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Chemistry and Biology of Cylindrols: Novel Inhibitors of Ras Farnesyl-Protein Transferase from Cylindrocarpon lucidum

Singh, Sheo B ; Ball, Richard G ; Bills, Gerald F ; Cascales, Carmen ; Gibbs, Jackson B ; Goetz, Michael A ; Hoogsteen, Karst ; Jenkins, Rosalind G ; Liesch, Jerrold M ; Lingham, Russell B ; Silverman, Keith C ; Zink, Deborah L

The Journal of organic chemistry, 01 November 1996, Vol.61(22), pp.7727-7737 [Peer Reviewed Journal]

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Novel Monoclonal Antibody Is an Allosteric Insulin Receptor Antagonist That Induces Insulin Resistance

Cieniewicz, Anne ; Kirchner, Thomas ; Hinke, Simon ; Nanjunda, Rupesh ; D'Aquino, Katharine ; Boayke, Ken ; Cooper, Philip ; Perkinson, Robert ; Chiu, Mark ; Jarantow, Stephen ; Johnson, Dana ; Whaley, Jean ; Lacy, Eilyn ; Lingham, Russell ; Liang, Yin ; Kihm, Anthony

Diabetes, Jan 1, 2017, p.206 [Peer Reviewed Journal]

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TIM-3 Suppresses Anti-CD3/CD28-Induced TCR Activation and IL-2 Expression through the NFAT Signaling Pathway

Tomkowicz, Brian ; Walsh, Eileen ; Cotty, Adam ; Verona, Raluca ; Sabins, Nina ; Kaplan, Fred ; Santulli-Marotto, Sandy ; Chen-Ni, Chin ; Mooney, Jill ; Lingham, Russell ; Naso, Michael ; Mccabe, Timothy

PLoS One, Oct 2015, Vol.10(10), p.e0140694 [Peer Reviewed Journal]

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Discovery of N-Bis(4-methoxyphenyl)methyl-4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamide (MK-8617), an Orally Active Pan-Inhibitor of Hypoxia-Inducible Factor Prolyl Hydroxylase 1-3 (HIF PHD1-3) for the Treatment of Anemia

Debenham, John S ; Madsen-Duggan, Christina ; Clements, Matthew J ; Walsh, Thomas F ; Kuethe, Jeffrey T ; Reibarkh, Mikhail ; Salowe, Scott P ; Sonatore, Lisa M ; Hajdu, Richard ; Milligan, James A ; Visco, Denise M ; Zhou, Dan ; Lingham, Russell B ; Stickens, Dominique ; Demartino, Julie A ; Tong, Xinchun ; Wolff, Michael ; Pang, Jianmei ; Miller, Randy R ; Sherer, Edward C ; Hale, Jeffrey J

Journal of medicinal chemistry, 22 December 2016, Vol.59(24), pp.11039-11049 [Peer Reviewed Journal]

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EGF potentiation of VEGF production is cell density dependent in H292 EGFR wild type NSCLC cell line

Ranayhossaini, Daniel J ; Lu, Jin ; Mabus, John ; Gervais, Alexis ; Lingham, Russell B ; Fursov, Natalie

International journal of molecular sciences, 30 September 2014, Vol.15(10), pp.17686-704 [Peer Reviewed Journal]

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Novel method demonstrates differential ligand activation and phosphatase-mediated deactivation of insulin receptor tyrosine-specific phosphorylation

Cieniewicz, Anne M ; Cooper, Philip R ; Mcgehee, Jennifer ; Lingham, Russell B ; Kihm, Anthony J

Cellular Signalling, August 2016, Vol.28(8), pp.1037-1047 [Peer Reviewed Journal]

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7
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1,3,8-Triazaspiro4.5decane-2,4-diones as efficacious pan-inhibitors of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) for the treatment of anemia

Vachal, Petr ; Miao, Shouwu ; Pierce, Joan M ; Guiadeen, Deodial ; Colandrea, Vincent J ; Wyvratt, Matthew J ; Salowe, Scott P ; Sonatore, Lisa M ; Milligan, James A ; Hajdu, Richard ; Gollapudi, Anantha ; Keohane, Carol A ; Lingham, Russell B ; Mandala, Suzanne M ; Demartino, Julie A ; Tong, Xinchun ; Wolff, Michael ; Steinhuebel, Dietrich ; Kieczykowski, Gerard R ; Fleitz, Fred J ; Chapman, Kevin ; Athanasopoulos, John ; Adam, Gregory ; Akyuz, Can D ; Jena, Dhirendra K ; Lusen, Jeffrey W ; Meng, Juncai ; Stein, Benjamin D ; Xia, Lei ; Sherer, Edward C ; Hale, Jeffrey J

