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Nucleoside, nucleotide, and non-nucleoside inhibitors of hepatitis C virus NS5B RNA-dependent RNA-polymerase

Sofia, Michael J ; Chang, Wonsuk ; Furman, Phillip A ; Mosley, Ralph T ; Ross, Bruce S

Journal of medicinal chemistry, 22 March 2012, Vol.55(6), pp.2481-531 [Peer Reviewed Journal]

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Correction to Nucleoside, Nucleotide, and Non-Nucleoside Inhibitors of Hepatitis C Virus NS5B RNA-Dependent RNA-Polymerase

Sofia, Michael J ; Chang, Wonsuk ; Furman, Phillip A ; Mosley, Ralph T ; Ross, Bruce S

Journal of medicinal chemistry, 13 April 2017, Vol.60(7), pp.3219 [Peer Reviewed Journal]

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Adenosine deaminase-like protein 1 (ADAL1): characterization and substrate specificity in the hydrolysis of N(6)- or O(6)-substituted purine or 2-aminopurine nucleoside monophosphates

Murakami, Eisuke ; Bao, Haiying ; Mosley, Ralph T ; Du, Jinfa ; Sofia, Michael J ; Furman, Phillip A

Journal of medicinal chemistry, 25 August 2011, Vol.54(16), pp.5902-14 [Peer Reviewed Journal]

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Use of 2'-spirocyclic ethers in HCV nucleoside design

Du, Jinfa ; Chun, Byoung-Kwon ; Mosley, Ralph T ; Bansal, Shalini ; Bao, Haiying ; Espiritu, Christine ; Lam, Angela M ; Murakami, Eisuke ; Niu, Congrong ; Micolochick Steuer, Holly M ; Furman, Phillip A ; Sofia, Michael J

Journal of medicinal chemistry, 13 March 2014, Vol.57(5), pp.1826-35 [Peer Reviewed Journal]

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Discovery of a novel class of potent HCV NS4B inhibitors: SAR studies on piperazinone derivatives

Kakarla, Ramesh ; Liu, Jian ; Naduthambi, Devan ; Chang, Wonsuk ; Mosley, Ralph T ; Bao, Donghui ; Steuer, Holly M Micolochick ; Keilman, Meg ; Bansal, Shalini ; Lam, Angela M ; Seibel, William ; Neilson, Sandra ; Furman, Phillip A ; Sofia, Michael J

Journal of medicinal chemistry, 13 March 2014, Vol.57(5), pp.2136-60 [Peer Reviewed Journal]

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Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry

Rohrer, Susan ; Birzin, Elizabeth ; Mosley, Ralph ; Berk, Scott

Science, Oct 23, 1998, Vol.282(5389), pp.737-40 [Peer Reviewed Journal]

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Molecular and structural basis for the roles of hepatitis C virus polymerase NS5B amino acids 15, 223, and 321 in viral replication and drug resistance

Lam, Angela M ; Edwards, Thomas E ; Mosley, Ralph T ; Murakami, Eisuke ; Bansal, Shalini ; Lugo, Christopher ; Bao, Haiying ; Otto, Michael J ; Sofia, Michael J ; Furman, Phillip A

Antimicrobial agents and chemotherapy, November 2014, Vol.58(11), pp.6861-9 [Peer Reviewed Journal]

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Benzimidazolones: a new class of selective peroxisome proliferator-activated receptor γ (PPARγ) modulators

Liu, Weiguo ; Lau, Fiona ; Liu, Kun ; Wood, Harold B ; Zhou, Gaochao ; Chen, Yuli ; Li, Ying ; Akiyama, Taro E ; Castriota, Gino ; Einstein, Monica ; Wang, Chualin ; Mccann, Margaret E ; Doebber, Thomas W ; Wu, Margaret ; Chang, Ching H ; Mcnamara, Lesley ; Mckeever, Brian ; Mosley, Ralph T ; Berger, Joel P ; Meinke, Peter T

Journal of medicinal chemistry, 22 December 2011, Vol.54(24), pp.8541-54 [Peer Reviewed Journal]

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Synthesis and biological activities of potent peptidomimetics selective for somatostatin receptor subtype 2

Yang, Lihu ; Berk, Scott ; Rohrer, Susan ; Mosley, Ralph

Proceedings of the National Academy of Sciences of the United States of America, Sep 1, 1998, Vol.95(18), pp.10836-10841 [Peer Reviewed Journal]

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Phenylpropenamide derivatives: Anti-hepatitis B virus activity of the Z isomer, SAR and the search for novel analogs

Wang, Peiyuan ; Naduthambi, Devan ; Mosley, Ralph T ; Niu, Congrong ; Furman, Phillip A ; Otto, Michael J ; Sofia, Michael J

