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Negative regulators of integrin activity

Pouwels, Jeroen ; Nevo, Jonna ; Pellinen, Teijo ; Ylänne, Jari ; Ivaska, Johanna

Journal of cell science, 15 July 2012, Vol.125(Pt 14), pp.3271-80 [Peer Reviewed Journal]

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A novel monoclonal antibody to human laminin α5 chain strongly inhibits integrin-mediated cell adhesion and migration on laminins 511 and 521

Wondimu, Zenebech ; Omrani, Shahin ; Ishikawa, Taichi ; Javed, Fawad ; Oikawa, Yuko ; Virtanen, Ismo ; Juronen, Erkki ; Ingerpuu, Sulev ; Patarroyo, Manuel

PloS one, 2013, Vol.8(1), pp.e53648 [Peer Reviewed Journal]

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The integrin inhibitor cilengitide affects meningioma cell motility and invasion

Wilisch-Neumann, Annette ; Kliese, Nadine ; Pachow, Doreen ; Schneider, Thomas ; Warnke, Jan-Peter ; Braunsdorf, Werner Ek ; Böhmer, Frank-Dietmar ; Hass, Peter ; Pasemann, Diana ; Helbing, Cornelia ; Kirches, Elmar ; Mawrin, Christian

Clinical cancer research : an official journal of the American Association for Cancer Research, 01 October 2013, Vol.19(19), pp.5402-12 [Peer Reviewed Journal]

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Vicrostatin - an anti-invasive multi-integrin targeting chimeric disintegrin with tumor anti-angiogenic and pro-apoptotic activities

Minea, Radu O ; Helchowski, Corey M ; Zidovetzki, Samuel J ; Costa, Fritz K ; Swenson, Stephen D ; Markland, Francis S

PloS one, 03 June 2010, Vol.5(6), pp.e10929 [Peer Reviewed Journal]

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Integrins as therapeutic targets: lessons and opportunities

Cox, Dermot ; Brennan, Marian ; Moran, Niamh

Nature reviews. Drug discovery, October 2010, Vol.9(10), pp.804-20 [Peer Reviewed Journal]

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Introducing lasso peptides as molecular scaffolds for drug design: engineering of an integrin antagonist

Knappe, Thomas A ; Manzenrieder, Florian ; Mas-Moruno, Carlos ; Linne, Uwe ; Sasse, Florenz ; Kessler, Horst ; Xie, Xiulan ; Marahiel, Mohamed A

Angewandte Chemie (International ed. in English), 05 September 2011, Vol.50(37), pp.8714-7 [Peer Reviewed Journal]

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Integrin inhibition promotes atypical anoikis in glioma cells

Silginer, M ; Weller, M ; Ziegler, U ; Roth, P

Cell death & disease, 23 January 2014, Vol.5, pp.e1012 [Peer Reviewed Journal]

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Integrins as therapeutic targets

Goodman, Simon L ; Picard, Martin

Trends in pharmacological sciences, July 2012, Vol.33(7), pp.405-12 [Peer Reviewed Journal]

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Emergence of Small-Molecule Non-RGD-Mimetic Inhibitors for RGD Integrins

Miller, Lisa M ; Pritchard, John M ; Macdonald, Simon J F ; Jamieson, Craig ; Watson, Allan J B

Journal of medicinal chemistry, 27 April 2017, Vol.60(8), pp.3241-3251 [Peer Reviewed Journal]

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10
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A human monoclonal antibody 264RAD targeting αvβ6 integrin reduces tumour growth and metastasis, and modulates key biomarkers in vivo

Eberlein, C ; Kendrew, J ; Mcdaid, K ; Alfred, A ; Kang, J S ; Jacobs, V N ; Ross, S J ; Rooney, C ; Smith, N R ; Rinkenberger, J ; Cao, A ; Churchman, A ; Marshall, J F ; Weir, H M ; Bedian, V ; Blakey, D C ; Foltz, I N ; Barry, S T

Oncogene, 12 September 2013, Vol.32(37), pp.4406-16 [Peer Reviewed Journal]

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Tyrosine modified analogues of the α4β7 integrin inhibitor biotin-R₈ERY prepared via Click Chemistry: synthesis and biological evaluation

Papst, Stefanie ; Noisier, Anaïs ; Brimble, Margaret A ; Yang, Yi ; Krissansen, Geoffrey W

Bioorganic & medicinal chemistry, 15 April 2012, Vol.20(8), pp.2638-44 [Peer Reviewed Journal]

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Strategies to inhibit tumor associated integrin receptors: rationale for dual and multi-antagonists

Sheldrake, Helen M ; Patterson, Laurence H

Journal of medicinal chemistry, 14 August 2014, Vol.57(15), pp.6301-15 [Peer Reviewed Journal]

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13
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Orally available and efficacious α4β1/α4β7 integrin inhibitors