Journal of medicinal chemistry, 12 April 2012, Vol.55(7), pp.2945-59 [Peer Reviewed Journal]

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8
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Discovery, structure and HIV-1 integrase inhibitory activities of integracins, novel dimeric alkyl aromatics from Cytonaema sp

Singh, Sheo B ; Zink, Deborah L ; Bills, Gerald F ; Pelaez, Fernando ; Teran, Ana ; Collado, Javier ; Silverman, Keith C ; Lingham, Russell B ; Felock, Peter ; Hazuda, Daria J

Tetrahedron Letters, 2002, Vol.43(9), pp.1617-1620 [Peer Reviewed Journal]

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9
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Cylindrol A: A novel inhibitor of Ras farnesyl-protein transferase from Cylindrocarpon lucidum

Singh, Sheo B ; Zink, Deborah L ; Bills, Gerald F ; Jenkins, Rosalind G ; Silverman, Keith C ; Lingham, Russell B

Tetrahedron Letters, 1995, Vol.36(28), pp.4935-4938 [Peer Reviewed Journal]

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10
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Integramides A and B, two novel non-ribosomal linear peptides containing nine C(alpha)-methyl amino acids produced by fungal fermentations that are inhibitors of HIV-1 integrase

Singh, Sheo B ; Herath, Kithsiri ; Guan, Ziqiang ; Zink, Deborah L ; Dombrowski, Anne W ; Polishook, Jon D ; Silverman, Keith C ; Lingham, Russell B ; Felock, Peter J ; Hazuda, Daria J

Organic letters, 02 May 2002, Vol.4(9), pp.1431-4 [Peer Reviewed Journal]

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11
Integramides A and B, Two Novel Non-Ribosomal Linear Peptides Containing Nine C α -Methyl Amino Acids Produced by Fungal Fermentations That Are Inhibitors of HIV-1 Integrase
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Integramides A and B, Two Novel Non-Ribosomal Linear Peptides Containing Nine C α -Methyl Amino Acids Produced by Fungal Fermentations That Are Inhibitors of HIV-1 Integrase

Singh, Sheo B. ; Herath, Kithsiri ; Guan, Ziqiang ; Zink, Deborah L. ; Dombrowski, Anne W. ; Polishook, Jon D. ; Silverman, Keith C. ; Lingham, Russell B. ; Felock, Peter J. ; Hazuda, Daria J.

Organic Letters, 09/2002, Vol.4(19), pp.3337-3337 [Peer Reviewed Journal]

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12
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Structure, stereochemistry, and biological activity of integramycin, a novel hexacyclic natural product produced by Actinoplanes sp. that inhibits HIV-1 integrase

Singh, Sheo B ; Zink, Deborah L ; Heimbach, Brian ; Genilloud, Olga ; Teran, Ana ; Silverman, Keith C ; Lingham, Russell B ; Felock, Peter ; Hazuda, Daria J

Organic letters, 04 April 2002, Vol.4(7), pp.1123-6 [Peer Reviewed Journal]

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13
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Unique pharmacology of a novel allosteric agonist/sensitizer insulin receptor monoclonal antibody

Hinke, Simon A ; Cieniewicz, Anne M ; Kirchner, Thomas ; D'Aquino, Katharine ; Nanjunda, Rupesh ; Aligo, Jason ; Perkinson, Robert ; Cooper, Philip ; Boayke, Ken ; Chiu, Mark L ; Jarantow, Steve ; Lacy, Eilyn R ; Liang, Yin ; Johnson, Dana L ; Whaley, Jean M ; Lingham, Russell B ; Kihm, Anthony J

Molecular Metabolism, April 2018, Vol.10, pp.87-99 [Peer Reviewed Journal]

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14
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Novel Monoclonal Antibody Is an Allosteric Insulin Receptor Antagonist That Induces Insulin Resistance

Cieniewicz, Anne M ; Kirchner, Thomas ; Hinke, Simon A ; Nanjunda, Rupesh ; D'Aquino, Katharine ; Boayke, Ken ; Cooper, Philip R ; Perkinson, Robert ; Chiu, Mark L ; Jarantow, Stephen ; Johnson, Dana L ; Whaley, Jean M ; Lacy, Eilyn R ; Lingham, Russell B ; Liang, Yin ; Kihm, Anthony J

