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In vitro evaluation of the inhibitory potential of pharmaceutical excipients on human carboxylesterase 1A and 2

Zhang, Chengliang ; Xu, Yanjiao ; Zhong, Qiaoni ; Li, Xiping ; Gao, Ping ; Feng, Chengyang ; Chu, Qian ; Chen, Yuan ; Liu, Dong

PloS one, 2014, Vol.9(4), pp.e93819 [Peer Reviewed Journal]

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Inhibition of baicalin on metabolism of phenacetin, a probe of CYP1A2, in human liver microsomes and in rats

Gao, Na ; Qi, Bing ; Liu, Fang-Jun ; Fang, Yan ; Zhou, Jun ; Jia, Lin-Jing ; Qiao, Hai-Ling

PloS one, 2014, Vol.9(2), pp.e89752 [Peer Reviewed Journal]

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Triclocarban mediates induction of xenobiotic metabolism through activation of the constitutive androstane receptor and the estrogen receptor alpha

Yueh, Mei-Fei ; Li, Tao ; Evans, Ronald M ; Hammock, Bruce ; Tukey, Robert H

PloS one, 2012, Vol.7(6), pp.e37705 [Peer Reviewed Journal]

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Use of In Vitro and Predictive In Silico Models to Study the Inhibition of Cytochrome P4503A by Stilbenes

Basheer, Loai ; Schultz, Keren ; Fichman, Merav ; Kerem, Zohar

PloS one, 2015, Vol.10(10), pp.e0141061 [Peer Reviewed Journal]

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Inhibition of genistein glucuronidation by bisphenol A in human and rat liver microsomes

Coughlin, Janis L ; Thomas, Paul E ; Buckley, Brian

Drug metabolism and disposition: the biological fate of chemicals, March 2012, Vol.40(3), pp.481-5 [Peer Reviewed Journal]

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Direct oxidation and covalent binding of isoniazid to rodent liver and human hepatic microsomes: humans are more like mice than rats

Metushi, Imir G ; Nakagawa, Tetsuya ; Uetrecht, Jack

Chemical research in toxicology, 19 November 2012, Vol.25(11), pp.2567-76 [Peer Reviewed Journal]

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Effects and mechanisms of rifampin on hepatotoxicity of acetaminophen in mice

He, Min ; Zhang, Shijun ; Jiao, Yang ; Lin, Xing ; Huang, Jianchun ; Chen, Chunxia ; Chen, Zhaoni ; Huang, Renbin

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, September 2012, Vol.50(9), pp.3142-9 [Peer Reviewed Journal]

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Electrophilicities and Protein Covalent Binding of Demethylation Metabolites of Colchicine

Guo, Xiucai ; Lin, Dongju ; Li, Weiwei ; Wang, Kai ; Peng, Ying ; Zheng, Jiang

Chemical research in toxicology, 21 March 2016, Vol.29(3), pp.296-302 [Peer Reviewed Journal]

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Identification of a new reactive metabolite of pyrrolizidine alkaloid retrorsine: (3H-pyrrolizin-7-yl)methanol

Fashe, Muluneh M ; Juvonen, Risto O ; Petsalo, Aleksanteri ; Rahnasto-Rilla, Minna ; Auriola, Seppo ; Soininen, Pasi ; Vepsäläinen, Jouko ; Pasanen, Markku

Chemical research in toxicology, 17 November 2014, Vol.27(11), pp.1950-7 [Peer Reviewed Journal]

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Antioxidant capacity of flavonoids in hepatic microsomes is not reflected by antioxidant effects in vivo

Duthie, Garry ; Morrice, Philip

Oxidative medicine and cellular longevity, 2012, Vol.2012, pp.165127 [Peer Reviewed Journal]

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11
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Kinetics of trihalogenated acetic acid metabolism and isoform specificity in liver microsomes

Saghir, Shakil A ; Ghanayem, Burhan I ; Schultz, Irvin R

International journal of toxicology, October 2011, Vol.30(5), pp.551-61 [Peer Reviewed Journal]

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Discovery and SAR of 2-arylbenzotriazoles and 2-arylindazoles as potential treatments for Duchenne muscular dystrophy

