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Correction: Pharmacological and Genetic Modulation of REV-ERB Activity and Expression Affects Orexigenic Gene Expression

Amador, Ariadna ; Wang, Yongjun ; Banerjee, Subhashis ; Kamenecka, Theodore M ; Solt, Laura A ; Burris, Thomas P

PLoS ONE, 2016, Vol.11(5) [Peer Reviewed Journal]

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Synthesis of 2-aryl-2H-tetrazoles via a regioselective [3+2] cycloaddition reaction

Patouret, Remi ; Kamenecka, Theodore M

Tetrahedron Letters, 06 April 2016, Vol.57(14), pp.1597-1599 [Peer Reviewed Journal]

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Multigram-scale synthesis of enantiopure 3,3-difluoroproline

Doebelin, Christelle ; He, Yuanjun ; Kamenecka, Theodore M

Tetrahedron Letters, 14 December 2016, Vol.57(50), pp.5658-5660 [Peer Reviewed Journal]

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LXR-Mediated Inhibition of CD4 + T Helper Cells (LXR/ROR Regulation of T Cell Function)

Solt, Laura A ; Kamenecka, Theodore M ; Burris, Thomas P Cooney, Austin John (Editor)

2012, Vol.7(9), p.e46615 [Peer Reviewed Journal]

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Site‐Selective γ‐C(sp3)−H and γ‐C(sp2)−H Arylation of Free Amino Esters Promoted by a Catalytic Transient Directing Group

Lin, Hua ; Wang, Chao ; Bannister, Thomas D. ; Kamenecka, Theodore M.

Chemistry – A European Journal, 05 July 2018, Vol.24(38), pp.9535-9541 [Peer Reviewed Journal]

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Noncanonical agonist PPARγ ligands modulate the response to DNA damage and sensitize cancer cells to cytotoxic chemotherapy

Khandekar, Melin J ; Banks, Alexander S ; Laznik-Bogoslavski, Dina ; White, James P ; Choi, Jang Hyun ; Kazak, Lawrence ; Lo, James C ; Cohen, Paul ; Wong, Kwok-Kin ; Kamenecka, Theodore M ; Griffin, Patrick R ; Spiegelman, Bruce M

Proceedings of the National Academy of Sciences of the United States of America, 16 January 2018, Vol.115(3), pp.561-566 [Peer Reviewed Journal]

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Hypocretin (orexin) facilitates reward by attenuating the antireward effects of its cotransmitter dynorphin in ventral tegmental area

Muschamp, John W ; Hollander, Jonathan A ; Thompson, Jennifer L ; Voren, George ; Hassinger, Linda C ; Onvani, Sara ; Kamenecka, Theodore M ; Borgland, Stephanie L ; Kenny, Paul J ; Carlezon, William A

Proceedings of the National Academy of Sciences of the United States of America, 22 April 2014, Vol.111(16), pp.E1648-55 [Peer Reviewed Journal]

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Nuclear receptor RORα regulates pathologic retinal angiogenesis by modulating SOCS3-dependent inflammation

Sun, Ye ; Liu, Chi-Hsiu ; Sangiovanni, John Paul ; Evans, Lucy P ; Tian, Katherine T ; Zhang, Bing ; Stahl, Andreas ; Pu, William T ; Kamenecka, Theodore M ; Solt, Laura A ; Chen, Jing

Proceedings of the National Academy of Sciences of the United States of America, 18 August 2015, Vol.112(33), pp.10401-6 [Peer Reviewed Journal]

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9
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Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists

Solt, Laura A ; Wang, Yongjun ; Banerjee, Subhashis ; Hughes, Travis ; Kojetin, Douglas J ; Lundasen, Thomas ; Shin, Youseung ; Liu, Jin ; Cameron, Michael D ; Noel, Romain ; Yoo, Seung-Hee ; Takahashi, Joseph S ; Butler, Andrew A ; Kamenecka, Theodore M ; Burris, Thomas P

Nature, 29 March 2012, Vol.485(7396), pp.62-8 [Peer Reviewed Journal]

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Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5

Choi, Jang Hyun ; Banks, Alexander S ; Estall, Jennifer L ; Kajimura, Shingo ; Boström, Pontus ; Laznik, Dina ; Ruas, Jorge L ; Chalmers, Michael J ; Kamenecka, Theodore M ; Blüher, Matthias ; Griffin, Patrick R ; Spiegelman, Bruce M

