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31 Results  for Everything (Includes Articles)

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Antidiabetic and antisteatotic effects of the selective fatty acid synthase (FAS) inhibitor platensimycin in mouse models of diabetes

Wu, Margaret ; Singh, Sheo B ; Wang, Jun ; Chung, Christine C ; Salituro, Gino ; Karanam, Bindhu V ; Lee, Sang Ho ; Powles, Maryann ; Ellsworth, Kenneth P ; Lassman, Michael E ; Miller, Corey ; Myers, Robert W ; Tota, Michael R ; Zhang, Bei B ; Li, Cai

Proceedings of the National Academy of Sciences of the United States of America, 29 March 2011, Vol.108(13), pp.5378-83 [Peer Reviewed Journal]

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Identification and Characterization of Sebaceous Gland Atrophy-Sparing DGAT1 Inhibitors

Muise, Eric S ; Zhu, Yonghua ; Verras, Andreas ; Karanam, Bindhu V ; Gorski, Judith ; Weingarth, Drew ; Lin, Hua V ; Hwa, Joyce ; Thompson, John R ; Hu, Guanghui ; Liu, Jian ; He, Shuwen ; Devita, Robert J ; Shen, Dong-Ming ; Pinto, Shirly Slominski, Andrzej T. (editor)

PLoS ONE, 2014, Vol.9(2) [Peer Reviewed Journal]

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2-(3aR,4R,5S,7aS)-5-{(1S)-1-3,5-bis(trifluoromethyl)phenyl-2-hydroxyethoxy}-4-(2-methylphenyl)octahydro-2H-isoindol-2-yl-1,3-oxazol-4(5H)-one: a potent human NK1 receptor antagonist with multiple clearance pathways

Kassick, Andrew J ; Jiang, Jinlong ; Bunda, Jaime ; Wilson, David ; Bao, Jianming ; Lu, Huagang ; Lin, Peter ; Ball, Richard G ; Doss, George A ; Tong, Xinchun ; Tsao, Kwei-Lan C ; Wang, Hong ; Chicchi, Gary ; Karanam, Bindhu ; Tschirret-Guth, Richard ; Samuel, Koppara ; Hora, Donald F ; Kumar, Sanjeev ; Madeira, Maria ; Eng

Journal of medicinal chemistry, 25 July 2013, Vol.56(14), pp.5940-8 [Peer Reviewed Journal]

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Pharmacological inhibition of diacylglycerol acyltransferase 1 reduces body weight and modulates gut peptide release—Potential insight into mechanism of action

Liu, Jinqi ; Gorski, Judith N. ; Gold, Stephen J. ; Chen, Dunlu ; Chen, Shirley ; Forrest, Gail ; Itoh, Yoshiki ; Marsh, Donald J. ; Mclaren, David G. ; Shen, Zhu ; Sonatore, Lisa ; Carballo‐Jane, Ester ; Craw, Stephanie ; Guan, Xiaoming ; Karanam, Bindhu ; Sakaki, Junichi ; Szeto, Daphne ; Tong, Xinchun ; Xiao, Jianying ; Yoshimoto, Ryo ; Yu, Hong ; Roddy, Thomas P. ; Balkovec, James ; Pinto, Shirly

Obesity, July 2013, Vol.21(7), pp.1406-1415 [Peer Reviewed Journal]

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Pharmacodynamic Responses to combined treatment regimens with the calcium sensing receptor antagonist JTT-305/MK-5442 and alendronate in osteopenic ovariectomized rats

Fisher, John E ; Scott, Kevin ; Wei, Nan ; Zhao, Jing Z ; Cusick, Tara ; Tijerina, Monica ; Karanam, Bindhu ; Duong, Le ; Glantschnig, Helmut

Bone, June 2012, Vol.50(6), pp.1332-1342 [Peer Reviewed Journal]

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Potential mechanism of enhanced postprandial glucagon‐like peptide‐1 release following treatment with a diacylglycerol acyltransferase 1 inhibitor

Liu, Jinqi ; Mclaren, David G. ; Chen, Dunlu ; Kan, Yanqing ; Stout, Steven J. ; Shen, Xiaolan ; Murphy, Beth Ann ; Forrest, Gail ; Karanam, Bindhu ; Sonatore, Lisa ; He, Shuwen ; Roddy, Thomas P. ; Pinto, Shirly

Pharmacology Research & Perspectives, December 2015, Vol.3(6), pp.n/a-n/a [Peer Reviewed Journal]

