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11 Results  for Everything (Includes Articles)

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Design, synthesis, and biological activity of potent and orally available G protein-coupled receptor 40 agonists

Sasaki, Shinobu ; Kitamura, Shuji ; Negoro, Nobuyuki ; Suzuki, Masami ; Tsujihata, Yoshiyuki ; Suzuki, Nobuhiro ; Santou, Takashi ; Kanzaki, Naoyuki ; Harada, Masataka ; Tanaka, Yasuhiro ; Kobayashi, Makoto ; Tada, Norio ; Funami, Miyuki ; Tanaka, Toshimasa ; Yamamoto, Yoshio ; Fukatsu, Kohji ; Yasuma, Tsuneo ; Momose, Yu

Journal of medicinal chemistry, 10 March 2011, Vol.54(5), pp.1365-78 [Peer Reviewed Journal]

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Optimization of (2,3-dihydro-1-benzofuran-3-yl)acetic acids: discovery of a non-free fatty acid-like, highly bioavailable G protein-coupled receptor 40/free fatty acid receptor 1 agonist as a glucose-dependent insulinotropic agent

Negoro, Nobuyuki ; Sasaki, Shinobu ; Mikami, Satoshi ; Ito, Masahiro ; Tsujihata, Yoshiyuki ; Ito, Ryo ; Suzuki, Masami ; Takeuchi, Koji ; Suzuki, Nobuhiro ; Miyazaki, Junichi ; Santou, Takashi ; Odani, Tomoyuki ; Kanzaki, Naoyuki ; Funami, Miyuki ; Morohashi, Akio ; Nonaka, Masami ; Matsunaga, Shinichiro ; Yasuma, Tsuneo ; Momose, Yu

Journal of medicinal chemistry, 26 April 2012, Vol.55(8), pp.3960-74 [Peer Reviewed Journal]

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Discovery of phenylpropanoic acid derivatives containing polar functionalities as potent and orally bioavailable G protein-coupled receptor 40 agonists for the treatment of type 2 diabetes

Mikami, Satoshi ; Kitamura, Shuji ; Negoro, Nobuyuki ; Sasaki, Shinobu ; Suzuki, Masami ; Tsujihata, Yoshiyuki ; Miyazaki, Takeshi ; Ito, Ryo ; Suzuki, Nobuhiro ; Miyazaki, Junichi ; Santou, Takashi ; Kanzaki, Naoyuki ; Funami, Miyuki ; Tanaka, Toshimasa ; Yasuma, Tsuneo ; Momose, Yu

Journal of medicinal chemistry, 26 April 2012, Vol.55(8), pp.3756-76 [Peer Reviewed Journal]

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Identification of fused-ring alkanoic acids with improved pharmacokinetic profiles that act as G protein-coupled receptor 40/free fatty acid receptor 1 agonists

Negoro, Nobuyuki ; Sasaki, Shinobu ; Ito, Masahiro ; Kitamura, Shuji ; Tsujihata, Yoshiyuki ; Ito, Ryo ; Suzuki, Masami ; Takeuchi, Koji ; Suzuki, Nobuhiro ; Miyazaki, Junichi ; Santou, Takashi ; Odani, Tomoyuki ; Kanzaki, Naoyuki ; Funami, Miyuki ; Tanaka, Toshimasa ; Yasuma, Tsuneo ; Momose, Yu

Journal of medicinal chemistry, 23 February 2012, Vol.55(4), pp.1538-52 [Peer Reviewed Journal]

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A new class of non-thiazolidinedione, non-carboxylic-acid-based highly selective peroxisome proliferator-activated receptor (PPAR) γ agonists: Design and synthesis of benzylpyrazole acylsulfonamides

Rikimaru, Kentaro ; Wakabayashi, Takeshi ; Abe, Hidenori ; Imoto, Hiroshi ; Maekawa, Tsuyoshi ; Ujikawa, Osamu ; Murase, Katsuhito ; Matsuo, Takanori ; Matsumoto, Mitsuharu ; Nomura, Chisako ; Tsuge, Hiroko ; Arimura, Naoto ; Kawakami, Kazutoshi ; Sakamoto, Junichi ; Funami, Miyuki ; Mol, Clifford D ; Snell, Gyorgy P ; Bragstad, Kenneth A ; Sang, Bi-Ching ; Dougan, Douglas R