Nature, 22 July 2010, Vol.466(7305), pp.451-6 [Peer Reviewed Journal]

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11
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Ablation of PM20D1 reveals -acyl amino acid control of metabolism and nociception

Long, Jonathan Z ; Roche, Alexander M ; Berdan, Charles A ; Louie, Sharon M ; Roberts, Amanda J ; Svensson, Katrin J ; Dou, Florence Y ; Bateman, Leslie A ; Mina, Amir I ; Deng, Zhaoming ; Jedrychowski, Mark P ; Lin, Hua ; Kamenecka, Theodore M ; Asara, John M ; Griffin, Patrick R ; Banks, Alexander S ; Nomura, Daniel K ; Spiegelman, Bruce M

Proceedings of the National Academy of Sciences of the United States of America, 17 July 2018, Vol.115(29), pp.E6937-E6945 [Peer Reviewed Journal]

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12
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Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand

Solt, Laura A ; Kumar, Naresh ; Nuhant, Philippe ; Wang, Yongjun ; Lauer, Janelle L ; Liu, Jin ; Istrate, Monica A ; Kamenecka, Theodore M ; Roush, William R ; Vidović, Dušica ; Schürer, Stephan C ; Xu, Jihong ; Wagoner, Gail ; Drew, Paul D ; Griffin, Patrick R ; Burris, Thomas P

Nature, 28 April 2011, Vol.472(7344), pp.491-4 [Peer Reviewed Journal]

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Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation

Choi, Jang Hyun ; Banks, Alexander S ; Kamenecka, Theodore M ; Busby, Scott A ; Chalmers, Michael J ; Kumar, Naresh ; Kuruvilla, Dana S ; Shin, Youseung ; He, Yuanjun ; Bruning, John B ; Marciano, David P ; Cameron, Michael D ; Laznik, Dina ; Jurczak, Michael J ; Schürer, Stephan C ; Vidović, Dušica ; Shulman

Nature, 04 September 2011, Vol.477(7365), pp.477-81 [Peer Reviewed Journal]

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Suppression of T^sub H^17 differentiation and autoimmunity by a synthetic ROR ligand

Solt, Laura ; Kumar, Naresh ; Nuhant, Philippe ; Wang, Yongjun ; Lauer, Janelle ; Liu, Jin ; Istrate, Monica ; Kamenecka, Theodore ; Roush, William ; Vidovic, Dusica ; Schürer, Stephan ; Xu, Jihong ; Wagoner, Gail ; Drew, Paul ; Griffin, Patrick ; Burris, Thomas

Nature, Apr 28, 2011, Vol.472(7344), pp.491-4 [Peer Reviewed Journal]

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Adipocyte-specific deletion of Ip6k1 reduces diet-induced obesity by enhancing AMPK-mediated thermogenesis

Zhu, Qingzhang ; Ghoshal, Sarbani ; Rodrigues, Ana ; Gao, Su ; Asterian, Alice ; Kamenecka, Theodore M ; Barrow, James C ; Chakraborty, Anutosh

The Journal of clinical investigation, 01 November 2016, Vol.126(11), pp.4273-4288 [Peer Reviewed Journal]

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16
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Pharmacological Targeting the REV-ERBs in Sleep/Wake Regulation

Amador, Ariadna ; Huitron-Resendiz, Salvador ; Roberts, Amanda J ; Kamenecka, Theodore M ; Solt, Laura A ; Burris, Thomas P Cermakian, Nicolas (editor)

PLoS ONE, 2016, Vol.11(9) [Peer Reviewed Journal]

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17
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11. Orexin-1 Receptor Antagonists as Novel Smoking Cessation Agents

Kenny, Paul ; Kamenecka, Theodore ; Voren, George ; Duncan, Alexander ; Howe, Matthew ; Hollander, Jonathan ; Damez-Warno, Diane ; Lu, Qun ; Bali, Purva ; Burli, Roland ; Gurrell, Ian ; Mather, Robert J ; Brandon, Nicholas J

Biological Psychiatry, 01 May 2018, Vol.83(9), pp.S4-S5 [Peer Reviewed Journal]

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Probing the Complex Binding Modes of the PPARγ Partial Agonist 2-Chloro-N-(3-chloro-4-((5-chlorobenzodthiazol-2-yl)thio)phenyl)-4-(trifluoromethyl)benzenesulfonamide (T2384) to Orthosteric and Allosteric Sites with NMR Spectroscopy

