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18 Results  for Everything (Includes Articles)

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The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1)

Garcia-Calvo, Margarita ; Lisnock, Jeanmarie ; Bull, Herbert G ; Hawes, Brian E ; Burnett, Duane A ; Braun, Matthew P ; Crona, James H ; Davis, Harry R ; Dean, Dennis C ; Detmers, Patricia A ; Graziano, Michael P ; Hughes, Meredith ; Macintyre, D Euan ; Ogawa, Anthony ; O'Neill, Kim A ; Iyer, Sai Prasad N ; Shevell, Diane E ; Smith, Marsha M ; Tang, Yui S ; Makarewicz, Amanda M ; Ujjainwalla, Feroze ; Altmann, Scott W ; Chapman, Kevin T ; Thornberry, Nancy A

Proceedings of the National Academy of Sciences of the United States of America, 07 June 2005, Vol.102(23), pp.8132-7 [Peer Reviewed Journal]

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Spiroimidazolidinone NPC1L1 inhibitors. Part 2: Structure–activity studies and in vivo efficacy

Howell, Kobporn L ; Devita, Robert J ; Garcia-Calvo, Margarita ; Meurer, Roger D ; Lisnock, Jeanmarie ; Bull, Herbert G ; Mcmasters, Daniel R ; Mccann, Margaret E ; Mills, Sander G

Bioorganic & Medicinal Chemistry Letters, 2010, Vol.20(23), pp.6929-6932 [Peer Reviewed Journal]

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Pyrazoles as non-classical bioisosteres in prolylcarboxypeptidase (PrCP) inhibitors

Graham, Thomas H ; Shu, Min ; Verras, Andreas ; Chen, Qing ; Garcia-Calvo, Margarita ; Li, Xiaohua ; Lisnock, Jeanmarie ; Tong, Xinchun ; Tung, Elaine C ; Wiltsie, Judyann ; Hale, Jeffrey J ; Pinto, Shirly ; Shen, Dong-Ming

Bioorganic & Medicinal Chemistry Letters, 01 April 2014, Vol.24(7), pp.1657-1660 [Peer Reviewed Journal]

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Mineralocorticoid receptor antagonists: Identification of heterocyclic amide replacements in the oxazolidinedione series

Cox, Jason M ; Chu, Hong D ; Yang, Christine ; Shen, Hong C ; Wu, Zhicai ; Balsells, Jaume ; Crespo, Alejandro ; Brown, Patricia ; Zamlynny, Beata ; Wiltsie, Judyann ; Clemas, Joseph ; Gibson, Jack ; Contino, Lisa ; Lisnock, Jeanmarie ; Zhou, Gaochao ; Garcia-Calvo, Margarita ; Bateman, Thomas ; Xu, Ling ; Tong, Xinchun ; Crook, Martin ; Sinclair, Peter

Bioorganic & Medicinal Chemistry Letters, 01 April 2014, Vol.24(7), pp.1681-1684 [Peer Reviewed Journal]

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A new class of prolylcarboxypeptidase inhibitors, Part 2: The aminocyclopentanes

Graham, Thomas H ; Liu, Wensheng ; Verras, Andreas ; Reibarkh, Mikhail ; Bleasby, Kelly ; Bhatt, Urmi R ; Chen, Qing ; Garcia-Calvo, Margarita ; Geissler, Wayne M ; Gorski, Judith N ; He, Huaibing ; Lassman, Michael E ; Lisnock, Jeanmarie ; Li, Xiaohua ; Shen, Zhu ; Tong, Xinchun ; Tung, Elaine C ; Wiltsie, Judyann ; Xie, Dan ; Xu, Suoyu ; Xiao, Jianying ; Hale, Jeffrey J ; Pinto, Shirly ; Shen, Dong-Ming

Bioorganic & Medicinal Chemistry Letters, 15 April 2012, Vol.22(8), pp.2818-2822 [Peer Reviewed Journal]

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Discovery of novel non-steroidal reverse indole mineralocorticoid receptor antagonists

Ogawa, Anthony K ; Bunte, Ellen Vande ; Mal, Rudrajit ; Lan, Ping ; Sun, Zhongxiang ; Crespo, Alejandro ; Wiltsie, Judyann ; Clemas, Joseph ; Gibson, Jack ; Contino, Lisa ; Lisnock, Jeanmarie ; Zhou, Gaochao ; Garcia-Calvo, Margarita ; Jochnowitz, Nina ; Ma, Xiuying ; Pan, Yi ; Brown, Patricia ; Zamlynny, Beata ; Bateman, Thomas ; Leung, Dennis ; Xu, Ling ; Tong, Xinchun ; Liu, Kun ; Crook, Martin ; Sinclair, Peter

Bioorganic & Medicinal Chemistry Letters, 15 June 2016, Vol.26(12), pp.2866-2869 [Peer Reviewed Journal]

