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1
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Article
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Kinetic mechanisms of Ca ++/calmodulin dependent protein kinases

Huynh, Q. Khai ; Pagratis, Nikos

Archives of Biochemistry and Biophysics, 2011, Vol.506(2), pp.130-136 [Peer Reviewed Journal]

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Lipid Sensing Apolipoprotein A-I for Novel High-Throughput Lipidation Assays

Niedziela-Majka, Anita ; Lad, Latesh ; Chishom, Jeffrey W ; Lagpacan, Leanna ; Schwartz, Karen ; Hung, Magdeleine ; Jin, Debi ; Fung, Wanchi ; Brendza, Katherine M ; Liu, Xioahong ; Pagratis, Nikos ; Sakowicz, Roman

Biophysical Journal, 31 January 2012, Vol.102(3), pp.65a-65a [Peer Reviewed Journal]

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Functional label-free assays for characterizing the in vitro mechanism of action of small molecule modulators of capsid assembly

Lad, Latesh ; Clancy, Sheila ; Koditek, David ; Wong, Melanie H ; Jin, Debi ; Niedziela-Majka, Anita ; Papalia, Giuseppe A ; Hung, Magdeleine ; Yant, Stephen ; Somoza, John R ; Hu, Eric ; Chou, Chienhung ; Tse, Winston ; Halcomb, Randall ; Sakowicz, Roman ; Pagratis, Nikos

Biochemistry, 07 April 2015, Vol.54(13), pp.2240-8 [Peer Reviewed Journal]

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In Vitro Antiviral Activity and Resistance Profile Characterization of the Hepatitis C Virus NS5A Inhibitor Ledipasvir

Cheng, Guofeng ; Tian, Yang ; Doehle, Brian ; Peng, Betty ; Corsa, Amoreena ; Lee, Yu-Jen ; Gong, Ruoyu ; Yu, Mei ; Han, Bin ; Xu, Simin ; Dvory-Sobol, Hadas ; Perron, Michel ; Xu, Yili ; Mo, Hongmei ; Pagratis, Nikos ; Link, John O ; Delaney, William

Antimicrobial agents and chemotherapy, 11 January 2016, Vol.60(3), pp.1847-1853 [Peer Reviewed Journal]

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Abyssomicin 2 reactivates latent HIV-1 by a PKC- and HDAC-independent mechanism

León, Brian ; Navarro, Gabriel ; Dickey, Bailey J ; Stepan, George ; Tsai, Angela ; Jones, Gregg S ; Morales, Monica E ; Barnes, Tiffany ; Ahmadyar, Shekeba ; Tsiang, Manuel ; Geleziunas, Romas ; Cihlar, Tomas ; Pagratis, Nikos ; Tian, Yang ; Yu, Helen ; Linington, Roger G

Organic letters, 16 January 2015, Vol.17(2), pp.262-5 [Peer Reviewed Journal]

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6
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A small-molecule inhibitor of hepatitis C virus infectivity

Bush, Caroline O ; Pokrovskii, Maria V ; Saito, Roland ; Morganelli, Philip ; Canales, Eda ; Clarke, Michael O ; Lazerwith, Scott E ; Golde, Justin ; Reid, Brian G ; Babaoglu, Kerim ; Pagratis, Nikos ; Zhong, Weidong ; Delaney, William E ; Paulson, Matthew S ; Beran, Rudolf K F

Antimicrobial agents and chemotherapy, 2014, Vol.58(1), pp.386-96 [Peer Reviewed Journal]

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7
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High-Throughput Kinetic Screening of Hybridomas to Identify High-Affinity Antibodies Using Bio-Layer Interferometry

Lad, Latesh ; Clancy, Sheila ; Kovalenko, Maria ; Liu, Chian ; Hui, Terence ; Smith, Victoria ; Pagratis, Nikos Howes, Rob (Editor) ; Mcgivern, Joseph G (Editor)

Journal of Biomolecular Screening, April 2015, Vol.20(4), pp.498-507 [Peer Reviewed Journal]

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8
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Inhibitions of late INa and CaMKII act synergistically to prevent ATX-II-induced atrial fibrillation in isolated rat right atria

Liang, Faquan ; Fan, Peidong ; Jia, Jessie ; Yang, Suya ; Jiang, Zhan ; Karpinski, Serge ; Kornyeyev, Dmytro ; Pagratis, Nikos ; Belardinelli, Luiz ; Yao, Lina

Journal of Molecular and Cellular Cardiology, May 2016, Vol.94, pp.122-130 [Peer Reviewed Journal]

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9
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Search for small molecule activators of latent HIV

Geleziunas Romas ; Stepan George ; Wei George ; Yu Helen ; Graupe Michael ; Pagratis Nikos ; Barnes Tiffany ; Cihlar Tomas ; Hesselgesser Joe

Retrovirology, 01 May 2012, Vol.9(Suppl 1), p.O2 [Peer Reviewed Journal]

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10
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Identification of potent and selective amidobipyridyl inhibitors of protein kinase D

