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1
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Measurement and differentiation of ligand-induced calmodulin conformations by dual polarization interferometry

Coan, Kristin E D ; Swann, Marcus J ; Ottl, Johannes

Analytical chemistry, 07 February 2012, Vol.84(3), pp.1586-91 [Peer Reviewed Journal]

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Measurement and Differentiation of Ligand-Induced Calmodulin Conformations by Dual Polarization Interferometry

Coan, Kristin ; Swann, Marcus ; Ottl, Johannes

Analytical Chemistry, Feb 7, 2012, p.1586 [Peer Reviewed Journal]

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3
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Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide

Fischer, Eric S. ; Böhm, Kerstin ; Lydeard, John R. ; Yang, Haidi ; Stadler, Michael B. ; Cavadini, Simone ; Nagel, Jane ; Serluca, Fabrizio ; Acker, Vincent ; Lingaraju, Gondichatnahalli M. ; Tichkule, Ritesh B. ; Schebesta, Michael ; Forrester, William C. ; Schirle, Markus ; Hassiepen, Ulrich ; Ottl, Johannes ; Hild, Marc ; Beckwith, Rohan E. J. ; Harper, J. Wade ; Jenkins, Jeremy L. ; Thomä, Nicolas H.

Fischer, E. S., K. Böhm, J. R. Lydeard, H. Yang, M. B. Stadler, S. Cavadini, J. Nagel, et al. 2015. “Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide.” Nature 512 (7512): 49-53. doi:10.1038/nature13527. http://dx.doi.org/10.1038/nature13527. [Peer Reviewed Journal]

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Disulfide-Bridged Heterotrimeric Collagen Peptides Containing the Collagenase Cleavage Site of Collagen Type I. Synthesis and Conformational Properties
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Disulfide-Bridged Heterotrimeric Collagen Peptides Containing the Collagenase Cleavage Site of Collagen Type I. Synthesis and Conformational Properties

Ottl, Johannes ; Moroder, Luis

Journal of the American Chemical Society, 02/1999, Vol.121(4), pp.653-661 [Peer Reviewed Journal]

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Bioorthogonal Probes for the Study of MDM2‐p53 Inhibitors in Cells and Development of High‐Content Screening Assays for Drug Discovery

D' Alessandro, Pier Luca ; Buschmann, Nicole ; Kaufmann, Markus ; Furet, Pascal ; Baysang, Frederic ; Brunner, Reto ; Marzinzik, Andreas ; Vorherr, Thomas ; Stachyra, Therese‐Marie ; Ottl, Johannes ; Lizos, Dimitrios E. ; Cobos‐Correa, Amanda

Angewandte Chemie International Edition, 23 December 2016, Vol.55(52), pp.16026-16030 [Peer Reviewed Journal]

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Optimizing a Weakly Binding Fragment into a Potent RORγt Inverse Agonist with Efficacy in an in Vivo Inflammation Model

Carcache, David A ; Vulpetti, Anna ; Kallen, Joerg ; Mattes, Henri ; Orain, David ; Stringer, Rowan ; Vangrevelinghe, Eric ; Wolf, Romain M ; Kaupmann, Klemens ; Ottl, Johannes ; Dawson, Janet ; Cooke, Nigel G ; Hoegenauer, Klemens ; Billich, Andreas ; Wagner, Juergen ; Guntermann, Christine ; Hintermann, Samuel

Journal of medicinal chemistry, 09 August 2018, Vol.61(15), pp.6724-6735 [Peer Reviewed Journal]

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7
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Conformational changes of calmodulin on calcium and Peptide binding monitored by film bulk acoustic resonators

Nirschl, Martin ; Ottl, Johannes ; Vörös, Janos

Biosensors, 14 December 2011, Vol.1(4), pp.164-76 [Peer Reviewed Journal]

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8
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A new strategy for regioselective interstrand disulfide bridging of multiple cysteine peptides

Ottl, Johannes ; Moroder, Luis

Tetrahedron Letters, 1999, Vol.40(8), pp.1487-1490 [Peer Reviewed Journal]

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9
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A novel class of oral direct renin inhibitors: highly potent 3,5-disubstituted piperidines bearing a tricyclic p3-p1 pharmacophore

Ostermann, Nils ; Ruedisser, Simon ; Ehrhardt, Claus ; Breitenstein, Werner ; Marzinzik, Andreas ; Jacoby, Edgar ; Vangrevelinghe, Eric ; Ottl, Johannes ; Klumpp, Martin ; Hartwieg, J Constanze D ; Cumin, Frederic ; Hassiepen, Ulrich ; Trappe, Jörg ; Sedrani, Richard ; Geisse, Sabine ; Gerhartz, Bernd ; Richert, Paul ; Francotte, Eric ; Wagner, Trixie ; Krömer, Markus ; Kosaka, Takatoshi ; Webb, Randy L ; Rigel, Dean F ; Maibaum, Jürgen ; Baeschlin, Daniel K

