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Aα-Val360: a marker of neutrophil elastase and COPD disease activity

Carter, Richard I ; Ungurs, Michael J ; Mumford, Richard A ; Stockley, Robert A

The European respiratory journal, January 2013, Vol.41(1), pp.31-8 [Peer Reviewed Journal]

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The fibrinogen cleavage product Aα-Val360, a specific marker of neutrophil elastase activity in vivo

Carter, Richard I ; Mumford, Richard A ; Treonze, Kelly M ; Finke, Paul E ; Davies, Phillip ; Si, Qian ; Humes, John L ; Dirksen, Asger ; Piitulainen, Eeva ; Ahmad, Ali ; Stockley, Robert A

Thorax, August 2011, Vol.66(8), pp.686-91 [Peer Reviewed Journal]

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Heterocycle-substituted proline dipeptides as potent VLA-4 antagonists

Reger, Thomas S ; Zunic, Jasmine ; Stock, Nicholas ; Wang, Bowei ; Smith, Nicholas D ; Munoz, Benito ; Green, Mitchell D ; Gardner, Michael F ; James, Joyce P ; Chen, Weichao ; Alves, Kenneth ; Si, Qian ; Treonze, Kelly M ; Lingham, Russell B ; Mumford, Richard A

Bioorganic & Medicinal Chemistry Letters, 2010, Vol.20(3), pp.1173-1176 [Peer Reviewed Journal]

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Proteinase activities of the golden hamster eggs and cells of the cumulus oophorus

Mumford, Richard A ; Hartmann, John F ; Ashe, Bonnie M ; Zimmerman, Morris

Developmental Biology, 1981, Vol.81(2), pp.332-335 [Peer Reviewed Journal]

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Discovery of N-{N-(3-cyanophenyl)sulfonyl-4(R)-cyclobutylamino-(L)-prolyl}-4-(3',5'-dichloroisonicotinoyl) amino-(L)-phenylalanine (MK-0668), an extremely potent and orally active antagonist of very late antigen-4

Lin, Linus S ; Lanza, Thomas ; Jewell, James P ; Liu, Ping ; Jones, Carrie ; Kieczykowski, Gerard R ; Treonze, Kelly ; Si, Qian ; Manior, Salony ; Koo, Gloria ; Tong, Xinchun ; Wang, Junying ; Schuelke, Anne ; Pivnichny, James ; Wang, Regina ; Raab, Conrad ; Vincent, Stella ; Davies, Philip ; Maccoss, Malcolm ; Mumford, Richard A ; Hagmann, William K

Journal of medicinal chemistry, 11 June 2009, Vol.52(11), pp.3449-52 [Peer Reviewed Journal]

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Comparative assessment of the ligand and metal ion binding properties of integrins alpha9beta1 and alpha4beta1

Pepinsky, R Blake ; Mumford, Richard A ; Chen, Ling Ling ; Leone, Diane ; Amo, Suzanne E ; Riper, Gail Van ; Whitty, Adrian ; Dolinski, Brian ; Lobb, Roy R ; Dean, Dennis C ; Chang, Linda L ; Raab, Conrad E ; Si, Qian ; Hagmann, William K ; Lingham, Russell B

Biochemistry, 04 June 2002, Vol.41(22), pp.7125-41 [Peer Reviewed Journal]

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7
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PROTEASE ACTIVITIES PRESENT IN DOG PANCREATIC MEMBRANES THAT PROCESS HUMAN PRE‐PLACENTAL LACTOGEN

Zimmerman, Morris ; Ashe, Bonnie M. ; Alberts, Alfred W. ; Pierzchala, Patricia A. ; Powers, James C. ; Nishino, Norikazu ; Strauss, Arnold W. ; Mumford, Richard A.