Meredith, Erik L ; Beattie, Kimberly ; Burgis, Robin ; Capparelli, Michael ; Chapo, Joseph ; Dipietro, Lucian ; Gamber, Gabriel ; Enyedy, Istvan ; Hood, David B ; Hosagrahara, Vinayak ; Jewell, Charles ; Koch, Keith A ; Lee, Wendy ; Lemon, Douglas D ; Mckinsey, Timothy A ; Miranda, Karl ; Pagratis, Nikos ; Phan, Dillon ; Plato, Craig ; Rao, Chang ; Rozhitskaya, Olga ; Soldermann, Nicolas ; Springer, Clayton ; Van Eis, Maurice ; Vega, Richard B ; Yan, Wanlin ; Zhu, Qingming ; Monovich, Lauren G

Journal of medicinal chemistry, 12 August 2010, Vol.53(15), pp.5422-38 [Peer Reviewed Journal]

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11
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Novel hepatitis C virus reporter replicon cell lines enable efficient antiviral screening against genotype 1a

Robinson, Margaret ; Yang, Huiling ; Sun, Siu-Chi ; Peng, Betty ; Tian, Yang ; Pagratis, Nikos ; Greenstein, Andrew E ; Delaney, William E

Antimicrobial agents and chemotherapy, August 2010, Vol.54(8), pp.3099-106 [Peer Reviewed Journal]

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12
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Lipid-Sensing High-Throughput ApoA-I Assays

Niedziela-Majka, Anita ; Lad, Latesh ; Chisholm, Jeffrey W ; Lagpacan, Leanna ; Schwartz, Karen ; Hung, Magdeleine ; Jin, Debi ; Fung, Wanchi ; Brendza, Katherine M ; Liu, Xiaohong ; Pagratis, Nikos ; Sakowicz, Roman

Journal of Biomolecular Screening, September 2012, Vol.17(8), pp.1050-1061 [Peer Reviewed Journal]

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13
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Homogeneous BTK Occupancy Assay for Pharmacodynamic Assessment of Tirabrutinib (GS-4059/ONO-4059) Target Engagement

Yu, Helen ; Truong, Hoa ; Mitchell, Scott A ; Liclican, Albert ; Gosink, John J ; Li, Wanying ; Lin, Julie ; Feng, Joy Y ; Jürgensmeier, Juliane M ; Billin, Andrew ; Xu, Ren ; Patterson, Scott ; Pagratis, Nikos

SLAS Discovery, October 2018, Vol.23(9), pp.919-929 [Peer Reviewed Journal]

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14
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Screening and Identification of a Novel Class of TGF-β Type 1 Receptor Kinase Inhibitor

Huynh, Q. Khai ; Wise, Sarah J ; Koch, Keith A ; Castonguay, Laurie A ; Reid, Brian G ; Pagratis, Erinn E ; Koditek, David ; Glascock, Christopher B ; Pitts, Kelly R ; Turner, Benjamin A ; Liu, Xiaohong ; Hung, Magdeleine ; Han, Bin ; Pagratis, Nikos

Journal of Biomolecular Screening, August 2011, Vol.16(7), pp.724-733 [Peer Reviewed Journal]

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15
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Study of marine natural products including resorcyclic acid lactones from Humicola fuscoatra that reactivate latent HIV-1 expression in an in vitro model of central memory CD4+ T cells

Mejia, Eric J ; Loveridge, Steven T ; Stepan, George ; Tsai, Angela ; Jones, Gregg S ; Barnes, Tiffany ; White, Kimberly N ; Drašković, Marija ; Tenney, Karen ; Tsiang, Manuel ; Geleziunas, Romas ; Cihlar, Tomas ; Pagratis, Nikos ; Tian, Yang ; Yu, Helen ; Crews, Phillip

Journal of natural products, 28 March 2014, Vol.77(3), pp.618-24 [Peer Reviewed Journal]

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16
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Optimized High-Throughput Screen for Hepatitis C Virus Translation Inhibitors

Berry, Katherine E ; Peng, Betty ; Koditek, David ; Beeman, Douglas ; Pagratis, Nikos ; Perry, Jason K ; Parrish, Jay ; Zhong, Weidong ; Doudna, Jennifer A ; Shih, I-Hung

Journal of Biomolecular Screening, February 2011, Vol.16(2), pp.211-220 [Peer Reviewed Journal]

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17
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3,5-Diarylazoles as novel and selective inhibitors of protein kinase D

Gamber, Gabriel G ; Meredith, Erik ; Zhu, Qingming ; Yan, Wanlin ; Rao, Chang ; Capparelli, Michael ; Burgis, Robin ; Enyedy, Istvan ; Zhang, Ji-Hu ; Soldermann, Nicolas ; Beattie, Kimberley ; Rozhitskaya, Olga ; Koch, Keith A ; Pagratis, Nikos ; Hosagrahara, Vinayak ; Vega, Richard B ; Mckinsey, Timothy A ; Monovich, Lauren

Bioorganic & Medicinal Chemistry Letters, 2011, Vol.21(5), pp.1447-1451 [Peer Reviewed Journal]

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18
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Identification of orally available naphthyridine protein kinase D inhibitors

