ; Berger, Gregory D ; Parsons, William H

Tetrahedron Letters, 1994, Vol.35(16), pp.2451-2454 [Peer Reviewed Journal]

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17
32-Indolyl Ether Derivatives of Ascomycin:  Three-Dimensional Structures of Complexes with FK506-Binding Protein
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32-Indolyl Ether Derivatives of Ascomycin:  Three-Dimensional Structures of Complexes with FK506-Binding Protein

Becker, Joseph W. ; Rotonda, Jennifer ; Cryan, John G. ; Martin, Mary ; Parsons, William H. ; Sinclair, Peter J. ; Wiederrecht, Greg ; Wong, Frederick

Journal of Medicinal Chemistry, 07/1999, Vol.42(15), pp.2798-2804 [Peer Reviewed Journal]

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18
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Characterization of a new class of potent inhibitors of the voltage-gated sodium channel Nav1.7

Williams, Brande S ; Felix, John P ; Priest, Birgit T ; Brochu, Richard M ; Dai, Kefei ; Hoyt, Scott B ; London, Clare ; Tang, Yui S ; Duffy, Joseph L ; Parsons, William H ; Kaczorowski, Gregory J ; Garcia, Maria L

Biochemistry, 18 December 2007, Vol.46(50), pp.14693-703 [Peer Reviewed Journal]

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Discovery of 3-piperidinyl-1-cyclopentanecarboxamide as a novel scaffold for highly potent CC chemokine receptor 2 antagonists

Yang, Lihu ; Butora, Gabor ; Jiao, Richard X ; Pasternak, Alex ; Zhou, Changyou ; Parsons, William H ; Mills, Sander G ; Vicario, Pasquale P ; Ayala, Julia M ; Cascieri, Margaret A ; Maccoss, Malcolm

Journal of medicinal chemistry, 31 May 2007, Vol.50(11), pp.2609-11 [Peer Reviewed Journal]

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20
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Substituted biaryl pyrazoles as sodium channel blockers

Tyagarajan, Sriram ; Chakravarty, Prasun K ; Zhou, Bishan ; Taylor, Brett ; Fisher, Michael H ; Wyvratt, Mathew J ; Lyons, Kathy ; Klatt, Tracy ; Li, Xiaohua ; Kumar, Sanjeev ; Williams, Brande ; Felix, John ; Priest, Birgit T ; Brochu, Richard M ; Warren, Vivien ; Smith, Mchardy ; Garcia, Maria ; Kaczorowski, Gregory J ; Martin, William J ; Abbadie, Catherine ; Mcgowan, Erin ; Jochnowitz, Nina ; Parsons, William H

Bioorganic & Medicinal Chemistry Letters, 2010, Vol.20(18), pp.5480-5483 [Peer Reviewed Journal]

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Substituted biaryl oxazoles, imidazoles, and thiazoles as sodium channel blockers

Tyagarajan, Sriram ; Chakravarty, Prasun K ; Zhou, Bishan ; Fisher, Michael H ; Wyvratt, Mathew J ; Lyons, Kathy ; Klatt, Tracy ; Li, Xiaohua ; Kumar, Sanjeev ; Williams, Brande ; Felix, John ; Priest, Birgit T ; Brochu, Richard M ; Warren, Vivien ; Smith, Mchardy ; Garcia, Maria ; Kaczorowski, Gregory J ; Martin, William J ; Abbadie, Catherine ; Mcgowan, Erin ; Jochnowitz, Nina ; Parsons, William H

Bioorganic & Medicinal Chemistry Letters, 2010, Vol.20(18), pp.5536-5540 [Peer Reviewed Journal]

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Chemoselective removal and replacement of the C-4′ and C-6 acyl esters of zaragozic Acid A

Burk, Robert M ; Berger, Gregory D ; Bugianesi, Robert L ; Girotra, Narindar N ; Parsons, William H ; Ponpipom, Mitree M

Tetrahedron Letters, 1993, Vol.34(6), pp.975-978 [Peer Reviewed Journal]

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23
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Isotopic Method for the Determination of Density in Compressible Systems

