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Use of 13C18 oleic acid and mass isotopomer distribution analysis to study synthesis of plasma triglycerides in vivo: analytical and experimental considerations

Mclaren, David G ; Cardasis, Helene L ; Stout, Steven J ; Wang, Sheng-Ping ; Mendoza, Vivienne ; Castro-Perez, Jose M ; Miller, Paul L ; Murphy, Beth A ; Cumiskey, Anne-Marie ; Cleary, Michele A ; Johns, Douglas G ; Previs, Stephen F ; Roddy, Thomas P

Analytical chemistry, 02 July 2013, Vol.85(13), pp.6287-94 [Peer Reviewed Journal]

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On-and Off-Target Pharmacology of Torcetrapib

Johns, Douglas ; Duffy, Joseph ; Fisher, Timothy ; Hubbard, Brian ; Forrest, Michael

Drugs, 2012, Vol.72(4), pp.491-507 [Peer Reviewed Journal]

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Anacetrapib and dalcetrapib differentially alters HDL metabolism and macrophage-to-feces reverse cholesterol transport at similar levels of CETP inhibition in hamsters

Briand, François ; Thieblemont, Quentin ; Muzotte, Elodie ; Burr, Noémie ; Urbain, Isabelle ; Sulpice, Thierry ; Johns, Douglas G

European Journal of Pharmacology, 05 October 2014, Vol.740, pp.135-143 [Peer Reviewed Journal]

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Inhibition of cholesteryl ester transfer protein increases cholesteryl ester content of large HDL independently of HDL-to-HDL homotypic transfer: In vitro vs in vivo comparison using anacetrapib and dalcetrapib

Johns, Douglas G ; Chen, Ying ; Wang, Sheng-Ping ; Castro-Perez, Jose ; Previs, Stephen F ; Roddy, Thomas P

European Journal of Pharmacology, 05 September 2015, Vol.762, pp.256-262 [Peer Reviewed Journal]

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Equilibration of 2H labeling between body water and free amino acids: Enabling studies of proteome synthesis

Herath, Kithsiri ; Bhat, Gowi ; Miller, Paul L ; Wang, Sheng-Ping ; Kulick, Alison ; Andrews-Kelly, Genevieve ; Johnson, Christopher ; Rohm, Rory J ; Lassman, Michael E ; Previs, Stephen F ; Johns, Douglas G ; Hubbard, Brian K ; Roddy, Thomas P

Analytical Biochemistry, 2011, Vol.415(2), pp.197-199 [Peer Reviewed Journal]

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Headspace analyses of 2H labeling of acetone: Enabling studies of fatty acid oxidation in vivo

Mahsut, Ablatt ; Wang, Sheng-Ping ; Mclaren, David G ; Bhat, Gowri ; Herath, Kithsiri ; Miller, Paul L ; Hubbard, Brian K ; Johns, Douglas G ; Previs, Stephen F ; Roddy, Thomas P

Analytical Biochemistry, 2011, Vol.408(2), pp.351-353 [Peer Reviewed Journal]

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Effects of anacetrapib on plasma lipids, apolipoproteins and PCSK9 in healthy, lean rhesus macaques

Roddy, Thomas P ; Mclaren, David G ; Chen, Ying ; Xie, Dan ; Dunn, Keiana ; Kulick, Alison ; Szeto, Daphne ; Forrest, Gail ; Albanese, Kelly ; Donnelly, Marcie ; Gai, Cesaire ; Gewain, Andrew ; Lederman, Harmony ; Jensen, Kristian K ; Ai, Xi ; Vachal, Petr ; Akinsanya, Karen O ; Cleary, Michele A ; Previs, Stephen F ; Dansky

European journal of pharmacology, 05 October 2014, Vol.740, pp.410-6 [Peer Reviewed Journal]

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Lipidome of atherosclerotic plaques from hypercholesterolemic rabbits

Bojic, Lazar A ; Mclaren, David G ; Shah, Vinit ; Previs, Stephen F ; Johns, Douglas G ; Castro-Perez, Jose M

International journal of molecular sciences, 15 December 2014, Vol.15(12), pp.23283-93 [Peer Reviewed Journal]

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Characterization of anacetrapib distribution into the lipid droplet of adipose tissue in mice and human cultured adipocytes

