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Canada and the First World War: A Canadian War Museum Internet Exhibition

Cook, Tim ; Lyons, Kathryn

Canadian Military History, Summer 2008, Vol.17(3), p.39 [Peer Reviewed Journal]

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Fosmetpantotenate (RE-024), a phosphopantothenate replacement therapy for pantothenate kinase-associated neurodegeneration: Mechanism of action and efficacy in nonclinical models

Elbaum, Daniel ; Beconi, Maria G ; Monteagudo, Edith ; Di Marco, Annalise ; Quinton, Maria S ; Lyons, Kathryn A ; Vaino, Andrew ; Harper, Steven

PloS one, 2018, Vol.13(3), pp.e0192028 [Peer Reviewed Journal]

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Synthesis and evaluation of [(1 R)-1-amino-2-(2,5-difluorophenyl)ethyl]cyclohexanes and 4-[(1 R)-1-amino-2-(2,5-difluorophenyl)ethyl]piperidines as DPP-4 inhibitors

Chen, Ping ; Caldwell, Charles G. ; Ashton, Wallace ; Wu, Joseph K. ; He, Huaibing ; Lyons, Kathryn A. ; Thornberry, Nancy A. ; Weber, Ann E.

Bioorganic & Medicinal Chemistry Letters, 2011, Vol.21(6), pp.1880-1886 [Peer Reviewed Journal]

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The discovery of novel 5,6,5- and 5,5,6-tricyclic pyrrolidines as potent and selective DPP-4 inhibitors

Cox, Jason M. ; Chu, Hong D. ; Kuethe, Jeffrey T. ; Gao, Ying-Duo ; Scapin, Giovanna ; Eiermann, George ; He, Huaibing ; Li, Xiaohua ; Lyons, Kathryn A. ; Metzger, Joseph ; Petrov, Aleksandr ; Wu, Joseph K. ; Xu, Shiyao ; Sinha-Roy, Ranabir ; Weber, Ann E. ; Biftu, Tesfaye

Bioorganic & Medicinal Chemistry Letters, 1 June 2016, Vol.26(11), pp.2622-2626 [Peer Reviewed Journal]

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A novel benzazepinone sodium channel blocker with oral efficacy in a rat model of neuropathic pain

Hoyt, Scott B. ; London, Clare ; Abbadie, Catherine ; Felix, John P. ; Garcia, Maria L. ; Jochnowitz, Nina ; Karanam, Bindhu V. ; Li, Xiaohua ; Lyons, Kathryn A. ; Mcgowan, Erin ; Priest, Birgit T. ; Smith, Mchardy M. ; Warren, Vivien A. ; Thomas-Fowlkes, Brande S. ; Kaczorowski, Gregory J. ; Duffy, Joseph L.

Bioorganic & Medicinal Chemistry Letters, 15 June 2013, Vol.23(12), pp.3640-3645 [Peer Reviewed Journal]

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Pyridinesulfonylureas and pyridinesulfonamides as selective bombesin receptor subtype-3 (BRS-3) agonists

Lo, Michael M.-C. ; Chobanian, Harry R. ; Palyha, Oksana ; Kan, Yanqing ; Kelly, Theresa M. ; Guan, Xiao-Ming ; Reitman, Marc L. ; Dragovic, Jasminka ; Lyons, Kathryn A. ; Nargund, Ravi P. ; Lin, Linus S.

Bioorganic & Medicinal Chemistry Letters, 2011, Vol.21(7), pp.2040-2043 [Peer Reviewed Journal]

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Structure–activity-relationship of amide and sulfonamide analogs of omarigliptin

Chen, Ping ; Feng, Dennis ; Qian, Xiaoxia ; Apgar, James ; Wilkening, Robert ; Kuethe, Jeffrey T. ; Gao, Ying-Duo ; Scapin, Giovanna ; Cox, Jason ; Doss, George ; Eiermann, George ; He, Huaibing ; Li, Xiaohua ; Lyons, Kathryn A. ; Metzger, Joseph ; Petrov, Aleksandr ; Wu, Joseph K. ; Xu, Shiyao ; Weber, Ann E. ; Yan, Youwei ; Roy, Ranabir Sinha ; Biftu, Tesfaye

