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Chemoselective Reduction of α-Cyano Carbonyl Compounds: Application to the Preparation of Heterocycles

Pollack, Scott R ; Kuethe, Jeffrey T

Organic letters, 16 December 2016, Vol.18(24), pp.6388-6391 [Peer Reviewed Journal]

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A concise synthesis of 3,4-fused spiro[isobenzofuran-3-ones], spiro[furo[3,4-b]pyridin-5(7H)-ones], 3-aryl-, and alkylphthalides

Kuethe, Jeffrey T ; Maloney, Kevin M

Tetrahedron, 24 June 2013, Vol.69(25), pp.5248-5258 [Peer Reviewed Journal]

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3
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A practical, one-pot synthesis of sulfonylated pyridines

Maloney, Kevin M ; Kuethe, Jeffrey T ; Linn, Kathleen

Organic letters, 07 January 2011, Vol.13(1), pp.102-5 [Peer Reviewed Journal]

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4
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Magnetically driven agitation in a tube mixer affords clog-resistant fast mixing independent of linear velocity

Dolman, Sarah J ; Nyrop, Jason L ; Kuethe, Jeffrey T

The Journal of organic chemistry, 04 February 2011, Vol.76(3), pp.993-6 [Peer Reviewed Journal]

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5
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Asymmetric Synthesis of a Potent HIV-1 Integrase Inhibitor

Kuethe, Jeffrey T ; Humphrey, Guy R ; Journet, Michel ; Peng, Zhihui ; Childers, Karla G

The Journal of organic chemistry, 04 November 2016, Vol.81(21), pp.10256-10265 [Peer Reviewed Journal]

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6
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Synthesis of stable isotope‐labeled metabolites of asenapine

Kuethe, Jeffrey T.

Journal of Labelled Compounds and Radiopharmaceuticals, 15 May 2012, Vol.55(5), pp.180-185 [Peer Reviewed Journal]

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7
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A biocatalytic/reductive etherification approach to substituted piperidinyl ethers

Kuethe, Jeffrey T ; Janey, Jacob M ; Truppo, Matthew ; Arredondo, Juan ; Li, Tao ; Yong, Kelvin ; He, Shuwen

Tetrahedron, 29 July 2014, Vol.70(30), pp.4563-4570 [Peer Reviewed Journal]

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8
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Development of a palladium-catalyzed α-arylation of cyclopropyl nitriles

Mccabe Dunn, Jamie M ; Kuethe, Jeffrey T ; Orr, Robert K ; Tudge, Matthew ; Campeau, Louis-Charles

Organic letters, 19 December 2014, Vol.16(24), pp.6314-7 [Peer Reviewed Journal]

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9
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Development of a stereoselective and scalable process for the preparation of a methylcyclobutanol-pyridyl ether

Kuethe, Jeffrey T ; Basu, Kallol ; Orr, Robert K ; Ashley, Eric ; Poirier, Marc ; Tan, Lushi

Bioorganic & Medicinal Chemistry, 15 February 2018, Vol.26(4), pp.938-944 [Peer Reviewed Journal]

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10
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Synthesis of vaniprevir (MK-7009): lactamization to prepare a 20-membered corrected macrocycle

Song, Zhiguo J ; Tellers, David M ; Journet, Michel ; Kuethe, Jeffrey T ; Lieberman, David ; Humphrey, Guy ; Zhang, Fei ; Peng, Zhihui ; Waters, Marjorie S ; Zewge, Daniel ; Nolting, Andrew ; Zhao, Dalian ; Reamer, Robert A ; Dormer, Peter G ; Belyk, Kevin M ; Davies, Ian W ; Devine, Paul N ; Tschaen, David M

The Journal of organic chemistry, 07 October 2011, Vol.76(19), pp.7804-15 [Peer Reviewed Journal]

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11
Correction to Synthesis of Vaniprevir (MK-7009): Lactamization To Prepare a 22-Membered Macrocycle
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Correction to Synthesis of Vaniprevir (MK-7009): Lactamization To Prepare a 22-Membered Macrocycle

Song, Zhiguo J. ; Tellers, David M. ; Journet, Michel ; Kuethe, Jeffrey T. ; Lieberman, David ; Humphrey, Guy ; Zhang, Fei ; Peng, Zhihui ; Waters, Marjorie S. ; Zewge, Daniel ; Nolting, Andrew ; Zhao, Dalian ; Reamer, Robert A. ; Dormer, Peter G. ; Belyk, Kevin M. ; Davies, Ian W. ; Devine, Paul N. ; Tschaen, David M.

