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Erratum to: Comparison of Treatment with Sitagliptin or Sulfonylurea in Patients with Type 2 Diabetes Mellitus and Mild Renal Impairment: A Post Hoc Analysis of Clinical Trials

Ommen, Elizabeth S ; Xu, Lei ; O’neill, Edward A ; Goldstein, Barry J ; Kaufman, Keith D ; Engel, Samuel S

Diabetes Therapy, 2015, Vol.6(1), p.97-98 [Peer Reviewed Journal]

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Use of Prohibited Medication, a Potentially Overlooked Confounder in Clinical Trials: Omarigliptin (Once-weekly DPP-4 Inhibitor) Monotherapy Trial in 18- to 45-year-olds

Gantz, Ira ; Sokolova, Liubov ; Jain, Lokesh ; Iredale, Carol ; O'Neill, Edward A ; Wei, Ziwen ; Lam, Raymond ; Suryawanshi, Shailaja ; Kaufman, Keith D ; Engel, Samuel S ; Lai, Eseng

Clinical Therapeutics, October 2017, Vol.39(10), pp.2024-2037 [Peer Reviewed Journal]

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Efficacy and Safety of Sitagliptin in Hispanic/Latino Patients with Type 2 Diabetes: A Pooled Analysis from Ten Randomized, Placebo-Controlled Phase 3 Clinical Trials

Raji, Annaswamy ; Long, Jianmin ; Lam, Raymond L H ; O'Neill, Edward A ; Engel, Samuel S

Diabetes therapy : research, treatment and education of diabetes and related disorders, August 2018, Vol.9(4), pp.1581-1589 [Peer Reviewed Journal]

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Characteristics of Elderly Patients Initiating Sitagliptin or Non-DPP-4-Inhibitor Oral Antihyperglycemic Agents: Analysis of a Cross-Sectional US Claims Database

Wang, Tongtong ; Mcneill, Ann Marie ; Chen, Yong ; O'Neill, Edward A ; Engel, Samuel S

Diabetes therapy : research, treatment and education of diabetes and related disorders, February 2018, Vol.9(1), pp.309-315 [Peer Reviewed Journal]

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A Randomized, Placebo-Controlled Trial Evaluating the Safety and Efficacy of Adding Omarigliptin to Antihyperglycemic Therapies in Japanese Patients with Type 2 Diabetes and Inadequate Glycemic Control

Gantz, Ira ; Okamoto, Taro ; Ito, Yuka ; Sato, Asako ; Okuyama, Kotoba ; O'Neill, Edward A ; Engel, Samuel S ; Lai, Eseng

Diabetes therapy : research, treatment and education of diabetes and related disorders, August 2017, Vol.8(4), pp.793-810 [Peer Reviewed Journal]

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A randomized, placebo‐ and sitagliptin‐controlled trial of the safety and efficacy of omarigliptin, a once‐weekly dipeptidyl peptidase‐4 inhibitor, in Japanese patients with type 2 diabetes

Gantz, Ira ; Okamoto, Taro ; Ito, Yuka ; Okuyama, Kotoba ; O' Neill, Edward A. ; Kaufman, Keith D. ; Engel, Samuel S. ; Lai, Eseng

Diabetes, Obesity and Metabolism, November 2017, Vol.19(11), pp.1602-1609 [Peer Reviewed Journal]

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Synthesis and biological activity of pyridopyridazin-6-one p38 MAP kinase inhibitors. Part 1

Tynebor, Robert M ; Chen, Meng-Hsin ; Natarajan, Swaminathan R ; O’neill, Edward A ; Thompson, James E ; Fitzgerald, Catherine E ; O’keefe, Stephen J ; Doherty, James B

Bioorganic & Medicinal Chemistry Letters, 01 January 2011, Vol.21(1), pp.411-416 [Peer Reviewed Journal]

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Comparison of treatment with sitagliptin or sulfonylurea in patients with type 2 diabetes mellitus and mild renal impairment: a post hoc analysis of clinical trials

Ommen, Elizabeth S ; Xu, Lei ; O'Neill, Edward A ; Goldstein, Barry J ; Kaufman, Keith D ; Engel, Samuel S