Hughes, Travis S ; Shang, Jinsai ; Brust, Richard ; De Vera, Ian Mitchelle S ; Fuhrmann, Jakob ; Ruiz, Claudia ; Cameron, Michael D ; Kamenecka, Theodore M ; Kojetin, Douglas J

Journal of medicinal chemistry, 23 November 2016, Vol.59(22), pp.10335-10341 [Peer Reviewed Journal]

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19
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Structure–Activity Relationship of 2,4-Dichloro-N-(3,5-dichloro-4-(quinolin-3-yloxy)phenyl)benzenesulfonamide (INT131) Analogs for PPARγ-Targeted Antidiabetics

Frkic, Rebecca L ; He, Yuanjun ; Rodriguez, Beatriz B ; Chang, Mi Ra ; Kuruvilla, Dana ; Ciesla, Anthony ; Abell, Andrew D ; Kamenecka, Theodore M ; Griffin, Patrick R ; Bruning, John B Argonne National Lab. (Anl), Argonne, Il (United States). Advanced Photon Source (APS) (Corporate Author)

Journal of Medicinal Chemistry, 09 May 2017, Vol.60(11) [Peer Reviewed Journal]

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20
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GLP-1 acts on habenular avoidance circuits to control nicotine intake

Tuesta, Luis M ; Chen, Zuxin ; Duncan, Alexander ; Fowler, Christie D ; Ishikawa, Masago ; Lee, Brian R ; Liu, Xin-An ; Lu, Qun ; Cameron, Michael ; Hayes, Matthew R ; Kamenecka, Theodore M ; Pletcher, Matthew ; Kenny, Paul J

Nature neuroscience, May 2017, Vol.20(5), pp.708-716 [Peer Reviewed Journal]

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21
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Rev-erb-[alpha] modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy

Woldt, Estelle ; Sebti, Yasmine ; Solt, Laura ; Duhem, Christian ; Lancel, Steve ; Eeckhoute, Jérôme ; Hesselink, Matthijs K ; Paquet, Charlotte ; Delhaye, Stéphane ; Shin, Youseung ; Kamenecka, Theodore ; Schaart, Gert ; Lefebvre, Philippe ; Nevière, Rémi ; Burris

Nature Medicine, Aug 2013, Vol.19(8), pp.1039-46 [Peer Reviewed Journal]

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22
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Insular hypocretin transmission regulates nicotine reward

Hollander, Jonathan A ; Lu, Qun ; Cameron, Michael D ; Kamenecka, Theodore M ; Kenny, Paul J

Proceedings of the National Academy of Sciences of the United States of America, 09 December 2008, Vol.105(49), pp.19480-5 [Peer Reviewed Journal]

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23
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Discovery of Hydrolysis-Resistant Isoindoline N-Acyl Amino Acid Analogues that Stimulate Mitochondrial Respiration

Lin, Hua ; Long, Jonathan Z ; Roche, Alexander M ; Svensson, Katrin J ; Dou, Florence Y ; Chang, Mi Ra ; Strutzenberg, Timothy ; Ruiz, Claudia ; Cameron, Michael D ; Novick, Scott J ; Berdan, Charles A ; Louie, Sharon M ; Nomura, Daniel K ; Spiegelman, Bruce M ; Griffin, Patrick R ; Kamenecka, Theodore M

Journal of medicinal chemistry, 12 April 2018, Vol.61(7), pp.3224-3230 [Peer Reviewed Journal]

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24
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Discovery through Total Synthesis: A Retrospective on the Himastatin Problem

Kamenecka, Theodore M. ; Danishefsky, Samuel J.

Chemistry – A European Journal, 05 January 2001, Vol.7(1), pp.41-63 [Peer Reviewed Journal]

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Kamenecka, Theodore M. ; Danishefsky, Samuel J.