Bioorganic & Medicinal Chemistry Letters, 15 December 2015, Vol.25(24), pp.5767-5771 [Peer Reviewed Journal]

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A potent and selective indole N-type calcium channel (Ca v2.2) blocker for the treatment of pain

Tyagarajan, Sriram ; Chakravarty, Prasun K. ; Park, Min ; Zhou, Bishan ; Herrington, James B. ; Ratliff, Kevin ; Bugianesi, Randall M. ; Williams, Brande ; Haedo, Rodolfo J. ; Swensen, Andrew M. ; Warren, Vivien A. ; Smith, Mchardy ; Garcia, Maria ; Kaczorowski, Gregory J. ; Mcmanus, Owen B. ; Lyons, Kathryn A. ; Li, Xiaohua ; Madeira, Maria ; Karanam, Bindhu ; Green, Mitchell ; Forrest, Michael J. ; Abbadie, Catherine ; Mcgowan, Erin ; Mistry, Shruti ; Jochnowitz, Nina ; Duffy, Joseph L.

Bioorganic & Medicinal Chemistry Letters, 2011, Vol.21(2), pp.869-873 [Peer Reviewed Journal]

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Aminopiperidine sulfonamide Cav2.2 channel inhibitors for the treatment of chronic pain

Shao, Pengcheng P ; Ye, Feng ; Chakravarty, Prasun K ; Varughese, Deepu J ; Herrington, James B ; Dai, Ge ; Bugianesi, Randal M ; Haedo, Rodolfo J ; Swensen, Andrew M ; Warren, Vivien A ; Smith, Mchardy M ; Garcia, Maria L ; Mcmanus, Owen B ; Lyons, Kathryn A ; Li, Xiaohua ; Green, Mitchell ; Jochnowitz, Nina ; Mcgowan, Erin ; Mistry, Shruti ; Sun, Shu-Yu ; Abbadie, Catherine ; Kaczorowski, Gregory J ; Duffy, Joseph L

Journal of medicinal chemistry, 26 November 2012, Vol.55(22), pp.9847-55 [Peer Reviewed Journal]

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Synthesis of 7-benzyl-5-(piperidin-1-yl)-6,7,8,9-tetrahydro-3 H-pyrazolo[3,4- c][2,7]naphthyridin-1-ylamine and its analogs as bombesin receptor subtype-3 agonists

Guo, Cheng ; Guzzo, Peter R. ; Hadden, Mark ; Sargent, Bruce J. ; Yet, Larry ; Kan, Yanqing ; Palyha, Oksana ; Kelly, Theresa M. ; Guan, Xiaoming ; Rosko, Kim ; Gagen, Karen ; Metzger, Joseph M. ; Dragovic, Jasminka ; Lyons, Kathryn ; Lin, Linus S. ; Nargund, Ravi P.

Bioorganic & Medicinal Chemistry Letters, 2010, Vol.20(9), pp.2785-2789 [Peer Reviewed Journal]

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The role of working memory in decoding emotions

Phillips, Louise H ; Channon, Shelley ; Tunstall, Mary ; Hedenstrom, Anna ; Lyons, Kathryn

Emotion (Washington, D.C.), April 2008, Vol.8(2), pp.184-91 [Peer Reviewed Journal]

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Discovery of a novel class of biphenyl pyrazole sodium channel blockers for treatment of neuropathic pain

Tyagarajan, Sriram ; Chakravarty, Prasun K. ; Zhou, Bishan ; Taylor, Brett ; Eid, Ronsar ; Fisher, Michael H. ; Parsons, William H. ; Wyvratt, Mathew J. ; Lyons, Kathryn A. ; Klatt, Tracy ; Li, Xiaohua ; Kumar, Sanjeev ; Williams, Brande ; Felix, John ; Priest, Birgit T. ; Brochu, Richard M. ; Warren, Vivien ; Smith, Mchardy ; Garcia, Maria ; Kaczorowski, Gregory J. ; Martin, William J. ; Abbadie, Catherine ; Mcgowan, Erin ; Jochnowitz, Nina ; Weber, Ann ; Duffy, Joseph L.

