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QSAR studies on BK channel activators

Coi, Alessio ; Fiamingo, Francesca Lidia ; Livi, Oreste ; Calderone, Vincenzo ; Martelli, Alma ; Massarelli, Ilaria ; Bianucci, Anna Maria

Bioorganic & Medicinal Chemistry, 2009, Vol.17(1), pp.319-325 [Peer Reviewed Journal]

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2
Novel 3-Aralkyl-7-(amino-substituted)-1,2,3-triazolo[4,5- d ]pyrimidines with High Affinity toward A 1 Adenosine Receptors
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Novel 3-Aralkyl-7-(amino-substituted)-1,2,3-triazolo[4,5- d ]pyrimidines with High Affinity toward A 1 Adenosine Receptors

Betti, Laura ; Biagi, Giuliana ; Giannaccini, Gino ; Giorgi, Irene ; Livi, Oreste ; Lucacchini, Antonio ; Manera, Clementina ; Scartoni, Valerio

Journal of Medicinal Chemistry, 02/1998, Vol.41(5), pp.668-673 [Peer Reviewed Journal]

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3
Synthesis and Biological Evaluation of New Imidazole, Pyrimidine, and Purine Derivatives and Analogs as Inhibitors of Xanthine Oxidase
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Synthesis and Biological Evaluation of New Imidazole, Pyrimidine, and Purine Derivatives and Analogs as Inhibitors of Xanthine Oxidase

Biagi, Giuliana ; Costantini, Alberto ; Costantino, Luca ; Giorgi, Irene ; Livi, Oreste ; Pecorari, Piergiorgio ; Rinaldi, Marcella ; Scartoni, Valerio

Journal of Medicinal Chemistry, 01/1996, Vol.39(13), pp.2529-2535 [Peer Reviewed Journal]

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2,9-Disubstituted- N 6-(arylcarbamoyl)-8-azaadenines as new selective A 3 adenosine receptor antagonists: Synthesis, biochemical and molecular modelling studies

Biagi, Giuliana ; Bianucci, Anna Maria ; Coi, Alessio ; Costa, Barbara ; Fabbrini, Laura ; Giorgi, Irene ; Livi, Oreste ; Micco, Iolanda ; Pacchini, Federica ; Santini, Edoardo ; Leonardi, Michele ; Nofal, Fatena Ahmad ; Salerni, Oreste Leroy ; Scartoni, Valerio

Bioorganic & Medicinal Chemistry, 2005, Vol.13(15), pp.4679-4693 [Peer Reviewed Journal]

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New N 6 ‐substituted 8‐alkyl‐2‐phenylmethylsulfanyl‐adenines. II

Biagi, Giuliana ; Giorgi, Irene ; Livi, Oreste ; Pacchini, Federica ; Scartoni, Valerio ; Salerni, Oreste Leroy

Journal of Heterocyclic Chemistry, July 2004, Vol.41(4), pp.581-585 [Peer Reviewed Journal]

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New N 6 -substituted 8-alkyl-2-phenylmethylsulfanyl-adenines. II
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New N 6 -substituted 8-alkyl-2-phenylmethylsulfanyl-adenines. II

Biagi, Giuliana ; Giorgi, Irene ; Livi, Oreste ; Pacchini, Federica ; Scartoni, Valerio ; Salerni, Oreste Leroy

Journal of Heterocyclic Chemistry, 07/2004, Vol.41(4), pp.581-585 [Peer Reviewed Journal]

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1,5-Diarylsubstituted 1,2,3-triazoles as potassium channel activators. VI

Biagi, Giuliana ; Calderone, Vincenzo ; Giorgi, Irene ; Livi, Oreste ; Martinotti, Enrica ; Martelli, Alma ; Nardi, Antonio

Il Farmaco, 2004, Vol.59(5), pp.397-404 [Peer Reviewed Journal]

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Preparation of new N 6 , 9‐disubstituted 2‐phenyl‐adenines and corresponding 8‐azaadenines.: A feasibility study for application to solid‐phase Synthesis. I

Biagi, Giuliana ; Giorgi, Irene ; Livi, Oreste ; Pacchini, Federica ; Scartoni, Valerio ; Salerni, Oreste Leroy

Journal of Heterocyclic Chemistry, July 2004, Vol.41(4), pp.575-580 [Peer Reviewed Journal]

