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Canada and the First World War: A Canadian War Museum Internet Exhibition

Cook, Tim ; Lyons, Kathryn

Canadian Military History, Summer 2008, Vol.17(3), p.39 [Peer Reviewed Journal]

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Fosmetpantotenate (RE-024), a phosphopantothenate replacement therapy for pantothenate kinase-associated neurodegeneration: Mechanism of action and efficacy in nonclinical models

Elbaum, Daniel ; Beconi, Maria G ; Monteagudo, Edith ; Di Marco, Annalise ; Quinton, Maria S ; Lyons, Kathryn A ; Vaino, Andrew ; Harper, Steven

PloS one, 2018, Vol.13(3), pp.e0192028 [Peer Reviewed Journal]

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Aminopiperidine sulfonamide Cav2.2 channel inhibitors for the treatment of chronic pain

Shao, Pengcheng P ; Ye, Feng ; Chakravarty, Prasun K ; Varughese, Deepu J ; Herrington, James B ; Dai, Ge ; Bugianesi, Randal M ; Haedo, Rodolfo J ; Swensen, Andrew M ; Warren, Vivien A ; Smith, Mchardy M ; Garcia, Maria L ; Mcmanus, Owen B ; Lyons, Kathryn A ; Li, Xiaohua ; Green, Mitchell ; Jochnowitz, Nina ; Mcgowan, Erin ; Mistry, Shruti ; Sun, Shu-Yu ; Abbadie, Catherine ; Kaczorowski, Gregory J ; Duffy, Joseph L

Journal of medicinal chemistry, 26 November 2012, Vol.55(22), pp.9847-55 [Peer Reviewed Journal]

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The Role of Working Memory in Decoding Emotions

Phillips, Louise H. ; Channon, Shelley ; Tunstall, Mary ; Hedenstrom, Anna ; Lyons, Kathryn

Emotion, 2008, Vol.8(2), pp.184-191 [Peer Reviewed Journal]

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Synthesis and evaluation of [(1 R)-1-amino-2-(2,5-difluorophenyl)ethyl]cyclohexanes and 4-[(1 R)-1-amino-2-(2,5-difluorophenyl)ethyl]piperidines as DPP-4 inhibitors

Chen, Ping ; Caldwell, Charles G ; Ashton, Wallace ; Wu, Joseph K ; He, Huaibing ; Lyons, Kathryn A ; Thornberry, Nancy A ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 2011, Vol.21(6), pp.1880-1886 [Peer Reviewed Journal]

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Pharmacokinetics of memantine in rats and mice

Beconi, Maria G ; Howland, David ; Park, Larry ; Lyons, Kathryn ; Giuliano, Joseph ; Dominguez, Celia ; Munoz-Sanjuan, Ignacio ; Pacifici, Robert

PLoS currents, 15 December 2011, Vol.3, pp.RRN1291

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The discovery of novel 5,6,5- and 5,5,6-tricyclic pyrrolidines as potent and selective DPP-4 inhibitors

Cox, Jason M ; Chu, Hong D ; Kuethe, Jeffrey T ; Gao, Ying-Duo ; Scapin, Giovanna ; Eiermann, George ; He, Huaibing ; Li, Xiaohua ; Lyons, Kathryn A ; Metzger, Joseph ; Petrov, Aleksandr ; Wu, Joseph K ; Xu, Shiyao ; Sinha-Roy, Ranabir ; Weber, Ann E ; Biftu, Tesfaye

Bioorganic & Medicinal Chemistry Letters, 01 June 2016, Vol.26(11), pp.2622-2626 [Peer Reviewed Journal]

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Metabolism and pharmacokinetics of JM6 in mice: JM6 is not a prodrug for Ro-61-8048

Beconi, Maria G ; Yates, Dawn ; Lyons, Kathryn ; Matthews, Kim ; Clifton, Steve ; Mead, Tania ; Prime, Michael ; Winkler, Dirk ; O'Connell, Catherine ; Walter, Daryl ; Toledo-Sherman, Leticia ; Munoz-Sanjuan, Ignacio ; Dominguez, Celia