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Discovery of novel oxazolidinedione derivatives as potent and selective mineralocorticoid receptor antagonists

Yang, Christine ; Shen, Hong C ; Wu, Zhicai ; Chu, Hong D ; Cox, Jason M ; Balsells, Jaume ; Crespo, Alejandro ; Brown, Patricia ; Zamlynny, Beata ; Wiltsie, Judyann ; Clemas, Joseph ; Gibson, Jack ; Contino, Lisa ; Lisnock, Jeanmarie ; Zhou, Gaochao ; Garcia-Calvo, Margarita ; Bateman, Tom ; Xu, Ling ; Tong, Xinchun ; Crook, Martin ; Sinclair, Peter

Bioorganic & Medicinal Chemistry Letters, 01 August 2013, Vol.23(15), pp.4388-4392 [Peer Reviewed Journal]

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Activation of JNK3α1 Requires both MKK4 and MKK7:  Kinetic Characterization of in Vitro Phosphorylated JNK3α1
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Activation of JNK3α1 Requires both MKK4 and MKK7:  Kinetic Characterization of in Vitro Phosphorylated JNK3α1

Lisnock, Jeanmarie ; Griffin, Patrick ; Calaycay, Jimmy ; Frantz, Betsy ; Parsons, Janey ; O'Keefe, Stephen J. ; Lograsso, Philip

Biochemistry, 03/2000, Vol.39(11), pp.3141-3148 [Peer Reviewed Journal]

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Discovery of benzimidazole oxazolidinediones as novel and selective nonsteroidal mineralocorticoid receptor antagonists

Yang, Christine ; Balsells, Jaume ; Chu, Hong D ; Cox, Jason M ; Crespo, Alejandro ; Ma, Xiuying ; Contino, Lisa ; Brown, Patricia ; Gao, Sheng ; Zamlynny, Beata ; Wiltsie, Judyann ; Clemas, Joseph ; Lisnock, Jeanmarie ; Gibson, Jack ; Zhou, Gaochao ; Garcia-Calvo, Margarita ; Bateman, Thomas J ; Tong, Vincent ; Xu, Ling ; Crook, Martin ; Sinclair, Peter ; Shen, Hong C

ACS medicinal chemistry letters, 09 April 2015, Vol.6(4), pp.461-5 [Peer Reviewed Journal]

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Discovery and optimization of orally active cyclohexane-based prolylcarboxypeptidase (PrCP) inhibitors

Debenham, John S ; Graham, Thomas H ; Verras, Andreas ; Zhang, Yong ; Clements, Matthew J ; Kuethe, Jeffrey T ; Madsen-Duggan, Christina ; Liu, Wensheng ; Bhatt, Urmi R ; Chen, Dunlu ; Chen, Qing ; Garcia-Calvo, Margarita ; Geissler, Wayne M ; He, Huaibing ; Li, Xiaohua ; Lisnock, Jeanmarie ; Shen, Zhu ; Tong, Xinchun ; Tung, Elaine C ; Wiltsie, Judyann ; Xu, Suoyu ; Hale, Jeffrey J ; Pinto, Shirly ; Shen, Dong-Ming

Bioorganic & Medicinal Chemistry Letters, 01 December 2013, Vol.23(23), pp.6228-6233 [Peer Reviewed Journal]

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A new class of prolylcarboxypeptidase inhibitors, Part 1: Discovery and evaluation

Graham, Thomas H ; Liu, Wensheng ; Verras, Andreas ; Sebhat, Iyassu K ; Xiong, Yusheng ; Bleasby, Kelly ; Bhatt, Urmi R ; Chen, Qing ; Garcia-Calvo, Margarita ; Geissler, Wayne M ; Gorski, Judith N ; He, Huaibing ; Lassman, Michael E ; Lisnock, Jeanmarie ; Li, Xiaohua ; Shen, Zhu ; Tong, Xinchun ; Tung, Elaine C ; Wiltsie, Judyann ; Xiao, Jianying ; Xie, Dan ; Xu, Suoyu ; Hale, Jeffrey J ; Pinto, Shirly ; Shen, Dong-Ming

Bioorganic & Medicinal Chemistry Letters, 15 April 2012, Vol.22(8), pp.2811-2817 [Peer Reviewed Journal]

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Potent DGAT1 Inhibitors in the Benzimidazole Class with a Pyridyl-oxy-cyclohexanecarboxylic Acid Moiety

