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9 Results  for Everything (Includes Articles)

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Synthesis and biological evaluation of 3,3-difluoropyridine-2,4(1H,3H)-dione and 3-deaza-3-fluorouracil base and nucleoside derivatives

Robins, Morris J ; Yang, Hong ; Miranda, Karl ; Peterson, Matt A ; De Clercq, Erik ; Balzarini, Jan

Journal of medicinal chemistry, 14 May 2009, Vol.52(9), pp.3018-27 [Peer Reviewed Journal]

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A novel kinase inhibitor establishes a predominant role for protein kinase D as a cardiac class IIa histone deacetylase kinase

Monovich, Lauren ; Vega, Richard B ; Meredith, Erik ; Miranda, Karl ; Rao, Chang ; Capparelli, Michael ; Lemon, Douglas D ; Phan, Dillon ; Koch, Keith A ; Chapo, Joseph A ; Hood, David B ; Mckinsey, Timothy A

FEBS Letters, 05 February 2010, Vol.584(3), pp.631-637 [Peer Reviewed Journal]

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The Discovery of N-(1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-5-((6- ((methylamino)methyl)pyrimidin-4-yl)oxy)-1H-indole-1-carboxamide (Acrizanib), a VEGFR-2 Inhibitor Specifically Designed for Topical Ocular Delivery, as a Therapy for Neovascular Age-Related Macular Degeneration

Adams, Christopher M ; Anderson, Karen ; Artman, Gerald ; Bizec, Jean-Claude ; Cepeda, Rosemarie ; Elliott, Jason ; Fassbender, Elizabeth ; Ghosh, Malay ; Hanks, Shawn ; Hardegger, Leo A ; Hosagrahara, Vinayak P ; Jaffee, Bruce ; Jendza, Keith ; Ji, Nan ; Johnson, Leland ; Lee, Wendy ; Liu, Donglei ; Liu, Fang ; Long, Debby ; Ma, Fupeng ; Mainolfi, Nello ; Meredith, Erik L ; Miranda, Karl ; Peng, Yao ; Poor, Stephen ; Powers, James ; Qiu, Yubin ; Rao, Chang ; Shen, Siyuan ; Sivak, Jeremy M ; Solovay, Catherine ; Tarsa, Peter ; Woolfenden, Amber ; Zhang, Chun ; Zhang, Yiqin

Journal of medicinal chemistry, 22 February 2018, Vol.61(4), pp.1622-1635 [Peer Reviewed Journal]

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Discovery of Oral VEGFR-2 Inhibitors with Prolonged Ocular Retention That Are Efficacious in Models of Wet Age-Related Macular Degeneration

Meredith, Erik L ; Mainolfi, Nello ; Poor, Stephen ; Qiu, Yubin ; Miranda, Karl ; Powers, James ; Liu, Donglei ; Ma, Fupeng ; Solovay, Catherine ; Rao, Chang ; Johnson, Leland ; Ji, Nan ; Artman, Gerald ; Hardegger, Leo ; Hanks, Shawn ; Shen, Siyuan ; Woolfenden, Amber ; Fassbender, Elizabeth ; Sivak, Jeremy M ; Zhang, Yiqin ; Long, Debby ; Cepeda, Rosemarie ; Liu, Fang ; Hosagrahara, Vinayak P ; Lee, Wendy ; Tarsa, Peter ; Anderson, Karen ; Elliott, Jason ; Jaffee, Bruce

Journal of medicinal chemistry, 10 December 2015, Vol.58(23), pp.9273-86 [Peer Reviewed Journal]

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Identification of potent and selective amidobipyridyl inhibitors of protein kinase D

Meredith, Erik L ; Beattie, Kimberly ; Burgis, Robin ; Capparelli, Michael ; Chapo, Joseph ; Dipietro, Lucian ; Gamber, Gabriel ; Enyedy, Istvan ; Hood, David B ; Hosagrahara, Vinayak ; Jewell, Charles ; Koch, Keith A ; Lee, Wendy ; Lemon, Douglas D ; Mckinsey, Timothy A ; Miranda, Karl ; Pagratis, Nikos ; Phan, Dillon ; Plato, Craig ; Rao, Chang ; Rozhitskaya, Olga ; Soldermann, Nicolas ; Springer, Clayton ; Van Eis, Maurice ; Vega, Richard B ; Yan, Wanlin ; Zhu, Qingming ; Monovich, Lauren G

Journal of medicinal chemistry, 12 August 2010, Vol.53(15), pp.5422-38 [Peer Reviewed Journal]

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Identification of orally available naphthyridine protein kinase D inhibitors

Meredith, Erik L ; Ardayfio, Ophelia ; Beattie, Kimberly ; Dobler, Markus R ; Enyedy, Istvan ; Gaul, Christoph ; Hosagrahara, Vinayak ; Jewell, Charles ; Koch, Keith ; Lee, Wendy ; Lehmann, Hansjoerg ; Mckinsey, Timothy A ; Miranda, Karl ; Pagratis, Nikos ; Pancost, Margaret ; Patnaik, Anup ; Phan, Dillon ; Plato, Craig ; Qian, Ming ; Rajaraman, Vasumathy ; Rao, Chang ; Rozhitskaya, Olga ; Ruppen, Thomas ; Shi, Jie ; Siska, Sarah J ; Springer, Clayton ; Van Eis, Maurice ; Vega, Richard B ; Von Matt, Anette ; Yang, Lihua ; Yoon, Taeyoung ; Zhang, Ji-Hu ; Zhu, Na ; Monovich, Lauren G

Journal of medicinal chemistry, 12 August 2010, Vol.53(15), pp.5400-21 [Peer Reviewed Journal]

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Synthesis and antiviral evaluation of 6-(alkyl-heteroaryl)furo2,3-dpyrimidin-2(3H)-one nucleosides and analogues with ethynyl, ethenyl, and ethyl spacers at C6 of the furopyrimidine core

Robins, Morris J ; Nowak, Ireneusz ; Rajwanshi, Vivek K ; Miranda, Karl ; Cannon, John F ; Peterson, Matt A ; Andrei, Graciela ; Snoeck, Robert ; De Clercq, Erik ; Balzarini, Jan

Journal of medicinal chemistry, 09 August 2007, Vol.50(16), pp.3897-905 [Peer Reviewed Journal]

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Synthesis and biological evaluation of 6-(alkyn-1-yl)furo2,3-dpyrimidin-2(3H)-one base and nucleoside derivatives

Robins, Morris J ; Miranda, Karl ; Rajwanshi, Vivek K ; Peterson, Matt A ; Andrei, Graciela ; Snoeck, Robert ; De Clercq, Erik ; Balzarini, Jan

Journal of medicinal chemistry, 12 January 2006, Vol.49(1), pp.391-8 [Peer Reviewed Journal]

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Discovery and in Vivo Evaluation of Potent Dual CYP11B2 (Aldosterone Synthase) and CYP11B1 Inhibitors

Meredith, Erik L ; Ksander, Gary ; Monovich, Lauren G ; Papillon, Julien P N ; Liu, Qian ; Miranda, Karl ; Morris, Patrick ; Rao, Chang ; Burgis, Robin ; Capparelli, Michael ; Hu, Qi-Ying ; Singh, Alok ; Rigel, Dean F ; Jeng, Arco Y ; Beil, Michael ; Fu, Fumin ; Hu, Chii-Whei ; Lasala, Daniel

ACS medicinal chemistry letters, 12 December 2013, Vol.4(12), pp.1203-7 [Peer Reviewed Journal]

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