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Preparation of new N 6 , 9-disubstituted 2-phenyl-adenines and corresponding 8-azaadenines.: A feasibility study for application to solid-phase Synthesis. I
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Preparation of new N 6 , 9-disubstituted 2-phenyl-adenines and corresponding 8-azaadenines.: A feasibility study for application to solid-phase Synthesis. I

Biagi, Giuliana ; Giorgi, Irene ; Livi, Oreste ; Pacchini, Federica ; Scartoni, Valerio ; Salerni, Oreste Leroy

Journal of Heterocyclic Chemistry, 07/2004, Vol.41(4), pp.575-580 [Peer Reviewed Journal]

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10
New 1,2,3-triazolo[4,5- d ]1,2,4-triazolo[3,4- b ]pyridazine derivatives II
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New 1,2,3-triazolo[4,5- d ]1,2,4-triazolo[3,4- b ]pyridazine derivatives II

Biagi, Giuliana ; Ciambrone, Fabio ; Giorgi, Irene ; Livi, Oreste ; Scartoni, Valerio ; Barili, Pier Luigi

Journal of Heterocyclic Chemistry, 09/2002, Vol.39(5), pp.889-893 [Peer Reviewed Journal]

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New 1,2,3‐triazolo[4,5‐ e ]1,2,4‐triazolo[4,3‐ c ]pyrimidine derivatives II

Biagi, Giuliana ; Giorgi, Irene ; Livi, Oreste ; Pacchini, Federica ; Scartoni, Valerio

Journal of Heterocyclic Chemistry, September 2002, Vol.39(5), pp.885-888 [Peer Reviewed Journal]

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12
New 1,2,3-triazolo[4,5- e ]1,2,4-triazolo[4,3- c ]pyrimidine derivatives II
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New 1,2,3-triazolo[4,5- e ]1,2,4-triazolo[4,3- c ]pyrimidine derivatives II

Biagi, Giuliana ; Giorgi, Irene ; Livi, Oreste ; Pacchini, Federica ; Scartoni, Valerio

Journal of Heterocyclic Chemistry, 09/2002, Vol.39(5), pp.885-888 [Peer Reviewed Journal]

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13
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New 5-substituted-1-(2-hydroxybenzoyl)-benzotriazoles, potassium channel activators. IV

Biagi, Giuliana ; Giorgi, Irene ; Livi, Oreste ; Scartoni, Valerio ; Barili, Pier Luigi ; Calderone, Vincenzo ; Martinotti, Enrica

Il Farmaco, 2001, Vol.56(11), pp.827-834 [Peer Reviewed Journal]

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14
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2-Alkyloxyalkylthiohypoxanthines as new potent inhibitors of xanthine oxidase

Biagi, Giuliana ; Giorgi, Irene ; Pacchini, Federica ; Livi, Oreste ; Scartoni, Valerio

Il Farmaco, 2001, Vol.56(11), pp.809-813 [Peer Reviewed Journal]

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15
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New 2-(2′-phenyl-9′-benzyl-8′-azapurin-6′-ylamino)-carboxylic acid methylesters as ligands for A 1 adenosine receptors

Biagi, Giuliana ; Giorgi, Irene ; Pacchini, Federica ; Livi, Oreste ; Scartoni, Valerio

Il Farmaco, 2001, Vol.56(12), pp.929-931 [Peer Reviewed Journal]

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16
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Some structural changes on triazolyl-benzotriazoles and triazolyl-benzimidazolones as potential potassium channel activators. III

Biagi, Giuliana ; Calderone, Vincenzo ; Giorgi, Irene ; Livi, Oreste ; Scartoni, Valerio ; Baragatti, Barbara ; Martinotti, Enrica

Il Farmaco, 2001, Vol.56(11), pp.841-849 [Peer Reviewed Journal]

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17
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Characterization and preliminary use of 1-, 2- and 3-methyl-5-phenyl-7-chloro-1,2,3-triazolo[4,5-d]pyrimidine as reaction intermediates

Biagi, Giuliana ; Giorgi, Irene ; Livi, Oreste ; Scartoni, Valerio ; Barili, Pier Luigi

Il Farmaco, 2003, Vol.58(8), pp.551-556 [Peer Reviewed Journal]

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18
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N6-Cycloalkyl-2-phenyl-3-deaza-8-azaadenines: a new class of A 1 adenosine receptor ligands. A comparison with the corresponding adenines and 8-azaadenines

Biagi, Giuliana ; Giorgi, Irene ; Livi, Oreste ; Nardi, Antonio ; Pacchini, Federica ; Scartoni, Valerio ; Lucacchini, Antonio