Drug metabolism and disposition: the biological fate of chemicals, December 2012, Vol.40(12), pp.2297-306 [Peer Reviewed Journal]

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A novel benzazepinone sodium channel blocker with oral efficacy in a rat model of neuropathic pain

Hoyt, Scott B ; London, Clare ; Abbadie, Catherine ; Felix, John P ; Garcia, Maria L ; Jochnowitz, Nina ; Karanam, Bindhu V ; Li, Xiaohua ; Lyons, Kathryn A ; Mcgowan, Erin ; Priest, Birgit T ; Smith, Mchardy M ; Warren, Vivien A ; Thomas-Fowlkes, Brande S ; Kaczorowski, Gregory J ; Duffy, Joseph L

Bioorganic & Medicinal Chemistry Letters, 15 June 2013, Vol.23(12), pp.3640-3645 [Peer Reviewed Journal]

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A single-run liquid chromatography mass spectrometry method to quantify neuroactive kynurenine pathway metabolites in rat plasma

Orsatti, Laura ; Speziale, Roberto ; Orsale, Maria Vittoria ; Caretti, Fulvia ; Veneziano, Maria ; Zini, Matteo ; Monteagudo, Edith ; Lyons, Kathryn ; Beconi, Maria ; Chan, Kelvin ; Herbst, Todd ; Toledo-Sherman, Leticia ; Munoz-Sanjuan, Ignacio ; Bonelli, Fabio ; Dominguez, Celia

Journal of Pharmaceutical and Biomedical Analysis, 25 March 2015, Vol.107, pp.426-431 [Peer Reviewed Journal]

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11
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Pyridinesulfonylureas and pyridinesulfonamides as selective bombesin receptor subtype-3 (BRS-3) agonists

Lo, Michael M.-C ; Chobanian, Harry R ; Palyha, Oksana ; Kan, Yanqing ; Kelly, Theresa M ; Guan, Xiao-Ming ; Reitman, Marc L ; Dragovic, Jasminka ; Lyons, Kathryn A ; Nargund, Ravi P ; Lin, Linus S

Bioorganic & Medicinal Chemistry Letters, 2011, Vol.21(7), pp.2040-2043 [Peer Reviewed Journal]

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Structure–activity-relationship of amide and sulfonamide analogs of omarigliptin

Chen, Ping ; Feng, Dennis ; Qian, Xiaoxia ; Apgar, James ; Wilkening, Robert ; Kuethe, Jeffrey T ; Gao, Ying-Duo ; Scapin, Giovanna ; Cox, Jason ; Doss, George ; Eiermann, George ; He, Huaibing ; Li, Xiaohua ; Lyons, Kathryn A ; Metzger, Joseph ; Petrov, Aleksandr ; Wu, Joseph K ; Xu, Shiyao ; Weber, Ann E ; Yan, Youwei

Bioorganic & Medicinal Chemistry Letters, 15 December 2015, Vol.25(24), pp.5767-5771 [Peer Reviewed Journal]

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Synthesis of 7-benzyl-5-(piperidin-1-yl)-6,7,8,9-tetrahydro-3 H-pyrazolo[3,4- c][2,7]naphthyridin-1-ylamine and its analogs as bombesin receptor subtype-3 agonists

Guo, Cheng ; Guzzo, Peter R ; Hadden, Mark ; Sargent, Bruce J ; Yet, Larry ; Kan, Yanqing ; Palyha, Oksana ; Kelly, Theresa M ; Guan, Xiaoming ; Rosko, Kim ; Gagen, Karen ; Metzger, Joseph M ; Dragovic, Jasminka ; Lyons, Kathryn ; Lin, Linus S ; Nargund, Ravi P

Bioorganic & Medicinal Chemistry Letters, 2010, Vol.20(9), pp.2785-2789 [Peer Reviewed Journal]

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14
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A potent and selective indole N-type calcium channel (Ca v2.2) blocker for the treatment of pain