Bioorganic & Medicinal Chemistry Letters, 2011, Vol.21(15), pp.4642-4647 [Peer Reviewed Journal]

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11
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Sordarin derivatives induce a novel conformation of the yeast ribosome translocation factor eEF2

Søe, Rikke ; Mosley, Ralph T ; Justice, Michael ; Nielsen-Kahn, Jennifer ; Shastry, Mythili ; Merrill, A Rod ; Andersen, Gregers R

The Journal of biological chemistry, 05 January 2007, Vol.282(1), pp.657-66 [Peer Reviewed Journal]

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Inhibition of hepatitis C virus NS5A by fluoro-olefin based γ-turn mimetics

Chang, Wonsuk ; Mosley, Ralph T ; Bansal, Shalini ; Keilman, Meg ; Lam, Angela M ; Furman, Phillip A ; Otto, Michael J ; Sofia, Michael J

Bioorganic & Medicinal Chemistry Letters, 15 April 2012, Vol.22(8), pp.2938-2942 [Peer Reviewed Journal]

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13
Assignment of the Liposidomycin Diazepanone Stereochemistry
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Assignment of the Liposidomycin Diazepanone Stereochemistry

Knapp, Spencer ; Morriello, Gregori J. ; Nandan, Santosh R. ; Emge, Thomas J. ; Doss, George A. ; Mosley, Ralph T. ; Chen, Lijian

The Journal of Organic Chemistry, 08/2001, Vol.66(17), pp.5822-5831 [Peer Reviewed Journal]

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The synthesis and conformational analysis of amino acid–tetrahydroanthranilic acid hybrids

Imbriglio, Jason E ; Dirocco, Daniel ; Raghavan, Subharekha ; Ball, Richard G ; Tsou, Nancy ; Mosley, Ralph T ; Tata, James R ; Colletti, Steven L

Tetrahedron Letters, 2008, Vol.49(33), pp.4897-4900 [Peer Reviewed Journal]

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Structure of hepatitis C virus polymerase in complex with primer-template RNA

Mosley, Ralph T ; Edwards, Thomas E ; Murakami, Eisuke ; Lam, Angela M ; Grice, Rena L ; Du, Jinfa ; Sofia, Michael J ; Furman, Philip A ; Otto, Michael J

Journal of virology, June 2012, Vol.86(12), pp.6503-11 [Peer Reviewed Journal]

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Structure and chemistry of apicidins, a class of novel cyclic tetrapeptides without a terminal alpha-keto epoxide as inhibitors of histone deacetylase with potent antiprotozoal activities

Singh, Sheo B ; Zink, Deborah L ; Liesch, Jerrold M ; Mosley, Ralph T ; Dombrowski, Anne W ; Bills, Gerald F ; Darkin-Rattray, Sandra J ; Schmatz, Dennis M ; Goetz, Michael A

The Journal of organic chemistry, 08 February 2002, Vol.67(3), pp.815-25 [Peer Reviewed Journal]

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17
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Novel transannular rearrangements of azalide iminoethers

Wilkening, Robert R ; Ratcliffe, Ronald W ; Doss, George A ; Mosley, Ralph T ; Ball, Richard G

Tetrahedron, 1997, Vol.53(50), pp.16923-16944 [Peer Reviewed Journal]

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18
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Determination of the relative and absolute stereochemistry of sphingofungins A, B, C, and D

Frank, Vanmiddlesworth ; Dufresne, Claude ; Wincott, Francine E ; Mosley, Ralph T ; Wilson, Kenneth E

Tetrahedron Letters, 1992, Vol.33(3), pp.297-300 [Peer Reviewed Journal]

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19
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Discovery of 5-aryloxy-2,4-thiazolidinediones as potent GPR40 agonists

Zhou, Changyou ; Tang, Cheng ; Chang, Eric ; Ge, Min ; Lin, Songnian ; Cline, Eric ; Tan, Carina P ; Feng, Yue ; Zhou, Yun-Ping ; Eiermann, George J ; Petrov, Aleksandr ; Salituro, Gino ; Meinke, Peter ; Mosley, Ralph ; Akiyama, Taro E ; Einstein, Monica ; Kumar, Sanjeev ; Berger, Joel ; Howard, Andrew D ; Thornberry, Nancy ; Mills, Sander G ; Yang, Lihu

Bioorganic & Medicinal Chemistry Letters, 2010, Vol.20(3), pp.1298-1301 [Peer Reviewed Journal]

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20
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Selective small-molecule agonists of G protein-coupled receptor 40 promote glucose-dependent insulin secretion and reduce blood glucose in mice