Annals of the New York Academy of Sciences, May 1980, Vol.343(1), pp.405-414 [Peer Reviewed Journal]

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8
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Alpha(4)beta(7)/alpha(4)beta(1) dual integrin antagonists block alpha(4)beta(7)-dependent adhesion under shear flow

Egger, Linda A ; Kidambi, Usha ; Cao, Jin ; Van Riper, Gail ; Mccauley, Ermengilda ; Mumford, Richard A ; Amo, Suzanne ; Lingham, Russell ; Lanza, Thomas ; Lin, Linus S ; De Laszlo, Stephen E ; Young, David N ; Kopka, Ihor E ; Tong, Sharon ; Pikounis, Bill ; Benson, Evelyn ; Warwood, Sarah ; Bargatze, Robert F ; Hagmann, William K ; Schmidt, John A ; Detmers, Patricia A

The Journal of pharmacology and experimental therapeutics, July 2002, Vol.302(1), pp.153-62 [Peer Reviewed Journal]

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Constraining the amide bond in N-Sulfonylated dipeptide VLA-4 antagonists

Chang, Linda L ; Yang, Ginger X ; Mccauley, Ermengilda ; Mumford, Richard A ; Schmidt, John A ; Hagmann, William K

Bioorganic & Medicinal Chemistry Letters, 2008, Vol.18(5), pp.1688-1691 [Peer Reviewed Journal]

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10
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Purification of α- and β-galactosidases by affinity chromatography

Kanfer, Julian N ; Petrovich, George ; Mumford, Richard A

Analytical Biochemistry, 1973, Vol.55(1), pp.301-305 [Peer Reviewed Journal]

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11
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Direct Assay of Aα(1–21), a PMN Elastase‐Specific Cleavage Product of Fibrinogen, in the Chimpanzee

Mumford, Richard A. ; Williams, Hollis ; Mao, Jennifer ; Dahlgren, Mary Ellen ; Frankenfield, Dale ; Nolan, Thomas ; Schaffer, Linda ; Doherty, James B. ; Fletcher, Daniel ; Hand, Karen ; Bonney, Robert ; Humes, John L. ; Pacholok, Stephen ; Hanlon, William ; Davies, Philip

Annals of the New York Academy of Sciences, May 1991, Vol.624(1), pp.167-178 [Peer Reviewed Journal]

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12
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N-Aryl 2,6-Dimethoxybiphenylalanine Analogues as VLA-4 Antagonists

Doherty, George A ; Kamenecka, Theodore ; Mccauley, Ermenegilda ; Van Riper, Gail ; Mumford, Richard A ; Tong, Sharon ; Hagmann, William K

Bioorganic & Medicinal Chemistry Letters, 2002, Vol.12(5), pp.729-731 [Peer Reviewed Journal]

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A small molecule alpha4beta1/alpha4beta7 antagonist differentiates between the low-affinity states of alpha4beta1 and alpha4beta7: characterization of divalent cation dependence

Egger, Linda A ; Cao, Jin ; Mccallum, Christine ; Kidambi, Usha ; Van Riper, Gail ; Mccauley, Ermengilda ; Mumford, Richard A ; Lanza, Thomas J ; Lin, Linus S ; De Laszlo, Stephen E ; Young, David N ; Yang, Ginger ; Dean, Dennis C ; Raab, Conrad E ; Wallace, Mike A ; Jones, Allen N ; Hagmann, William K ; Schmidt, John A ; Pepinsky, R Blake ; Scott, Daniel M ; Lee, Wen-Cherng ; Cornebise, Mark A ; Detmers, Patricia A

The Journal of pharmacology and experimental therapeutics, September 2003, Vol.306(3), pp.903-13 [Peer Reviewed Journal]

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Use of an antibody against the matrix metalloproteinase–generated aggrecan neoepitope fvdipen‐cooh to assess the effects of stromelysin in a rabbit model of cartilage degradation

Bayne, Ellen Kahn ; Macnaul, Karen L. ; Donatelli, Susan A. ; Christen, Amy ; Griffin, Patrick R. ; Hoerrner, Lori A. ; Calaycay, Jimmy R. ; Ayala, Julia M. ; Chapman, Kevin ; Hagmann, William ; Weidner, Jeffrey R. ; Mcdonnell, Joseph ; Moore, Vernon L. ; Mumford, Richard A. ; Lark, Michael W. ; Hutchinson, Nancy I.