Bioorganic & Medicinal Chemistry Letters, 2010, Vol.20(24), pp.7479-7482 [Peer Reviewed Journal]

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13
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Pharmacokinetics of memantine in rats and mice

Beconi, Maria G ; Howland, David ; Park, Larry ; Lyons, Kathryn ; Giuliano, Joseph ; Dominguez, Celia ; Munoz-Sanjuan, Ignacio ; Pacifici, Robert

PLoS currents, 15 December 2011, Vol.3, pp.RRN1291

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14
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A single-run liquid chromatography mass spectrometry method to quantify neuroactive kynurenine pathway metabolites in rat plasma

Orsatti, Laura ; Speziale, Roberto ; Orsale, Maria Vittoria ; Caretti, Fulvia ; Veneziano, Maria ; Zini, Matteo ; Monteagudo, Edith ; Lyons, Kathryn ; Beconi, Maria ; Chan, Kelvin ; Herbst, Todd ; Toledo-Sherman, Leticia ; Munoz-Sanjuan, Ignacio ; Bonelli, Fabio ; Dominguez, Celia

Journal of Pharmaceutical and Biomedical Analysis, 25 March 2015, Vol.107, pp.426-431 [Peer Reviewed Journal]

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15
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Highly constrained bicyclic VLA-4 antagonists

Chang, Linda L. ; Truong, Quang ; Doss, George A. ; Maccoss, Malcolm ; Lyons, Kathryn ; Mccauley, Ermengilda ; Mumford, Richard ; Forrest, Gail ; Vincent, Stella ; Schmidt, John A. ; Hagmann, William K.

Bioorganic & Medicinal Chemistry Letters, 2007, Vol.17(3), pp.597-601 [Peer Reviewed Journal]

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16
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Aminopiperidine-fused imidazoles as dipeptidyl peptidase-IV inhibitors

Edmondson, Scott D. ; Mastracchio, Anthony ; Cox, Jason M. ; Eiermann, George J. ; He, Huaibing ; Lyons, Kathryn A. ; Patel, Reshma A. ; Patel, Sangita B. ; Petrov, Aleksandr ; Scapin, Giovanna ; Wu, Joseph K. ; Xu, Shiyao ; Zhu, Bing ; Thornberry, Nancy A. ; Roy, Ranabir Sinha ; Weber, Ann E.

Bioorganic & Medicinal Chemistry Letters, 1 August 2009, Vol.19(15), pp.4097-4101 [Peer Reviewed Journal]

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17
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Imidazopiperidine amides as dipeptidyl peptidase IV inhibitors for the treatment of diabetes

Chen, Ping ; Caldwell, Charles G. ; Mathvink, Robert J. ; Leiting, Barbara ; Marsilio, Frank ; Patel, Reshma A. ; Wu, Joseph K. ; He, Huaibing ; Lyons, Kathryn A. ; Thornberry, Nancy A. ; Weber, Ann E.

Bioorganic & Medicinal Chemistry Letters, 2007, Vol.17(21), pp.5853-5857 [Peer Reviewed Journal]

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18
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Discovery of 3-aminopiperidines as potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitors

Cox, Jason M. ; Harper, Bart ; Mastracchio, Anthony ; Leiting, Barbara ; Sinha Roy, Ranabir ; Patel, Reshma A. ; Wu, Joseph K. ; Lyons, Kathryn A. ; He, Huaibing ; Xu, Shiyao ; Zhu, Bing ; Thornberry, Nancy A. ; Weber, Ann E. ; Edmondson, Scott D.