Tan, Carina P ; Feng, Yue ; Zhou, Yun-Ping ; Eiermann, George J ; Petrov, Aleksandr ; Zhou, Changyou ; Lin, Songnian ; Salituro, Gino ; Meinke, Peter ; Mosley, Ralph ; Akiyama, Taro E ; Einstein, Monica ; Kumar, Sanjeev ; Berger, Joel P ; Mills, Sander G ; Thornberry, Nancy A ; Yang, Lihu ; Howard, Andrew D

Diabetes, August 2008, Vol.57(8), pp.2211-9 [Peer Reviewed Journal]

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21
4-Aza-3-oxo-5α-androst-1-ene-17β- N -arylcarboxamides as Dual Inhibitors of Human Type 1 and Type 2 Steroid 5α-Reductases. Dramatic Effect of N -Aryl Substituents on Type 1 and Type 2 5α-Reductase Inhibitory Potency
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4-Aza-3-oxo-5α-androst-1-ene-17β- N -arylcarboxamides as Dual Inhibitors of Human Type 1 and Type 2 Steroid 5α-Reductases. Dramatic Effect of N -Aryl Substituents on Type 1 and Type 2 5α-Reductase Inhibitory Potency

Bakshi, Raman K. ; Rasmusson, Gary H. ; Patel, Gool F. ; Mosley, Ralph T. ; Chang, Benedict ; Ellsworth, Kenneth ; Harris, Georgianna S. ; Tolman, Richard L.

Journal of Medicinal Chemistry, 01/1996, Vol.39(5), pp.1192-1192 [Peer Reviewed Journal]

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22
Spiro[1 H -indene-1,4‘-piperidine] Derivatives As Potent and Selective Non-Peptide Human Somatostatin Receptor Subtype 2 (sst 2 ) Agonists
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Spiro[1 H -indene-1,4‘-piperidine] Derivatives As Potent and Selective Non-Peptide Human Somatostatin Receptor Subtype 2 (sst 2 ) Agonists

Yang, Lihu ; Guo, Liangqin ; Pasternak, Alexander ; Mosley, Ralph ; Rohrer, Susan ; Birzin, Elizabeth ; Foor, Forrest ; Cheng, Kang ; Schaeffer, James ; Patchett, Arthur A.

Journal of Medicinal Chemistry, 06/1998, Vol.41(13), pp.2175-2179 [Peer Reviewed Journal]

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23
Molecular Determinants of Ligand Binding to the Human Melanocortin-4 Receptor †
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Molecular Determinants of Ligand Binding to the Human Melanocortin-4 Receptor †

Yang, Ying-Kui ; Fong, Tung M. ; Dickinson, Chris J. ; Mao, Cheri ; Li, Ji-Yao ; Tota, Michael R. ; Mosley, Ralph ; Van Der Ploeg, Lex H. T. ; Gantz, Ira

Biochemistry, 12/2000, Vol.39(48), pp.14900-14911 [Peer Reviewed Journal]

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24
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Estrogen receptor ligands. II. Discovery of benzoxathiins as potent, selective estrogen receptor alpha modulators

Kim, Seongkon ; Wu, Jane Y ; Birzin, Elizabeth T ; Frisch, Katalin ; Chan, Wanda ; Pai, Lee-Yuh ; Yang, Yi Tien ; Mosley, Ralph T ; Fitzgerald, Paula M D ; Sharma, Nandini ; Dahllund, Johanna ; Thorsell, Ann-Gerd ; Dininno, Frank ; Rohrer, Susan P ; Schaeffer, James M ; Hammond, Milton L

Journal of medicinal chemistry, 22 April 2004, Vol.47(9), pp.2171-5 [Peer Reviewed Journal]

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25
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Reagent Selector: using Synthon Analysis to visualize reagent properties and assist in combinatorial library design

Mosley, Ralph T ; Culberson, J Christopher ; Kraker, Bryan ; Feuston, Bradley P ; Sheridan, Robert P ; Conway, John F ; Forbes, Joseph K ; Chakravorty, Subhas J ; Kearsley, Simon K

Journal of chemical information and modeling, 2005, Vol.45(5), pp.1439-46 [Peer Reviewed Journal]

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26
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Erratum to “A simple method for visualizing the differences between related receptor sites”: [J. Mol. Graph. Mod. 21 (2002) 71–79]

Sheridan, Robert P ; Holloway, M.Katharine ; Mcgaughey, Georgia ; Mosley, Ralph T ; Singh, Suresh B

Journal of Molecular Graphics and Modelling, 2002, Vol.21(3), pp.215-215 [Peer Reviewed Journal]

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27
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A simple method for visualizing the differences between related receptor sites

Sheridan, Robert P ; Holloway, M Katharine ; Mcgaughey, Georgia ; Mosley, Ralph T ; Singh, Suresh B

Journal of molecular graphics & modelling, December 2002, Vol.21(3), pp.217-25 [Peer Reviewed Journal]

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28
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1 H‐NMR studies on a potent and selective antagonist at human melanocortin receptor 4 (hMC‐4R

Victoria Silva Elipe, Maria ; Mosley, Ralph T. ; Bednarek, Maria A. ; Arison, Byron H.