Journal of medicinal chemistry, 28 March 2013, Vol.56(6), pp.2196-206 [Peer Reviewed Journal]

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10
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Applications of Biophysics in High-Throughput Screening Hit Validation

Genick, Christine Clougherty ; Barlier, Danielle ; Monna, Dominique ; Brunner, Reto ; Bé, Céline ; Scheufler, Clemens ; Ottl, Johannes

Journal of Biomolecular Screening, June 2014, Vol.19(5), pp.707-714 [Peer Reviewed Journal]

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11
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Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED

Li, Ling ; Zhang, Hailong ; Zhang, Man ; Zhao, Mengxi ; Feng, Lijian ; Luo, Xiao ; Gao, Zhenting ; Huang, Ying ; Ardayfio, Ophelia ; Ji-Hu, Zhang ; Lin, Ying ; Fan, Hong ; Li, Guobin ; Liu, Lei ; Feng, Leying ; Luo, Fangjun ; Lin, Teng ; Qi, Wei ; Ottl, Johannes ; Lingel, Andreas ; Bussiere, Dirksen ; Yu, Zhengtian ; Atadja, Peter ; Lu, Chris ; Li, En ; Gu, Justin ; Zhao, Kehao

PLoS One, Jan 2017, Vol.12(1), p.e0169855 [Peer Reviewed Journal]

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An Alternative Thiol-Reactive Dye to Analyze Ligand Interactions with the Chemokine Receptor CXCR2 Using a New Thermal Shift Assay Format

Bergsdorf, Christian ; Fiez-Vandal, Cédric ; Sykes, David A ; Bernet, Pascal ; Aussenac, Sonia ; Charlton, Steven J ; Schopfer, Ulrich ; Ottl, Johannes ; Duckely, Myriam

Journal of Biomolecular Screening, March 2016, Vol.21(3), pp.243-251 [Peer Reviewed Journal]

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13
Heterotrimeric Collagen Peptides as Fluorogenic Collagenase Substrates:  Synthesis, Conformational Properties, and Enzymatic Digestion †
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Heterotrimeric Collagen Peptides as Fluorogenic Collagenase Substrates:  Synthesis, Conformational Properties, and Enzymatic Digestion †

Müller, J. Constanze D. ; Ottl, Johannes ; Moroder, Luis

Biochemistry, 05/2000, Vol.39(17), pp.5111-5116 [Peer Reviewed Journal]

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14
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Crystal structure of human estrogen-related receptor alpha in complex with a synthetic inverse agonist reveals its novel molecular mechanism

Kallen, Joerg ; Lattmann, Rene ; Beerli, Rene ; Blechschmidt, Anke ; Blommers, Marcel J J ; Geiser, Martin ; Ottl, Johannes ; Schlaeppi, Jean-Marc ; Strauss, Andre ; Fournier, Brigitte

The Journal of biological chemistry, 10 August 2007, Vol.282(32), pp.23231-9 [Peer Reviewed Journal]

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15
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Characterization of phosphopeptide motifs specific for the Src homology 2 domains of signal transducer and activator of transcription 1 (STAT1) and STAT3

Wiederkehr-Adam, Michèle ; Ernst, Philipp ; Müller, Kurt ; Bieck, Elke ; Gombert, Frank O ; Ottl, Johannes ; Graff, Patrick ; Grossmüller, Fred ; Heim, Markus H

The Journal of biological chemistry, 02 May 2003, Vol.278(18), pp.16117-28 [Peer Reviewed Journal]

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16
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Large Scale Meta-Analysis of Fragment-Based Screening Campaigns: Privileged Fragments and Complementary Technologies

Kutchukian, Peter S ; Wassermann, Anne Mai ; Lindvall, Mika K ; Wright, S. Kirk ; Ottl, Johannes ; Jacob, Jaison ; Scheufler, Clemens ; Marzinzik, Andreas ; Brooijmans, Natasja ; Glick, Meir

Journal of Biomolecular Screening, June 2015, Vol.20(5), pp.588-596 [Peer Reviewed Journal]

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17
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Bioorthogonal Probes for the Study of MDM2‐p53 Inhibitors in Cells and Development of High‐Content Screening Assays for Drug Discovery

D' Alessandro, Pier Luca ; Buschmann, Nicole ; Kaufmann, Markus ; Furet, Pascal ; Baysang, Frederic ; Brunner, Reto ; Marzinzik, Andreas ; Vorherr, Thomas ; Stachyra, Therese‐Marie ; Ottl, Johannes ; Lizos, Dimitrios E. ; Cobos‐Correa, Amanda

Angewandte Chemie, 23 December 2016, Vol.128(52), pp.16260-16264 [Peer Reviewed Journal]

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18
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Structure of lipoprotein lipase in complex with GPIHBP1