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A novel benzazepinone sodium channel blocker with oral efficacy in a rat model of neuropathic pain

Hoyt, Scott B ; London, Clare ; Abbadie, Catherine ; Felix, John P ; Garcia, Maria L ; Jochnowitz, Nina ; Karanam, Bindhu V ; Li, Xiaohua ; Lyons, Kathryn A ; Mcgowan, Erin ; Priest, Birgit T ; Smith, Mchardy M ; Warren, Vivien A ; Thomas-Fowlkes, Brande S ; Kaczorowski, Gregory J ; Duffy, Joseph L

Bioorganic & Medicinal Chemistry Letters, 15 June 2013, Vol.23(12), pp.3640-3645 [Peer Reviewed Journal]

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A potent and selective indole N-type calcium channel (Ca v2.2) blocker for the treatment of pain

Tyagarajan, Sriram ; Chakravarty, Prasun K ; Park, Min ; Zhou, Bishan ; Herrington, James B ; Ratliff, Kevin ; Bugianesi, Randall M ; Williams, Brande ; Haedo, Rodolfo J ; Swensen, Andrew M ; Warren, Vivien A ; Smith, Mchardy ; Garcia, Maria ; Kaczorowski, Gregory J ; Mcmanus, Owen B ; Lyons, Kathryn A ; Li, Xiaohua ; Madeira, Maria ; Karanam, Bindhu ; Green, Mitchell

Bioorganic & Medicinal Chemistry Letters, 2011, Vol.21(2), pp.869-873 [Peer Reviewed Journal]

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Discovery of Spirocyclic Aldosterone Synthase Inhibitors as Potential Treatments for Resistant Hypertension

Petrilli, Whitney L ; Hoyt, Scott B ; London, Clare ; Mcmasters, Daniel ; Verras, Andreas ; Struthers, Mary ; Cully, Doris ; Wisniewski, Thomas ; Ren, Ning ; Bopp, Charlene ; Sok, Andrea ; Chen, Qing ; Li, Ying ; Tung, Elaine ; Tang, Wei ; Salituro, Gino ; Knemeyer, Ian ; Karanam, Bindhu ; Clemas, Joseph ; Zhou

ACS medicinal chemistry letters, 12 January 2017, Vol.8(1), pp.128-132 [Peer Reviewed Journal]

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Metabolism and excretion of anacetrapib, a novel inhibitor of the cholesteryl ester transfer protein, in humans

Kumar, Sanjeev ; Tan, Eugene Y ; Hartmann, Georgy ; Biddle, Zachary ; Bergman, Arthur J ; Dru, James ; Ho, Jonathan Z ; Jones, Allen N ; Staskiewicz, Steve J ; Braun, Matthew P ; Karanam, Bindhu ; Dean, Dennis C ; Gendrano, Isaias Noel ; Graves, Mark W ; Wagner, John A ; Krishna, Rajesh

Drug metabolism and disposition: the biological fate of chemicals, March 2010, Vol.38(3), pp.474-83 [Peer Reviewed Journal]

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11
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Potent DGAT1 Inhibitors in the Benzimidazole Class with a Pyridyl-oxy-cyclohexanecarboxylic Acid Moiety

He, Shuwen ; Hong, Qingmei ; Lai, Zhong ; Wu, Zhicai ; Yu, Yang ; Kim, David W ; Ting, Pauline C ; Kuethe, Jeffrey T ; Yang, Ginger X ; Jian, Tianying ; Liu, Jian ; Guiadeen, Deodial ; Krikorian, Arto D ; Sperbeck, Donald M ; Sonatore, Lisa M ; Wiltsie, Judyann ; Chung, Christine C ; Gibson, Jack T ; Lisnock, Jeanmarie ; Murphy

ACS medicinal chemistry letters, 08 August 2013, Vol.4(8), pp.773-8 [Peer Reviewed Journal]

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12
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Discovery of a Potent and Selective DGAT1 Inhibitor with a Piperidinyl-oxy-cyclohexanecarboxylic Acid Moiety

He, Shuwen ; Hong, Qingmei ; Lai, Zhong ; Yang, David X ; Ting, Pauline C ; Kuethe, Jeffrey T ; Cernak, Timothy A ; Dykstra, Kevin D ; Sperbeck, Donald M ; Wu, Zhicai ; Yu, Yang ; Yang, Ginger X ; Jian, Tianying ; Liu, Jian ; Guiadeen, Deodial ; Krikorian, Arto D ; Sonatore, Lisa M ; Wiltsie, Judyann ; Liu, Jinqi ; Gorski