Diabetes therapy : research, treatment and education of diabetes and related disorders, March 2015, Vol.6(1), pp.29-40 [Peer Reviewed Journal]

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A randomised, double‐blind, trial of the safety and efficacy of omarigliptin (a once‐weekly DPP‐4 inhibitor) in subjects with type 2 diabetes and renal impairment

Chacra, Antonio ; Gantz, Ira ; Mendizabal, Geraldine ; Durlach, Lucila ; O' Neill, Edward A. ; Zimmer, Zachary ; Suryawanshi, Shailaja ; Engel, Samuel S. ; Lai, Eseng

International Journal of Clinical Practice, June 2017, Vol.71(6), pp.n/a-n/a [Peer Reviewed Journal]

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Synthesis and biological activity of pyridopyridazin-6-one p38α MAP kinase inhibitors. Part 2

Tynebor, Robert M ; Chen, Meng-Hsin ; Natarajan, Swaminathan R ; O’neill, Edward A ; Thompson, James E ; Fitzgerald, Catherine E ; O’keefe, Stephen J ; Doherty, James B

Bioorganic & Medicinal Chemistry Letters, 15 September 2012, Vol.22(18), pp.5979-5983 [Peer Reviewed Journal]

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A randomized clinical trial of the efficacy and safety of sitagliptin compared with dapagliflozin in patients with type 2 diabetes mellitus and mild renal insufficiency: The CompoSIT‐R study

Scott, Russell ; Morgan, Jerry ; Zimmer, Zachary ; Lam, Raymond L. H. ; O' Neill, Edward A. ; Kaufman, Keith D. ; Engel, Samuel S. ; Raji, Annaswamy

Diabetes, Obesity and Metabolism, December 2018, Vol.20(12), pp.2876-2884 [Peer Reviewed Journal]

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A randomized, placebo-controlled study of the cardiovascular safety of the once-weekly DPP-4 inhibitor omarigliptin in patients with type 2 diabetes mellitus

Gantz, Ira ; Chen, Menghui ; Suryawanshi, Shailaja ; Ntabadde, Catherine ; Shah, Sukrut ; O'Neill, Edward A ; Engel, Samuel S ; Kaufman, Keith D ; Lai, Eseng

Cardiovascular diabetology, 11 September 2017, Vol.16(1), pp.112 [Peer Reviewed Journal]

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A potential mechanism of cyclosporine‐associated bone pain: Comment on the radiologic vignette by Stone et al

O' Neill, Edward A. ; Sloan, Victor S.

Arthritis & Rheumatism, March 1998, Vol.41(3), pp.565-566 [Peer Reviewed Journal]

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Synthesis and biological activity of 2 H-quinolizin-2-one based p38α MAP kinase inhibitors

Tynebor, Robert M ; Chen, Meng-Hsin ; Natarajan, Swaminathan R ; O’neill, Edward A ; Thompson, James E ; Fitzgerald, Catherine E ; O’keefe, Stephen J ; Doherty, James B

Bioorganic & Medicinal Chemistry Letters, 2010, Vol.20(9), pp.2765-2769 [Peer Reviewed Journal]

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Randomized clinical trial comparing the efficacy and safety of treatment with the once‐weekly dipeptidyl peptidase‐4 (DPP‐4) inhibitor omarigliptin or the once‐daily DPP‐4 inhibitor sitagliptin in patients with type 2 diabetes inadequately controlled on metformin monotherapy

Goldenberg, Ronald ; Gantz, Ira ; Andryuk, Paula J. ; O' Neill, Edward A. ; Kaufman, Keith D. ; Lai, Eseng ; Wang, Yin Na ; Suryawanshi, Shailaja ; Engel, Samuel S.