Tyagarajan, Sriram ; Chakravarty, Prasun K ; Park, Min ; Zhou, Bishan ; Herrington, James B ; Ratliff, Kevin ; Bugianesi, Randall M ; Williams, Brande ; Haedo, Rodolfo J ; Swensen, Andrew M ; Warren, Vivien A ; Smith, Mchardy ; Garcia, Maria ; Kaczorowski, Gregory J ; Mcmanus, Owen B ; Lyons, Kathryn A ; Li, Xiaohua ; Madeira, Maria ; Karanam, Bindhu ; Green, Mitchell

Bioorganic & Medicinal Chemistry Letters, 2011, Vol.21(2), pp.869-873 [Peer Reviewed Journal]

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Improved Cav2.2 Channel Inhibitors through a gem-Dimethylsulfone Bioisostere Replacement of a Labile Sulfonamide

Shao, Pengcheng P ; Ye, Feng ; Chakravarty, Prasun K ; Herrington, James B ; Dai, Ge ; Bugianesi, Randal M ; Haedo, Rodolfo J ; Swensen, Andrew M ; Warren, Vivien A ; Smith, Mchardy M ; Garcia, Maria L ; Mcmanus, Owen B ; Lyons, Kathryn A ; Li, Xiaohua ; Green, Mitchell ; Jochnowitz, Nina ; Mcgowan, Erin ; Mistry, Shruti ; Sun, Shu-Yu ; Abbadie

ACS medicinal chemistry letters, 14 November 2013, Vol.4(11), pp.1064-8 [Peer Reviewed Journal]

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16
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Discovery of MK-5046, a Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity

Sebhat, Iyassu K ; Franklin, Christopher ; Lo, Michael M-C ; Chen, David ; Jewell, James P ; Miller, Randy ; Pang, Jianmei ; Palyha, Oksana ; Kan, Yanqing ; Kelly, Theresa M ; Guan, Xiao-Ming ; Marsh, Donald J ; Kosinski, Jennifer A ; Metzger, Joseph M ; Lyons, Kathryn ; Dragovic, Jasminka ; Guzzo, Peter R ; Henderson, Alan J ; Reitman, Marc L ; Nargund

ACS medicinal chemistry letters, 13 January 2011, Vol.2(1), pp.43-7 [Peer Reviewed Journal]

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17
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A peripherally acting Na(v)1.7 sodium channel blocker reverses hyperalgesia and allodynia on rat models of inflammatory and neuropathic pain

Mcgowan, Erin ; Hoyt, Scott B ; Li, Xiaohua ; Lyons, Kathryn A ; Abbadie, Catherine

Anesthesia and analgesia, September 2009, Vol.109(3), pp.951-8 [Peer Reviewed Journal]

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18
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Discovery of potent and selective dipeptidyl peptidase IV inhibitors derived from beta-aminoamides bearing subsituted triazolopiperazines

Kim, Dooseop ; Kowalchick, Jennifer E ; Brockunier, Linda L ; Parmee, Emma R ; Eiermann, George J ; Fisher, Michael H ; He, Huaibing ; Leiting, Barbara ; Lyons, Kathryn ; Scapin, Giovanna ; Patel, Sangita B ; Petrov, Aleksandr ; Pryor, Kellyann D ; Roy, Ranabir Sinha ; Wu, Joseph K ; Zhang, Xiaoping ; Wyvratt, Matthew J ; Zhang, Bei B ; Zhu, Lan ; Thornberry

Journal of medicinal chemistry, 14 February 2008, Vol.51(3), pp.589-602 [Peer Reviewed Journal]

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19
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Analgesic effects of a substituted N-triazole oxindole (TROX-1), a state-dependent, voltage-gated calcium channel 2 blocker