Diabetes, January 2017, Vol.66(1), pp.206-217 [Peer Reviewed Journal]

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15
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Heterocycle-substituted proline dipeptides as potent VLA-4 antagonists

Reger, Thomas S ; Zunic, Jasmine ; Stock, Nicholas ; Wang, Bowei ; Smith, Nicholas D ; Munoz, Benito ; Green, Mitchell D ; Gardner, Michael F ; James, Joyce P ; Chen, Weichao ; Alves, Kenneth ; Si, Qian ; Treonze, Kelly M ; Lingham, Russell B ; Mumford, Richard A

Bioorganic & Medicinal Chemistry Letters, 2010, Vol.20(3), pp.1173-1176 [Peer Reviewed Journal]

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16
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Structure and absolute stereochemistry of HIV-1 integrase inhibitor integric acid. A novel eremophilane sesquiterpenoid produced by a Xylaria sp

Singh, Sheo B ; Zink, Deborah ; Polishook, Jon ; Valentino, Delia ; Shafiee, Ali ; Silverman, Keith ; Felock, Peter ; Teran, Ana ; Vilella, Dolores ; Hazuda, Daria J ; Lingham, Russell B

Tetrahedron Letters, 1999, Vol.40(50), pp.8775-8779 [Peer Reviewed Journal]

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17
Fusidienol A:  A Novel Ras Farnesyl-Protein Transferase Inhibitor from Phoma sp.
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Fusidienol A:  A Novel Ras Farnesyl-Protein Transferase Inhibitor from Phoma sp.

Singh, Sheo B. ; Ball, Richard G. ; Zink, Deborah L. ; Monaghan, Richard L. ; Polishook, Jon D. ; Sanchez, Manuel ; Pelaez, Fernando ; Silverman, Keith C. ; Lingham, Russell B.

The Journal of Organic Chemistry, 10/1997, Vol.62(21), pp.7485-7488 [Peer Reviewed Journal]

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18
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Efficient syntheses, human and yeast farnesyl-protein transferase inhibitory activities of chaetomellic acids and analogues

Singh, Sheo B ; Jayasuriya, Hiranthi ; Silverman, Keith C ; Bonfiglio, Cynthia A ; Williamson, Joanne M ; Lingham, Russell B

Bioorganic & Medicinal Chemistry, March 2000, Vol.8(3), pp.571-580 [Peer Reviewed Journal]

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19
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Comparative assessment of the ligand and metal ion binding properties of integrins alpha9beta1 and alpha4beta1

Pepinsky, R Blake ; Mumford, Richard A ; Chen, Ling Ling ; Leone, Diane ; Amo, Suzanne E ; Riper, Gail Van ; Whitty, Adrian ; Dolinski, Brian ; Lobb, Roy R ; Dean, Dennis C ; Chang, Linda L ; Raab, Conrad E ; Si, Qian ; Hagmann, William K ; Lingham, Russell B

Biochemistry, 04 June 2002, Vol.41(22), pp.7125-41 [Peer Reviewed Journal]

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20
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Optimization of erythropoietin production with controlled glycosylation-PEGylated erythropoietin produced in glycoengineered Pichia pastoris

Nett, Juergen H ; Gomathinayagam, Sujatha ; Hamilton, Stephen R ; Gong, Bing ; Davidson, Robert C ; Du, Min ; Hopkins, Daniel ; Mitchell, Teresa ; Mallem, Muralidhar R ; Nylen, Adam ; Shaikh, Seemab S ; Sharkey, Nathan ; Barnard, Gavin C ; Copeland, Victoria ; Liu, Liming ; Evers, Raymond ; Li, Yan ; Gray, Peter M ; Lingham, Russell B ; Visco, Denise ; Forrest, Gail ; Demartino, Julie ; Linden, Thomas ; Potgieter, Thomas I ; Wildt, Stefan ; Stadheim, Terrance A ; D’anjou, Marc ; Li, Huijuan ; Sethuraman, Natarajan

Journal of Biotechnology, January 2012, Vol.157(1), pp.198-206 [Peer Reviewed Journal]

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21
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Fusidienol: A novel inhibitor of Ras farnesyl-protein transferase from Fusidium griseum

Singh, Sheo B ; Jones, E.Tracy ; Goetz, Michael A ; Bills, Gerald F ; Nallin-Omstead, Mary ; Jenkins, Rosalind G ; Lingham, Russell B ; Silverman, Keith C ; Gibbs, Jackson B