Xu, Ying-Zi ; Smith, Jenifer L ; Semko, Christopher M ; Rossiter, Kassandra I ; Fukuda, Juri Y ; Dappen, Michael S ; Quincy, David A ; Konradi, Andrei W ; Mao, Wenxian ; Welch, Brent ; Dreyer, Mark L ; Samant, Bhushan ; Zhang, Hongbin ; Lugar, Judevin ; Liao, Zhenmei ; Henschel, Carrol ; Petersen, Eric ; Vandevert, Christopher ; Shoemaker, Mark ; Wehner, Nancy ; Mutter, Linda ; Shopp, George ; Krimm, Michael ; Chen, Linda ; Wipke, Brian ; Dofiles, Lilibeth ; Gallager, Ian ; Sauer, John-Michael ; Messersmith, Elizabeth K ; Pleiss, Michael A ; Bard, Frederique ; Yednock, Ted A

Bioorganic & medicinal chemistry letters, 01 August 2013, Vol.23(15), pp.4370-3 [Peer Reviewed Journal]

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Chelate oxorhenium to assemble new integrin antagonists

Le Gal, Julien ; Gonera, Marta ; Lelait, Marie-Anne ; Servent, Denis ; Dugave, Christophe

Journal of inorganic biochemistry, June 2011, Vol.105(6), pp.880-6 [Peer Reviewed Journal]

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15
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Uso potencial de componentes del veneno de serpiente en el tratamiento del cáncer.
Potential use of snake venom components in cancer treatment

Vivas, Dan ; Inga, Rosío ; Yarlequé, Armando

Revista peruana de medicina experimental y salud publica, 2012, Vol.29(3), pp.396-401 [Peer Reviewed Journal]

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16
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Identification of N-acyl 4-(5-pyrimidine-2,4-dionyl)phenylalanine derivatives and their orally active prodrug esters as dual-acting alpha4-beta1 and alpha4-beta7 receptor antagonists

Sidduri, Achyutharao ; Tilley, Jefferson W ; Lou, Jianping ; Tare, Nadine ; Cavallo, Gary ; Frank, Karl ; Pamidimukkala, Anjula ; Choi, Duk Soon ; Gerber, Louise ; Railkar, Aruna ; Renzetti, Louis

Bioorganic & medicinal chemistry letters, 15 February 2013, Vol.23(4), pp.1026-31 [Peer Reviewed Journal]

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17
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Integrin antagonists prevent costimulatory blockade-resistant transplant rejection by CD8(+) memory T cells

Kitchens, W H ; Haridas, D ; Wagener, M E ; Song, M ; Kirk, A D ; Larsen, C P ; Ford, M L

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, January 2012, Vol.12(1), pp.69-80 [Peer Reviewed Journal]

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18
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Integrins: Integrating the Biology and Therapy of Cell-cell Interactions

Pandolfi, Franco ; Franza, Laura ; Altamura, Simona ; Mandolini, Claudia ; Cianci, Rossella ; Ansari, Aftab ; Kurnick, James T

Clinical therapeutics, December 2017, Vol.39(12), pp.2420-2436 [Peer Reviewed Journal]

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19
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Gene electrotransfer of plasmid AMEP, an integrin-targeted therapy, has antitumor and antiangiogenic action in murine B16 melanoma

Bosnjak, M ; Dolinsek, T ; Cemazar, M ; Kranjc, S ; Blagus, T ; Markelc, B ; Stimac, M ; Zavrsnik, J ; Kamensek, U ; Heller, L ; Bouquet, C ; Turk, B ; Sersa, G

Gene therapy, July 2015, Vol.22(7), pp.578-90 [Peer Reviewed Journal]

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20
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A novel treatment for glioblastoma: integrin inhibition

Chamberlain, Marc C ; Cloughsey, Timothy ; Reardon, David A ; Wen, Patrick Y

Expert review of neurotherapeutics, April 2012, Vol.12(4), pp.421-35 [Peer Reviewed Journal]

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21
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Integrin-based therapeutics: biological basis, clinical use and new drugs

Ley, Klaus ; Rivera-Nieves, Jesus ; Sandborn, William J ; Shattil, Sanford

Nature reviews. Drug discovery, March 2016, Vol.15(3), pp.173-83 [Peer Reviewed Journal]

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22
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A label-free approach to identify inhibitors of alpha4beta7-mediated cell adhesion to MadCAM

Bova, Michael P ; Nguyen, Lan ; Wallace, William ; Garrido, Caroline ; Xu, Ying-Zi ; Semko, Chris ; Cockcroft, Kelly ; Sandberg, Eric ; Bard, Frederique

Journal of biomolecular screening, June 2011, Vol.16(5), pp.536-44 [Peer Reviewed Journal]

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23
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Leukocyte traffic control: a novel therapeutic strategy for inflammatory bowel disease--an update

Cesarini, Monica ; Fiorino, Gionata

Expert review of clinical immunology, April 2013, Vol.9(4), pp.301-6 [Peer Reviewed Journal]

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24
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Integrin inhibitors go with the gut

Holmes, David

Nature reviews. Drug discovery, June 2013, Vol.12(6), pp.411-2 [Peer Reviewed Journal]

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25
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The presence of the WGD motif in CC8 heterodimeric disintegrin increases its inhibitory effect on alphaII(b)beta3, alpha(v)beta3, and alpha5beta1 integrins