De Moor, Olivier ; Dorgan, Colin R ; Johnson, Peter D ; Lambert, Adam G ; Lecci, Cristina ; Maillol, Carole ; Nugent, Gary ; Poignant, Séverine D ; Price, Paul D ; Pye, Richard J ; Storer, Richard ; Tinsley, Jonathon M ; Vickers, Richard ; Well, Renate Van ; Wilkes, Fraser J ; Wilson, Francis X ; Wren, Stephen P ; Wynne, Graham M

Bioorganic & medicinal chemistry letters, 15 August 2011, Vol.21(16), pp.4828-31 [Peer Reviewed Journal]

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Metabolism of methyleugenol in liver microsomes and primary hepatocytes: pattern of metabolites, cytotoxicity, and DNA-adduct formation

Cartus, Alexander T ; Herrmann, Kristin ; Weishaupt, Lucas W ; Merz, Karl-Heinz ; Engst, Wolfram ; Glatt, Hansruedi ; Schrenk, Dieter

Toxicological sciences : an official journal of the Society of Toxicology, September 2012, Vol.129(1), pp.21-34 [Peer Reviewed Journal]

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Assessment of a novel β2-adrenoceptor agonist, trantinterol, for interference with human liver cytochrome P450 enzymes activities

Jiang, Kun ; Li, Kunjie ; Qin, Feng ; Lu, Xiumei ; Li, Famei

Toxicology in vitro : an international journal published in association with BIBRA, August 2011, Vol.25(5), pp.1033-8 [Peer Reviewed Journal]

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Oxidative DNA damage following microsome/Cu(II)-mediated activation of the estrogens, 17β-estradiol, equilenin, and equilin: role of reactive oxygen species

Spencer, Wendy A ; Vadhanam, Manicka V ; Jeyabalan, Jeyaprakash ; Gupta, Ramesh C

Chemical research in toxicology, 20 February 2012, Vol.25(2), pp.305-14 [Peer Reviewed Journal]

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Evaluation of the inhibition potential of plumbagin against cytochrome P450 using LC-MS/MS and cocktail approach

Chen, Ang ; Zhou, Xiaojing ; Tang, Shuowen ; Liu, Mingyao ; Wang, Xin

Scientific reports, 22 June 2016, Vol.6, pp.28482 [Peer Reviewed Journal]

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17
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Effect of endogenous steroid hormones on 17-alpha-hydroxyprogesterone caproate metabolism

Cuppett, Courtney D ; Zhao, Yang ; Caritis, Steve ; Zhang, Shimin ; Zhao, Wenchen ; Venkataramanan, Raman

American journal of obstetrics and gynecology, January 2013, Vol.208(1), pp.86.e1-6 [Peer Reviewed Journal]

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18
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Selective inhibition of cytochrome P450 2D6 by Sarpogrelate and its active metabolite, M-1, in human liver microsomes

Cho, Doo-Yeoun ; Bae, Soo Hyeon ; Lee, Joeng Kee ; Kim, Yang Weon ; Kim, Bom-Taeck ; Bae, Soo Kyung

Drug metabolism and disposition: the biological fate of chemicals, January 2014, Vol.42(1), pp.33-9 [Peer Reviewed Journal]

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19
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Metabolism of the hepatotoxic compound sophoraflavanone G in rat liver microsomes

Chen, Ping ; Zhang, Xiuwen ; Huang, Taomin ; Yu, Qianqian ; Cheng, Nengneng

Journal of food science, July 2014, Vol.79(7), pp.T1462-8 [Peer Reviewed Journal]

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20
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Suggesting a testing strategy for possible endocrine effects of drug metabolites

Jacobsen, N W ; Brooks, B W ; Halling-Sørensen, B

Regulatory toxicology and pharmacology : RTP, April 2012, Vol.62(3), pp.441-8 [Peer Reviewed Journal]

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21
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In vitro assessment of cytochrome P450 inhibition and induction potential of felotaxel (SHR110008)

Ding, Yi ; Jia, Yanyan ; Lu, Chengtao ; Liu, Wenxing ; Yang, Jing ; Song, Ying ; Zhu, Yanrong ; Yang, Lin ; Ding, Likun ; Wen, Aidong

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, June 2012, Vol.66(4), pp.318-21 [Peer Reviewed Journal]