ACS medicinal chemistry letters, 09 October 2014, Vol.5(10), pp.1082-7 [Peer Reviewed Journal]

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13
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Discovery of MK-4409, a Novel Oxazole FAAH Inhibitor for the Treatment of Inflammatory and Neuropathic Pain

Chobanian, Harry R ; Guo, Yan ; Liu, Ping ; Chioda, Marc D ; Fung, Selena ; Lanza, Thomas J ; Chang, Linda ; Bakshi, Raman K ; Dellureficio, James P ; Hong, Qingmei ; Mclaughlin, Mark ; Belyk, Kevin M ; Krska, Shane W ; Makarewicz, Amanda K ; Martel, Elliot J ; Leone, Joseph F ; Frey, Lisa ; Karanam, Bindhu ; Madeira, Maria ; Alvaro

ACS medicinal chemistry letters, 12 June 2014, Vol.5(6), pp.717-21 [Peer Reviewed Journal]

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14
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Species differential stereoselective oxidation of a methylsulfide metabolite of MK-0767 (+/-)-5-(2,4-dioxothiazolidin-5-yl)methyl-2-methoxy-N-(4-trifluoromethyl)phenylmethylbenzamide, a peroxisome proliferator-activated receptor dual agonist

Karanam, Bindhu V ; Welch, Christopher J ; Reddy, Vijay G ; Chilenski, Jennifer ; Biba, Mirlinda ; Vincent, Stella

Drug metabolism and disposition: the biological fate of chemicals, October 2004, Vol.32(10), pp.1061-8 [Peer Reviewed Journal]

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Trace level quantification of deuterated 17β‐estradiol and estrone in ovariectomized mouse plasma and brain using liquid chromatography/tandem mass spectrometry following dansylation reaction

Xia, Yuan‐Qing ; Chang, Steve W. ; Patel, Shefali ; Bakhtiar, Ray ; Karanam, Bindhu ; Evans, David C.

Rapid Communications in Mass Spectrometry, 30 July 2004, Vol.18(14), pp.1621-1628 [Peer Reviewed Journal]

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16
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Discovery of MK-1421, a Potent, Selective sstr3 Antagonist, as a Development Candidate for Type 2 Diabetes

Shah, Shrenik K ; He, Shuwen ; Guo, Liangqin ; Truong, Quang ; Qi, Hongbo ; Du, Wu ; Lai, Zhong ; Liu, Jian ; Jian, Tianying ; Hong, Qingmei ; Dobbelaar, Peter ; Ye, Zhixiong ; Sherer, Edward ; Feng, Zhe ; Yu, Yang ; Wong, Frederick ; Samuel, Koppara ; Madiera, Maria ; Karanam, Bindhu V ; Reddy

ACS Medicinal Chemistry Letters, 2015, Vol.6(5), p.513-517 [Peer Reviewed Journal]

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17
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Discovery of MK-3168: A PET Tracer for Imaging Brain Fatty Acid Amide Hydrolase

Liu, Ping ; Hamill, Terence G ; Chioda, Marc ; Chobanian, Harry ; Fung, Selena ; Guo, Yan ; Chang, Linda ; Bakshi, Raman ; Hong, Qingmei ; Dellureficio, James ; Lin, Linus S ; Abbadie, Catherine ; Alexander, Jessica ; Jin, Hong ; Mandala, Suzanne ; Shiao, Lin-Lin ; Li, Wenping ; Sanabria, Sandra ; Williams, David ; Zeng

ACS medicinal chemistry letters, 13 June 2013, Vol.4(6), pp.509-13 [Peer Reviewed Journal]

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18
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In vitro metabolism of MK-0767 (+/-)-5-(2,4-dioxothiazolidin-5-yl)methyl-2-methoxy-N-(4-trifluoromethyl)-phenyl methylbenzamide, a peroxisome proliferator-activated receptor alpha/gamma agonist. II. Identification of metabolites by liquid chromatography-tandem mass spectrometry

Liu, David Q ; Karanam, Bindhu V ; Doss, George A ; Sidler, Rick R ; Vincent, Stella H ; Hop, Cornelis E C A

Drug metabolism and disposition: the biological fate of chemicals, September 2004, Vol.32(9), pp.1023-31 [Peer Reviewed Journal]