Biopolymers, April 2003, Vol.68(4), pp.512-527 [Peer Reviewed Journal]

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29
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A simple method for visualizing the differences between related receptor sites

Sheridan, Robert P ; Holloway, M.Katharine ; Mcgaughey, Georgia ; Mosley, Ralph T ; Singh, Suresh B

Journal of Molecular Graphics and Modelling, 2002, Vol.21(1), pp.71-79 [Peer Reviewed Journal]

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30
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1H-NMR studies on a potent and selective antagonist at human melanocortin receptor 4 (hMC-4R)

Victoria Silva Elipe, Maria ; Mosley, Ralph T ; Bednarek, Maria A ; Arison, Byron H

Biopolymers, April 2003, Vol.68(4), pp.512-27 [Peer Reviewed Journal]

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31
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What's all the FLAP about?: 5-lipoxygenase-activating protein inhibitors for inflammatory diseases

Evans, Jilly F ; Ferguson, Andrew D ; Mosley, Ralph T ; Hutchinson, John H

Trends in Pharmacological Sciences, 2008, Vol.29(2), pp.72-78 [Peer Reviewed Journal]

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32
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Benzo[b]thiophene-based histone deacetylase inhibitors

Witter, David J ; Belvedere, Sandro ; Chen, Liqiang ; Secrist, J. Paul ; Mosley, Ralph T ; Miller, Thomas A

Bioorganic & Medicinal Chemistry Letters, 15 August 2007, Vol.17(16), pp.4562-4567 [Peer Reviewed Journal]

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33
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Design and pharmacology of N-(3R)-1,2,3,4-tetrahydroisoquinolinium- 3-ylcarbonyl-(1R)-1-(4-chlorobenzyl)- 2-4-cyclohexyl-4-(1H-1,2,4-triazol- 1-ylmethyl)piperidin-1-yl-2-oxoethylamine (1), a potent, selective, melanocortin subtype-4 receptor agonist

Sebhat, Iyassu K ; Martin, William J ; Ye, Zhixiong ; Barakat, Khaled ; Mosley, Ralph T ; Johnston, David B R ; Bakshi, Raman ; Palucki, Brenda ; Weinberg, David H ; Macneil, Tanya ; Kalyani, Rubana N ; Tang, Rui ; Stearns, Ralph A ; Miller, Randy R ; Tamvakopoulos, Constantin ; Strack, Alison M ; Mcgowan, Erin ; Cashen, Doreen E ; Drisko, Jennifer E ; Hom, Gary J ; Howard, Andrew D ; Macintyre, D Euan ; Van Der Ploeg, Lex H T ; Patchett, Arthur A ; Nargund, Ravi P

Journal of medicinal chemistry, 10 October 2002, Vol.45(21), pp.4589-93 [Peer Reviewed Journal]

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34
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Tetrahydrofluorenones with conformationally restricted side chains as selective estrogen receptor beta ligands

Wildonger, Kenneth J ; Ratcliffe, Ronald W ; Mosley, Ralph T ; Hammond, Milton L ; Birzin, Elizabeth T ; Rohrer, Susan P

Bioorganic & Medicinal Chemistry Letters, 2006, Vol.16(17), pp.4462-4466 [Peer Reviewed Journal]

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35
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Comparison of 2-phenylspiroindenes and 2-phenylspiroindenediones as estrogen receptor ligands—modeling and binding data don't agree

Blizzard, Timothy A ; Mosley, Ralph T ; Birzin, Elizabeth T ; Chan, Wanda ; Hammond, Milton L

Bioorganic & Medicinal Chemistry Letters, 08 March 2004, Vol.14(5), pp.1317-1321 [Peer Reviewed Journal]

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36
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Amino acid substitution of arginine 80 in 17β-hydroxysteroid dehydrogenase type 3 and its effect on NADPH cofactor binding and oxidation/reduction kinetics

Mckeever, Brian M ; Hawkins, Barton K ; Geissler, Wayne M ; Wu, Ling ; Sheridan, Robert P ; Mosley, Ralph T ; Andersson, Stefan

BBA - Proteins and Proteomics, 2002, Vol.1601(1), pp.29-37 [Peer Reviewed Journal]

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