Meredith, Erik L ; Ardayfio, Ophelia ; Beattie, Kimberly ; Dobler, Markus R ; Enyedy, Istvan ; Gaul, Christoph ; Hosagrahara, Vinayak ; Jewell, Charles ; Koch, Keith ; Lee, Wendy ; Lehmann, Hansjoerg ; Mckinsey, Timothy A ; Miranda, Karl ; Pagratis, Nikos ; Pancost, Margaret ; Patnaik, Anup ; Phan, Dillon ; Plato, Craig ; Qian, Ming ; Rajaraman, Vasumathy ; Rao, Chang ; Rozhitskaya, Olga ; Ruppen, Thomas ; Shi, Jie ; Siska, Sarah J ; Springer, Clayton ; Van Eis, Maurice ; Vega, Richard B ; Von Matt, Anette ; Yang, Lihua ; Yoon, Taeyoung ; Zhang, Ji-Hu ; Zhu, Na ; Monovich, Lauren G

Journal of medicinal chemistry, 12 August 2010, Vol.53(15), pp.5400-21 [Peer Reviewed Journal]

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19
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Discovery of potent and selective inhibitors of calmodulin-dependent kinase II (CaMKII)

Koltun, Dmitry O ; Parkhill, Eric Q ; Kalla, Rao ; Perry, Thao D ; Elzein, Elfatih ; Li, Xiaofen ; Simonovich, Scott P ; Ziebenhaus, Christopher ; Hansen, Timothy R ; Marchand, Bruno ; Hung, Wailok K ; Lagpacan, Leanna ; Hung, Magdeleine ; Aoyama, Ron G ; Murray, Bernard P ; Perry, Jason K ; Somoza, John R ; Villaseñor, Armando G ; Pagratis, Nikos ; Zablocki, Jeff A

Bioorganic & Medicinal Chemistry Letters, 01 February 2018, Vol.28(3), pp.541-546 [Peer Reviewed Journal]

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20
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Small molecule phenotypic screen using a MEF2/ HDAC5 mammalian two-hybrid assay

Papst, Philip ; Sweeney, Meghan ; Roberts, Charles ; Gorczynski, Richard J ; Pagratis, Nikos C

Journal of Cardiac Failure, August 2004, Vol.10(4), pp.S56-S56 [Peer Reviewed Journal]

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21
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Detection of bacteriophage φ6 minus-strand rna and novel rnrna isoconformers synthesized in vivo and in vitro, by strand-separating agarose gels

Pagratis, Nikos ; Revel, Helen R

Virology, 1990, Vol.177(1), pp.273-280 [Peer Reviewed Journal]

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22
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Minus-strand rna synthesis by the segmented double-stranded RNA bacteriophage φ6 requires continuous protein synthesis

Pagratis, Nikos ; Revel, Helen R

Virology, 1990, Vol.177(1), pp.281-288 [Peer Reviewed Journal]

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23
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Research Dataset
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CCDC 1048480: Experimental Crystal Structure Determination

León, Brian ; Navarro, Gabriel ; Dickey, Bailey J. ; Stepan, George ; Tsai, Angela ; Jones, Gregg S. ; Morales, Monica E. ; Barnes, Tiffany ; Ahmadyar, Shekeba ; Tsiang, Manuel ; Geleziunas, Romas ; Cihlar, Tomas ; Pagratis, Nikos ; Tian, Yang ; Yu, Helen ; Linington, Roger G.

2015

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24
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Genome mapping and protein coding region identification using bacteriophage Mu

Groisman, Eduardo A ; Pagratis, Nikos ; Casadaban, Malcolm J

Gene, 1991, Vol.99(1), pp.1-7 [Peer Reviewed Journal]

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25
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Affinities between the binding partners of the HIV-1 integrase dimer-lens epithelium-derived growth factor (IN dimer-LEDGF) complex

Tsiang, Manuel ; Jones, Gregg S ; Hung, Magdeleine ; Mukund, Susmith ; Han, Bin ; Liu, Xiaohong ; Babaoglu, Kerim ; Lansdon, Eric ; Chen, Xiaowu ; Todd, Jacob ; Cai, Terrence ; Pagratis, Nikos ; Sakowicz, Roman ; Geleziunas, Romas

The Journal of biological chemistry, 27 November 2009, Vol.284(48), pp.33580-99 [Peer Reviewed Journal]

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26
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Suppression of HDAC nuclear export and cardiomyocyte hypertrophy by novel irreversible inhibitors of CRM1

Monovich, Lauren ; Koch, Keith A ; Burgis, Robin ; Osimboni, Ekundayo ; Mann, Thierry ; Wall, Daniel ; Gao, Jinhai ; Feng, Yan ; Vega, Richard B ; Turner, Benjamin A ; Hood, David B ; Law, Andy ; Papst, Philip J ; Koditek, David ; Chapo, Joseph A ; Reid, Brian G ; Melvin, Lawrence S ; Pagratis, Nikos C ; Mckinsey, Timothy A

BBA - Gene Regulatory Mechanisms, 2009, Vol.1789(5), pp.422-431 [Peer Reviewed Journal]

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