Johns, Douglas G ; Levoci, Lauretta ; Krsmanovic, Mihajlo ; Lu, Min ; Hartmann, Georgy ; Xu, Suoyu ; Wang, Sheng-Ping ; Chen, Ying ; Bateman, Thomas ; Blaustein, Robert O

Drug metabolism and disposition: the biological fate of chemicals, 19 December 2018 [Peer Reviewed Journal]

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Use of Microcomputed Tomography to Measure the Relaxin-induced Expansion of Intrapubic Ligaments in Mice

Zimmerman, Heather A ; Kennan, Richard P ; Zhang, Chunlian ; Shah, Kashmira ; Johns, Douglas G ; Lynch, Joseph J ; Dajee, Maya

Comparative medicine, 01 August 2017, Vol.67(4), pp.330-334 [Peer Reviewed Journal]

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11
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Inverse relationship between LDL cholesterol and PCSK9 plasma levels in dyslipidemic cynomolgus monkeys: Effects of LDL lowering by ezetimibe in the absence of statins

Hentze, Hannes ; Jensen, Kristian K ; Chia, Ser Mien ; Johns, Douglas G ; Shaw, Rachel J ; Davis, Harry R ; Shih, Shian-Jiun ; Wong, Kenny K

Atherosclerosis, November 2013, Vol.231(1), pp.84-90 [Peer Reviewed Journal]

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Regulation of the ADMA-DDAH system in endothelial cells: a novel mechanism for the sterol response element binding proteins, SREBP1c and -2

Ivashchenko, Christine Y ; Bradley, Benjamin T ; Ao, Zhaohui ; Leiper, James ; Vallance, Patrick ; Johns, Douglas G

American journal of physiology. Heart and circulatory physiology, January 2010, Vol.298(1), pp.H251-8 [Peer Reviewed Journal]

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Assessing the mechanisms of cholesteryl ester transfer protein inhibitors

Zhang, Meng ; Lei, Dongsheng ; Peng, Bo ; Yang, Mickey ; Zhang, Lei ; Charles, M Art ; Rye, Kerry-Anne ; Krauss, Ronald M ; Johns, Douglas G ; Ren, Gang

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Development of a High-Throughput Cell-Based Assay for Superoxide Production in HL-60 Cells

Seitz, Patricia M ; Cooper, Rona ; Gatto, Gregory J ; Ramon, Fernando ; Sweitzer, Thomas D ; Johns, Douglas G ; Davenport, Elizabeth A ; Ames, Robert S ; Kallal, Lorena A

Journal of Biomolecular Screening, April 2010, Vol.15(4), pp.388-397 [Peer Reviewed Journal]

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15
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Tracking fatty acid kinetics in distinct lipoprotein fractions in vivo: a novel high-throughput approach for studying dyslipidemia in rodent models

Mclaren, David G ; Wang, Sheng-Ping ; Stout, Steven J ; Xie, Dan ; Miller, Paul L ; Mendoza, Vivienne ; Rosa, Raymond ; Castro-Perez, Jose ; Previs, Stephen F ; Johns, Douglas G ; Roddy, Thomas P

Journal of lipid research, January 2013, Vol.54(1), pp.276-81 [Peer Reviewed Journal]

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16
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Enhancing Studies of Pharmacodynamic Mechanisms via Measurements of Metabolic Flux: Fundamental Concepts and Guiding Principles for Using Stable Isotope Tracers

Daurio, Natalie A ; Wang, Sheng-Ping ; Chen, Ying ; Zhou, Haihong ; Mclaren, David G ; Roddy, Thomas P ; Johns, Douglas G ; Milot, Denise ; Kasumov, Takhar ; Erion, Mark D ; Kelley, David E ; Previs, Stephen F

The Journal of pharmacology and experimental therapeutics, October 2017, Vol.363(1), pp.80-91 [Peer Reviewed Journal]

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17
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Identifying static and kinetic lipid phenotypes by high resolution UPLC-MS: unraveling diet-induced changes in lipid homeostasis by coupling metabolomics and fluxomics

Castro-Perez, Jose M ; Roddy, Thomas P ; Shah, Vinit ; Mclaren, David G ; Wang, Sheng-Ping ; Jensen, Kristian ; Vreeken, Rob J ; Hankemeier, Thomas ; Johns, Douglas G ; Previs, Stephen F ; Hubbard, Brian K