Arthritis & Rheumatism, October 1995, Vol.38(10), pp.1400-1409 [Peer Reviewed Journal]

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15
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Purification of β-glucosidase activities from bovine spleen by affinity chromatography

Kanfer, Julian N ; Mumford, Richard A ; Raghavan, Srinivasa S ; Byrd, James

Analytical Biochemistry, 1974, Vol.60(1), pp.200-205 [Peer Reviewed Journal]

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16
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Influence of acid surrogates toward potency of VLA-4 antagonist

Venkatraman, Shankar ; Lim, Jongwon ; Cramer, Merryl ; Gardner, Michael F ; James, Joyce ; Alves, Kenneth ; Lingham, Russell B ; Mumford, Richard A ; Munoz, Benito

Bioorganic & Medicinal Chemistry Letters, 2005, Vol.15(18), pp.4053-4056 [Peer Reviewed Journal]

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17
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Discovery of N-{ N-[(3-cyanobenzene) sulfonyl]-4( R)-(3,3-difluoropiperidin-1-yl)-( l)-prolyl}-4-[(3′,5′-dichloro-isonicotinoyl) amino]-( l)-phenylalanine (MK-0617), a highly potent and orally active VLA-4 antagonist

Venkatraman, Shankar ; Lebsack, Alec D ; Alves, Kenneth ; Gardner, Michael F ; James, Joyce ; Lingham, Russell B ; Maniar, Salony ; Mumford, Richard A ; Si, Qian ; Stock, Nicholas ; Treonze, Kelly M ; Wang, Bowei ; Zunic, Jasmine ; Munoz, Benito

Bioorganic & Medicinal Chemistry Letters, 2009, Vol.19(19), pp.5803-5806 [Peer Reviewed Journal]

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18
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Bioisosteric replacement of anilide with benzoxazole: potent and orally bioavailable antagonists of VLA-4

Lin, Linus S ; Lanza, Thomas J ; Castonguay, Laurie A ; Kamenecka, Theodore ; Mccauley, Ermenegilda ; Van Riper, Gail ; Egger, Linda A ; Mumford, Richard A ; Tong, Xinchun ; Maccoss, Malcolm ; Schmidt, John A ; Hagmann, William K

Bioorganic & Medicinal Chemistry Letters, 03 May 2004, Vol.14(9), pp.2331-2334 [Peer Reviewed Journal]

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19
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The discovery of small molecule carbamates as potent dual α 4β 1/α 4β 7 integrin antagonists

Chang, Linda L ; Truong, Quang ; Mumford, Richard A ; Egger, Linda A ; Kidambi, Usha ; Lyons, Kathryn ; Mccauley, Ermengilda ; Van Riper, Gail ; Vincent, Stella ; Schmidt, John A ; Maccoss, Malcolm ; Hagmann, William K

Bioorganic & Medicinal Chemistry Letters, 2002, Vol.12(2), pp.159-163 [Peer Reviewed Journal]

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20
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Specific and dual antagonists of α 4β 1 and α 4β 7 integrins

Lin, Linus S ; Lanza, Thomas ; Mccauley, Ermenegilda ; Riper, Gail Van ; Kidambi, Usha ; Cao, Jin ; Egger, Linda A ; Mumford, Richard A ; Schmidt, John A ; Maccoss, Malcolm ; Hagmann, William K

Bioorganic & Medicinal Chemistry Letters, 2002, Vol.12(2), pp.133-136 [Peer Reviewed Journal]

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21
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N-(3-Phenylsulfonyl-3-piperidinoyl)-phenylalanine derivatives as potent, selective VLA-4 antagonists

Gutteridge, Clare E ; de Laszlo, Stephen E ; Kamenecka, Theodore M ; Mccauley, Ermengilda ; van Riper, Gail ; Mumford, Richard A ; Kidambi, Usha ; Egger, Linda A ; Tong, Sharon ; Hagmann, William K

Bioorganic & Medicinal Chemistry Letters, 2003, Vol.13(5), pp.885-890 [Peer Reviewed Journal]

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22
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Protease activities present in wheat germ and rabbit reticulocyte lysates

Mumford, Richard A ; Pickett, Cecil B ; Zimmerman, Morris ; Strauss, Arnold W

Biochemical and Biophysical Research Communications, 1981, Vol.103(2), pp.565-572 [Peer Reviewed Journal]

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23
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Characterization of α 4β 1 (CD49d/CD29) on equine leukocytes: Potential utility of a potent α 4β 1 (CD49d/CD29) receptor antagonist in the treatment of equine heaves (recurrent airway obstruction)

