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Selective inhibition of platelet responses to bisenoic prostaglandins proceedings

Macintyre, D E

British journal of pharmacology, June 1977, Vol.60(2), pp.293P-294P [Peer Reviewed Journal]

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Platelet-activating factor stimulates phosphatidylinositol turnover in human platelets

Macintyre, D E ; Pollock, W K

The Biochemical journal, 15 May 1983, Vol.212(2), pp.433-7 [Peer Reviewed Journal]

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3
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Desensitization and antagonism of vasopressin-induced phosphoinositide metabolism and elevation of cytosolic free calcium concentration in human platelets

Pollock, W K ; Macintyre, D E

The Biochemical journal, 15 February 1986, Vol.234(1), pp.67-73 [Peer Reviewed Journal]

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4
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Inhibition of platelet-activating-factor-induced human platelet activation by prostaglandin D2. Differential sensitivity of platelet transduction processes and functional responses to inhibition by cyclic AMP

Bushfield, M ; Mcnicol, A ; Macintyre, D E

The Biochemical journal, 15 November 1985, Vol.232(1), pp.267-71 [Peer Reviewed Journal]

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Possible mechanisms of the potentiation of blood-platelet activation by adrenaline

Bushfield, M ; Mcnicol, A ; Macintyre, D E

The Biochemical journal, 01 February 1987, Vol.241(3), pp.671-6 [Peer Reviewed Journal]

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6
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An NK1 receptor antagonist affects the circadian regulation of locomotor activity in golden hamsters

Challet, E ; Naylor, E ; Metzger, J M ; Macintyre, D E ; Turek, F W

Brain research, 27 July 1998, Vol.800(1), pp.32-9 [Peer Reviewed Journal]

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7
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Mice overexpressing chemokine ligand 2 (CCL2) in astrocytes display enhanced nociceptive responses

Menetski, J ; Mistry, S ; Lu, M ; Mudgett, J S ; Ransohoff, R M ; Demartino, J A ; Macintyre, D E ; Abbadie, C

Neuroscience, 09 November 2007, Vol.149(3), pp.706-14 [Peer Reviewed Journal]

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8
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Regulation of platelet cytosolic free calcium by cyclic nucleotides and protein kinase C

Macintyre, D. E. ; Bushfield, M. ; Shaw, A. M.

FEBS Letters, 02 September 1985, Vol.188(2), pp.383-388 [Peer Reviewed Journal]

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9
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Tumour‐promoting phorbol esters inhibit agonist‐induced phosphatidate formation and Ca2+ flux in human platelets

Macintyre, D. E. ; Mcnicol, A. ; Drummond, A. H.

FEBS Letters, 28 January 1985, Vol.180(2), pp.160-164 [Peer Reviewed Journal]

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10
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Differing roles for platelet-activating factor during inflammation of the lung and subarachnoid space. The special case of Streptococcus pneumoniae

Cabellos, C ; Macintyre, D E ; Forrest, M ; Burroughs, M ; Prasad, S ; Tuomanen, E

The Journal of clinical investigation, August 1992, Vol.90(2), pp.612-8 [Peer Reviewed Journal]

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11
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Lipopolysaccharide-induced hypotension and vascular hyporeactivity in the rat: tissue analysis of nitric oxide synthase mRNA and protein expression in the presence and absence of dexamethasone, NG-monomethyl-L-arginine or indomethacin

Hom, G J ; Grant, S K ; Wolfe, G ; Bach, T J ; Macintyre, D E ; Hutchinson, N I

The Journal of pharmacology and experimental therapeutics, January 1995, Vol.272(1), pp.452-9 [Peer Reviewed Journal]

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12
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Effects of protein kinase C activation on human platelet cyclic AMP metabolism

Bushfield, M ; Hopple, S L ; Gibson, I F ; Murdoch, F A ; Macintyre, D E

FEBS letters, 05 October 1987, Vol.222(2), pp.299-304 [Peer Reviewed Journal]

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13
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Thromboxane-induced phosphatidate formation in human platelets. Relationship to receptor occupancy and to changes in cytosolic free calcium