Tetrahedron Letters, 1994, Vol.35(27), pp.4693-4696 [Peer Reviewed Journal]

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22
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Alpha(4)beta(7)/alpha(4)beta(1) dual integrin antagonists block alpha(4)beta(7)-dependent adhesion under shear flow

Egger, Linda A ; Kidambi, Usha ; Cao, Jin ; Van Riper, Gail ; Mccauley, Ermengilda ; Mumford, Richard A ; Amo, Suzanne ; Lingham, Russell ; Lanza, Thomas ; Lin, Linus S ; De Laszlo, Stephen E ; Young, David N ; Kopka, Ihor E ; Tong, Sharon ; Pikounis, Bill ; Benson, Evelyn ; Warwood, Sarah ; Bargatze, Robert F ; Hagmann, William K ; Schmidt, John A ; Detmers, Patricia A

The Journal of pharmacology and experimental therapeutics, July 2002, Vol.302(1), pp.153-62 [Peer Reviewed Journal]

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23
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Isolation and structure determination of pycnidione, A novel bistropolone stromelysin inhibitor from a Phoma sp

Harris, Guy H ; Hoogsteen, Karst ; Silverman, Keith C ; Raghoobar, Susan L ; Bills, Gerald F ; Lingham, Russell B ; Smith, Jack L ; Dougherty, Harry W ; Cascales, Carmen ; Peláez, Fernando

Tetrahedron, 1993, Vol.49(11), pp.2139-2144 [Peer Reviewed Journal]

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24
Clavaric Acid and Steroidal Analogues as Ras- and FPP-Directed Inhibitors of Human Farnesyl-Protein Transferase
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Clavaric Acid and Steroidal Analogues as Ras- and FPP-Directed Inhibitors of Human Farnesyl-Protein Transferase

Lingham, Russell B. ; Silverman, Keith C. ; Jayasuriya, Hiranthi ; Kim, B. Moon ; Amo, Suzanne E. ; Wilson, Francine R. ; Rew, Deborah J. ; Schaber, Michael D. ; Bergstrom, James D. ; Koblan, Kenneth S. ; Graham, Samuel L. ; Kohl, Nancy E. ; Gibbs, Jackson B. ; Singh, Sheo B.

Journal of Medicinal Chemistry, 11/1998, Vol.41(23), pp.4492-4501 [Peer Reviewed Journal]

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25
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Regulation of rat brain [formula omitted] activity by cyclic AMP

Lingham, Russell B ; Sen, Amar K

BBA - Biomembranes, 1982, Vol.688(2), pp.475-485 [Peer Reviewed Journal]

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26
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Isolation and structure of chaetomellic acids A and B from Chaetomella acutiseta: farnesyl pyrophosphate mimic inhibitors of ras farnesyl-protein transferase

Singh, Sheo B ; Zink, Deborah L ; Liesch, Jerrold M ; Goetz, Michael A ; Jenkins, Rosalind G ; Nallin-Omstead, Mary ; Silverman, Keith C ; Bills, Gerald F ; Mosley, Ralph T ; Gibbs, Jackson B ; Albers-Schonberg, Georg ; Lingham, Russell B

Tetrahedron, 1993, Vol.49(27), pp.5917-5926 [Peer Reviewed Journal]

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27
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Influence of acid surrogates toward potency of VLA-4 antagonist

Venkatraman, Shankar ; Lim, Jongwon ; Cramer, Merryl ; Gardner, Michael F ; James, Joyce ; Alves, Kenneth ; Lingham, Russell B ; Mumford, Richard A ; Munoz, Benito

Bioorganic & Medicinal Chemistry Letters, 2005, Vol.15(18), pp.4053-4056 [Peer Reviewed Journal]

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28
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The induction of [formula omitted] in the salt gland of the duck

Lingham, Russell B ; Stewart, David J ; Sen, Amar K

BBA - Biomembranes, 1980, Vol.601, pp.229-234 [Peer Reviewed Journal]

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29
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Four novel bis-(naphtho-γ-pyrones) isolated from Fusarium species as inhibitors of HIV-1 integrase

Singh, Sheo B ; Zink, Deborah L ; Bills, Gerald F ; Teran, Ana ; Silverman, Keith C ; Lingham, Russell B ; Felock, Peter ; Hazuda, Daria J

Bioorganic & Medicinal Chemistry Letters, 2003, Vol.13(4), pp.713-717 [Peer Reviewed Journal]