Abbadie, Catherine ; Mcmanus, Owen B ; Sun, Shu-Yu ; Bugianesi, Randal M ; Dai, Ge ; Haedo, Rodolfo J ; Herrington, James B ; Kaczorowski, Gregory J ; Smith, Mchardy M ; Swensen, Andrew M ; Warren, Vivien A ; Williams, Brande ; Arneric, Stephen P ; Eduljee, Cyrus ; Snutch, Terrance P ; Tringham, Elizabeth W ; Jochnowitz, Nina ; Liang, Annie ; Euan Macintyre, D ; Mcgowan

The Journal of pharmacology and experimental therapeutics, August 2010, Vol.334(2), pp.545-55 [Peer Reviewed Journal]

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20
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Discovery of a novel class of biphenyl pyrazole sodium channel blockers for treatment of neuropathic pain

Tyagarajan, Sriram ; Chakravarty, Prasun K ; Zhou, Bishan ; Taylor, Brett ; Eid, Ronsar ; Fisher, Michael H ; Parsons, William H ; Wyvratt, Mathew J ; Lyons, Kathryn A ; Klatt, Tracy ; Li, Xiaohua ; Kumar, Sanjeev ; Williams, Brande ; Felix, John ; Priest, Birgit T ; Brochu, Richard M ; Warren, Vivien ; Smith, Mchardy ; Garcia, Maria ; Kaczorowski, Gregory J

Bioorganic & Medicinal Chemistry Letters, 2010, Vol.20(24), pp.7479-7482 [Peer Reviewed Journal]

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21
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(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(4-1,2,4triazolo1,5-a-pyridin-6-ylphenyl)butanamide: a selective alpha-amino amide dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes

Edmondson, Scott D ; Mastracchio, Anthony ; Mathvink, Robert J ; He, Jiafang ; Harper, Bart ; Park, You-Jung ; Beconi, Maria ; Di Salvo, Jerry ; Eiermann, George J ; He, Huaibing ; Leiting, Barbara ; Leone, Joseph F ; Levorse, Dorothy A ; Lyons, Kathryn ; Patel, Reshma A ; Patel, Sangita B ; Petrov, Aleksandr ; Scapin, Giovanna ; Shang, Jackie ; Roy

Journal of medicinal chemistry, 15 June 2006, Vol.49(12), pp.3614-27 [Peer Reviewed Journal]

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22
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(2R)-4-oxo-4-3-(trifluoromethyl)-5,6-dihydro1,2,4triazolo4,3-apyrazin-7(8H)-yl-1-(2,4,5-trifluorophenyl)butan-2-amine: a potent, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes

Kim, Dooseop ; Wang, Liping ; Beconi, Maria ; Eiermann, George J ; Fisher, Michael H ; He, Huaibing ; Hickey, Gerard J ; Kowalchick, Jennifer E ; Leiting, Barbara ; Lyons, Kathryn ; Marsilio, Frank ; Mccann, Margaret E ; Patel, Reshma A ; Petrov, Aleksandr ; Scapin, Giovanna ; Patel, Sangita B ; Roy, Ranabir Sinha ; Wu, Joseph K ; Wyvratt, Matthew J ; Zhang

Journal of medicinal chemistry, 13 January 2005, Vol.48(1), pp.141-51 [Peer Reviewed Journal]

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23
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Dipeptidyl peptidase IV inhibition for the treatment of type 2 diabetes: potential importance of selectivity over dipeptidyl peptidases 8 and 9

Lankas, George R ; Leiting, Barbara ; Roy, Ranabir Sinha ; Eiermann, George J ; Beconi, Maria G ; Biftu, Tesfaye ; Chan, Chi-Chung ; Edmondson, Scott ; Feeney, William P ; He, Huaibing ; Ippolito, Dawn E ; Kim, Dooseop ; Lyons, Kathryn A ; Ok, Hyun O ; Patel, Reshma A ; Petrov, Aleksandr N ; Pryor, Kelly Ann ; Qian, Xiaoxia ; Reigle, Leah ; Woods

Diabetes, October 2005, Vol.54(10), pp.2988-94 [Peer Reviewed Journal]

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24
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Highly constrained bicyclic VLA-4 antagonists