Bioorganic & Medicinal Chemistry, 15 January 2012, Vol.20(2), pp.714-733 [Peer Reviewed Journal]

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Structure–activity relationships and key structural feature of pyridyloxybenzene-acylsulfonamides as new, potent, and selective peroxisome proliferator-activated receptor (PPAR) γ Agonists

Rikimaru, Kentaro ; Wakabayashi, Takeshi ; Abe, Hidenori ; Tawaraishi, Taisuke ; Imoto, Hiroshi ; Yonemori, Jinichi ; Hirose, Hideki ; Murase, Katsuhito ; Matsuo, Takanori ; Matsumoto, Mitsuharu ; Nomura, Chisako ; Tsuge, Hiroko ; Arimura, Naoto ; Kawakami, Kazutoshi ; Sakamoto, Junichi ; Funami, Miyuki ; Mol, Clifford D ; Snell, Gyorgy P ; Bragstad, Kenneth A ; Sang, Bi-Ching

Bioorganic & Medicinal Chemistry, 15 May 2012, Vol.20(10), pp.3332-3358 [Peer Reviewed Journal]

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TAK-875, an orally available G protein-coupled receptor 40/free fatty acid receptor 1 agonist, enhances glucose-dependent insulin secretion and improves both postprandial and fasting hyperglycemia in type 2 diabetic rats

Tsujihata, Yoshiyuki ; Ito, Ryo ; Suzuki, Masami ; Harada, Ayako ; Negoro, Nobuyuki ; Yasuma, Tsuneo ; Momose, Yu ; Takeuchi, Koji

The Journal of pharmacology and experimental therapeutics, October 2011, Vol.339(1), pp.228-37 [Peer Reviewed Journal]

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Novel 5-substituted 2,4-thiazolidinedione and 2,4-oxazolidinedione derivatives as insulin sensitizers with antidiabetic activities

Momose, Yu ; Maekawa, Tsuyoshi ; Yamano, Tohru ; Kawada, Mitsuru ; Odaka, Hiroyuki ; Ikeda, Hitoshi ; Sohda, Takashi

Journal of medicinal chemistry, 28 March 2002, Vol.45(7), pp.1518-34 [Peer Reviewed Journal]

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A novel oxyiminoalkanoic acid derivative, TAK-559, activates human peroxisome proliferator-activated receptor subtypes

Sakamoto, Junichi ; Kimura, Hiroyuki ; Moriyama, Shinji ; Imoto, Hiroshi ; Momose, Yu ; Odaka, Hiroyuki ; Sawada, Hidekazu

European Journal of Pharmacology, 2004, Vol.495(1), pp.17-26 [Peer Reviewed Journal]

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Discovery of TAK-875: A Potent, Selective, and Orally Bioavailable GPR40 Agonist

Negoro, Nobuyuki ; Sasaki, Shinobu ; Mikami, Satoshi ; Ito, Masahiro ; Suzuki, Masami ; Tsujihata, Yoshiyuki ; Ito, Ryo ; Harada, Ayako ; Takeuchi, Koji ; Suzuki, Nobuhiro ; Miyazaki, Junichi ; Santou, Takashi ; Odani, Tomoyuki ; Kanzaki, Naoyuki ; Funami, Miyuki ; Tanaka, Toshimasa ; Kogame, Akifumi ; Matsunaga, Shinichiro ; Yasuma, Tsuneo ; Momose

ACS medicinal chemistry letters, 09 September 2010, Vol.1(6), pp.290-4 [Peer Reviewed Journal]

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Activation of Human Peroxisome Proliferator-Activated Receptor (PPAR) Subtypes by Pioglitazone

Sakamoto, Junichi ; Kimura, Hiroyuki ; Moriyama, Shinji ; Odaka, Hiroyuki ; Momose, Yu ; Sugiyama, Yasuo ; Sawada, Hidekazu

Biochemical and Biophysical Research Communications, 30 November 2000, Vol.278(3), pp.704-711 [Peer Reviewed Journal]

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