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29 Results  for Everything (Includes Articles)

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1
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Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists

Mandala, Suzanne ; Hajdu, Richard ; Bergstrom, James ; Quackenbush, Elizabeth ; Xie, Jenny ; Milligan, James ; Thornton, Rosemary ; Shei, Gan-Ju ; Card, Deborah ; Keohane, Carolann ; Rosenbach, Mark ; Hale, Jeffrey ; Lynch, Christopher L ; Rupprecht, Kathleen ; Parsons, William ; Rosen, Hugh

Science (New York, N.Y.), 12 April 2002, Vol.296(5566), pp.346-9 [Peer Reviewed Journal]

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Sphingoid base 1-phosphate phosphatase: A key regulator of sphingolipid metabolism and stress response

Mandala, Suzanne ; Thornton, Rosemary ; Tu, Zhenxing ; Kurtz, Myra

Proceedings of the National Academy of Sciences of the United States of America, Jan 6, 1998, Vol.95(1), pp.150-155 [Peer Reviewed Journal]

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Molecular cloning and characterization of a lipid phosphohydrolase that degrades sphingosine-1- phosphate and induces cell death

Mandala, Suzanne ; Thornton, Rosemary ; Galve-Roperh, Ismael ; Poulton, Samantha

Proceedings of the National Academy of Sciences of the United States of America, Jul 5, 2000, Vol.97(14), pp.7859-7864 [Peer Reviewed Journal]

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4
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Expression of the sphingosine 1-phosphate receptor, S1P1, on T-cells controls thymic emigration

Allende, Maria L ; Dreier, Jennifer L ; Mandala, Suzanne ; Proia, Richard L

The Journal of biological chemistry, 09 April 2004, Vol.279(15), pp.15396-401 [Peer Reviewed Journal]

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5
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1,3,8-Triazaspiro4.5decane-2,4-diones as efficacious pan-inhibitors of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) for the treatment of anemia

Vachal, Petr ; Miao, Shouwu ; Pierce, Joan M ; Guiadeen, Deodial ; Colandrea, Vincent J ; Wyvratt, Matthew J ; Salowe, Scott P ; Sonatore, Lisa M ; Milligan, James A ; Hajdu, Richard ; Gollapudi, Anantha ; Keohane, Carol A ; Lingham, Russell B ; Mandala, Suzanne M ; Demartino, Julie A ; Tong, Xinchun ; Wolff, Michael ; Steinhuebel, Dietrich ; Kieczykowski, Gerard R ; Fleitz, Fred J ; Chapman, Kevin ; Athanasopoulos, John ; Adam, Gregory ; Akyuz, Can D ; Jena, Dhirendra K ; Lusen, Jeffrey W ; Meng, Juncai ; Stein, Benjamin D ; Xia, Lei ; Sherer, Edward C ; Hale, Jeffrey J

Journal of medicinal chemistry, 12 April 2012, Vol.55(7), pp.2945-59 [Peer Reviewed Journal]

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Skoura, Athanasia ; Sanchez, Teresa ; Claffey, Kevin ; Mandala, Suzanne

Journal of Clinical Investigation, Sep 2007, Vol.117(9), pp.2506-2516 [Peer Reviewed Journal]

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Characterization of murine sphingosine-1-phosphate phosphohydrolase

Le Stunff, Hervé ; Peterson, Courtney ; Thornton, Rosemary ; Milstien, Sheldon ; Mandala, Suzanne M ; Spiegel, Sarah

The Journal of biological chemistry, 15 March 2002, Vol.277(11), pp.8920-7 [Peer Reviewed Journal]

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8
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Sphingosine-1-Phosphate Phosphatases

Mandala, Suzanne M

Prostaglandins and Other Lipid Mediators, 2001, Vol.64(1), pp.143-156 [Peer Reviewed Journal]

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9
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Essential role of sphingosine 1-phosphate receptor 2 in pathological angiogenesis of the mouse retina

Skoura, Athanasia ; Sanchez, Teresa ; Claffey, Kevin ; Mandala, Suzanne M ; Proia, Richard L ; Hla, Timothy

The Journal of clinical investigation, September 2007, Vol.117(9), pp.2506-16 [Peer Reviewed Journal]

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10
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Sphingosine-1-phosphate agonists increase macrophage homing, lymphocyte contacts, and endothelial junctional complex formation in murine lymph nodes

Singer, Irwin I ; Tian, Min ; Wickham, L Alexandra ; Lin, Jeffrey ; Matheravidathu, Scaria S ; Forrest, Michael J ; Mandala, Suzanne ; Quackenbush, Elizabeth J