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19
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Identification and metabolism of a novel dihydrohydroxy-S-glutathionyl conjugate of a peroxisome proliferator-activated receptor agonist, MK-0767 (+/-)-5-(2,4-dioxothiazolidin-5-yl)methyl-2-methoxy-N-(4-trifluoromethyl) phenylmethylbenzamide, in rats

Reddy, Vijay Bhasker G ; Doss, George A ; Creighton, Mellissa ; Kochansky, Christopher J ; Vincent, Stella H ; Franklin, Ronald B ; Karanam, Bindhu V

Drug metabolism and disposition: the biological fate of chemicals, October 2004, Vol.32(10), pp.1154-61 [Peer Reviewed Journal]

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20
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In vitro metabolism of MK-0767 (+/-)-5-(2,4-dioxothiazolidin-5-yl)methyl-2-methoxy-N-(4-trifluoromethyl) phenylmethylbenzamide, a peroxisome proliferator-activated receptor alpha/gamma agonist. I. Role of cytochrome P450, methyltransferases, flavin monooxygenases, and esterases

Karanam, Bindhu V ; Hop, Cornelis E C A ; Liu, David Q ; Wallace, Mike ; Dean, Dennis ; Satoh, Hiroya ; Komuro, Masakatsu ; Awano, Katsuya ; Vincent, Stella H

Drug metabolism and disposition: the biological fate of chemicals, September 2004, Vol.32(9), pp.1015-22 [Peer Reviewed Journal]

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21
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In vitro metabolism of FK-506 in rat, rabbit, and human liver microsomes: Identification of a major metabolite and of cytochrome P450 3A as the major enzymes responsible for its metabolism

Vincent, Styliani H ; Karanam, Bindhu V ; Painter, Susan K ; Chiu, Shuet-Hing L

Archives of Biochemistry and Biophysics, 1992, Vol.294(2), pp.454-460 [Peer Reviewed Journal]

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22
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Absorption, metabolism, and excretion of (14)CMK-0524, a prostaglandin D(2) receptor antagonist, in humans

Karanam, Bindhu ; Madeira, Maria ; Bradley, Scott ; Wenning, Larissa ; Desai, Rajesh ; Soli, Eric ; Schenk, David ; Jones, Allen ; Dean, Brian ; Doss, George ; Garrett, Graigory ; Crumley, Tami ; Nirula, Ajay ; Lai, Eseng

Drug metabolism and disposition: the biological fate of chemicals, July 2007, Vol.35(7), pp.1196-202 [Peer Reviewed Journal]

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23
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Metabolism of MK-0524, a prostaglandin D2 receptor 1 antagonist, in microsomes and hepatocytes from preclinical species and humans

Dean, Brian J ; Chang, Steve ; Silva Elipe, Maria Victoria ; Xia, Yuan-Qing ; Braun, Matt ; Soli, Eric ; Zhao, Yuming ; Franklin, Ronald B ; Karanam, Bindhu

Drug metabolism and disposition: the biological fate of chemicals, February 2007, Vol.35(2), pp.283-92 [Peer Reviewed Journal]

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24
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Mechanistic studies on the metabolic scission of thiazolidinedione derivatives to acyclic thiols

Reddy, Vijay Bhasker G ; Karanam, Bindhu V ; Gruber, Wendy L ; Wallace, Michael A ; Vincent, Stella H ; Franklin, Ronald B ; Baillie, Thomas A

Chemical research in toxicology, May 2005, Vol.18(5), pp.880-8 [Peer Reviewed Journal]

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25
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Imidazopyridines: A novel class of hNa v1.7 channel blockers

London, Clare ; Hoyt, Scott B ; Parsons, William H ; Williams, Brande S ; Warren, Vivien A ; Tschirret-Guth, Richard ; Smith, Mchardy M ; Priest, Birgit T ; Mcgowan, Erin ; Martin, William J ; Lyons, Kathryn A ; Li, Xiaohua ; Karanam, Bindhu V ; Jochnowitz, Nina ; Garcia, Maria L ; Felix, John P ; Dean, Brian ; Abbadie, Catherine ; Kaczorowski, Gregory J ; Duffy, Joseph L

Bioorganic & Medicinal Chemistry Letters, 2008, Vol.18(5), pp.1696-1701 [Peer Reviewed Journal]

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26
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Discovery of imidazole carboxamides as potent and selective CCK1R agonists