Treonze, Kelly M ; Alves, Kenneth ; Fischer, Paul ; Hagmann, William K ; Hora, Donald ; Kulick, Alison ; Vakerich, Ken ; Smith, Nicholas D ; Lingham, Russell B ; Maniar, Salony ; Reger, Thomas S ; Zunic, Jasmine ; Munoz, Benito ; Prasit, Peppi ; Nicholson, Donald ; Si, Qian ; Judd, Keith ; Nicolich, Susan ; Kellerhouse, Patricia ; Thompson, Donald ; Mumford, Richard A

Veterinary Immunology and Immunopathology, 2009, Vol.130(1), pp.79-87 [Peer Reviewed Journal]

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24
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A specific proteinase 3 activity footprint in α 1 -antitrypsin deficiency

Newby, Paul R ; Crossley, Diana ; Crisford, Helena ; Stockley, James A ; Mumford, Richard A ; Carter, Richard I ; Bolton, Charlotte E ; Hopkinson, Nicholas S ; Mahadeva, Ravi ; Steiner, Michael C ; Wilkinson, Tom M.A ; Sapey, Elizabeth ; Stockley, Robert A

ERJ Open Research, 2019, Vol.5(3) [Peer Reviewed Journal]

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25
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Human leukocyte acid hydrolases: Characterization of eleven lysosomal enzymes and study of reaction conditions for their automated analysis

Kolodny, Edwin H ; Mumford, Richard A

Clinica Chimica Acta, 1976, Vol.70(2), pp.247-257 [Peer Reviewed Journal]

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26
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Formation of polymorphonuclear leukocyte elastase: α1 proteinase inhibitor complex and Aα(1–21) fibrinopeptide in human blood stimulated with the calcium ionophore A23187 : A model to characterize inhibitors of polymorphonuclear leukocyte elastase

Pacholok, Stephen G ; Davies, Philip ; Dorn, Conrad ; Finke, Paul ; Hanlon, William A ; Mumford, Richard A ; Humes, John L

Biochemical Pharmacology, 1995, Vol.49(10), pp.1513-1520 [Peer Reviewed Journal]

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27
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Bicyclic amidine inhibitors of nitric oxide synthase: discovery of perhydro-iminopyrindine and perhydro-iminoquinoline as potent, orally active inhibitors of inducible nitric oxide synthase

Guthikonda, Ravindra N ; Shah, Shrenik K ; Pacholok, Stephen G ; Humes, John L ; Mumford, Richard A ; Grant, Stephan K ; Chabin, Renee M ; Green, Barbara G ; Tsou, Nancy ; Ball, Richard ; Fletcher, Daniel S ; Luell, Silvi ; Euan Macintyre, D ; Maccoss, Malcolm

Bioorganic & Medicinal Chemistry Letters, 2005, Vol.15(8), pp.1997-2001 [Peer Reviewed Journal]

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28
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Amidines as amide bond replacements in VLA-4 antagonists

Kamenecka, Theodore M ; Park, You-Jung ; Lin, Linus S ; de Laszlo, Stephen ; Mccauley, Ermengilda D ; Van Riper, Gail ; Egger, Linda ; Kidambi, Usha ; Mumford, Richard A ; Tong, Sharon ; Tang, Wei ; Colletti, Adria ; Teffera, Yohannes ; Stearns, Ralph ; Maccoss, Malcolm ; Schmidt, John A ; Hagmann, William K

Bioorganic & Medicinal Chemistry Letters, 03 May 2004, Vol.14(9), pp.2323-2326 [Peer Reviewed Journal]

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29
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N-Isonicotinoyl-( l)-4-aminophenylalanine derivatives as tight binding VLA-4 antagonists

Doherty, George A ; Yang, Ginger X ; Borges, Edite ; Tong, Sharon ; Mccauley, Ermengilda D ; Treonz, Kelly M ; Van Riper, Gail ; Pacholok, Stephen ; Si, Qian ; Koo, Gloria C ; Shah, Kashmira ; Mumford, Richard A ; Hagmann, William K

Bioorganic & Medicinal Chemistry Letters, 2003, Vol.13(11), pp.1891-1895 [Peer Reviewed Journal]