Chang, Linda L ; Truong, Quang ; Doss, George A ; Maccoss, Malcolm ; Lyons, Kathryn ; Mccauley, Ermengilda ; Mumford, Richard ; Forrest, Gail ; Vincent, Stella ; Schmidt, John A ; Hagmann, William K

Bioorganic & Medicinal Chemistry Letters, 2007, Vol.17(3), pp.597-601 [Peer Reviewed Journal]

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25
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Dual Targeting of CCR2 and CX3CR1 in an Arterial Injury Model of Vascular Inflammation

Jerath, Maya ; Liu, Peng ; Rojas, Mauricio ; Struthers, Mary ; Demartino, Julie ; Lyons, Kathryn ; Peng, Ruoqi ; Yang, Lihu ; Patel, Dhaval

Clinical Immunology, 2007, Vol.123, pp.S161-S162 [Peer Reviewed Journal]

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26
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Aminopiperidine-fused imidazoles as dipeptidyl peptidase-IV inhibitors

Edmondson, Scott D ; Mastracchio, Anthony ; Cox, Jason M ; Eiermann, George J ; He, Huaibing ; Lyons, Kathryn A ; Patel, Reshma A ; Patel, Sangita B ; Petrov, Aleksandr ; Scapin, Giovanna ; Wu, Joseph K ; Xu, Shiyao ; Zhu, Bing ; Thornberry, Nancy A ; Roy, Ranabir Sinha ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 01 August 2009, Vol.19(15), pp.4097-4101 [Peer Reviewed Journal]

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27
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Design, synthesis, and biological evaluation of triazolopiperazine-based β-amino amides as potent, orally active dipeptidyl peptidase IV (DPP-4) inhibitors

Kowalchick, Jennifer E ; Leiting, Barbara ; Pryor, Kellyann D ; Marsilio, Frank ; Wu, Joseph K ; He, Huaibing ; Lyons, Kathryn A ; Eiermann, George J ; Petrov, Aleksandr ; Scapin, Giovanna ; Patel, Reshma A ; Thornberry, Nancy A ; Weber, Ann E ; Kim, Dooseop

Bioorganic & Medicinal Chemistry Letters, 2007, Vol.17(21), pp.5934-5939 [Peer Reviewed Journal]

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28
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Imidazopiperidine amides as dipeptidyl peptidase IV inhibitors for the treatment of diabetes

Chen, Ping ; Caldwell, Charles G ; Mathvink, Robert J ; Leiting, Barbara ; Marsilio, Frank ; Patel, Reshma A ; Wu, Joseph K ; He, Huaibing ; Lyons, Kathryn A ; Thornberry, Nancy A ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 2007, Vol.17(21), pp.5853-5857 [Peer Reviewed Journal]

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29
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Discovery of 3-aminopiperidines as potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitors

Cox, Jason M ; Harper, Bart ; Mastracchio, Anthony ; Leiting, Barbara ; Sinha Roy, Ranabir ; Patel, Reshma A ; Wu, Joseph K ; Lyons, Kathryn A ; He, Huaibing ; Xu, Shiyao ; Zhu, Bing ; Thornberry, Nancy A ; Weber, Ann E ; Edmondson, Scott D

Bioorganic & Medicinal Chemistry Letters, 15 August 2007, Vol.17(16), pp.4579-4583 [Peer Reviewed Journal]

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30
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Dipeptidyl peptidase IV inhibitors derived from β-aminoacylpiperidines bearing a fused thiazole, oxazole, isoxazole, or pyrazole

Ashton, Wallace T ; Sisco, Rosemary M ; Dong, Hong ; Lyons, Kathryn A ; He, Huaibing ; Doss, George A ; Leiting, Barbara ; Patel, Reshma A ; Wu, Joseph K ; Marsilio, Frank ; Thornberry, Nancy A ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 2005, Vol.15(9), pp.2253-2258 [Peer Reviewed Journal]

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31
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Discovery of potent and selective phenylalanine based dipeptidyl peptidase IV inhibitors