Zhu, Cheng ; Hansen, Alexa R ; Bateman, Thomas ; Chen, Zhesheng ; Holt, Tom G ; Hubert, James A ; Karanam, Bindhu V ; Lee, Susan J ; Pan, Jie ; Qian, Su ; Reddy, Vijay B.G ; Reitman, Marc L ; Strack, Alison M ; Tong, Vincent ; Weingarth, Drew T ; Wolff, Michael S ; Macneil, Doug J ; Weber, Ann E ; Duffy, Joseph L ; Edmondson, Scott D

Bioorganic & Medicinal Chemistry Letters, 2008, Vol.18(15), pp.4393-4396 [Peer Reviewed Journal]

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27
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Orally bioavailable, indole-based nonpeptide GnRH receptor antagonists with high potency and functional activity

Ashton, Wallace T ; Sisco, Rosemary M ; Kieczykowski, Gerard R ; Yang, Yi Tien ; Yudkovitz, Joel B ; Cui, Jisong ; Mount, George R ; Ren, Rena Ning ; Wu, Tsuei-Ju ; Shen, Xiaolan ; Lyons, Kathryn A ; Mao, An-Hua ; Carlin, Josephine R ; Karanam, Bindhu V ; Vincent, Stella H ; Cheng, Kang ; Goulet, Mark T

Bioorganic & Medicinal Chemistry Letters, 2001, Vol.11(19), pp.2597-2602 [Peer Reviewed Journal]

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28
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Benzazepinone Na v1.7 blockers: Potential treatments for neuropathic pain

Hoyt, Scott B ; London, Clare ; Ok, Hyun ; Gonzalez, Edward ; Duffy, Joseph L ; Abbadie, Catherine ; Dean, Brian ; Felix, John P ; Garcia, Maria L ; Jochnowitz, Nina ; Karanam, Bindhu V ; Li, Xiaohua ; Lyons, Kathryn A ; Mcgowan, Erin ; Macintyre, D. Euan ; Martin, William J ; Priest, Birgit T ; Smith, Mchardy M ; Tschirret-Guth, Richard ; Warren, Vivien A

Bioorganic & Medicinal Chemistry Letters, 2007, Vol.17(22), pp.6172-6177 [Peer Reviewed Journal]

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29
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2-Arylindoles as gonadotropin releasing hormone (GnRH) antagonists: optimization of the tryptamine side chain

Young, Jonathan R ; Huang, Song X ; Walsh, Thomas F ; Wyvratt, Matthew J ; Yang, Yi Tien ; Yudkovitz, Joel B ; Cui, Jisong ; Mount, George R ; Ren, Rena Ning ; Wu, Tsuei-Ju ; Shen, Xiaolan ; Lyons, Kathryn A ; Mao, An-Hua ; Carlin, Josephine R ; Karanam, Bindhu V ; Vincent, Stella H ; Cheng, Kang ; Goulet, Mark T

Bioorganic & Medicinal Chemistry Letters, 2002, Vol.12(5), pp.827-832 [Peer Reviewed Journal]

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30
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Accelerating the discovery of DGAT1 inhibitors through the application of parallel medicinal chemistry (PMC)

Yu, Yang ; Wu, Zhicai ; Shi, Zhi-Cai ; He, Shuwen ; Lai, Zhong ; Cernak, Timothy A ; Vachal, Petr ; Liu, Min ; Liu, Jian ; Hong, Qingmei ; Jian, Tianying ; Guiadeen, Deodial ; Krikorian, Arto ; Sperbeck, Donald M ; Verras, Andreas ; Sonatore, Lisa M ; Murphy, Beth A ; Wiltsie, Judyann ; Chung, Christine C ; Gorski, Judith N

Bioorganic & Medicinal Chemistry Letters, 01 June 2019, Vol.29(11), pp.1380-1385 [Peer Reviewed Journal]

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Benzimidazole-based DGAT1 inhibitors with a [3.1.0] bicyclohexane carboxylic acid moiety

He, Shuwen ; Lai, Zhong ; Hong, Qingmei ; Shang, Jackie ; Reibarkh, Mikhail ; Kuethe, Jeffrey T ; Liu, Jian ; Guiadeen, Deodial ; Krikorian, Arto D ; Cernak, Timothy A ; Dykstra, Kevin D ; Sperbeck, Donald M ; Wu, Zhicai ; Yu, Yang ; Yang, Ginger X ; Jian, Tianying ; Verras, Andreas ; Sonatore, Lisa M ; Wiltsie, Judyann ; Chung, Christine C

Bioorganic & Medicinal Chemistry Letters, 15 May 2019, Vol.29(10), pp.1182-1186 [Peer Reviewed Journal]

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