Chase, Grafton D ; Parsons, William H

Journal of Pharmaceutical Sciences, April 1965, Vol.54(4), pp.528-530 [Peer Reviewed Journal]

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24
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Study of Density Gradients in Certain Oil-in-Water Emulsions Using Multichannel Gamma Ray Analysis

Parsons, William H ; Dondero, David L

Journal of Pharmaceutical Sciences, December 1969, Vol.58(12), pp.1449-1452 [Peer Reviewed Journal]

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25
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Discovery of a novel class of biphenyl pyrazole sodium channel blockers for treatment of neuropathic pain

Tyagarajan, Sriram ; Chakravarty, Prasun K ; Zhou, Bishan ; Taylor, Brett ; Eid, Ronsar ; Fisher, Michael H ; Parsons, William H ; Wyvratt, Mathew J ; Lyons, Kathryn A ; Klatt, Tracy ; Li, Xiaohua ; Kumar, Sanjeev ; Williams, Brande ; Felix, John ; Priest, Birgit T ; Brochu, Richard M ; Warren, Vivien ; Smith, Mchardy ; Garcia, Maria ; Kaczorowski, Gregory J ; Martin, William J ; Abbadie, Catherine ; Mcgowan, Erin ; Jochnowitz, Nina ; Weber, Ann ; Duffy, Joseph L

Bioorganic & Medicinal Chemistry Letters, 2010, Vol.20(24), pp.7479-7482 [Peer Reviewed Journal]

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Identification of a new class of inhibitors of the voltage-gated potassium channel, Kv1.3, with immunosuppressant properties

Schmalhofer, William A ; Bao, Jianming ; Mcmanus, Owen B ; Green, Brian ; Matyskiela, Mary ; Wunderler, Denise ; Bugianesi, Randal M ; Felix, John P ; Hanner, Markus ; Linde-Arias, Ana-Rosa ; Ponte, Cristiano G ; Velasco, Lucia ; Koo, Gloria ; Staruch, Mary Jo ; Miao, Shouwu ; Parsons, William H ; Rupprecht, Kathleen ; Slaughter, Robert S ; Kaczorowski, Gregory J ; Garcia, Maria L

Biochemistry, 18 June 2002, Vol.41(24), pp.7781-94 [Peer Reviewed Journal]

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Identification and Biochemical Characterization of a Novel Nortriterpene Inhibitor of the Human Lymphocyte Voltage-Gated Potassium Channel, Kv1.3
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Identification and Biochemical Characterization of a Novel Nortriterpene Inhibitor of the Human Lymphocyte Voltage-Gated Potassium Channel, Kv1.3

Felix, John P. ; Bugianesi, Randal M. ; Schmalhofer, William A. ; Borris, Robert ; Goetz, Michael A. ; Hensens, Otto D. ; Bao, Jian-Ming ; Kayser, Frank ; Parsons, William H. ; Rupprecht, Kathleen ; Garcia, Maria L. ; Kaczorowski, Gregory J. ; Slaughter, Robert S.

Biochemistry, 04/1999, Vol.38(16), pp.4922-4930 [Peer Reviewed Journal]

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28
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3-Amino-1-alkyl-cyclopentane carboxamides as small molecule antagonists of the human and murine CC chemokine receptor 2

Butora, Gabor ; Jiao, Richard ; Parsons, William H ; Vicario, Pasquale P ; Jin, Hong ; Ayala, Julia M ; Cascieri, Margaret A ; Yang, Lihu

Bioorganic & Medicinal Chemistry Letters, 2007, Vol.17(13), pp.3636-3641 [Peer Reviewed Journal]

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Metabolism of the radioprotective agent triammonium 2‐dithiocarbamyl‐3‐dithiocarbonylthiopropanoate in the mouse

Foye, William O. ; Chu, Rita S. F. ; Shah, Kirit A. ; Parsons, William H.