European Journal of Medicinal Chemistry, 2003, Vol.38(11), pp.983-990 [Peer Reviewed Journal]

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19
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New 1,2,3‐triazolo[4,5‐ d ]1,2,4‐triazolo[3,4‐ b ]pyridazine derivatives II

Biagi, Giuliana ; Ciambrone, Fabio ; Giorgi, Irene ; Livi, Oreste ; Scartoni, Valerio ; Barili, Pier Luigi

Journal of Heterocyclic Chemistry, September 2002, Vol.39(5), pp.889-893 [Peer Reviewed Journal]

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20
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Triazolylbenzimidazolthiones and derivatives of the new 1,2,3‐triazolo[ 1,5‐ a ][ 1,3,5]benzotriazepine heterocycle

Biagi, Giuliana ; Giorgi, Irene ; Livi, Oreste ; Nardi, Antonio ; Scartoni, Valerio

Journal of Heterocyclic Chemistry, November 2002, Vol.39(6), pp.1293-1298 [Peer Reviewed Journal]

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21
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New 1,2,3-triazolo[1,5-a]quinoxalines: synthesis and binding to benzodiazepine and adenosine receptors. II

Biagi, Giuliana ; Giorgi, Irene ; Livi, Oreste ; Scartoni, Valerio ; Betti, Laura ; Giannaccini, Gino ; Trincavelli, Maria Letizia

European Journal of Medicinal Chemistry, 2002, Vol.37(7), pp.565-571 [Peer Reviewed Journal]

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22
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1,2,3-Triazol-carboxanilides and 1,2,3-triazol-( N-benzyl)-carboxamides as BK-potassium channel activators. XII

Calderone, Vincenzo ; Fiamingo, Francesca Lidia ; Amato, Gabriella ; Giorgi, Irene ; Livi, Oreste ; Martelli, Alma ; Martinotti, Enrica

European Journal of Medicinal Chemistry, 2008, Vol.43(11), pp.2618-2626 [Peer Reviewed Journal]

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23
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New amido derivatives as potential BKCa potassium channel activators. XI

Calderone, Vincenzo ; Fiamingo, Francesca Lidia ; Amato, Gabriella ; Giorgi, Irene ; Livi, Oreste ; Martelli, Alma ; Martinotti, Enrica

European Journal of Medicinal Chemistry, 2008, Vol.43(4), pp.792-799 [Peer Reviewed Journal]

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24
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Synthesis of new 2-phenyladenines and 2-phenylpteridines and biological evaluation as adenosine receptor ligands

Giorgi, Irene ; Biagi, Giuliana ; Livi, Oreste ; Leonardi, Michele ; Scartoni, Valerio ; Pietra, Daniele

Archiv der Pharmazie, February 2007, Vol.340(2), pp.81-7 [Peer Reviewed Journal]

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25
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Synthesis of New 2‐Phenyladenines and 2‐Phenylpteridines and Biological Evaluation as Adenosine Receptor Ligands

Giorgi, Irene ; Biagi, Giuliana ; Livi, Oreste ; Leonardi, Michele ; Scartoni, Valerio ; Pietra, Daniele

Archiv der Pharmazie, February 2007, Vol.340(2), pp.81-87 [Peer Reviewed Journal]

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26
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Heterocyclic analogs of benzanilide derivatives as potassium channel activators. IX

Calderone, Vincenzo ; Fiamingo, Francesca Lidia ; Giorgi, Irene ; Leonardi, Michele ; Livi, Oreste ; Martelli, Alma ; Martinotti, Enrica

European Journal of Medicinal Chemistry, 2006, Vol.41(6), pp.761-767 [Peer Reviewed Journal]

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27
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1,4- and 2,4-substituted-1,2,3-triazoles as potential potassium channel activators. VII

Calderone, Vincenzo ; Giorgi, Irene ; Livi, Oreste ; Martinotti, Enrica ; Martelli, Alma ; Nardi, Antonio

Il Farmaco, 2005, Vol.60(5), pp.367-375 [Peer Reviewed Journal]

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28
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New C(2)‐substituted 8‐alkylsulfanyl‐9‐phenylmethyl‐hypoxanthines III

Biagi, Giuliana ; Giorgi, Irene ; Livi, Oreste ; Pacchini, Federica ; Scartoni, Valerio ; Salerni, Oreste Leroy

Journal of Heterocyclic Chemistry, July 2005, Vol.42(5), pp.743-749 [Peer Reviewed Journal]