Diabetes, Obesity and Metabolism, March 2017, Vol.19(3), pp.394-400 [Peer Reviewed Journal]

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Double-blind, randomized clinical trial comparing the efficacy and safety of continuing or discontinuing the dipeptidyl peptidase-4 inhibitor sitagliptin when initiating insulin glargine therapy in patients with type 2 diabetes: The CompoSIT-I Study

Roussel, Ronan ; García, Santiago D ; Zhang, Yilong ; Shah, Suneri ; Darmiento, Carolyn ; Shankar, R Ravi ; Golm, Gregory T ; Lam, Raymond L H ; O'Neill, Edward A ; Gantz, Ira ; Kaufman, Keith D ; Engel, Samuel S

Diabetes, obesity & metabolism, 04 November 2018 [Peer Reviewed Journal]

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Double‐blind, randomized clinical trial comparing the efficacy and safety of continuing or discontinuing the dipeptidyl peptidase‐4 inhibitor sitagliptin when initiating insulin glargine therapy in patients with type 2 diabetes: The CompoSIT‐I Study

Roussel, Ronan ; Duran‐García, Santiago ; Zhang, Yilong ; Shah, Suneri ; Darmiento, Carolyn ; Shankar, R. Ravi ; Golm, Gregory T. ; Lam, Raymond L. H. ; O' Neill, Edward A. ; Gantz, Ira ; Kaufman, Keith D. ; Engel, Samuel S.

Diabetes, Obesity and Metabolism, April 2019, Vol.21(4), pp.781-790 [Peer Reviewed Journal]

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18
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Randomized clinical trial of the safety and efficacy of sitagliptin and metformin co‐administered to Chinese patients with type 2 diabetes mellitus

Ji, Linong ; Han, Ping ; Wang, Xiaoyue ; Liu, Jingdong ; Zheng, Shaoxiong ; Jou, Ying‐Ming ; O' Neill, Edward A ; Golm, Gregory T ; Engel, Samuel S ; Kaufman, Keith D ; Shankar, R Ravi

Journal of Diabetes Investigation, September 2016, Vol.7(5), pp.727-736 [Peer Reviewed Journal]

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A randomized, double-blind trial evaluating the efficacy and safety of monotherapy with the once-weekly dipeptidyl peptidase-4 inhibitor omarigliptin in people with type 2 diabetes

Home, Philip ; Shankar, R. Ravi ; Gantz, Ira ; Iredale, Carol ; O'Neill, Edward A ; Jain, Lokesh ; Pong, Annpey ; Suryawanshi, Shailaja ; Engel, Samuel S ; Kaufman, Keith D ; Lai, Eseng

Diabetes Research and Clinical Practice, April 2018, Vol.138, pp.253-261 [Peer Reviewed Journal]

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Extended-release niacin/laropiprant significantly improves lipid levels in type 2 diabetes mellitus irrespective of baseline glycemic control

Bays, Harold E ; Brinton, Eliot A ; Triscari, Joseph ; Chen, Erluo ; Maccubbin, Darbie ; Maclean, Alexandra A ; Gibson, Kendra L ; Ruck, Rae Ann ; Johnson-Levonas, Amy O ; O'Neill, Edward A ; Mitchel, Yale B

Vascular health and risk management, 2015, Vol.11, pp.165-72 [Peer Reviewed Journal]

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21
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A randomized clinical trial evaluating the safety and efficacy of sitagliptin added to the combination of sulfonylurea and metformin in patients with type 2 diabetes mellitus and inadequate glycemic control

Moses, Robert G. ; Round, Elizabeth ; Shentu, Yue ; Golm, Gregory T. ; O' Neill, Edward A. ; Gantz, Ira ; Engel, Samuel S. ; Kaufman, Keith D. ; Goldstein, Barry J.

Journal of Diabetes, September 2016, Vol.8(5), pp.701-711 [Peer Reviewed Journal]

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22
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A randomized, placebo-controlled clinical trial evaluating the safety and efficacy of the once-weekly DPP-4 inhibitor omarigliptin in patients with type 2 diabetes mellitus inadequately controlled by glimepiride and metformin

Lee, Seung-Hwan ; Gantz, Ira ; Round, Elizabeth ; Latham, Melanie ; O'Neill, Edward A ; Ceesay, Paulette ; Suryawanshi, Shailaja ; Kaufman, Keith D ; Engel, Samuel S ; Lai, Eseng

BMC endocrine disorders, 06 November 2017, Vol.17(1), pp.70 [Peer Reviewed Journal]

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23
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Design, synthesis, and biological evaluation of aminopyrazine derivatives as inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2)

Lin, Songnian ; Malkani, Sunita ; Lombardo, Matthew ; Yang, Lihu ; Mills, Sander G ; Chapman, Kevin ; Thompson, James E ; Zhang, Wen Xiao ; Wang, Ruixiu ; Cubbon, Rose M ; O’neill, Edward A ; Hale, Jeffrey J

