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16 Results  for Everything (Includes Articles)

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1
Applications of Vinylogous Mannich Reactions. Total Syntheses of the Ergot Alkaloids Rugulovasines A and B and Setoclavine
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Applications of Vinylogous Mannich Reactions. Total Syntheses of the Ergot Alkaloids Rugulovasines A and B and Setoclavine

Liras, Spiros ; Lynch, Christopher L. ; Fryer, Andrew M. ; Vu, Binh T. ; Martin, Stephen F.

Journal of the American Chemical Society, 06/2001, Vol.123(25), pp.5918-5924 [Peer Reviewed Journal]

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2
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Application of AlMe 3-mediated amidation reactions to solution phase peptide synthesis

Martin, Stephen F ; Dwyer, Michael P ; Lynch, Christopher L

Tetrahedron Letters, 1998, Vol.39(12), pp.1517-1520 [Peer Reviewed Journal]

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3
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Binding of 2-aryl-4-(piperidin-1-yl)butanamines and 1,3,4-trisubstituted pyrrolidines to human CCR5: a molecular modeling-guided mutagenesis study of the binding pocket

Castonguay, Laurie A ; Weng, Youmin ; Adolfsen, William ; Di Salvo, Jerry ; Kilburn, Ruth ; Caldwell, Charles G ; Daugherty, Bruce L ; Finke, Paul E ; Hale, Jeffrey J ; Lynch, Christopher L ; Mills, Sander G ; Maccoss, Malcolm ; Springer, Martin S ; Demartino, Julie A

Biochemistry, 18 February 2003, Vol.42(6), pp.1544-50 [Peer Reviewed Journal]

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4
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A rational utilization of high-throughput screening affords selective, orally bioavailable 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 receptor agonists

Hale, Jeffrey J ; Lynch, Christopher L ; Neway, William ; Mills, Sander G ; Hajdu, Richard ; Keohane, Carol Ann ; Rosenbach, Mark J ; Milligan, James A ; Shei, Gan-Ju ; Parent, Stephen A ; Chrebet, Gary ; Bergstrom, James ; Card, Deborah ; Ferrer, Marc ; Hodder, Peter ; Strulovici, Berta ; Rosen, Hugh ; Mandala, Suzanne

Journal of medicinal chemistry, 30 December 2004, Vol.47(27), pp.6662-5 [Peer Reviewed Journal]

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5
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CCR5 antagonists: 3-(pyrrolidin-1-yl)propionic acid analogues with potent anti-HIV activity

Lynch, Christopher L ; Hale, Jeffrey J ; Budhu, Richard J ; Gentry, Amy L ; Finke, Paul E ; Caldwell, Charles G ; Mills, Sander G ; Maccoss, Malcolm ; Shen, Dong-Ming ; Chapman, Kevin T ; Malkowitz, Lorraine ; Springer, Martin S ; Gould, Sandra L ; Demartino, Julie A ; Siciliano, Salvatore J ; Cascieri, Margaret A ; Carella, Anthony ; Carver, Gwen ; Holmes, Karen ; Schleif

Organic letters, 10 July 2003, Vol.5(14), pp.2473-5 [Peer Reviewed Journal]

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6
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Discovery of potent 3,5-diphenyl-1,2,4-oxadiazole sphingosine-1-phosphate-1 (S1P1) receptor agonists with exceptional selectivity against S1P2 and S1P3

Li, Zhen ; Chen, Weirong ; Hale, Jeffrey J ; Lynch, Christopher L ; Mills, Sander G ; Hajdu, Richard ; Keohane, Carol Ann ; Rosenbach, Mark J ; Milligan, James A ; Shei, Gan-Ju ; Chrebet, Gary ; Parent, Stephen A ; Bergstrom, James ; Card, Deborah ; Forrest, Michael ; Quackenbush, Elizabeth J ; Wickham, L Alexandra ; Vargas, Hugo ; Evans, Rose M ; Rosen