Bioorganic & Medicinal Chemistry Letters, 15 August 2007, Vol.17(16), pp.4579-4583 [Peer Reviewed Journal]

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19
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Design, synthesis, and biological evaluation of triazolopiperazine-based β-amino amides as potent, orally active dipeptidyl peptidase IV (DPP-4) inhibitors

Kowalchick, Jennifer E. ; Leiting, Barbara ; Pryor, Kellyann D. ; Marsilio, Frank ; Wu, Joseph K. ; He, Huaibing ; Lyons, Kathryn A. ; Eiermann, George J. ; Petrov, Aleksandr ; Scapin, Giovanna ; Patel, Reshma A. ; Thornberry, Nancy A. ; Weber, Ann E. ; Kim, Dooseop

Bioorganic & Medicinal Chemistry Letters, 2007, Vol.17(21), pp.5934-5939 [Peer Reviewed Journal]

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20
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Dipeptidyl peptidase IV inhibitors derived from β-aminoacylpiperidines bearing a fused thiazole, oxazole, isoxazole, or pyrazole

Ashton, Wallace T. ; Sisco, Rosemary M. ; Dong, Hong ; Lyons, Kathryn A. ; He, Huaibing ; Doss, George A. ; Leiting, Barbara ; Patel, Reshma A. ; Wu, Joseph K. ; Marsilio, Frank ; Thornberry, Nancy A. ; Weber, Ann E.

Bioorganic & Medicinal Chemistry Letters, 2005, Vol.15(9), pp.2253-2258 [Peer Reviewed Journal]

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21
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Discovery of potent and selective phenylalanine based dipeptidyl peptidase IV inhibitors

Xu, Jinyou ; Wei, Lan ; Mathvink, Robert ; He, Jiafang ; Park, You-Jung ; He, Huaibing ; Leiting, Barbara ; Lyons, Kathryn A. ; Marsilio, Frank ; Patel, Reshma A. ; Wu, Joseph K. ; Thornberry, Nancy A. ; Weber, Ann E.

Bioorganic & Medicinal Chemistry Letters, 16 May 2005, Vol.15(10), pp.2533-2536 [Peer Reviewed Journal]

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22
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The discovery of small molecule carbamates as potent dual α 4β 1/α 4β 7 integrin antagonists

Chang, Linda L. ; Truong, Quang ; Mumford, Richard A. ; Egger, Linda A. ; Kidambi, Usha ; Lyons, Kathryn ; Mccauley, Ermengilda ; Van Riper, Gail ; Vincent, Stella ; Schmidt, John A. ; Maccoss, Malcolm ; Hagmann, William K.

Bioorganic & Medicinal Chemistry Letters, 2002, Vol.12(2), pp.159-163 [Peer Reviewed Journal]

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23
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Improved Cav2.2 Channel Inhibitors through a gem-Dimethylsulfone Bioisostere Replacement of a Labile Sulfonamide

Shao, Pengcheng P ; Ye, Feng ; Chakravarty, Prasun K ; Herrington, James B ; Dai, Ge ; Bugianesi, Randal M ; Haedo, Rodolfo J ; Swensen, Andrew M ; Warren, Vivien A ; Smith, Mchardy M ; Garcia, Maria L ; Mcmanus, Owen B ; Lyons, Kathryn A ; Li, Xiaohua ; Green, Mitchell ; Jochnowitz, Nina ; Mcgowan, Erin ; Mistry, Shruti ; Sun, Shu-Yu ; Abbadie, Catherine ; Kaczorowski, Gregory J ; Duffy, Joseph L

ACS medicinal chemistry letters, 14 November 2013, Vol.4(11), pp.1064-8 [Peer Reviewed Journal]

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24
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Discovery of MK-5046, a Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity

Sebhat, Iyassu K ; Franklin, Christopher ; Lo, Michael M-C ; Chen, David ; Jewell, James P ; Miller, Randy ; Pang, Jianmei ; Palyha, Oksana ; Kan, Yanqing ; Kelly, Theresa M ; Guan, Xiao-Ming ; Marsh, Donald J ; Kosinski, Jennifer A ; Metzger, Joseph M ; Lyons, Kathryn ; Dragovic, Jasminka ; Guzzo, Peter R ; Henderson, Alan J ; Reitman, Marc L ; Nargund, Ravi P ; Wyvratt, Matthew J ; Lin, Linus S