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30
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N-(Arylacetyl)-biphenylalanines as Potent VLA-4 Antagonists

Li, Bing ; de Laszlo, Stephen E ; Kamenecka, Theodore M ; Kopka, Ihor E ; Durette, Philippe L ; Lanza, Jr, Thomas ; Maccoss, Malcolm ; Tong, Sharon ; Mumford, Richard A ; Mccauley, Ermengilda D ; Van Riper, Gail ; Schmidt, John A ; Hagmann, William K

Bioorganic & Medicinal Chemistry Letters, 2002, Vol.12(16), pp.2141-2144 [Peer Reviewed Journal]

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31
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N-Aryl-prolyl-dipeptides as potent antagonists of VLA-4

Kamenecka, Theodore M ; Lanza, Jr, Thomas ; de Laszlo, Stephen E ; Li, Bing ; Mccauley, Ermengilda D ; Van Riper, Gail ; Egger, Linda A ; Kidambi, Usha ; Mumford, Richard A ; Tong, Sharon ; Maccoss, Malcolm ; Schmidt, John A ; Hagmann, William K

Bioorganic & Medicinal Chemistry Letters, 2002, Vol.12(16), pp.2205-2208 [Peer Reviewed Journal]

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32
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Corrigendum to “ N-Isonicotinoyl-( l)-4-aminophenylalanine Derivatives as Tight Binding VLA-4 Antagonists”[Bioorg. Med. Chem. Lett. 13 (2003) 1891]

Doherty, George A ; Yang, Ginger X ; Borges, Edite ; Tong, Sharon ; Mccauley, Ermengilda D ; Treonz, Kelly M ; Van Riper, Gail ; Pacholok, Stephen ; Si, Qian ; Koo, Gloria C ; Shah, Kashmira ; Mumford, Richard A ; Hagmann, William K

Bioorganic & Medicinal Chemistry Letters, 2003, Vol.13(17), pp.2937-2938 [Peer Reviewed Journal]

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33
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N-Tetrahydrofuroyl-( l)-phenylalanine derivatives as potent VLA-4 antagonists

Yang, Ginger X ; Chang, Linda L ; Truong, Quang ; Doherty, George A ; Magriotis, Plato A ; de Laszlo, Stephen E ; Li, Bing ; Maccoss, Malcolm ; Kidambi, Usha ; Egger, Linda A ; Mccauley, Ermengilda ; Van Riper, Gail ; Mumford, Richard A ; Schmidt, John A ; Hagmann, William K

Bioorganic & Medicinal Chemistry Letters, 2002, Vol.12(11), pp.1497-1500 [Peer Reviewed Journal]

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34
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Substituted tetrahydrofuroyl-1-phenylalanine derivatives as potent and specific VLA-4 antagonists

Doherty, George A ; Yang, Ginger X ; Borges, Edite ; Chang, Linda L ; Maccoss, Malcolm ; Tong, Sharon ; Kidambi, Usha ; Egger, Linda A ; Mccauley, Ermenegilda ; Van Riper, Gail ; Mumford, Richard A ; Schmidt, John A ; Hagmann, William K

Bioorganic & Medicinal Chemistry Letters, 2002, Vol.12(11), pp.1501-1505 [Peer Reviewed Journal]

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35
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Synthetic segments of the mammalian βAR are preferentially recognized by cAMP-dependent protein kinase and protein kinase C

Blake, Allan D ; Mumford, Richard A ; Vincent Strout, H ; Slater, Eve E ; Strader, Catherine D

Biochemical and Biophysical Research Communications, 1987, Vol.147(1), pp.168-173 [Peer Reviewed Journal]

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36
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Phosphorous acid analogs of L-680,833, a potent monocyclic β-lactam inhibitor of human leukocyte elastase

Durette, Philippe L ; Chabin, Renee M ; Fletcher, Daniel S ; Green, Barbara G ; Hanlon, William A ; Humes, John L ; Knight, Wilson B ; Lanza, Thomas J ; Mumford, Richard A ; Pacholok, Stephen ; Maccoss, Malcolm

Bioorganic & Medicinal Chemistry Letters, 1995, Vol.5(3), pp.271-274 [Peer Reviewed Journal]

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