Arora, Rishi ; Nimonkar, Amitabh V ; Baird, Daniel ; Wang, Chunhua ; Chiu, Chun-Hao ; Horton, Patricia A ; Hanrahan, Susan ; Cubbon, Rose ; Weldon, Stephen ; Tschantz, William R ; Mueller, Sascha ; Brunner, Reto ; Lehr, Philipp ; Meier, Peter ; Ottl, Johannes ; Voznesensky, Andrei ; Pandey, Pramod ; Smith, Thomas M ; Stojanovic, Aleksandar ; Flyer, Alec ; Benson, Timothy E ; Romanowski, Michael J ; Trauger, John W

Proceedings of the National Academy of Sciences of the United States of America, 21 May 2019, Vol.116(21), pp.10360-10365 [Peer Reviewed Journal]

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19
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Design and synthesis of heterotrimeric collagen peptides with a built-in cystine-knot Models for collagen catabolism by matrix-metalloproteases

Ottl, Johannes ; Battistuta, Roberto ; Pieper, Michael ; Tschesche, Harald ; Bode, Wolfram ; Kühn, Klaus ; Moroder, Luis

FEBS Letters, 1996, Vol.398(1), pp.31-36 [Peer Reviewed Journal]

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20
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Synthesis and characterization of fluorescent ubiquitin derivatives as highly sensitive substrates for the deubiquitinating enzymes UCH-L3 and USP-2

Tirat, Aline ; Schilb, Alain ; Riou, Virginie ; Leder, Lukas ; Gerhartz, Bernd ; Zimmermann, Johann ; Worpenberg, Susanne ; Eidhoff, Ulf ; Freuler, Felix ; Stettler, Thomas ; Mayr, Lorenz ; Ottl, Johannes ; Leuenberger, Beate ; Filipuzzi, Ireos

Analytical Biochemistry, 2005, Vol.343(2), pp.244-255 [Peer Reviewed Journal]

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21
Preparation and Photoactivation of Caged Fluorophores and Caged Proteins Using a New Class of Heterobifunctional, Photocleavable Cross-Linking Reagents
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Preparation and Photoactivation of Caged Fluorophores and Caged Proteins Using a New Class of Heterobifunctional, Photocleavable Cross-Linking Reagents

Ottl, Johannes ; Gabriel, Daniela ; Marriott, Gerard

Bioconjugate Chemistry, 03/1998, Vol.9(2), pp.143-151 [Peer Reviewed Journal]

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22
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Encoded Library Technologies as Integrated Lead Finding Platforms for Drug Discovery

Ottl, Johannes ; Leder, Lukas ; Schaefer, Jonas V ; Dumelin, Christoph E

Molecules (Basel, Switzerland), 25 April 2019, Vol.24(8) [Peer Reviewed Journal]

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23
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Heterotrimeric collagen peptides containing functional epitopes. Synthesis of single‐stranded collagen type I peptides related to the collagenase cleavage site

Ottl, Johannes ; Jürgen Musiol, Hans ; Moroder, Luis

Journal of Peptide Science, February 1999, Vol.5(2), pp.103-110 [Peer Reviewed Journal]

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24
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Development and Implementation of a Highly Miniaturized Confocal 2D-FIDA–Based High-Throughput Screening Assay to Search for Active Site Modulators of the Human Heat Shock Protein 90β

Schilb, Alain ; Riou, Virginie ; Schoepfer, Joseph ; Ottl, Johannes ; Müller, Kurt ; Chene, Patrick ; Mayr, Lorenz M ; Filipuzzi, Ireos

Journal of Biomolecular Screening, October 2004, Vol.9(7), pp.569-577 [Peer Reviewed Journal]

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25
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Readout Technologies for Highly Miniaturized Kinase Assays Applicable to High-Throughput Screening in a 1536-Well Format

Klumpp, Martin ; Boettcher, Andreas ; Becker, Damaris ; Meder, Gabriele ; Blank, Jutta ; Leder, Lukas ; Forstner, Michael ; Ottl, Johannes ; Mayr, Lorenz M

Journal of Biomolecular Screening, September 2006, Vol.11(6), pp.617-633 [Peer Reviewed Journal]

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26
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CCDC 898747: Experimental Crystal Structure Determination

Ostermann, Nils ; Ruedisser, Simon ; Ehrhardt, Claus ; Breitenstein, Werner ; Marzinzik, Andreas ; Jacoby, Edgar ; Vangrevelinghe, Eric ; Ottl, Johannes ; Klumpp, Martin ; Hartwieg, J. Constanze D. ; Cumin, Frederic ; Hassiepen, Ulrich ; Trappe, Jörg ; Sedrani, Richard ; Geisse, Sabine ; Gerhartz, Bernd ; Richert, Paul ; Francotte, Eric ; Wagner, Trixie ; Krömer, Markus ; Kosaka, Takatoshi ; Webb, Randy L. ; Rigel, Dean F. ; Maibaum, Jürgen ; Baeschlin, Daniel K.

2016

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