Pollock, W K ; Armstrong, R A ; Brydon, L J ; Jones, R L ; Macintyre, D E

The Biochemical journal, 01 May 1984, Vol.219(3), pp.833-42 [Peer Reviewed Journal]

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14
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Beta-3 adrenergic receptor agonists cause an increase in gastrointestinal transit time in wild-type mice, but not in mice lacking the beta-3 adrenergic receptor

Fletcher, D S ; Candelore, M R ; Grujic, D ; Lowell, B B ; Luell, S ; Susulic, V S ; Macintyre, D E

The Journal of pharmacology and experimental therapeutics, November 1998, Vol.287(2), pp.720-4 [Peer Reviewed Journal]

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15
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The morphological and biochemical characterization of a line of rat promegakaryoblasts

Weinstein, R ; Stemerman, M B ; Macintyre, D E ; Steinberg, H N ; Maciag, T

Blood, July 1981, Vol.58(1), pp.110-21 [Peer Reviewed Journal]

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16
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Beta(3)-adrenoceptor agonist-induced increases in lipolysis, metabolic rate, facial flushing, and reflex tachycardia in anesthetized rhesus monkeys

Hom, G J ; Forrest, M J ; Bach, T J ; Brady, E ; Candelore, M R ; Cascieri, M A ; Fletcher, D J ; Fisher, M H ; Iliff, S A ; Mathvink, R ; Metzger, J ; Pecore, V ; Saperstein, R ; Shih, T ; Weber, A E ; Wyvratt, M ; Zafian, P ; Macintyre, D E

The Journal of pharmacology and experimental therapeutics, April 2001, Vol.297(1), pp.299-307 [Peer Reviewed Journal]

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17
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4,4-Disubstituted piperidine high-affinity NK1 antagonists: structure-activity relationships and in vivo activity

Stevenson, G I ; Huscroft, I ; Macleod, A M ; Swain, C J ; Cascieri, M A ; Chicchi, G G ; Graham, M I ; Harrison, T ; Kelleher, F J ; Kurtz, M ; Ladduwahetty, T ; Merchant, K J ; Metzger, J M ; Macintyre, D E ; Sadowski, S ; Sohal, B ; Owens, A P

Journal of medicinal chemistry, 05 November 1998, Vol.41(23), pp.4623-35 [Peer Reviewed Journal]

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18
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Structural optimization affording 2-(R)-(1-(R)-3, 5-bis(trifluoromethyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-oxo-1,2,4-triazol-5-yl)methylmorpholine, a potent, orally active, long-acting morpholine acetal human NK-1 receptor antagonist

Hale, J J ; Mills, S G ; Maccoss, M ; Finke, P E ; Cascieri, M A ; Sadowski, S ; Ber, E ; Chicchi, G G ; Kurtz, M ; Metzger, J ; Eiermann, G ; Tsou, N N ; Tattersall, F D ; Rupniak, N M ; Williams, A R ; Rycroft, W ; Hargreaves, R ; Macintyre, D E

Journal of medicinal chemistry, 05 November 1998, Vol.41(23), pp.4607-14 [Peer Reviewed Journal]

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19
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2(S)-((3,5-bis(trifluoromethyl)benzyl)-oxy)-3(S)-phenyl-4- ((3-oxo-1,2,4-triazol-5-yl)methyl)morpholine (1): a potent, orally active, morpholine-based human neurokinin-1 receptor antagonist

Hale, J J ; Mills, S G ; Maccoss, M ; Shah, S K ; Qi, H ; Mathre, D J ; Cascieri, M A ; Sadowski, S ; Strader, C D ; Macintyre, D E ; Metzger, J M

Journal of medicinal chemistry, 26 April 1996, Vol.39(9), pp.1760-2 [Peer Reviewed Journal]

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20
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Platelet membrane potential assessed with a fluorescent probe, dipropylthiadicarbocyanine: has this potential a role in triggering aggregation? proceedings