Journal of immunology (Baltimore, Md. : 1950), 01 December 2005, Vol.175(11), pp.7151-61 [Peer Reviewed Journal]

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11
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The S1P-analog FTY720 differentially modulates T-cell homing via HEV: T-cell-expressed S1P1 amplifies integrin activation in peripheral lymph nodes but not in Peyer patches

Halin, Cornelia ; Scimone, M Lucila ; Bonasio, Roberto ; Gauguet, Jean-Marc ; Mempel, Thorsten R ; Quackenbush, Elizabeth ; Proia, Richard L ; Mandala, Suzanne ; Von Andrian, Ulrich H

Blood, 15 August 2005, Vol.106(4), pp.1314-22 [Peer Reviewed Journal]

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12
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Mice deficient in sphingosine kinase 1 are rendered lymphopenic by FTY720

Allende, Maria L ; Sasaki, Teiji ; Kawai, Hiromichi ; Olivera, Ana ; Mi, Yide ; Van Echten-Deckert, Gerhild ; Hajdu, Richard ; Rosenbach, Mark ; Keohane, Carol Ann ; Mandala, Suzanne ; Spiegel, Sarah ; Proia, Richard L

The Journal of biological chemistry, 10 December 2004, Vol.279(50), pp.52487-92 [Peer Reviewed Journal]

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13
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A rational utilization of high-throughput screening affords selective, orally bioavailable 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 receptor agonists

Hale, Jeffrey J ; Lynch, Christopher L ; Neway, William ; Mills, Sander G ; Hajdu, Richard ; Keohane, Carol Ann ; Rosenbach, Mark J ; Milligan, James A ; Shei, Gan-Ju ; Parent, Stephen A ; Chrebet, Gary ; Bergstrom, James ; Card, Deborah ; Ferrer, Marc ; Hodder, Peter ; Strulovici, Berta ; Rosen, Hugh ; Mandala, Suzanne

Journal of medicinal chemistry, 30 December 2004, Vol.47(27), pp.6662-5 [Peer Reviewed Journal]

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14
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Synthesis, stereochemical determination and biochemical characterization of the enantiomeric phosphate esters of the novel immunosuppressive agent FTY720

Hale, Jeffrey J ; Yan, Lin ; Neway, William E ; Hajdu, Richard ; Bergstrom, James D ; Milligan, James A ; Shei, Gan-Ju ; Chrebet, Gary L ; Thornton, Rosemary A ; Card, Deborah ; Rosenbach, Mark ; Hughrosen ; Mandala, Suzanne

Bioorganic & Medicinal Chemistry, 15 September 2004, Vol.12(18), pp.4803-4807 [Peer Reviewed Journal]

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15
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Discovery of potent 3,5-diphenyl-1,2,4-oxadiazole sphingosine-1-phosphate-1 (S1P1) receptor agonists with exceptional selectivity against S1P2 and S1P3

Li, Zhen ; Chen, Weirong ; Hale, Jeffrey J ; Lynch, Christopher L ; Mills, Sander G ; Hajdu, Richard ; Keohane, Carol Ann ; Rosenbach, Mark J ; Milligan, James A ; Shei, Gan-Ju ; Chrebet, Gary ; Parent, Stephen A ; Bergstrom, James ; Card, Deborah ; Forrest, Michael ; Quackenbush, Elizabeth J ; Wickham, L Alexandra ; Vargas, Hugo ; Evans, Rose M ; Rosen, Hugh ; Mandala, Suzanne

Journal of medicinal chemistry, 06 October 2005, Vol.48(20), pp.6169-73 [Peer Reviewed Journal]

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16
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Discovery of MK-3168: A PET Tracer for Imaging Brain Fatty Acid Amide Hydrolase

Liu, Ping ; Hamill, Terence G ; Chioda, Marc ; Chobanian, Harry ; Fung, Selena ; Guo, Yan ; Chang, Linda ; Bakshi, Raman ; Hong, Qingmei ; Dellureficio, James ; Lin, Linus S ; Abbadie, Catherine ; Alexander, Jessica ; Jin, Hong ; Mandala, Suzanne ; Shiao, Lin-Lin ; Li, Wenping ; Sanabria, Sandra ; Williams, David ; Zeng, Zhizhen ; Hajdu, Richard ; Jochnowitz, Nina ; Rosenbach, Mark ; Karanam, Bindhu ; Madeira, Maria ; Salituro, Gino ; Powell, Joyce ; Xu, Ling ; Terebetski, Jenna L ; Leone, Joseph F ; Miller, Patricia ; Cook, Jacquelynn ; Holahan, Marie ; Joshi, Aniket ; O'Malley, Stacey ; Purcell, Mona ; Posavec, Diane ; Chen, Tsing-Bau ; Riffel, Kerry ; Williams, Mangay ; Hargreaves, Richard ; Sullivan, Kathleen A ; Nargund, Ravi P ; Devita, Robert J