Bioorganic & Medicinal Chemistry Letters, 15 November 2015, Vol.25(22), pp.5402-5408 [Peer Reviewed Journal]

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24
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Reconstituted HDL Elicits Marked Changes in Plasma Lipids Following Single-Dose Injection in C57Bl/6 Mice

Chen, Zhu ; O'Neill, Edward A ; Meurer, Roger D ; Gagen, Karen ; Luell, Silvi ; Wang, Sheng-Ping ; Ichetovkin, Marina ; Frantz-Wattley, Betsy ; Eveland, Suzanne ; Strack, Alison M ; Fisher, Timothy S ; Johns, Douglas G ; Sparrow, Carl P ; Wright, Samuel D ; Hubbard, Brian K ; Carballo-Jane, Ester

Journal of Cardiovascular Pharmacology and Therapeutics, September 2012, Vol.17(3), pp.315-323 [Peer Reviewed Journal]

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25
Kinetic Mechanism for p38 MAP Kinase
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Kinetic Mechanism for p38 MAP Kinase

Lograsso, Philip V. ; Frantz, Betsy ; Rolando, Anna M. ; O'Keefe, Stephen J. ; Hermes, Jeffery D. ; O'Neill, Edward A.

Biochemistry, 08/1997, Vol.36(34), pp.10422-10427 [Peer Reviewed Journal]

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26
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High-throughput simultaneous analysis of RNA, protein, and lipid biomarkers in heterogeneous tissue samples

Reiser, Vladimír ; Smith, Ryan C ; Xue, Jiyan ; Kurtz, Marc M ; Liu, Rong ; Legrand, Cheryl ; He, Xuanmin ; Yu, Xiang ; Wong, Peggy ; Hinchcliffe, John S ; Tanen, Michael R ; Lazar, Gloria ; Zieba, Renata ; Ichetovkin, Marina ; Chen, Zhu ; O'Neill, Edward A ; Tanaka, Wesley K ; Marton, Matthew J ; Liao, Jason ; Morris, Mark ; Hailman, Eric ; Tokiwa, George Y ; Plump, Andrew S

Clinical chemistry, November 2011, Vol.57(11), pp.1545-55 [Peer Reviewed Journal]

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27
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A gene expression signature that classifies human atherosclerotic plaque by relative inflammation status

Puig, Oscar ; Yuan, Jeffrey ; Stepaniants, Sergey ; Zieba, Renata ; Zycband, Emanuel ; Morris, Mark ; Coulter, Silvija ; Yu, Xiang ; Menke, John ; Woods, John ; Chen, Fabian ; Ramey, Dena R ; He, Xuanmin ; O'Neill, Edward A ; Hailman, Eric ; Johns, Douglas G ; Hubbard, Brian K ; Yee Lum, Pek ; Wright, Samuel D ; Desouza, Mary M ; Plump, Andrew ; Reiser, Vladimír

Circulation. Cardiovascular genetics, December 2011, Vol.4(6), pp.595-604 [Peer Reviewed Journal]

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28
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The three‐dimensional structure of MAP kinase p38β: different features of the ATP‐binding site in p38β compared with p38α

Patel, Sangita B. ; Cameron, Patricia M. ; O' Keefe, Stephen J. ; Frantz‐Wattley, Betsy ; Thompson, Jed ; O' Neill, Edward A. ; Tennis, Trevor ; Liu, Luping ; Becker, Joseph W. ; Scapin, Giovanna

Acta Crystallographica Section D, 01 August 2009, Vol.65(8), pp.777-785 [Peer Reviewed Journal]

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29
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Biochemical characterization of cholesteryl ester transfer protein inhibitors

Ranalletta, Mollie ; Bierilo, Kathleen K ; Chen, Ying ; Milot, Denise ; Chen, Qing ; Tung, Elaine ; Houde, Caroline ; Elowe, Nadine H ; Garcia-Calvo, Margarita ; Porter, Gene ; Eveland, Suzanne ; Frantz-Wattley, Betsy ; Kavana, Mike ; Addona, George ; Sinclair, Peter ; Sparrow, Carl ; O'Neill, Edward A ; Koblan, Ken S ; Sitlani, Ayesha ; Hubbard, Brian ; Fisher, Timothy S