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22
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Mechanism-based inhibition of cytochrome P450 (CYP)2A6 by chalepensin in recombinant systems, in human liver microsomes and in mice in vivo

Ueng, Yune-Fang ; Chen, Chien-Chih ; Chung, Yu-Ting ; Liu, Tsung-Yun ; Chang, Yu-Ping ; Lo, Wei-Sheng ; Murayama, Norie ; Yamazaki, Hiroshi ; Souček, Pavel ; Chau, Gar-Yang ; Chi, Chin-Wen ; Chen, Ruei-Ming ; Li, Ding-Tzai

British journal of pharmacology, July 2011, Vol.163(6), pp.1250-62 [Peer Reviewed Journal]

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23
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In vitro inhibition of cytochrome P450-mediated reactions by gemfibrozil, erythromycin, ciprofloxacin and fluoxetine in fish liver microsomes

Smith, Emily M ; Iftikar, Fathima I ; Higgins, Sarah ; Irshad, Anam ; Jandoc, Racquel ; Lee, Matthew ; Wilson, Joanna Y

Aquatic toxicology (Amsterdam, Netherlands), March 2012, Vol.109, pp.259-66 [Peer Reviewed Journal]

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24
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Metabolism evaluation of the anticancer candidate AC04 by biomimetic oxidative model and rat liver microsomes

Pigatto, Maiara Cássia ; Alves De Lima, Maria Do Carmo ; Galdino, Suely Lins ; Pitta, Ivan Da Rocha ; Vessecchi, Ricardo ; Assis, Marilda Das Dores ; Dos Santos, Joicy Santamalvina ; Dalla Costa, Teresa ; Lopes, Norberto Peporine

European journal of medicinal chemistry, September 2011, Vol.46(9), pp.4245-51 [Peer Reviewed Journal]

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25
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In vitro inhibitory effects of Wen-pi-tang-Hab-Wu-ling-san on human cytochrome P450 isoforms

Lee, H W ; Kim, D W ; Phapale, P B ; Lim, M-S ; Park, J ; Seo, J J ; Park, K M ; Park, Y-K ; Yoon, Y-R

Journal of clinical pharmacy and therapeutics, August 2011, Vol.36(4), pp.496-503 [Peer Reviewed Journal]

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26
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Effects of ketamine on human UDP-glucuronosyltransferases in vitro predict potential drug-drug interactions arising from ketamine inhibition of codeine and morphine glucuronidation

Uchaipichat, Verawan ; Raungrut, Pritsana ; Chau, Nuy ; Janchawee, Benjamas ; Evans, Allan M ; Miners, John O

Drug metabolism and disposition: the biological fate of chemicals, August 2011, Vol.39(8), pp.1324-8 [Peer Reviewed Journal]

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27
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Discovery and pharmacological profile of new 1H-indazole-3-carboxamide and 2H-pyrrolo3,4-cquinoline derivatives as selective serotonin 4 receptor ligands

Furlotti, Guido ; Alisi, Maria Alessandra ; Apicella, Claudia ; Capezzone De Joannon, Alessandra ; Cazzolla, Nicola ; Costi, Roberta ; Cuzzucoli Crucitti, Giuliana ; Garrone, Beatrice ; Iacovo, Alberto ; Magarò, Gabriele ; Mangano, Giorgina ; Miele, Gaetano ; Ombrato, Rosella ; Pescatori, Luca ; Polenzani, Lorenzo ; Rosi, Federica ; Vitiello, Marco ; Di Santo, Roberto

Journal of medicinal chemistry, 26 November 2012, Vol.55(22), pp.9446-66 [Peer Reviewed Journal]

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28
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Dose of Phenobarbital and Age of Treatment at Early Life are Two Key Factors for the Persistent Induction of Cytochrome P450 Enzymes in Adult Mouse Liver

Tien, Yun-Chen ; Liu, Ke ; Pope, Chad ; Wang, Pengcheng ; Ma, Xiaochao ; Zhong, Xiao-Bo

Drug metabolism and disposition: the biological fate of chemicals, December 2015, Vol.43(12), pp.1938-45 [Peer Reviewed Journal]

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29
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Diethylstilbestrol can effectively accelerate estradiol-17-O-glucuronidation, while potently inhibiting estradiol-3-O-glucuronidation