The Journal of Organic Chemistry, 11/18/2011, Vol.76(22), pp.9553-9553 [Peer Reviewed Journal]

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12
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A concise synthesis of functionalized 2,3-dihydrofuro[3,2-b], [3,2-c], and [2,3-b]pyridines

Kuethe, Jeffrey T

Tetrahedron, 23 August 2019, Vol.75(34) [Peer Reviewed Journal]

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13
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A novel domino reaction for the preparation of substituted non-racemic β-proline derivatives

Gilbert, Eric J ; Brunskill, Andrew ; Cai, Jiaqiang ; Cai, Yaxian ; Chu, Xin-Jie ; Dai, Xing ; Hao, Jinsong ; Kuethe, Jeffrey T ; Lai, Zhong ; Liu, Hong ; Mu, Cuizhi ; Qi, Yan ; Scott, Jack D ; Taoka, Brandon ; Truong, Quang ; Walsh, Shawn P ; Wu, Wen-Lian ; Cumming, Jared N

Tetrahedron, 06 October 2016, Vol.72(40), pp.6011-6020 [Peer Reviewed Journal]

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14
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Formal [4+2] cycloaddition reactions of N-sulfonyl-2,2′-biindoles: synthesis of indolo[2,3-a]carbazoles and indigo azines

Kuethe, Jeffrey T ; Davies, Ian W

Tetrahedron Letters, 17 May 2004, Vol.45(21), pp.4009-4012 [Peer Reviewed Journal]

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15
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Synthesis of disubstituted imidazo4,5-bpyridin-2-ones

Kuethe, Jeffrey T ; Wong, Audrey ; Davies, Ian W

The Journal of organic chemistry, 29 October 2004, Vol.69(22), pp.7752-4 [Peer Reviewed Journal]

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16
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Addition of indolyl and pyrrolyl grignard reagents to 1-acylpyridinium salts

Kuethe, Jeffrey T ; Comins, Daniel L

The Journal of organic chemistry, 16 April 2004, Vol.69(8), pp.2863-6 [Peer Reviewed Journal]

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17
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Asymmetric total synthesis of (+)-cannabisativine

Kuethe, Jeffrey T ; Comins, Daniel L

The Journal of organic chemistry, 06 August 2004, Vol.69(16), pp.5219-31 [Peer Reviewed Journal]

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18
Addition of Indolyl and Pyrrolyl Grignard Reagents to 1-Acylpyridinium Salts.
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Addition of Indolyl and Pyrrolyl Grignard Reagents to 1-Acylpyridinium Salts.

Kuethe, Jeffrey T. ; Comins, Daniel L.

The Journal of Organic Chemistry, 08/2004, Vol.69(16), pp.5516-5516 [Peer Reviewed Journal]

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19
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Tandem Diels–Alder cyclization/aromatization reactions of 5-vinyl-1-acyl-2-aryl-2,3-dihydro-4-pyridones

Kuethe, Jeffrey T ; Comins, Daniel L

Tetrahedron Letters, 2003, Vol.44(22), pp.4179-4182 [Peer Reviewed Journal]

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20
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A general synthesis of N-hydroxyindoles

Wong, Audrey ; Kuethe, Jeffrey T ; Davies, Ian W

The Journal of organic chemistry, 12 December 2003, Vol.68(25), pp.9865-6 [Peer Reviewed Journal]

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21
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The tandem Pummerer-isomünchnone route to (±)-pumiliotoxin C

Kuethe, Jeffrey T ; Padwa, Albert

Tetrahedron Letters, 1997, Vol.38(9), pp.1505-1508 [Peer Reviewed Journal]

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22
New Application of the Pummerer Reaction of Imidosulfoxides for the Generation of Mesoionic Dipoles †
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New Application of the Pummerer Reaction of Imidosulfoxides for the Generation of Mesoionic Dipoles †

Kuethe, Jeffrey T. ; Padwa, Albert

The Journal of Organic Chemistry, 02/1997, Vol.62(4), pp.774-775 [Peer Reviewed Journal]

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23
Additive and Vinylogous Pummerer Reactions of Amido Sulfoxides and Their Use in the Preparation of Nitrogen Containing Heterocycles
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Additive and Vinylogous Pummerer Reactions of Amido Sulfoxides and Their Use in the Preparation of Nitrogen Containing Heterocycles

Padwa, Albert ; Kuethe, Jeffrey T.