Macintyre, D E ; Montecucco, C ; Rink, T J

The Journal of physiology, April 1979, Vol.289, pp.34P-35P [Peer Reviewed Journal]

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21
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Platelet-aggregating activity of type I and type III collagens from human aorta and chicken skin

Barnes, M J ; Gordon, J L ; Macintyre, D E

The Biochemical journal, 15 December 1976, Vol.160(3), pp.647-51 [Peer Reviewed Journal]

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22
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Prostaglandin receptors on human platelets. Structure-activity relationships of stimulatory prostaglandins

Macintyre, D E ; Salzman, E W ; Gordon, J L

The Biochemical journal, 15 September 1978, Vol.174(3), pp.921-9 [Peer Reviewed Journal]

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23
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Desensitization of beta3-adrenergic receptor-stimulated adenylyl cyclase activity and lipolysis in rats

Vicario, P P ; Candelore, M R ; Schaeffer, M T ; Kelly, L ; Thompson, G M ; Brady, E J ; Saperstein, R ; Macintyre, D E ; Tota, L M ; Cascieri, M A

Life sciences, 1998, Vol.62(7), pp.627-38 [Peer Reviewed Journal]

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24
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Antagonism of human platelet responses to stimulatory and inhibitory prostaglandins

Macintyre, D E ; Salzman, E W

Progress in lipid research, 1981, Vol.20, pp.453-9 [Peer Reviewed Journal]

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25
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Phospholipid-induced human platelet activation: effects of calcium channel blockers and calcium chelators

Macintyre, D E ; Shaw, A M

Thrombosis research, 15 September 1983, Vol.31(6), pp.833-44 [Peer Reviewed Journal]

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26
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A potent, nonpeptidyl 1H-quinolone antagonist for the gonadotropin-releasing hormone receptor

Devita, R J ; Walsh, T F ; Young, J R ; Jiang, J ; Ujjainwalla, F ; Toupence, R B ; Parikh, M ; Huang, S X ; Fair, J A ; Goulet, M T ; Wyvratt, M J ; Lo, J L ; Ren, N ; Yudkovitz, J B ; Yang, Y T ; Cheng, K ; Cui, J ; Mount, G ; Rohrer, S P ; Schaeffer

Journal of medicinal chemistry, 15 March 2001, Vol.44(6), pp.917-22 [Peer Reviewed Journal]

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27
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Inhibition of platelet function by cis-unsaturated fatty acids

Macintyre, D E ; Hoover, R L ; Smith, M ; Steer, M ; Lynch, C ; Karnovsky, M J ; Salzman, E W

Blood, April 1984, Vol.63(4), pp.848-57 [Peer Reviewed Journal]

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28
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Discovery of a potent, orally bioavailable beta(3) adrenergic receptor agonist, (R)-N-4-2-2-hydroxy-2-(3-pyridinyl)ethylaminoethylphenyl-4-4 -4-(trifluoromethyl)phenylthiazol-2-ylbenzenesulfonamide

Mathvink, R J ; Tolman, J S ; Chitty, D ; Candelore, M R ; Cascieri, M A ; Colwell, L F ; Deng, L ; Feeney, W P ; Forrest, M J ; Hom, G J ; Macintyre, D E ; Miller, R R ; Stearns, R A ; Tota, L ; Wyvratt, M J ; Fisher, M H ; Weber, A E

Journal of medicinal chemistry, 19 October 2000, Vol.43(21), pp.3832-6 [Peer Reviewed Journal]

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29
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N-heteroaryl-2-phenyl-3-(benzyloxy)piperidines: a novel class of potent orally active human NK1 antagonists

Ladduwahetty, T ; Baker, R ; Cascieri, M A ; Chambers, M S ; Haworth, K ; Keown, L E ; Macintyre, D E ; Metzger, J M ; Owen, S ; Rycroft, W ; Sadowski, S ; Seward, E M ; Shepheard, S L ; Swain, C J ; Tattersall, F D ; Watt, A P ; Williamson, D W ; Hargreaves, R J

Journal of medicinal chemistry, 19 July 1996, Vol.39(15), pp.2907-14 [Peer Reviewed Journal]