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30
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Four novel bis-(naphtho-gamma-pyrones) isolated from Fusarium species as inhibitors of HIV-1 integrase

Singh, Sheo B ; Zink, Deborah L ; Bills, Gerald F ; Teran, Ana ; Silverman, Keith C ; Lingham, Russell B ; Felock, Peter ; Hazuda, Daria J

Bioorganic & medicinal chemistry letters, 24 February 2003, Vol.13(4), pp.713-7 [Peer Reviewed Journal]

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31
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Discovery of N-{ N-[(3-cyanobenzene) sulfonyl]-4( R)-(3,3-difluoropiperidin-1-yl)-( l)-prolyl}-4-[(3′,5′-dichloro-isonicotinoyl) amino]-( l)-phenylalanine (MK-0617), a highly potent and orally active VLA-4 antagonist

Venkatraman, Shankar ; Lebsack, Alec D ; Alves, Kenneth ; Gardner, Michael F ; James, Joyce ; Lingham, Russell B ; Maniar, Salony ; Mumford, Richard A ; Si, Qian ; Stock, Nicholas ; Treonze, Kelly M ; Wang, Bowei ; Zunic, Jasmine ; Munoz, Benito

Bioorganic & Medicinal Chemistry Letters, 2009, Vol.19(19), pp.5803-5806 [Peer Reviewed Journal]

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32
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Development of a High Throughput Scintillation Proximity Assay for Hepatitis C Virus NS3 Protease That Reduces the Proportion of Competitive Inhibitors Identified

Fowler, Anne ; Price-Jones, Molly ; Hughes, Kelvin ; Anson, John ; Lingham, Russell ; Schulman, Marvin

Journal of Biomolecular Screening, June 2000, Vol.5(3), pp.153-158 [Peer Reviewed Journal]

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33
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Kampanols: novel ras farnesyl-protein transferase inhibitors from Stachybotrys kampalensis

Singh, Sheo B ; Zink, Deborah L ; Williams, Marie ; Polishook, Jon D ; Sanchez, Manuel ; Silverman, Keith C ; Lingham, Russell B

Bioorganic & Medicinal Chemistry Letters, 1998, Vol.8(16), pp.2071-2076 [Peer Reviewed Journal]

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34
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Hinnuliquinone, a C 2-symmetric dimeric non-peptide fungal metabolite inhibitor of HIV-1 protease

Singh, Sheo B ; Ondeyka, John G ; Tsipouras, Nasios ; Ruby, Carolyn ; Sardana, Vinod ; Schulman, Marvin ; Sanchez, Manuel ; Pelaez, Fernando ; Stahlhut, Mark W ; Munshi, Sanjeev ; Olsen, David B ; Lingham, Russell B

Biochemical and Biophysical Research Communications, 2004, Vol.324(1), pp.108-113 [Peer Reviewed Journal]

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35
The Complestatins as HIV-1 Integrase Inhibitors. Efficient Isolation, Structure Elucidation, and Inhibitory Activities of Isocomplestatin, Chloropeptin I, New Complestatins, A and B, and Acid-Hydrolysis Products of Chloropeptin I
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The Complestatins as HIV-1 Integrase Inhibitors. Efficient Isolation, Structure Elucidation, and Inhibitory Activities of Isocomplestatin, Chloropeptin I, New Complestatins, A and B, and Acid-Hydrolysis Products of Chloropeptin I

Singh, Sheo B. ; Jayasuriya, Hiranthi ; Salituro, Gino M. ; Zink, Deborah L. ; Shafiee, Ali ; Heimbuch, Brian ; Silverman, Keith C. ; Lingham, Russell B. ; Genilloud, Olga ; Teran, Ana ; Vilella, Dolores ; Felock, Peter ; Hazuda, Daria

Journal of Natural Products, 07/2001, Vol.64(7), pp.874-882 [Peer Reviewed Journal]

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36
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Durhamycin A, a potent inhibitor of HIV Tat transactivation

Jayasuriya, Hiranthi ; Lingham, Russell B ; Graham, Pia ; Quamina, Donette ; Herranz, Lucia ; Genilloud, Olga ; Gagliardi, Magda ; Danzeisen, Renee ; Tomassini, Joanne E ; Zink, Deborah L ; Guan, Ziqiang ; Singh, Sheo B

Journal of natural products, August 2002, Vol.65(8), pp.1091-5 [Peer Reviewed Journal]

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