ACS medicinal chemistry letters, 13 June 2013, Vol.4(6), pp.509-13 [Peer Reviewed Journal]

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17
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Phytosphingosine 1-phosphate: a high affinity ligand for the S1P 4/Edg-6 receptor

Rios Candelore, Mari ; Wright, Michael J ; Tota, Laurie M ; Milligan, James ; Shei, Gan-Ju ; Bergstrom, James D ; Mandala, Suzanne M

Biochemical and Biophysical Research Communications, 2002, Vol.297(3), pp.600-606 [Peer Reviewed Journal]

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18
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Sphingosine 1-phosphate receptor agonists attenuate relapsing–remitting experimental autoimmune encephalitis in SJL mice

Webb, Michael ; Tham, Chui-Se ; Lin, Fen-Fen ; Lariosa-Willingham, Karen ; Yu, Naichen ; Hale, Jeffrey ; Mandala, Suzanne ; Chun, Jerold ; Rao, Tadimeti S

Journal of Neuroimmunology, 2004, Vol.153(1), pp.108-121 [Peer Reviewed Journal]

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19
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SAR studies of 3-arylpropionic acids as potent and selective agonists of sphingosine-1-phosphate receptor-1 (S1P 1) with enhanced pharmacokinetic properties

Yan, Lin ; Huo, Pei ; Hale, Jeffrey J ; Mills, Sander G ; Hajdu, Richard ; Keohane, Carol A ; Rosenbach, Mark J ; Milligan, James A ; Shei, Gan-Ju ; Chrebet, Gary ; Bergstrom, James ; Card, Deborah ; Mandala, Suzanne M

Bioorganic & Medicinal Chemistry Letters, 2007, Vol.17(3), pp.828-831 [Peer Reviewed Journal]

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20
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Identification of Leu276 of the S1P1 receptor and Phe263 of the S1P3 receptor in interaction with receptor specific agonists by molecular modeling, site-directed mutagenesis, and affinity studies

Deng, Qiaolin ; Clemas, Joseph A ; Chrebet, Gary ; Fischer, Paul ; Hale, Jeffrey J ; Li, Zhen ; Mills, Sander G ; Bergstrom, James ; Mandala, Suzanne ; Mosley, Ralph ; Parent, Stephen A

Molecular pharmacology, March 2007, Vol.71(3), pp.724-35 [Peer Reviewed Journal]

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21
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Highly selective and potent agonists of sphingosine-1-phosphate 1 (S1P 1) receptor

Vachal, Petr ; Toth, Leslie M ; Hale, Jeffrey J ; Yan, Lin ; Mills, Sander G ; Chrebet, Gary L ; Koehane, Carol A ; Hajdu, Richard ; Milligan, James A ; Rosenbach, Mark J ; Mandala, Suzanne

Bioorganic & Medicinal Chemistry Letters, 2006, Vol.16(14), pp.3684-3687 [Peer Reviewed Journal]

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22
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The discovery of 3-(N-alkyl)aminopropylphosphonic acids as potent S1P receptor agonists

Hale, Jeffrey J ; Doherty, George ; Toth, Leslie ; Li, Zhen ; Mills, Sander G ; Hajdu, Richard ; Ann Keohane, Carol ; Rosenbach, Mark ; Milligan, James ; Shei, Gan-Ju ; Chrebet, Gary ; Bergstrom, James ; Card, Deborah ; Rosen, Hugh ; Mandala, Suzanne

Bioorganic & Medicinal Chemistry Letters, 2004, Vol.14(13), pp.3495-3499 [Peer Reviewed Journal]

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23
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2-Aryl(pyrrolidin-4-yl)acetic acids are potent agonists of sphingosine-1-phosphate (S1P) receptors

Yan, Lin ; Budhu, Richard ; Huo, Pei ; Lynch, Christopher L ; Hale, Jeffrey J ; Mills, Sander G ; Hajdu, Richard ; Keohane, Carol A ; Rosenbach, Mark J ; Milligan, James A ; Shei, Gan-Ju ; Chrebet, Gary ; Bergstrom, James ; Card, Deborah ; Mandala, Suzanne M