Journal of Pharmaceutical Sciences, December 1971, Vol.60(12), pp.1839-1842 [Peer Reviewed Journal]

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30
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Alpha-aminothiazole-gamma-aminobutanoic amides as potent, small molecule CCR2 receptor antagonists

Zhou, Changyou ; Guo, Liangqin ; Parsons, William H ; Mills, Sander G ; Maccoss, Malcolm ; Vicario, Pasquale P ; Zweerink, Hans ; Cascieri, Margaret A ; Springer, Martin S ; Yang, Lihu

Bioorganic & medicinal chemistry letters, 15 January 2007, Vol.17(2), pp.309-14 [Peer Reviewed Journal]

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α-Aminothiazole-γ-aminobutanoic amides as potent, small molecule CCR2 receptor antagonists

Zhou, Changyou ; Guo, Liangqin ; Parsons, William H ; Mills, Sander G ; Maccoss, Malcolm ; Vicario, Pasquale P ; Zweerink, Hans ; Cascieri, Margaret A ; Springer, Martin S ; Yang, Lihu

Bioorganic & Medicinal Chemistry Letters, 2007, Vol.17(2), pp.309-314 [Peer Reviewed Journal]

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A disubstituted succinamide is a potent sodium channel blocker with efficacy in a rat pain model

Priest, Birgit T ; Garcia, Maria L ; Middleton, Richard E ; Brochu, Richard M ; Clark, Samantha ; Dai, Ge ; Dick, Ivy E ; Felix, John P ; Liu, Chou J ; Reiseter, Brita S ; Schmalhofer, William A ; Shao, Pengcheng P ; Tang, Yui S ; Chou, Margaret Z ; Kohler, Martin G ; Smith, Mchardy M ; Warren, Vivien A ; Williams, Brande S ; Cohen, Charles J ; Martin, William J ; Meinke, Peter T ; Parsons, William H ; Wafford, Keith A ; Kaczorowski, Gregory J

Biochemistry, 03 August 2004, Vol.43(30), pp.9866-76 [Peer Reviewed Journal]

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4-Amino-2-alkyl-butyramides as small molecule CCR2 antagonists with favorable pharmacokinetic properties

Butora, Gabor ; Morriello, Gregori J ; Kothandaraman, Shankaran ; Guiadeen, Deodialsingh ; Pasternak, Alexander ; Parsons, William H ; Maccoss, Malcolm ; Vicario, Pasquale P ; Cascieri, Margaret A ; Yang, Lihu

Bioorganic & Medicinal Chemistry Letters, 15 September 2006, Vol.16(18), pp.4715-4722 [Peer Reviewed Journal]

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Preparation and in vitro activities of naphthyl and indolyl ether derivatives of the FK-506 related immunosuppressive macrolide ascomycin

Sinclair, Peter J ; Wong, Frederick ; Staruch, Mary Jo ; Wiederrecht, Greg ; Parsons, William H ; Dumont, Francis ; Wyvratt, Mathew

Bioorganic & Medicinal Chemistry Letters, 1996, Vol.6(18), pp.2193-2196 [Peer Reviewed Journal]

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Discovery of a novel class of isoxazoline voltage gated sodium channel blockers

Shao, Pengcheng P ; Ye, Feng ; Weber, Ann E ; Li, Xiaohua ; Lyons, Kathryn A ; Parsons, William H ; Garcia, Maria L ; Priest, Birgit T ; Smith, Mchardy M ; Felix, John P ; Williams, Brande S ; Kaczorowski, Gregory J ; Mcgowan, Erin ; Abbadie, Catherine ; Martin, William J ; Mcmasters, Daniel R ; Gao, Ying-Duo

Bioorganic & Medicinal Chemistry Letters, 2009, Vol.19(18), pp.5329-5333 [Peer Reviewed Journal]

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Discovery of isoxazole voltage gated sodium channel blockers for treatment of chronic pain

Shao, Pengcheng P ; Ye, Feng ; Weber, Ann E ; Li, Xiaohua ; Lyons, Kathryn A ; Parsons, William H ; Garcia, Maria L ; Priest, Birgit T ; Smith, Mchardy M ; Felix, John P ; Williams, Brande S ; Kaczorowski, Gregory J ; Mcgowan, Erin ; Abbadie, Catherine ; Martin, William J ; Mcmasters, Daniel R ; Gao, Ying-Duo

Bioorganic & Medicinal Chemistry Letters, 2009, Vol.19(18), pp.5334-5338 [Peer Reviewed Journal]

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37