Xu, Jinyou ; Wei, Lan ; Mathvink, Robert ; He, Jiafang ; Park, You-Jung ; He, Huaibing ; Leiting, Barbara ; Lyons, Kathryn A ; Marsilio, Frank ; Patel, Reshma A ; Wu, Joseph K ; Thornberry, Nancy A ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 16 May 2005, Vol.15(10), pp.2533-2536 [Peer Reviewed Journal]

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32
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The discovery of small molecule carbamates as potent dual α 4β 1/α 4β 7 integrin antagonists

Chang, Linda L ; Truong, Quang ; Mumford, Richard A ; Egger, Linda A ; Kidambi, Usha ; Lyons, Kathryn ; Mccauley, Ermengilda ; Van Riper, Gail ; Vincent, Stella ; Schmidt, John A ; Maccoss, Malcolm ; Hagmann, William K

Bioorganic & Medicinal Chemistry Letters, 2002, Vol.12(2), pp.159-163 [Peer Reviewed Journal]

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33
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Discovery of a novel class of isoxazoline voltage gated sodium channel blockers

Shao, Pengcheng P ; Ye, Feng ; Weber, Ann E ; Li, Xiaohua ; Lyons, Kathryn A ; Parsons, William H ; Garcia, Maria L ; Priest, Birgit T ; Smith, Mchardy M ; Felix, John P ; Williams, Brande S ; Kaczorowski, Gregory J ; Mcgowan, Erin ; Abbadie, Catherine ; Martin, William J ; Mcmasters, Daniel R ; Gao, Ying-Duo

Bioorganic & Medicinal Chemistry Letters, 2009, Vol.19(18), pp.5329-5333 [Peer Reviewed Journal]

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34
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Discovery of isoxazole voltage gated sodium channel blockers for treatment of chronic pain

Shao, Pengcheng P ; Ye, Feng ; Weber, Ann E ; Li, Xiaohua ; Lyons, Kathryn A ; Parsons, William H ; Garcia, Maria L ; Priest, Birgit T ; Smith, Mchardy M ; Felix, John P ; Williams, Brande S ; Kaczorowski, Gregory J ; Mcgowan, Erin ; Abbadie, Catherine ; Martin, William J ; Mcmasters, Daniel R ; Gao, Ying-Duo

Bioorganic & Medicinal Chemistry Letters, 2009, Vol.19(18), pp.5334-5338 [Peer Reviewed Journal]

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35
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Imidazopyridines: A novel class of hNa v1.7 channel blockers

London, Clare ; Hoyt, Scott B ; Parsons, William H ; Williams, Brande S ; Warren, Vivien A ; Tschirret-Guth, Richard ; Smith, Mchardy M ; Priest, Birgit T ; Mcgowan, Erin ; Martin, William J ; Lyons, Kathryn A ; Li, Xiaohua ; Karanam, Bindhu V ; Jochnowitz, Nina ; Garcia, Maria L ; Felix, John P ; Dean, Brian ; Abbadie, Catherine ; Kaczorowski, Gregory J ; Duffy, Joseph L

Bioorganic & Medicinal Chemistry Letters, 2008, Vol.18(5), pp.1696-1701 [Peer Reviewed Journal]

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3-Amino-1,5-benzodiazepinones: Potent, state-dependent sodium channel blockers with anti-epileptic activity

Hoyt, Scott B ; London, Clare ; Wyvratt, Matthew J ; Fisher, Michael H ; Cashen, Doreen E ; Felix, John P ; Garcia, Maria L ; Li, Xiaohua ; Lyons, Kathryn A ; Euan Macintyre, D ; Martin, William J ; Priest, Birgit T ; Smith, Mchardy M ; Warren, Vivien A ; Williams, Brande S ; Kaczorowski, Gregory J ; Parsons, William H

Bioorganic & Medicinal Chemistry Letters, 2008, Vol.18(6), pp.1963-1966 [Peer Reviewed Journal]

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