ACS medicinal chemistry letters, 13 January 2011, Vol.2(1), pp.43-7 [Peer Reviewed Journal]

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25
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Discovery of a novel class of isoxazoline voltage gated sodium channel blockers

Shao, Pengcheng P. ; Ye, Feng ; Weber, Ann E. ; Li, Xiaohua ; Lyons, Kathryn A. ; Parsons, William H. ; Garcia, Maria L. ; Priest, Birgit T. ; Smith, Mchardy M. ; Felix, John P. ; Williams, Brande S. ; Kaczorowski, Gregory J. ; Mcgowan, Erin ; Abbadie, Catherine ; Martin, William J. ; Mcmasters, Daniel R. ; Gao, Ying-Duo

Bioorganic & Medicinal Chemistry Letters, 2009, Vol.19(18), pp.5329-5333 [Peer Reviewed Journal]

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26
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Discovery of isoxazole voltage gated sodium channel blockers for treatment of chronic pain

Shao, Pengcheng P. ; Ye, Feng ; Weber, Ann E. ; Li, Xiaohua ; Lyons, Kathryn A. ; Parsons, William H. ; Garcia, Maria L. ; Priest, Birgit T. ; Smith, Mchardy M. ; Felix, John P. ; Williams, Brande S. ; Kaczorowski, Gregory J. ; Mcgowan, Erin ; Abbadie, Catherine ; Martin, William J. ; Mcmasters, Daniel R. ; Gao, Ying-Duo

Bioorganic & Medicinal Chemistry Letters, 2009, Vol.19(18), pp.5334-5338 [Peer Reviewed Journal]

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27
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A peripherally acting Na(v)1.7 sodium channel blocker reverses hyperalgesia and allodynia on rat models of inflammatory and neuropathic pain

Mcgowan, Erin ; Hoyt, Scott B ; Li, Xiaohua ; Lyons, Kathryn A ; Abbadie, Catherine

Anesthesia and analgesia, September 2009, Vol.109(3), pp.951-8 [Peer Reviewed Journal]

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28
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Imidazopyridines: A novel class of hNa v1.7 channel blockers

London, Clare ; Hoyt, Scott B. ; Parsons, William H. ; Williams, Brande S. ; Warren, Vivien A. ; Tschirret-Guth, Richard ; Smith, Mchardy M. ; Priest, Birgit T. ; Mcgowan, Erin ; Martin, William J. ; Lyons, Kathryn A. ; Li, Xiaohua ; Karanam, Bindhu V. ; Jochnowitz, Nina ; Garcia, Maria L. ; Felix, John P. ; Dean, Brian ; Abbadie, Catherine ; Kaczorowski, Gregory J. ; Duffy, Joseph L.

Bioorganic & Medicinal Chemistry Letters, 2008, Vol.18(5), pp.1696-1701 [Peer Reviewed Journal]

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29
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3-Amino-1,5-benzodiazepinones: Potent, state-dependent sodium channel blockers with anti-epileptic activity

Hoyt, Scott B. ; London, Clare ; Wyvratt, Matthew J. ; Fisher, Michael H. ; Cashen, Doreen E. ; Felix, John P. ; Garcia, Maria L. ; Li, Xiaohua ; Lyons, Kathryn A. ; Euan Macintyre, D. ; Martin, William J. ; Priest, Birgit T. ; Smith, Mchardy M. ; Warren, Vivien A. ; Williams, Brande S. ; Kaczorowski, Gregory J. ; Parsons, William H.

Bioorganic & Medicinal Chemistry Letters, 2008, Vol.18(6), pp.1963-1966 [Peer Reviewed Journal]

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30
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Fluoroolefins as amide bond mimics in dipeptidyl peptidase IV inhibitors

Edmondson, Scott D. ; Wei, Lan ; Xu, Jinyou ; Shang, Jackie ; Xu, Shiyao ; Pang, Jianmei ; Chaudhary, Ashok ; Dean, Dennis C. ; He, Huaibing ; Leiting, Barbara ; Lyons, Kathryn A. ; Patel, Reshma A. ; Patel, Sangita B. ; Scapin, Giovanna ; Wu, Joseph K. ; Beconi, Maria G. ; Thornberry, Nancy A. ; Weber, Ann E.