Journal of lipid research, September 2010, Vol.51(9), pp.2739-52 [Peer Reviewed Journal]

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30
The Activation State of p38 Mitogen-Activated Protein Kinase Determines the Efficiency of ATP Competition for Pyridinylimidazole Inhibitor Binding
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The Activation State of p38 Mitogen-Activated Protein Kinase Determines the Efficiency of ATP Competition for Pyridinylimidazole Inhibitor Binding

Frantz, Betsy ; Klatt, Tracey ; Pang, Margaret ; Parsons, Janey ; Rolando, Anna ; Williams, Hollis ; Tocci, Michael J. ; O'Keef, Stephen J. ; O'Neill, Edward A.

Biochemistry, 09/1998, Vol.37(39), pp.13846-13853 [Peer Reviewed Journal]

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31
Molecular Basis for p38 Protein Kinase Inhibitor Specificity
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Molecular Basis for p38 Protein Kinase Inhibitor Specificity

Lisnock, Jeanmarie ; Tebben, Andy ; Frantz, Betsy ; O'Neill, Edward A. ; Croft, Gist ; O'Keefe, Stephen J. ; Li, Bing ; Hacker, Candice ; de Laszlo, Stephen ; Smith, Anthony ; Libby, Brian ; Liverton, Nigel ; Hermes, Jeffrey ; Lograsso, Philip

Biochemistry, 03/1999, Vol.38(11), pp.3456-3456 [Peer Reviewed Journal]

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32
Molecular Basis for p38 Protein Kinase Inhibitor Specificity
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Molecular Basis for p38 Protein Kinase Inhibitor Specificity

Lisnock, Jeanmarie ; Tebben, Andy ; Frantz, Betsy ; O'Neill, Edward A. ; Croft, Gist ; O'Keefe, Stephen J. ; Li, Bing ; Hacker, Candice ; de Laszlo, Stephen ; Smith, Anthony ; Libby, Brian ; Liverton, Nigel ; Hermes, Jeffrey ; Lograsso, Philip

Biochemistry, 11/1998, Vol.37(47), pp.16573-16581 [Peer Reviewed Journal]

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33
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Hybrid-designed inhibitors of p38 MAP kinase utilizing N-arylpyridazinones

Colletti, Steven L ; Frie, Jessica L ; Dixon, Elizabeth C ; Singh, Suresh B ; Choi, Bernard K ; Scapin, Giovanna ; Fitzgerald, Catherine E ; Kumar, Sanjeev ; Nichols, Elizabeth A ; O'Keefe, Stephen J ; O'Neill, Edward A ; Porter, Gene ; Samuel, Koppara ; Schmatz, Dennis M ; Schwartz, Cheryl D ; Shoop, Wesley L ; Thompson, Chris M ; Thompson, James E ; Wang, Ruixiu ; Woods, Andrea ; Zaller, Dennis M ; Doherty, James B

Journal of medicinal chemistry, 30 January 2003, Vol.46(3), pp.349-52 [Peer Reviewed Journal]

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34
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p38 MAP kinase inhibitors. Part 3: SAR on 3,4-dihydropyrimido[4,5- d]pyrimidin-2-ones and 3,4-dihydropyrido[4,3- d]pyrimidin-2-ones

Natarajan, Swaminathan R ; Wisnoski, David D ; Thompson, James E ; O’neill, Edward A ; O’keefe, Stephen J

Bioorganic & Medicinal Chemistry Letters, 2006, Vol.16(16), pp.4400-4404 [Peer Reviewed Journal]

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35
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Synthesis and biological activity of quinolinone and dihydroquinolinone p38 MAP kinase inhibitors

Chen, Meng-Hsin ; Fitzgerald, Patricia ; Singh, Suresh B ; O’neill, Edward A ; Schwartz, Cheryl D ; Thompson, Chris M ; O’keefe, Stephen J ; Zaller, Dennis M ; Doherty, James B

Bioorganic & Medicinal Chemistry Letters, 2008, Vol.18(6), pp.2222-2226 [Peer Reviewed Journal]

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36
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