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29
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Benzoyl and/or benzyl substituted 1,2,3-triazoles as potassium channel activators. VIII

Calderone, Vincenzo ; Giorgi, Irene ; Livi, Oreste ; Martinotti, Enrica ; Mantuano, Elisabetta ; Martelli, Alma ; Nardi, Antonio

European Journal of Medicinal Chemistry, 2005, Vol.40(6), pp.521-528 [Peer Reviewed Journal]

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30
New C(2)-substituted 8-alkylsulfanyl-9-phenylmethyl-hypoxanthines III
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New C(2)-substituted 8-alkylsulfanyl-9-phenylmethyl-hypoxanthines III

Biagi, Giuliana ; Giorgi, Irene ; Livi, Oreste ; Pacchini, Federica ; Scartoni, Valerio ; Salerni, Oreste Leroy

Journal of Heterocyclic Chemistry, 07/2005, Vol.42(5), pp.743-749 [Peer Reviewed Journal]

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31
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Benzoyl and/or benzyl substituted 1,2,3-triazoles as potassium channel activators. VIII

Calderone, Vincenzo ; Giorgi, Irene ; Livi, Oreste ; Martinotti, Enrica ; Mantuano, Elisabetta ; Martelli, Alma ; Nardi, Antonio

European journal of medicinal chemistry, June 2005, Vol.40(6), pp.521-8 [Peer Reviewed Journal]

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32
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Synthesis and biological activity of novel substituted benzanilides as potassium channel activators. V

Biagi, Giuliana ; Giorgi, Irene ; Livi, Oreste ; Nardi, Antonio ; Calderone, Vincenzo ; Martelli, Alma ; Martinotti, Enrica ; Leroy Salerni, Oreste

European Journal of Medicinal Chemistry, 2004, Vol.39(6), pp.491-498 [Peer Reviewed Journal]

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33
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erythro- and threo-2-Hydroxynonyl substituted 2-phenyladenines and 2-phenyl-8-azaadenines: ligands for A 1 adenosine receptors and adenosine deaminase

Biagi, Giuliana ; Giorgi, Irene ; Livi, Oreste ; Pacchini, Federica ; Rum, Pietro ; Scartoni, Valerio ; Costa, Barbara ; Mazzoni, Maria Rosa ; Giusti, Laura

Il Farmaco, 2002, Vol.57(3), pp.221-233 [Peer Reviewed Journal]

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34
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New N 6- or N(9)-hydroxyalkyl substituted 8-azaadenines or adenines as effective A 1 adenosine receptor ligands

Biagi, Giuliana ; Giorgi, Irene ; Leonardi, Michele ; Livi, Oreste ; Pacchini, Federica ; Scartoni, Valerio ; Costa, Barbara ; Lucacchini, Antonio

European Journal of Medicinal Chemistry, 2003, Vol.38(9), pp.801-810 [Peer Reviewed Journal]

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35
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N 6-1,3-Diphenylurea derivatives of 2-phenyl-9-benzyladenines and 8-azaadenines: Synthesis and biological evaluation as allosteric modulators of A 2A adenosine receptors

Giorgi, Irene ; Biagi, Giuliana ; Bianucci, Anna Maria ; Borghini, Alice ; Livi, Oreste ; Leonardi, Michele ; Pietra, Daniele ; Calderone, Vincenzo ; Martelli, Alma

European Journal of Medicinal Chemistry, 2008, Vol.43(8), pp.1639-1647 [Peer Reviewed Journal]

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36
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1,2,3‐Triazolo[4,5‐ e ]‐1,2,4‐triazolo[3,4‐ c ]pyrimidines

Biagi, Giuliana ; Giorgi, Irene ; Livi, Oreste ; Manera, Clementina ; Scartoni, Valerio

Journal of Heterocyclic Chemistry, September 1999, Vol.36(5), pp.1195-1198 [Peer Reviewed Journal]

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37
1,2,3-Triazolo[4,5- e ]-1,2,4-triazolo[3,4- c ]pyrimidines
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1,2,3-Triazolo[4,5- e ]-1,2,4-triazolo[3,4- c ]pyrimidines

Biagi, Giuliana ; Giorgi, Irene ; Livi, Oreste ; Manera, Clementina ; Scartoni, Valerio

Journal of Heterocyclic Chemistry, 09/1999, Vol.36(5), pp.1195-1198 [Peer Reviewed Journal]

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