He, Shuwen ; Hong, Qingmei ; Lai, Zhong ; Wu, Zhicai ; Yu, Yang ; Kim, David W ; Ting, Pauline C ; Kuethe, Jeffrey T ; Yang, Ginger X ; Jian, Tianying ; Liu, Jian ; Guiadeen, Deodial ; Krikorian, Arto D ; Sperbeck, Donald M ; Sonatore, Lisa M ; Wiltsie, Judyann ; Chung, Christine C ; Gibson, Jack T ; Lisnock, Jeanmarie ; Murphy, Beth A ; Gorski, Judith N ; Liu, Jinqi ; Chen, Dunlu ; Chen, Xiaoli ; Wolff, Michael ; Tong, Sharon X ; Madeira, Maria ; Karanam, Bindhu V ; Shen, Dong-Ming ; Balkovec, James M ; Pinto, Shirly ; Nargund, Ravi P ; Devita, Robert J

ACS medicinal chemistry letters, 08 August 2013, Vol.4(8), pp.773-8 [Peer Reviewed Journal]

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Discovery of a Potent and Selective DGAT1 Inhibitor with a Piperidinyl-oxy-cyclohexanecarboxylic Acid Moiety

He, Shuwen ; Hong, Qingmei ; Lai, Zhong ; Yang, David X ; Ting, Pauline C ; Kuethe, Jeffrey T ; Cernak, Timothy A ; Dykstra, Kevin D ; Sperbeck, Donald M ; Wu, Zhicai ; Yu, Yang ; Yang, Ginger X ; Jian, Tianying ; Liu, Jian ; Guiadeen, Deodial ; Krikorian, Arto D ; Sonatore, Lisa M ; Wiltsie, Judyann ; Liu, Jinqi ; Gorski, Judith N ; Chung, Christine C ; Gibson, Jack T ; Lisnock, Jeanmarie ; Xiao, Jianying ; Wolff, Michael ; Tong, Sharon X ; Madeira, Maria ; Karanam, Bindhu V ; Shen, Dong-Ming ; Balkovec, James M ; Pinto, Shirly ; Nargund, Ravi P ; Devita, Robert J

ACS medicinal chemistry letters, 09 October 2014, Vol.5(10), pp.1082-7 [Peer Reviewed Journal]

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Molecular Basis for p38 Protein Kinase Inhibitor Specificity
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Molecular Basis for p38 Protein Kinase Inhibitor Specificity

Lisnock, Jeanmarie ; Tebben, Andy ; Frantz, Betsy ; O'Neill, Edward A. ; Croft, Gist ; O'Keefe, Stephen J. ; Li, Bing ; Hacker, Candice ; de Laszlo, Stephen ; Smith, Anthony ; Libby, Brian ; Liverton, Nigel ; Hermes, Jeffrey ; Lograsso, Philip

Biochemistry, 03/1999, Vol.38(11), pp.3456-3456 [Peer Reviewed Journal]

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Molecular Basis for p38 Protein Kinase Inhibitor Specificity
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Molecular Basis for p38 Protein Kinase Inhibitor Specificity

Lisnock, Jeanmarie ; Tebben, Andy ; Frantz, Betsy ; O'Neill, Edward A. ; Croft, Gist ; O'Keefe, Stephen J. ; Li, Bing ; Hacker, Candice ; de Laszlo, Stephen ; Smith, Anthony ; Libby, Brian ; Liverton, Nigel ; Hermes, Jeffrey ; Lograsso, Philip

Biochemistry, 11/1998, Vol.37(47), pp.16573-16581 [Peer Reviewed Journal]

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Spiroimidazolidinone NPC1L1 inhibitors. 1: Discovery by 3D-similarity-based virtual screening

Mcmasters, Daniel R ; Garcia-Calvo, Margarita ; Maiorov, Vladimir ; Mccann, Margaret E ; Meurer, Roger D ; Bull, Herbert G ; Lisnock, Jeanmarie ; Howell, Kobporn L ; Devita, Robert J

Bioorganic & Medicinal Chemistry Letters, 01 June 2009, Vol.19(11), pp.2965-2968 [Peer Reviewed Journal]

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Multiple strategies for the preparation of a sulfur-35 labeled NPC1L1 radioligand

Simeone, Joseph P ; Braun, Matthew P ; Leone, Joseph F ; Lin, Peter ; Devita, Robert J ; Garcia-Calvo, Margarita ; Bull, Herb G ; Lisnock, Jeanmarie ; Dean, Dennis C

Bioorganic & Medicinal Chemistry Letters, 2009, Vol.19(17), pp.5033-5036 [Peer Reviewed Journal]

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A target for cholesterol absorption inhibitors in the enterocyte brush border membrane

Detmers, Patricia A ; Patel, Sushma ; Hernandez, Melba ; Montenegro, Judy ; Lisnock, Jeanmarie ; Pikounis, Bill ; Steiner, Mark ; Kim, Dooseop ; Sparrow, Carl ; Chao, Yu-Sheng ; Wright, Samuel D

BBA - Molecular and Cell Biology of Lipids, 2000, Vol.1486(2), pp.243-252 [Peer Reviewed Journal]

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