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10 Results  for Everything (Includes Articles)

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Ionization behavior of amino lipids for siRNA delivery: determination of ionization constants, SAR, and the impact of lipid pKa on cationic lipid-biomembrane interactions

Zhang, Jingtao ; Fan, Haihong ; Levorse, Dorothy A ; Crocker, Louis S

Langmuir : the ACS journal of surfaces and colloids, 01 March 2011, Vol.27(5), pp.1907-14 [Peer Reviewed Journal]

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Interaction of cholesterol-conjugated ionizable amino lipids with biomembranes: lipid polymorphism, structure-activity relationship, and implications for siRNA delivery

Zhang, Jingtao ; Fan, Haihong ; Levorse, Dorothy A ; Crocker, Louis S

Langmuir : the ACS journal of surfaces and colloids, 02 August 2011, Vol.27(15), pp.9473-83 [Peer Reviewed Journal]

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The elusive 8-fluoroadenosine: a simple non-enzymatic synthesis and characterization

Butora, Gabor ; Schmitt, Christoph ; Levorse, Dorothy A ; Streckfuss, Eric ; Doss, George A ; Maccoss, Malcolm

Tetrahedron, 2007, Vol.63(18), pp.3782-3789 [Peer Reviewed Journal]

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Difluoroethylamines as an amide isostere in inhibitors of cathepsin K

Isabel, Elise ; Mellon, Christophe ; Boyd, Michael J ; Chauret, Nathalie ; Deschênes, Denis ; Desmarais, Sylvie ; Falgueyret, Jean-Pierre ; Gauthier, Jacques Yves ; Khougaz, Karine ; Lau, Cheuk K ; Léger, Serge ; Levorse, Dorothy A ; Li, Chun Sing ; Massé, Frédéric ; David Percival, M ; Roy, Bruno ; Scheigetz, John ; Thérien, Michel ; Truong, Vouy Linh ; Wesolowski, Gregg ; Young, Robert N ; Zamboni, Robert ; Cameron Black, W

Bioorganic & Medicinal Chemistry Letters, 2011, Vol.21(3), pp.920-923 [Peer Reviewed Journal]

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Design and synthesis of a new class of malonyl-CoA decarboxylase inhibitors with anti-obesity and anti-diabetic activities

Tang, Haifeng ; Yan, Yan ; Feng, Zhe ; de Jesus, Reynalda K ; Yang, Lihu ; Levorse, Dorothy A ; Owens, Karen A ; Akiyama, Taro E ; Bergeron, Raynald ; Castriota, Gino A ; Doebber, Thomas W ; Ellsworth, Kenneth P ; Lassman, Michael E ; Li, Cai ; Wu, Margaret S ; Zhang, Bei B ; Chapman, Kevin T ; Mills, Sander G ; Berger, Joel P ; Pasternak, Alexander

Bioorganic & Medicinal Chemistry Letters, 2010, Vol.20(20), pp.6088-6092 [Peer Reviewed Journal]

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Discovery and X-ray crystallographic analysis of a spiropiperidine iminohydantoin inhibitor of beta-secretase

Barrow, James C ; Stauffer, Shaun R ; Rittle, Kenneth E ; Ngo, Phung L ; Yang, Zhiqiang ; Selnick, Harold G ; Graham, Samuel L ; Munshi, Sanjeev ; Mcgaughey, Georgia B ; Holloway, M Katharine ; Simon, Adam J ; Price, Eric A ; Sankaranarayanan, Sethu ; Colussi, Dennis ; Tugusheva, Katherine ; Lai, Ming-Tain ; Espeseth, Amy S ; Xu, Min ; Huang, Qian ; Wolfe, Abigail ; Pietrak, Beth ; Zuck, Paul ; Levorse, Dorothy A ; Hazuda, Daria ; Vacca, Joseph P

Journal of medicinal chemistry, 23 October 2008, Vol.51(20), pp.6259-62 [Peer Reviewed Journal]