Chemistry, 01/05/2001, Vol.7(1), pp.1-1 [Peer Reviewed Journal]

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26
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REV-ERBβ is required to maintain normal wakefulness and the wake-inducing effect of dual REV-ERB agonist SR9009

Amador, Ariadna ; Kamenecka, Theodore M ; Solt, Laura A ; Burris, Thomas P

Biochemical Pharmacology, April 2018, Vol.150, pp.1-8 [Peer Reviewed Journal]

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27
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Identification of SR8278, a synthetic antagonist of the nuclear heme receptor REV-ERB

Kojetin, Douglas ; Wang, Yongjun ; Kamenecka, Theodore M ; Burris, Thomas P

ACS chemical biology, 18 February 2011, Vol.6(2), pp.131-4 [Peer Reviewed Journal]

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28
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Pharmacologic Repression of Retinoic Acid Receptor–Related Orphan Nuclear Receptor γ Is Therapeutic in the Collagen‐Induced Arthritis Experimental Model

Chang, Mi Ra ; Lyda, Brent ; Kamenecka, Theodore M. ; Griffin, Patrick R.

Arthritis & Rheumatology, March 2014, Vol.66(3), pp.579-588 [Peer Reviewed Journal]

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29
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Discovery of a highly selective CYP3A4 inhibitor suitable for reaction phenotyping studies and differentiation of CYP3A4 and CYP3A5

Li, Xiaohai ; Song, Xinyi ; Kamenecka, Theodore M ; Cameron, Michael D

Drug metabolism and disposition: the biological fate of chemicals, September 2012, Vol.40(9), pp.1803-9 [Peer Reviewed Journal]

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Suppression of atherosclerosis by synthetic REV-ERB agonist

Sitaula, Sadichha ; Billon, Cyrielle ; Kamenecka, Theodore M ; Solt, Laura A ; Burris, Thomas P

Biochemical and Biophysical Research Communications, 08 May 2015, Vol.460(3), pp.566-571 [Peer Reviewed Journal]

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31
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Unorthodox Acetylcholine Binding Sites Formed by α5 and β3 Accessory Subunits in α4β2* Nicotinic Acetylcholine Receptors

Jain, Akansha ; Kuryatov, Alexander ; Wang, Jingyi ; Kamenecka, Theodore M ; Lindstrom, Jon

The Journal of biological chemistry, 04 November 2016, Vol.291(45), pp.23452-23463 [Peer Reviewed Journal]

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32
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Cytochrome P450-mediated bioactivation of the epidermal growth factor receptor inhibitor erlotinib to a reactive electrophile

Li, Xiaohai ; Kamenecka, Theodore M ; Cameron, Michael D

Drug metabolism and disposition: the biological fate of chemicals, July 2010, Vol.38(7), pp.1238-45 [Peer Reviewed Journal]

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33
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Construction of substituted cyclohexanones by reductive cyclization of 7-oxo-2,8-alkadienyl esters

Kamenecka, Theodore M ; Overman, Larry E ; Ly Sakata, Sylvie K

Organic letters, 10 January 2002, Vol.4(1), pp.79-82 [Peer Reviewed Journal]

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34
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Synthesis and SAR of 2-Phenoxypyridines as novel c-Jun N-terminal kinase inhibitors

Song, Xinyi ; Chen, Weimin ; Lin, Li ; Ruiz, Claudia H ; Cameron, Michael D ; Duckett, Derek R ; Kamenecka, Theodore M

Bioorganic & Medicinal Chemistry Letters, 2011, Vol.21(23), pp.7072-7075 [Peer Reviewed Journal]

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35
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A Novel α2/α4 Subtype-selective Positive Allosteric Modulator of Nicotinic Acetylcholine Receptors Acting from the C-tail of an α Subunit

Wang, Jingyi ; Kuryatov, Alexander ; Jin, Zhuang ; Norleans, Jack ; Kamenecka, Theodore M ; Kenny, Paul J ; Lindstrom, Jon

The Journal of biological chemistry, 27 November 2015, Vol.290(48), pp.28834-46 [Peer Reviewed Journal]

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An Accessory Agonist Binding Site Promotes Activation of α4β2* Nicotinic Acetylcholine Receptors

Wang, Jingyi ; Kuryatov, Alexander ; Sriram, Aarati ; Jin, Zhuang ; Kamenecka, Theodore M ; Kenny, Paul J ; Lindstrom, Jon

The Journal of biological chemistry, 29 May 2015, Vol.290(22), pp.13907-18 [Peer Reviewed Journal]

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37
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Identification of a selective RORγ ligand that suppresses T(H)17 cells and stimulates T regulatory cells

Solt, Laura A ; Kumar, Naresh ; He, Yuanjun ; Kamenecka, Theodore M ; Griffin, Patrick R ; Burris, Thomas P

ACS chemical biology, 21 September 2012, Vol.7(9), pp.1515-9 [Peer Reviewed Journal]

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