Bioorganic & Medicinal Chemistry Letters, 2008, Vol.18(7), pp.2409-2413 [Peer Reviewed Journal]

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31
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Discovery of Potent and Selective Dipeptidyl Peptidase IV Inhibitors Derived from [beta]-Aminoamides Bearing Subsituted Triazolopiperazines

Kim, Dooseop ;Kowalchick, Jennifer E. ;Brockunier, Linda L. ;Parmee, Emma R. ;Eiermann, George J. ;Fisher, Michael H. ;He, Huaibing ;Leiting, Barbara ;Lyons, Kathryn ;Scapin, Giovanna ;Patel, Sangita B. ;Petrov, Aleksandr ;Pryor, KellyAnn D. ;Roy, Ranabir Sinha ;Wu, Joseph K. ;Zhang, Xiaoping ;Wyvratt, Matthew J. ;Zhang, Bei B. ;Zhu, Lan ;Thornberry, Nancy A. ;Weber, Ann E.

J. Med. Chem., 2008, Vol.51(3) [Peer Reviewed Journal]

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Triazolopiperazine-amides as dipeptidyl peptidase IV inhibitors: Close analogs of JANUVIA™ (sitagliptin phosphate)

Kim, Dooseop ; Kowalchick, Jennifer E. ; Edmondson, Scott D. ; Mastracchio, Anthony ; Xu, Jinyou ; Eiermann, George J. ; Leiting, Barbara ; Wu, Joseph K. ; Pryor, Kellyann D. ; Patel, Reshma A. ; He, Huaibing ; Lyons, Kathryn A. ; Thornberry, Nancy A. ; Weber, Ann E.

Bioorganic & Medicinal Chemistry Letters, 2007, Vol.17(12), pp.3373-3377 [Peer Reviewed Journal]

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4-Aminophenylalanine and 4-aminocyclohexylalanine derivatives as potent, selective, and orally bioavailable inhibitors of dipeptidyl peptidase IV

Duffy, Joseph L. ; Kirk, Brian A. ; Wang, Liping ; Eiermann, George J. ; He, Huaibing ; Leiting, Barbara ; Lyons, Kathryn A. ; Patel, Reshma A. ; Patel, Sangita B. ; Petrov, Alexsandr ; Scapin, Giovanna ; Wu, Joseph K. ; Thornberry, Nancy A. ; Weber, Ann E.

Bioorganic & Medicinal Chemistry Letters, 2007, Vol.17(10), pp.2879-2885 [Peer Reviewed Journal]

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4-Arylcyclohexylalanine analogs as potent, selective, and orally active inhibitors of dipeptidyl peptidase IV

Kaelin, David E. ; Smenton, Abigail L. ; Eiermann, George J. ; He, Huaibing ; Leiting, Barbara ; Lyons, Kathryn A. ; Patel, Reshma A. ; Patel, Sangita B. ; Petrov, Alexsandr ; Scapin, Giovanna ; Wu, Joseph K. ; Thornberry, Nancy A. ; Weber, Ann E. ; Duffy, Joseph L.

Bioorganic & Medicinal Chemistry Letters, 2007, Vol.17(21), pp.5806-5811 [Peer Reviewed Journal]

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Discovery of potent, selective, and orally bioavailable pyridone-based dipeptidyl peptidase-4 inhibitors

Xu, Jinyou ; Wei, Lan ; Mathvink, Robert ; Edmondson, Scott D. ; Mastracchio, Anthony ; Eiermann, George J. ; He, Huaibing ; Leone, Joseph F. ; Leiting, Barbara ; Lyons, Kathryn A. ; Marsilio, Frank ; Patel, Reshma A. ; Petrov, Aleksandr ; Wu, Joseph K. ; Thornberry, Nancy A. ; Weber, Ann E.

Bioorganic & Medicinal Chemistry Letters, 2006, Vol.16(5), pp.1346-1349 [Peer Reviewed Journal]

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