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Discovery of N-{(1S,2S)-2-(3-cyanophenyl)- 3-4-(2-18Ffluoroethoxy)phenyl-1-methylpropyl}- 2-methyl-2-(5-methylpyridin-2-yl)oxypropanamide, a cannabinoid-1 receptor positron emission tomography tracer suitable for clinical use

Liu, Ping ; Lin, Linus S ; Hamill, Terence G ; Jewell, James P ; Lanza, Thomas J ; Gibson, Raymond E ; Krause, Stephen M ; Ryan, Christine ; Eng, Waisi ; Sanabria, Sandra ; Tong, Xinchun ; Wang, Junying ; Levorse, Dorothy A ; Owens, Karen A ; Fong, Tung M ; Shen, Chun-Pyn ; Lao, Julie ; Kumar, Sanjeev ; Yin, Wenji ; Payack, Joseph F ; Springfield, Shawn A ; Hargreaves, Richard ; Burns, H Donald ; Goulet, Mark T ; Hagmann, William K

Journal of medicinal chemistry, 26 July 2007, Vol.50(15), pp.3427-30 [Peer Reviewed Journal]

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(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(4-1,2,4triazolo1,5-a-pyridin-6-ylphenyl)butanamide: a selective alpha-amino amide dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes

Edmondson, Scott D ; Mastracchio, Anthony ; Mathvink, Robert J ; He, Jiafang ; Harper, Bart ; Park, You-Jung ; Beconi, Maria ; Di Salvo, Jerry ; Eiermann, George J ; He, Huaibing ; Leiting, Barbara ; Leone, Joseph F ; Levorse, Dorothy A ; Lyons, Kathryn ; Patel, Reshma A ; Patel, Sangita B ; Petrov, Aleksandr ; Scapin, Giovanna ; Shang, Jackie ; Roy, Ranabir Sinha ; Smith, Aaron ; Wu, Joseph K ; Xu, Shiyao ; Zhu, Bing ; Thornberry, Nancy A ; Weber, Ann E

Journal of medicinal chemistry, 15 June 2006, Vol.49(12), pp.3614-27 [Peer Reviewed Journal]

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Inhibition of Stromelysin-1 (MMP-3) by P 1 ‘-Biphenylylethyl Carboxyalkyl Dipeptides
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Inhibition of Stromelysin-1 (MMP-3) by P 1 ‘-Biphenylylethyl Carboxyalkyl Dipeptides

Esser, Craig K. ; Bugianesi, Robert L. ; Caldwell, Charles G. ; Chapman, Kevin T. ; Durette, Philippe L. ; Girotra, Narindar N. ; Kopka, Ihor E. ; Lanza, Thomas J. ; Levorse, Dorothy A. ; Maccoss, Malcolm ; Owens, Karen A. ; Ponpipom, Mitree M. ; Simeone, Joseph P. ; Harrison, Richard K. ; Niedzwiecki, Lisa ; Becker, Joseph W. ; Marcy, Alice I. ; Axel, Melinda G. ; Christen, Amy J. ; Mcdonnell, Joseph ; Moore, Vernon L. ; Olszewski, Julie M. ; Saphos, Cheryl ; Visco, Denise M. ; Shen, Frank ; Colletti, Adria ; Krieter, Philip A. ; Hagmann, William K.

Journal of Medicinal Chemistry, 03/1997, Vol.40(6), pp.1026-1040 [Peer Reviewed Journal]

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Cyclopentane-based human NK1 antagonists. Part 1: Discovery and initial SAR

Finke, Paul E ; Meurer, Laura C ; Levorse, Dorothy A ; Mills, Sander G ; Maccoss, Malcolm ; Sadowski, Sharon ; Cascieri, Margaret A ; Tsao, Kwei-Lan ; Chicchi, Gary G ; Metzger, Joseph M ; Macintyre, D. Euan

Bioorganic & Medicinal Chemistry Letters, 2006, Vol.16(17), pp.4497-4503 [Peer Reviewed Journal]

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