Journal of medicinal chemistry, 06 October 2005, Vol.48(20), pp.6169-73 [Peer Reviewed Journal]

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7
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Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists

Mandala, Suzanne ; Hajdu, Richard ; Bergstrom, James ; Quackenbush, Elizabeth ; Xie, Jenny ; Milligan, James ; Thornton, Rosemary ; Shei, Gan-Ju ; Card, Deborah ; Keohane, Carolann ; Rosenbach, Mark ; Hale, Jeffrey ; Lynch, Christopher L ; Rupprecht, Kathleen ; Parsons, William ; Rosen, Hugh

Science (New York, N.Y.), 12 April 2002, Vol.296(5566), pp.346-9 [Peer Reviewed Journal]

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8
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2-Aryl(pyrrolidin-4-yl)acetic acids are potent agonists of sphingosine-1-phosphate (S1P) receptors

Yan, Lin ; Budhu, Richard ; Huo, Pei ; Lynch, Christopher L ; Hale, Jeffrey J ; Mills, Sander G ; Hajdu, Richard ; Keohane, Carol A ; Rosenbach, Mark J ; Milligan, James A ; Shei, Gan-Ju ; Chrebet, Gary ; Bergstrom, James ; Card, Deborah ; Mandala, Suzanne M

Bioorganic & Medicinal Chemistry Letters, 01 July 2006, Vol.16(13), pp.3564-3568 [Peer Reviewed Journal]

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9
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Design and synthesis of conformationally constrained 3-(N-alkylamino)propylphosphonic acids as potent agonists of sphingosine-1-phosphate (S1P) receptors

Yan, Lin ; Hale, Jeffrey J ; Lynch, Christopher L ; Budhu, Richard ; Gentry, Amy ; Mills, Sander G ; Hajdu, Richard ; Keohane, Carol Ann ; Rosenbach, Mark J ; Milligan, James A ; Shei, Gan-Ju ; Chrebet, Gary ; Bergstrom, James ; Card, Deborah ; Rosen, Hugh ; Mandala, Suzanne M

Bioorganic & medicinal chemistry letters, 04 October 2004, Vol.14(19), pp.4861-6 [Peer Reviewed Journal]

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Design and synthesis of conformationally constrained 3-( N-alkylamino)propylphosphonic acids as potent agonists of sphingosine-1-phosphate (S1P) receptors

Yan, Lin ; Hale, Jeffrey J ; Lynch, Christopher L ; Budhu, Richard ; Gentry, Amy ; Mills, Sander G ; Hajdu, Richard ; Keohane, Carol Ann ; Rosenbach, Mark J ; Milligan, James A ; Shei, Gan-Ju ; Chrebet, Gary ; Bergstrom, James ; Card, Deborah ; Rosen, Hugh ; Mandala, Suzanne M

Bioorganic & Medicinal Chemistry Letters, 2004, Vol.14(19), pp.4861-4866 [Peer Reviewed Journal]

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11
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Discovery and Design of Novel HSP90 Inhibitors Using Multiple Fragment‐based Design Strategies

Huth, Jeffrey R. ; Park, Chang ; Petros, Andrew M. ; Kunzer, Aaron R. ; Wendt, Michael D. ; Wang, Xilu ; Lynch, Christopher L. ; Mack, Jamey C. ; Swift, Kerry M. ; Judge, Russell A. ; Chen, Jun ; Richardson, Paul L. ; Jin, Sha ; Tahir, Stephen K. ; Matayoshi, Edward D. ; Dorwin, Sarah A. ; Ladror, Uri S. ; Severin, Jean M. ; Walter, Karl A. ; Bartley, Diane M. ; Fesik, Stephen W. ; Elmore, Steven W. ; Hajduk, Philip J.