Journal of proteome research, 02 September 2011, Vol.10(9), pp.4281-90 [Peer Reviewed Journal]

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18
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HDL surface lipids mediate CETP binding as revealed by electron microscopy and molecular dynamics simulation

Zhang, Meng ; Charles, River ; Tong, Huimin ; Zhang, Lei ; Patel, Mili ; Wang, Francis ; Rames, Matthew J ; Ren, Amy ; Rye, Kerry-Anne ; Qiu, Xiayang ; Johns, Douglas G ; Charles, M. Arthur ; Ren, Gang Lawrence Berkeley National Lab. (Lbnl), Berkeley, Ca (United States) (Corporate Author)

Scientific Reports, 04 March 2015, Vol.5(3) [Peer Reviewed Journal]

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19
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Quantitative profiling of oxylipins in plasma and atherosclerotic plaques of hypercholesterolemic rabbits

Bojic, Lazar A ; Mclaren, David G ; Harms, Amy C ; Hankemeier, Thomas ; Dane, Adrie ; Wang, Sheng-Ping ; Rosa, Ray ; Previs, Stephen F ; Johns, Douglas G ; Castro-Perez, Jose M

Analytical and bioanalytical chemistry, January 2016, Vol.408(1), pp.97-105 [Peer Reviewed Journal]

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20
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Assessing the mechanisms of cholesteryl ester transfer protein inhibitors

Zhang, Meng ; Lei, Dongsheng ; Peng, Bo ; Yang, Mickey ; Zhang, Lei ; Charles, M. Art ; Rye, Kerry-Anne ; Krauss, Ronald M ; Johns, Douglas G ; Ren, Gang

BBA - Molecular and Cell Biology of Lipids, December 2017, Vol.1862(12), pp.1606-1617 [Peer Reviewed Journal]

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21
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In vivo effects of anacetrapib on preβ HDL: improvement in HDL remodeling without effects on cholesterol absorption

Wang, Sheng-Ping ; Daniels, Erin ; Chen, Ying ; Castro-Perez, Jose ; Zhou, Haihong ; Akinsanya, Karen O ; Previs, Stephen F ; Roddy, Thomas P ; Johns, Douglas G

Journal of lipid research, October 2013, Vol.54(10), pp.2858-65 [Peer Reviewed Journal]

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22
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In vivo isotopically labeled atherosclerotic aorta plaques in ApoE KO mice and molecular profiling by matrix‐assisted laser desorption/ionization mass spectrometric imaging

Castro‐Perez, Jose ; Hatcher, Nathan ; Kofi Karikari, Nana ; Wang, Sheng‐Ping ; Mendoza, Vivienne ; Shion, Henry ; Millar, Alan ; Shockcor, John ; Towers, Mark ; Mclaren, David ; Shah, Vinit ; Previs, Stephen ; Akinsanya, Karen ; Cleary, Michele ; Roddy, Thomas P. ; Johns, Douglas G.

Rapid Communications in Mass Spectrometry, 30 November 2014, Vol.28(22), pp.2471-2479 [Peer Reviewed Journal]

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23
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Measuring H(2)(18)O tracer incorporation on a QQQ-MS platform provides a rapid, transferable screening tool for relative protein synthesis

Conway, James P ; Johns, Douglas G ; Wang, Sheng-Ping ; Walker, Nykia D ; Mcavoy, Thomas A ; Zhou, Haihong ; Zhao, Xuemei ; Previs, Stephen F ; Roddy, Thomas P ; Hubbard, Brian K ; Yates, Nathan A ; Hendrickson, Ronald C

Journal of proteome research, 02 March 2012, Vol.11(3), pp.1591-7 [Peer Reviewed Journal]

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24
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Quantifying cholesterol synthesis in vivo using (2)H(2)O: enabling back-to-back studies in the same subject

Previs, Stephen F ; Mahsut, Ablatt ; Kulick, Alison ; Dunn, Keiana ; Andrews-Kelly, Genevieve ; Johnson, Christopher ; Bhat, Gowri ; Herath, Kithsiri ; Miller, Paul L ; Wang, Sheng-Ping ; Azer, Karim ; Xu, Jing ; Johns, Douglas G ; Hubbard, Brian K ; Roddy, Thomas P

