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8 Results  for Everything (Includes Articles)

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Design and synthesis of prolylcarboxypeptidase (PrCP) inhibitors to validate PrCP as a potential target for obesity

Zhou, Changyou ; Garcia-Calvo, Margareta ; Pinto, Shirly ; Lombardo, Matthew ; Feng, Zhe ; Bender, Kate ; Pryor, Kellyann D ; Bhatt, Urmi R ; Chabin, Renee M ; Geissler, Wayne M ; Shen, Zhu ; Tong, Xinchun ; Zhang, Zhoupeng ; Wong, Kenny K ; Roy, Ranabir Sinha ; Chapman, Kevin T ; Yang, Lihu ; Xiong, Yusheng

Journal of medicinal chemistry, 14 October 2010, Vol.53(19), pp.7251-63 [Peer Reviewed Journal]

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Discovery and development of benzo-[1,2,4]-triazolo-[1,4]-oxazepine GPR142 agonists for the treatment of diabetes

Wilson, Jonathan E ; Kurukulasuriya, Ravi ; Sinz, Christopher ; Lombardo, Matthew ; Bender, Kate ; Parker, Dann ; Sherer, Edward C ; Costa, Melissa ; Dingley, Karen ; Li, Xiaofang ; Mitelman, Stanley ; Tong, Sharon ; Bugianesi, Randal ; Ehrhardt, Anka ; Priest, Birgit ; Ratliff, Kevin ; Ujjainwalla, Feroze ; Nargund, Ravi ; Hagmann, William K ; Edmondson, Scott

Bioorganic & Medicinal Chemistry Letters, 15 June 2016, Vol.26(12), pp.2947-2951 [Peer Reviewed Journal]

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Design, synthesis, and biological evaluation of aminopyrazine derivatives as inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2)

Lin, Songnian ; Malkani, Sunita ; Lombardo, Matthew ; Yang, Lihu ; Mills, Sander G ; Chapman, Kevin ; Thompson, James E ; Zhang, Wen Xiao ; Wang, Ruixiu ; Cubbon, Rose M ; O’neill, Edward A ; Hale, Jeffrey J

Bioorganic & Medicinal Chemistry Letters, 15 November 2015, Vol.25(22), pp.5402-5408 [Peer Reviewed Journal]

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Discovery of a new class of potent prolylcarboxypeptidase inhibitors derived from alanine

Wu, Zhicai ; Yang, Cangming ; Xiong, Yusheng ; Feng, Zhe ; Lombardo, Matthew ; Verras, Andreas ; Chabin, Renee M ; Xu, Suoyu ; Tong, Xinchun ; Xie, Dan ; Lassman, Mike E ; Bhatt, Urmi R ; Garcia-Calvo, Margarita M ; Geissler, Wayne ; Shen, Zhu ; Chen, Qing ; Sinharoy, Ranabir ; Hale, Jeffrey J ; Tata, James R ; Pinto, Shirly ; Shen, Dong-Ming ; Colletti, Steven L

Bioorganic & Medicinal Chemistry Letters, 15 February 2012, Vol.22(4), pp.1774-1778 [Peer Reviewed Journal]

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Corrigendum to “Discovery of benzofuran propanoic acid GPR120 agonists: From uHTS hit to mechanism-based pharmacodynamic effects” [Bioorg. Med. Chem. Lett. 26 (2016) 5724–5728]

Lombardo, Matthew ; Bender, Kate ; London, Clare ; Plotkin, Michael A ; Kirkland, Melissa ; Mane, Joel ; Pachanski, Michele ; Geissler, Wayne ; Cummings, John ; Habulihaz, Bahanu ; Akiyama, Taro E ; Di Salvo, Jerry ; Madeira, Maria ; Pols, Joanna ; Powles, Mary Ann ; Finley, Michael F ; Johnson, Eric ; Roussel, Thomas ; Uebele, Victor N ; Crespo, Alejandro ; Leung, Dennis ; Alleyne, Candice ; Trusca, Dorina ; Lei, Ying ; Howard, Andrew D ; Ujjainwalla, Feroze ; Tata, James R ; Sinz, Christopher J

Bioorganic & Medicinal Chemistry Letters, 01 March 2017, Vol.27(5), pp.1333-1333 [Peer Reviewed Journal]

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Discovery of benzofuran propanoic acid GPR120 agonists: From uHTS hit to mechanism-based pharmacodynamic effects

Lombardo, Matthew ; Bender, Kate ; London, Clare ; Plotkin, Michael A ; Kirkland, Melissa ; Mane, Joel ; Pachanski, Michele ; Geissler, Wayne ; Cummings, John ; Habulihaz, Bahanu ; Akiyama, Taro E ; Di Salvo, Jerry ; Madeira, Maria ; Pols, Joanna ; Powles, Mary Ann ; Finley, Michael F ; Johnson, Eric ; Roussel, Thomas ; Uebele, Victor N ; Crespo, Alejandro ; Leung, Dennis ; Alleyne, Candice ; Trusca, Dorina ; Lei, Ying ; Howard, Andrew D ; Ujjainwalla, Feroze ; Tata, James R ; Sinz, Christopher J

Bioorganic & Medicinal Chemistry Letters, 01 December 2016, Vol.26(23), pp.5724-5728 [Peer Reviewed Journal]

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Design, Synthesis, and Evaluation of Novel and Selective G-protein Coupled Receptor 120 (GPR120) Spirocyclic Agonists

Cox, Jason M ; Chu, Hong D ; Chelliah, Mariappan V ; Debenham, John S ; Eagen, Keith ; Lan, Ping ; Lombardo, Matthew ; London, Clare ; Plotkin, Michael A ; Shah, Unmesh ; Sun, Zhongxiang ; Vaccaro, Henry M ; Venkatraman, Srikanth ; Suzuki, Takao ; Wang, Nengxue ; Ashley, Eric R ; Crespo, Alejandro ; Madeira, Maria ; Leung, Dennis H ; Alleyne, Candice ; Ogawa, Aimie M ; Souza, Sarah ; Thomas-Fowlkes, Brande ; Di Salvo, Jerry ; Weinglass, Adam ; Kirkland, Melissa ; Pachanski, Michele ; Powles, Mary Ann ; Tozzo, Effie ; Akiyama, Taro E ; Ujjainwalla, Feroze ; Tata, James R ; Sinz, Christopher J

ACS medicinal chemistry letters, 12 January 2017, Vol.8(1), pp.49-54 [Peer Reviewed Journal]

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Novel 1-(2-aminopyrazin-3-yl)methyl-2-thioureas as potent inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2)

Lin, Songnian ; Lombardo, Matthew ; Malkani, Sunita ; Hale, Jeffrey J ; Mills, Sander G ; Chapman, Kevin ; Thompson, James E ; Zhang, Wen Xiao ; Wang, Ruixiu ; Cubbon, Rose M ; O’neill, Edward A ; Luell, Silvi ; Carballo-Jane, Ester ; Yang, Lihu

Bioorganic & Medicinal Chemistry Letters, 2009, Vol.19(12), pp.3238-3242 [Peer Reviewed Journal]

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