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30
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Lack of effect of pertussis toxin on TNF-alpha-induced formation of reactive oxygen intermediates by human neutrophils

Meurer, R ; Macintyre, D E

Biochemical and biophysical research communications, 15 March 1989, Vol.159(2), pp.763-9 [Peer Reviewed Journal]

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31
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Malonaldehyde formation in intact platelets is catalysed by thromboxane synthase

Mcmillan, R M ; Macintyre, D E ; Booth, A ; Gordon, J L

The Biochemical journal, 15 November 1978, Vol.176(2), pp.595-8 [Peer Reviewed Journal]

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32
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Molecular approaches to the discovery of new treatments for obesity

Strader, C D ; Macintyre, D E ; Candelore, M R ; Parker, E M

Current opinion in chemical biology, August 1997, Vol.1(2), pp.204-9 [Peer Reviewed Journal]

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33
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Phosphorylated morpholine acetal human neurokinin-1 receptor antagonists as water-soluble prodrugs

Hale, J J ; Mills, S G ; Maccoss, M ; Dorn, C P ; Finke, P E ; Budhu, R J ; Reamer, R A ; Huskey, S E ; Luffer-Atlas, D ; Dean, B J ; Mcgowan, E M ; Feeney, W P ; Chiu, S H ; Cascieri, M A ; Chicchi, G G ; Kurtz, M M ; Sadowski, S ; Ber, E ; Tattersall, F D ; Rupniak

Journal of medicinal chemistry, 23 March 2000, Vol.43(6), pp.1234-41 [Peer Reviewed Journal]

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34
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Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass

Chen, A S ; Marsh, D J ; Trumbauer, M E ; Frazier, E G ; Guan, X M ; Yu, H ; Rosenblum, C I ; Vongs, A ; Feng, Y ; Cao, L ; Metzger, J M ; Strack, A M ; Camacho, R E ; Mellin, T N ; Nunes, C N ; Min, W ; Fisher, J ; Gopal-Truter, S ; Macintyre, D E ; Chen

Nature genetics, September 2000, Vol.26(1), pp.97-102 [Peer Reviewed Journal]

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35
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A selective human beta3 adrenergic receptor agonist increases metabolic rate in rhesus monkeys

Fisher, M H ; Amend, A M ; Bach, T J ; Barker, J M ; Brady, E J ; Candelore, M R ; Carroll, D ; Cascieri, M A ; Chiu, S H ; Deng, L ; Forrest, M J ; Hegarty-Friscino, B ; Guan, X M ; Hom, G J ; Hutchins, J E ; Kelly, L J ; Mathvink, R J ; Metzger, J M ; Miller, R R ; Ok

The Journal of clinical investigation, 01 June 1998, Vol.101(11), pp.2387-93 [Peer Reviewed Journal]

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36
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Regulation of macrophage lysosomal enzyme secretion: role of arachidonate metabolites, divalent cations and cyclic AMP

Mcmillan, R M ; Macintyre, D E ; Beesley, J E ; Gordon, J L

Journal of cell science, August 1980, Vol.44, pp.299-315 [Peer Reviewed Journal]

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37
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Platelet aggregaton by basement membrane-associated collagens

Barnes, M J ; Bailey, A J ; Gordon, J L ; Macintyre, D E

Thrombosis research, 1980, Vol.18(3-4), pp.375-88 [Peer Reviewed Journal]

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38
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Heparin opposes prostanoid and non-prostanoid platelet inhibitors by direct enhancement of aggregation

Macintyre, D E ; Handin, R I ; Rosenberg, R ; Salzman, E W

Thrombosis research, 1981, Vol.22(1-2), pp.167-75 [Peer Reviewed Journal]

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39
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The role of CD18 in IL-8 induced dermal and synovial inflammation

Forrest, M J ; Eiermann, G J ; Meurer, R ; Walakovits, L A ; Macintyre, D E

British journal of pharmacology, June 1992, Vol.106(2), pp.287-94 [Peer Reviewed Journal]

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