Journal of lipid research, July 2011, Vol.52(7), pp.1420-8 [Peer Reviewed Journal]

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25
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Inhibition of cholesteryl ester transfer protein by anacetrapib does not impair the anti-inflammatory properties of high density lipoprotein

Han, Seongah ; Levoci, Lauretta ; Fischer, Paul ; Wang, Sheng-Ping ; Gagen, Karen ; Chen, Ying ; Xie, Dan ; Fisher, Timothy ; Ehrhardt, Anka G ; Peier, Andrea M ; Johns, Douglas G

BBA - Molecular and Cell Biology of Lipids, April 2013, Vol.1831(4), pp.825-833 [Peer Reviewed Journal]

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26
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Anacetrapib promotes reverse cholesterol transport and bulk cholesterol excretion in Syrian golden hamsters

Castro-Perez, Jose ; Briand, François ; Gagen, Karen ; Wang, Sheng-Ping ; Chen, Ying ; Mclaren, David G ; Shah, Vinit ; Vreeken, Rob J ; Hankemeier, Thomas ; Sulpice, Thierry ; Roddy, Thomas P ; Hubbard, Brian K ; Johns, Douglas G

Journal of lipid research, November 2011, Vol.52(11), pp.1965-73 [Peer Reviewed Journal]

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27
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In vivo D2O labeling to quantify static and dynamic changes in cholesterol and cholesterol esters by high resolution LC/MS

Castro-Perez, Jose ; Previs, Stephen F ; Mclaren, David G ; Shah, Vinit ; Herath, Kithsiri ; Bhat, Gowri ; Johns, Douglas G ; Wang, Sheng-Ping ; Mitnaul, Lyndon ; Jensen, Kristian ; Vreeken, Robert ; Hankemeier, Thomas ; Roddy, Thomas P ; Hubbard, Brian K

Journal of lipid research, January 2011, Vol.52(1), pp.159-69 [Peer Reviewed Journal]

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28
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New methodologies for studying lipid synthesis and turnover: Looking backwards to enable moving forwards

Previs, Stephen F ; Mclaren, David G ; Wang, Sheng-Ping ; Stout, Steven J ; Zhou, Haihong ; Herath, Kithsiri ; Shah, Vinit ; Miller, Paul L ; Wilsie, Larissa ; Castro-Perez, Jose ; Johns, Douglas G ; Cleary, Michele A ; Roddy, Thomas P

BBA - Molecular Basis of Disease, March 2014, Vol.1842(3), pp.402-413 [Peer Reviewed Journal]

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29
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Inhibitory effects of putative peptidic urotensin-II receptor antagonists on urotensin-II-induced contraction of cat isolated respiratory smooth muscle

Behm, David J ; Ao, Zhaohui ; Camarda, Valeria ; Aiyar, Nambi V ; Johns, Douglas G ; Douglas, Stephen A

European Journal of Pharmacology, 15 June 2005, Vol.516(3), pp.276-281 [Peer Reviewed Journal]

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30
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Heme-oxygenase induction inhibits arteriolar thrombosis in vivo: Effect of the non-substrate inducer cobalt protoporphyrin

Johns, Douglas G ; Zelent, Dorothy ; Ao, Zhaohui ; Bradley, Benjamin T ; Cooke, Alexandra ; Contino, Lisa ; Hu, Erding ; Douglas, Stephen A ; Jaye, Michael C

European Journal of Pharmacology, 2009, Vol.606(1), pp.109-114 [Peer Reviewed Journal]

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31
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Evaluation of CETP activity in vivo under non-steady-state conditions: influence of anacetrapib on HDL-TG flux

Mclaren, David G ; Previs, Stephen F ; Phair, Robert D ; Stout, Steven J ; Xie, Dan ; Chen, Ying ; Salituro, Gino M ; Xu, Suoyu S ; Castro-Perez, Jose M ; Opiteck, Gregory J ; Akinsanya, Karen O ; Cleary, Michele A ; Dansky, Hayes M ; Johns, Douglas G ; Roddy, Thomas P

Journal of lipid research, March 2016, Vol.57(3), pp.398-409 [Peer Reviewed Journal]

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32
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Determination of low levels of 2 H‐labeling using high‐resolution mass spectrometry: Application in studies of lipid flux and beyond

Herath, Kithsiri B. ; Zhong, Wendy ; Yang, Jiong ; Mahsut, Ablatt ; Rohm, Rory J. ; Shah, Vinit ; Castro‐Perez, Jose ; Zhou, Haihong ; Attygalle, Athula B. ; Kang, Ling ; Singh, Sheo ; Johns, Douglas G. ; Cleary, Michele A. ; Hubbard, Brian K. ; Previs, Stephen F. ; Roddy, Thomas P.