Bioorganic & Medicinal Chemistry Letters, 01 July 2006, Vol.16(13), pp.3564-3568 [Peer Reviewed Journal]

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24
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2,5-Disubstituted pyrrolidine carboxylates as potent, orally active sphingosine-1-phosphate (S1P) receptor agonists

Colandrea, Vincent J ; Legiec, Irene E ; Huo, Pei ; Yan, Lin ; Hale, Jeffrey J ; Mills, Sander G ; Bergstrom, James ; Card, Deborah ; Chebret, Gary ; Hajdu, Richard ; Keohane, Carol Ann ; Milligan, James A ; Rosenbach, Mark J ; Shei, Gan-Ju ; Mandala, Suzanne M

Bioorganic & Medicinal Chemistry Letters, 2006, Vol.16(11), pp.2905-2908 [Peer Reviewed Journal]

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25
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Discovery of 3-arylpropionic acids as potent agonists of sphingosine-1-phosphate receptor-1 (S1P 1) with high selectivity against all other known S1P receptor subtypes

Yan, Lin ; Huo, Pei ; Doherty, George ; Toth, Lesile ; Hale, Jeffrey J ; Mills, Sander G ; Hajdu, Richard ; Keohane, Carol A ; Rosenbach, Mark J ; Milligan, James A ; Shei, Gan-Ju ; Chrebet, Gary ; Bergstrom, James ; Card, Deborah ; Quackenbush, Elizabeth ; Wickham, Alexandra ; Mandala, Suzanne M

Bioorganic & Medicinal Chemistry Letters, 2006, Vol.16(14), pp.3679-3683 [Peer Reviewed Journal]

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26
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Selecting against S1P 3 enhances the acute cardiovascular tolerability of 3-(N-benzyl)aminopropylphosphonic acid S1P receptor agonists

Hale, Jeffrey J ; Doherty, George ; Toth, Leslie ; Mills, Sander G ; Hajdu, Richard ; Ann Keohane, Carol ; Rosenbach, Mark ; Milligan, James ; Shei, Gan-Ju ; Chrebet, Gary ; Bergstrom, James ; Card, Deborah ; Forrest, Michael ; Sun, Shu-Yu ; West, Sarah ; Xie, Huijuan ; Nomura, Naomi ; Rosen, Hugh ; Mandala, Suzanne

Bioorganic & Medicinal Chemistry Letters, 2004, Vol.14(13), pp.3501-3505 [Peer Reviewed Journal]

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27
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Design and synthesis of conformationally constrained 3-(N-alkylamino)propylphosphonic acids as potent agonists of sphingosine-1-phosphate (S1P) receptors

Yan, Lin ; Hale, Jeffrey J ; Lynch, Christopher L ; Budhu, Richard ; Gentry, Amy ; Mills, Sander G ; Hajdu, Richard ; Keohane, Carol Ann ; Rosenbach, Mark J ; Milligan, James A ; Shei, Gan-Ju ; Chrebet, Gary ; Bergstrom, James ; Card, Deborah ; Rosen, Hugh ; Mandala, Suzanne M

Bioorganic & medicinal chemistry letters, 04 October 2004, Vol.14(19), pp.4861-6 [Peer Reviewed Journal]

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Potent S1P receptor agonists replicate the pharmacologic actions of the novel immune modulator FTY720

Hale, Jeffrey J ; Neway, William ; Mills, Sander G ; Hajdu, Richard ; Ann Keohane, Carol ; Rosenbach, Mark ; Milligan, James ; Shei, Gan-Ju ; Chrebet, Gary ; Bergstrom, James ; Card, Deborah ; Koo, Gloria C ; Koprak, Sam L ; Jackson, Jesse J ; Rosen, Hugh ; Mandala, Suzanne

Bioorganic & Medicinal Chemistry Letters, 2004, Vol.14(12), pp.3351-3355 [Peer Reviewed Journal]

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29
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Design and synthesis of conformationally constrained 3-( N-alkylamino)propylphosphonic acids as potent agonists of sphingosine-1-phosphate (S1P) receptors

Yan, Lin ; Hale, Jeffrey J ; Lynch, Christopher L ; Budhu, Richard ; Gentry, Amy ; Mills, Sander G ; Hajdu, Richard ; Keohane, Carol Ann ; Rosenbach, Mark J ; Milligan, James A ; Shei, Gan-Ju ; Chrebet, Gary ; Bergstrom, James ; Card, Deborah ; Rosen, Hugh ; Mandala, Suzanne M

Bioorganic & Medicinal Chemistry Letters, 2004, Vol.14(19), pp.4861-4866 [Peer Reviewed Journal]

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