Zhu, Liangliang ; Xiao, Ling ; Xia, Yangliu ; Zhou, Kun ; Wang, Huili ; Huang, Minyi ; Ge, Guangbo ; Wu, Yan ; Wu, Ganlin ; Yang, Ling

Toxicology and applied pharmacology, 01 March 2015, Vol.283(2), pp.109-16 [Peer Reviewed Journal]

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30
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Mutagenic assessment of Prestige fuel oil spilled on the shore and submitted to field trials of bioremediation

Sueiro, Rosa Ana ; Garrido, Manuel Joaquín ; Araujo, Manuel

The Science of the total environment, 01 November 2011, Vol.409(23), pp.4973-8 [Peer Reviewed Journal]

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31
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Discovery and lead optimization of a novel series of CC chemokine receptor 1 (CCR1)-selective piperidine antagonists via parallel synthesis

Cavallaro, Cullen L ; Briceno, Stephanie ; Chen, Jing ; Cvijic, Mary Ellen ; Davies, Paul ; Hynes, John ; Liu, Rui-Qin ; Mandlekar, Sandhya ; Rose, Anne V ; Tebben, Andrew J ; Van Kirk, Katy ; Watson, Andrew ; Wu, Hong ; Yang, Guchen ; Carter, Percy H

Journal of medicinal chemistry, 26 November 2012, Vol.55(22), pp.9643-53 [Peer Reviewed Journal]

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32
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Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinyl carbamates as potent and long acting muscarinic antagonists

Prat, Maria ; Buil, María Antonia ; Fernández, Maria Dolors ; Castro, Jordi ; Monleón, Juan Manuel ; Tort, Laia ; Casals, Gaspar ; Ferrer, Manuel ; Huerta, Josep Maria ; Espinosa, Sònia ; López, Manuel ; Segarra, Victor ; Gavaldà, Amadeu ; Miralpeix

Bioorganic & medicinal chemistry letters, 01 June 2011, Vol.21(11), pp.3457-61 [Peer Reviewed Journal]

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33
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Intrinsic electrophilicity of a 4-substituted-5-cyano-6-(2-methylpyridin-3-yloxy)pyrimidine derivative: structural characterization of glutathione conjugates in vitro

Kalgutkar, Amit S ; Mascitti, Vincent ; Sharma, Raman ; Walker, Gregory W ; Ryder, Tim ; Mcdonald, Thomas S ; Chen, Yue ; Preville, Cathy ; Basak, Arindrajit ; Mcclure, Kim F ; Kohrt, Jeffrey T ; Robinson, Ralph P ; Munchhof, Michael J ; Cornelius, Peter

Chemical research in toxicology, 18 February 2011, Vol.24(2), pp.269-78 [Peer Reviewed Journal]

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34
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Genotoxic and enzymatic effects of fluoranthene in microsomes and freshly isolated hepatocytes from sole (Solea solea)

Wessel, N ; Ménard, D ; Pichavant-Rafini, K ; Ollivier, H ; Le Goff, J ; Burgeot, T ; Akcha, F

Aquatic toxicology (Amsterdam, Netherlands), February 2012, Vol.108, pp.33-41 [Peer Reviewed Journal]

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35
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The effect of (-)-linalool on the metabolic activity of liver CYP enzymes in rats

Nosková, K ; Dovrtělová, G ; Zendulka, O ; Řemínek, R ; Juřica, J

Physiological research, 21 December 2016, Vol.65(Supplementum 4), pp.S499-S504 [Peer Reviewed Journal]

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36
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Selective inhibitory effects of mollugin on CYP1A2 in human liver microsomes

Kim, Heeyeon ; Choi, Hyun Kyu ; Jeong, Tae Cheon ; Jahng, Yurngdong ; Kim, Dong Hyun ; Lee, Seung-Ho ; Lee, Sangkyu

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, January 2013, Vol.51, pp.33-7 [Peer Reviewed Journal]

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37
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Effect of repeated dosing on rifampin exposure in BALB/c mice

Hosagrahara, Vinayak ; Reddy, Jitendar ; Ganguly, Samit ; Panduga, Vijender ; Ahuja, Vijaykamal ; Parab, Manish ; Giridhar, Jayashree

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 11 April 2013, Vol.49(1), pp.33-8 [Peer Reviewed Journal]

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