Calvete, Juan J ; Fox, Jay W ; Agelan, Alexis ; Niewiarowski, Stefan ; Marcinkiewicz, Cezary

Biochemistry, 12 February 2002, Vol.41(6), pp.2014-21 [Peer Reviewed Journal]

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26
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Inhibition of integrin-mediated adhesion and signaling disrupts retinal development

Li, Ming ; Sakaguchi, Donald S

Developmental biology, 01 November 2004, Vol.275(1), pp.202-14 [Peer Reviewed Journal]

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27
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E-Cadherin-Dependent Stimulation of Traction Force at Focal Adhesions via the Src and PI3K Signaling Pathways

Jasaitis, Audrius ; Estevez, Maruxa ; Heysch, Julie ; Ladoux, Benoit ; Dufour, Sylvie

Biophysical Journal, Jul 18, 2012, Vol.103(2), pp.175-84 [Peer Reviewed Journal]

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28
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Small molecule designed to target metal binding site in the alpha2I domain inhibits integrin function

Käpylä, Jarmo ; Pentikäinen, Olli T ; Nyrönen, Tommi ; Nissinen, Liisa ; Lassander, Sanna ; Jokinen, Johanna ; Lahti, Matti ; Marjamäki, Anne ; Johnson, Mark S ; Heino, Jyrki

Journal of medicinal chemistry, 31 May 2007, Vol.50(11), pp.2742-6 [Peer Reviewed Journal]

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29
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Vedolizumab: An integrin-receptor antagonist for treatment of Crohn's disease and ulcerative colitis

Hahn, Lindsay ; Beggs, Ashton ; Wahaib, Kristy ; Kodali, Leela ; Kirkwood, Vanessa

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 01 August 2015, Vol.72(15), pp.1271-8 [Peer Reviewed Journal]

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30
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First integrin inhibitor since Tysabri nears approval for IBD

Sheridan, Cormac

Nature biotechnology, March 2014, Vol.32(3), pp.205-7 [Peer Reviewed Journal]

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31
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Smurf1 inhibits integrin activation by controlling Kindlin-2 ubiquitination and degradation

Wei, Xiaofan ; Wang, Xiang ; Zhan, Jun ; Chen, Yuhan ; Fang, Weigang ; Zhang, Lingqiang ; Zhang, Hongquan

The Journal of cell biology, 01 May 2017, Vol.216(5), pp.1455-1471 [Peer Reviewed Journal]

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32
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Integrin αβ Blockade Preferentially Impacts CCR6 Lymphocyte Subsets in Blood and Mucosal Tissues of Naive Rhesus Macaques

Calenda, Giulia ; Keawvichit, Rassamon ; Arrode-Brusés, Géraldine ; Pattanapanyasat, Kovit ; Frank, Ines ; Byrareddy, Siddappa N ; Arthos, James ; Cicala, Claudia ; Grasperge, Brooke ; Blanchard, James L ; Gettie, Agegnehu ; Reimann, Keith A ; Ansari, Aftab A ; Martinelli, Elena

Journal of immunology (Baltimore, Md. : 1950), 15 January 2018, Vol.200(2), pp.810-820 [Peer Reviewed Journal]

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33
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A Small Molecule, Which Competes with MAdCAM-1, Activates Integrin α4β7 and Fails to Prevent Mucosal Transmission of SHIV-SF162P3

Arrode-Brusés, Géraldine ; Goode, Diana ; Kleinbeck, Kyle ; Wilk, Jolanta ; Frank, Ines ; Byrareddy, Siddappa ; Arthos, James ; Grasperge, Brooke ; Blanchard, James ; Zydowsky, Thomas ; Gettie, Agegnehu ; Martinelli, Elena

PLoS pathogens, June 2016, Vol.12(6), pp.e1005720 [Peer Reviewed Journal]

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34
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Selectively targeting the gut in inflammatory bowel disease: Targeting integrins

Parkes, Miles

Journal of gastroenterology and hepatology, September 2018, Vol.33 Suppl 3, pp.26 [Peer Reviewed Journal]

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35
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Structure-activity relationship study of the tumour-targeting peptide A20FMDV2 via modification of Lys16, Leu13, and N- and/or C-terminal functionality

Hung, Kuo-Yuan ; Harris, Paul W R ; Desai, Ami ; Marshall, John F ; Brimble, Margaret A

European journal of medicinal chemistry, 18 August 2017, Vol.136, pp.154-164 [Peer Reviewed Journal]

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36
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Alphav and beta1 integrins regulate dynamic compression-induced proteoglycan synthesis in 3D gel culture by distinct complementary pathways

Chai, D H ; Arner, E C ; Griggs, D W ; Grodzinsky, A J

Osteoarthritis and cartilage, February 2010, Vol.18(2), pp.249-56 [Peer Reviewed Journal]

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37
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Nanoparticle-integrin antagonist C16Y peptide treatment of choroidal neovascularization in rats

Kim, Hyuncheol ; Csaky, Karl G

Journal of controlled release : official journal of the Controlled Release Society, 03 March 2010, Vol.142(2), pp.286-93 [Peer Reviewed Journal]

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