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Design, synthesis, and biological evaluation of aminopyrazine derivatives as inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2)

Lin, Songnian ; Malkani, Sunita ; Lombardo, Matthew ; Yang, Lihu ; Mills, Sander G ; Chapman, Kevin ; Thompson, James E ; Zhang, Wen Xiao ; Wang, Ruixiu ; Cubbon, Rose M ; O’neill, Edward A ; Hale, Jeffrey J

Bioorganic & Medicinal Chemistry Letters, 15 November 2015, Vol.25(22), pp.5402-5408 [Peer Reviewed Journal]

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Discovery of orally active hepatoselective glucokinase activators for treatment of Type II Diabetes Mellitus

Xu, Jiayi ; Lin, Songnian ; Myers, Robert W ; Trujillo, Maria E ; Pachanski, Michele J ; Malkani, Sunita ; Chen, Hsuan-Shen ; Chen, Zhesheng ; Campbell, Brian ; Eiermann, George J ; Elowe, Nadine ; Farrer, Brian T ; Feng, Wen ; Fu, Qinghong ; Kats-Kagan, Roman ; Kavana, Michael ; Mcmasters, Daniel R ; Mitra, Kaushik ; Tong, Xinchun ; Xu, Libo ; Zhang, Fengqi ; Zhang, Rui ; Addona, George H ; Berger, Joel P ; Zhang, Bei ; Parmee, Emma R

Bioorganic & Medicinal Chemistry Letters, 01 May 2017, Vol.27(9), pp.2063-2068 [Peer Reviewed Journal]

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Novel, highly potent systemic glucokinase activators for the treatment of Type 2 Diabetes Mellitus

Xu, Jiayi ; Lin, Songnian ; Myers, Robert W ; Addona, George ; Berger, Joel P ; Campbell, Brian ; Chen, Hsuan-Shen ; Chen, Zhesheng ; Eiermann, George J ; Elowe, Nadine H ; Farrer, Brian T ; Feng, Wen ; Fu, Qinghong ; Kats-Kagan, Roman ; Kavana, Michael ; Malkani, Sunita ; Mcmasters, Daniel R ; Mitra, Kaushik ; Pachanski, Michele J ; Tong, Xinchun ; Trujillo, Maria E ; Xu, Libo ; Zhang, Bei ; Zhang, Fengqi ; Zhang, Rui ; Parmee, Emma R

Bioorganic & Medicinal Chemistry Letters, 01 May 2017, Vol.27(9), pp.2069-2073 [Peer Reviewed Journal]

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Novel 1-(2-aminopyrazin-3-yl)methyl-2-thioureas as potent inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2)

Lin, Songnian ; Lombardo, Matthew ; Malkani, Sunita ; Hale, Jeffrey J ; Mills, Sander G ; Chapman, Kevin ; Thompson, James E ; Zhang, Wen Xiao ; Wang, Ruixiu ; Cubbon, Rose M ; O’neill, Edward A ; Luell, Silvi ; Carballo-Jane, Ester ; Yang, Lihu

Bioorganic & Medicinal Chemistry Letters, 2009, Vol.19(12), pp.3238-3242 [Peer Reviewed Journal]

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