The Journal of Organic Chemistry, 06/1998, Vol.63(13), pp.4256-4268 [Peer Reviewed Journal]

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24
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Practical methodologies for the synthesis of indoles

Humphrey, Guy R ; Kuethe, Jeffrey T

Chemical reviews, July 2006, Vol.106(7), pp.2875-911 [Peer Reviewed Journal]

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25
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Discovery of N-Bis(4-methoxyphenyl)methyl-4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamide (MK-8617), an Orally Active Pan-Inhibitor of Hypoxia-Inducible Factor Prolyl Hydroxylase 1-3 (HIF PHD1-3) for the Treatment of Anemia

Debenham, John S ; Madsen-Duggan, Christina ; Clements, Matthew J ; Walsh, Thomas F ; Kuethe, Jeffrey T ; Reibarkh, Mikhail ; Salowe, Scott P ; Sonatore, Lisa M ; Hajdu, Richard ; Milligan, James A ; Visco, Denise M ; Zhou, Dan ; Lingham, Russell B ; Stickens, Dominique ; Demartino, Julie A ; Tong, Xinchun ; Wolff, Michael ; Pang, Jianmei ; Miller, Randy R ; Sherer, Edward C ; Hale, Jeffrey J

Journal of medicinal chemistry, 22 December 2016, Vol.59(24), pp.11039-11049 [Peer Reviewed Journal]

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26
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Preparation of 2-arylindole-4-carboxylic amide derivatives

Kuethe, Jeffrey T ; Davies, Ian W

Tetrahedron, 2006, Vol.62(49), pp.11381-11390 [Peer Reviewed Journal]

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27
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A facile synthesis of 2,3-disubstituted furo[2,3- b]pyridines

Beutner, Gregory L ; Kuethe, Jeffrey T ; Yasuda, Nobuyoshi

Tetrahedron Letters, 2009, Vol.50(7), pp.781-784 [Peer Reviewed Journal]

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28
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One-pot iodination of hydroxypyridines

Maloney, Kevin M ; Nwakpuda, Emily ; Kuethe, Jeffrey T ; Yin, Jingjun

The Journal of organic chemistry, 17 July 2009, Vol.74(14), pp.5111-4 [Peer Reviewed Journal]

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29
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Synthesis of stable isotope labeled anacetrapib, its major metabolites and [ 14 C]anacetrapib

Kuethe, Jeffrey T. ; Soli, Eric D. ; Royster, Pernilla ; Quinn, Catherine A.

Journal of Labelled Compounds and Radiopharmaceuticals, October 2013, Vol.56(12), pp.600-608 [Peer Reviewed Journal]

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30
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Practical preparation of benzyloxyacetic acids

Linn, Kathleen ; Kuethe, Jeffrey T ; Peng, Zhihui ; Yasuda, Nobuyoshi

Tetrahedron Letters, 2008, Vol.49(23), pp.3762-3765 [Peer Reviewed Journal]

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31
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A rapid synthesis of 2-aryl-5-substituted-2,3-dihydrobenzofurans

Kuethe, Jeffrey T ; Wong, Audrey ; Journet, Michel ; Davies, Ian W

The Journal of organic chemistry, 29 April 2005, Vol.70(9), pp.3727-9 [Peer Reviewed Journal]

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32
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Synthesis of novel KDR kinase inhibitors through catalytic reductive cyclization of o-nitrobenzylcarbonyl compounds

Wong, Audrey ; Kuethe, Jeffrey T ; Davies, Ian W ; Hughes, David L

The Journal of organic chemistry, 29 October 2004, Vol.69(22), pp.7761-4 [Peer Reviewed Journal]

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33
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Aza-Diels–Alder/intramolecular Heck cyclization approach to the tetrahydro-β-carboline skeleton of the ajmaline/sarpagine alkaloids

Kuethe, Jeffrey T ; Wong, Audrey ; Davies, Ian W ; Reider, Paul J

Tetrahedron Letters, 2002, Vol.43(21), pp.3871-3874 [Peer Reviewed Journal]

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34
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A practical method for preparation of 4-hydroxyquinolinone esters

Beutner, Gregory L ; Kuethe, Jeffrey T ; Yasuda, Nobuyoshi

The Journal of organic chemistry, 31 August 2007, Vol.72(18), pp.7058-61 [Peer Reviewed Journal]

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35
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Rearrangement of spiro-benzimidazolines: preparation of N-alkenyl- and N-alkyl-benzimidazol-2-ones

Kuethe, Jeffrey T ; Varon, Jack ; Childers, Karla G

Tetrahedron, 2007, Vol.63(46), pp.11489-11502 [Peer Reviewed Journal]

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36
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Diels-Alder reactions of 5-vinyl-1-acyl-2-aryl-2,3-dihydro-4-pyridones: regio- and stereoselective synthesis of octahydroquinolines

Kuethe, Jeffrey T ; Brooks, Clinton A ; Comins, Daniel L

Organic letters, 06 February 2003, Vol.5(3), pp.321-3 [Peer Reviewed Journal]

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37
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Effective strategy for the preparation of indolocarbazole aglycons and glycosides: total synthesis of tjipanazoles B, D, E, and I

Kuethe, Jeffrey T ; Wong, Audrey ; Davies, Ian W

Organic letters, 02 October 2003, Vol.5(20), pp.3721-3 [Peer Reviewed Journal]

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