Chemical Biology & Drug Design, July 2007, Vol.70(1), pp.1-12 [Peer Reviewed Journal]

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12
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Potent 1,3,4-trisubstituted pyrrolidine CCR5 receptor antagonists: effects of fused heterocycles on antiviral activity and pharmacokinetic properties

Kim, Dooseop ; Wang, Liping ; Hale, Jeffrey J ; Lynch, Christopher L ; Budhu, Richard J ; Maccoss, Malcolm ; Mills, Sander G ; Malkowitz, Lorraine ; Gould, Sandra L ; Demartino, Julie A ; Springer, Martin S ; Hazuda, Daria ; Miller, Michael ; Kessler, Joseph ; Hrin, Renee C ; Carver, Gwen ; Carella, Anthony ; Henry, Karen ; Lineberger, Janet ; Schleif, William A ; Emini, Emilio A

Bioorganic & Medicinal Chemistry Letters, 2005, Vol.15(8), pp.2129-2134 [Peer Reviewed Journal]

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13
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Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 2: Discovery of potent, selective, and orally bioavailable compounds

Shen, Dong-Ming ; Shu, Min ; Willoughby, Christopher A ; Shah, Shrenik ; Lynch, Christopher L ; Hale, Jeffrey J ; Mills, Sander G ; Chapman, Kevin T ; Malkowitz, Lorraine ; Springer, Martin S ; Gould, Sandra L ; Demartino, Julie A ; Siciliano, Salvatore J ; Lyons, Kathy ; Pivnichny, James V ; Kwei, Gloria Y ; Carella, Anthony ; Carver, Gwen ; Holmes, Karen ; Schleif, William A

Bioorganic & Medicinal Chemistry Letters, 23 February 2004, Vol.14(4), pp.941-945 [Peer Reviewed Journal]

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14
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CCR5 antagonists: bicyclic isoxazolidines as conformationally constrained N-1-substituted pyrrolidines

Lynch, Christopher L ; Gentry, Amy L ; Hale, Jeffrey J ; Mills, Sander G ; Maccoss, Malcolm ; Malkowitz, Lorraine ; Springer, Martin S ; Gould, Sandra L ; Demartino, Julie A ; Siciliano, Salvatore J ; Cascieri, Margaret A ; Doss, George ; Carella, Anthony ; Carver, Gwen ; Holmes, Karen ; Schleif, William A ; Danzeisen, Renee ; Hazuda, Daria ; Kessler, Joseph ; Lineberger, Janet

Bioorganic & Medicinal Chemistry Letters, 2002, Vol.12(4), pp.677-679 [Peer Reviewed Journal]

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15
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1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 4: Synthesis of N-1 acidic functionality affording analogues with enhanced antiviral activity against HIV

Lynch, Christopher L ; Hale, Jeffrey J ; Budhu, Richard J ; Gentry, Amy L ; Mills, Sander G ; Chapman, Kevin T ; Maccoss, Malcolm ; Malkowitz, Lorraine ; Springer, Martin S ; Gould, Sandra L ; Demartino, Julie A ; Siciliano, Salvatore J ; Cascieri, Margaret A ; Carella, Anthony ; Carver, Gwen ; Holmes, Karen ; Schleif, William A ; Danzeisen, Renee ; Hazuda, Daria ; Kessler, Joseph

Bioorganic & Medicinal Chemistry Letters, 21 October 2002, Vol.12(20), pp.3001-3004 [Peer Reviewed Journal]

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1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists: modifications of the arylpropylpiperidine side chains

Lynch, Christopher L ; Willoughby, Christopher A ; Hale, Jeffrey J ; Holson, Edward J ; Budhu, Richard J ; Gentry, Amy L ; Rosauer, Keith G ; Caldwell, Charles G ; Chen, Ping ; Mills, Sander G ; Maccoss, Malcolm ; Berk, Scott ; Chen, Liya ; Chapman, Kevin T ; Malkowitz, Lorraine ; Springer, Martin S ; Gould, Sandra L ; Demartino, Julie A ; Siciliano, Salvatore J ; Cascieri, Margaret A

Bioorganic & Medicinal Chemistry Letters, 2003, Vol.13(1), pp.119-123 [Peer Reviewed Journal]

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