Rapid Communications in Mass Spectrometry, 15 February 2014, Vol.28(3), pp.239-244 [Peer Reviewed Journal]

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33
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Quantifying apoprotein synthesis in rodents: coupling LC-MS/MS analyses with the administration of labeled water

Zhou, Haihong ; Li, Wenyu ; Wang, Sheng-Ping ; Mendoza, Vivienne ; Rosa, Raymond ; Hubert, James ; Herath, Kithsiri ; Mclaughlin, Theresa ; Rohm, Rory J ; Lassman, Michael E ; Wong, Kenny K ; Johns, Douglas G ; Previs, Stephen F ; Hubbard, Brian K ; Roddy, Thomas P

Journal of lipid research, June 2012, Vol.53(6), pp.1223-31 [Peer Reviewed Journal]

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34
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Demonstration of diet-induced decoupling of fatty acid and cholesterol synthesis by combining gene expression array and 2H2O quantification

Jensen, Kristian K ; Previs, Stephen F ; Zhu, Lei ; Herath, Kithsiri ; Wang, Sheng-Ping ; Bhat, Gowri ; Hu, Guanghui ; Miller, Paul L ; Mclaren, David G ; Shin, Myung K ; Vogt, Thomas F ; Wang, Liangsu ; Wong, Kenny K ; Roddy, Thomas P ; Johns, Douglas G ; Hubbard, Brian K

American journal of physiology. Endocrinology and metabolism, 15 January 2012, Vol.302(2), pp.E209-17 [Peer Reviewed Journal]

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35
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Localization of Fatty Acyl and Double Bond Positions in Phosphatidylcholines Using a Dual Stage CID Fragmentation Coupled with Ion Mobility Mass Spectrometry

Castro-Perez, Jose ; Roddy, Thomas ; Nibbering, Nico ; Shah, Vinit ; McLaren, David ; Previs, Stephen ; Attygalle, Athula ; Herath, Kithsiri ; Chen, Zhu ; Wang, Sheng-Ping ; Mitnaul, Lyndon ; Hubbard, Brian ; Vreeken, Rob ; Johns, Douglas ; Hankemeier, Thomas

Journal of The American Society for Mass Spectrometry, 2011, Vol.22(9), pp.1552-1567 [Peer Reviewed Journal]

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36
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Reconstituted HDL Elicits Marked Changes in Plasma Lipids Following Single-Dose Injection in C57Bl/6 Mice

Chen, Zhu ; O'Neill, Edward A ; Meurer, Roger D ; Gagen, Karen ; Luell, Silvi ; Wang, Sheng-Ping ; Ichetovkin, Marina ; Frantz-Wattley, Betsy ; Eveland, Suzanne ; Strack, Alison M ; Fisher, Timothy S ; Johns, Douglas G ; Sparrow, Carl P ; Wright, Samuel D ; Hubbard, Brian K ; Carballo-Jane, Ester

Journal of Cardiovascular Pharmacology and Therapeutics, September 2012, Vol.17(3), pp.315-323 [Peer Reviewed Journal]

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Discovery of Novel Indoline Cholesterol Ester Transfer Protein Inhibitors (CETP) through a Structure-Guided Approach

Wilson, Jonathan E ; Kurukulasuriya, Ravi ; Reibarkh, Mikhail ; Reiter, Maud ; Zwicker, Aaron ; Zhao, Kake ; Zhang, Fengqi ; Anand, Rajan ; Colandrea, Vincent J ; Cumiskey, Anne-Marie ; Crespo, Alejandro ; Duffy, Ruth A ; Murphy, Beth Ann ; Mitra, Kaushik ; Johns, Douglas G ; Duffy, Joseph L ; Vachal, Petr

ACS medicinal chemistry letters, 10 March 2016, Vol.7(3), pp.261-5 [Peer Reviewed Journal]

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