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C1 esterase inhibitor for prophylaxis against hereditary angioedema attacks : a review of the clinical effectiveness, cost-effectiveness, and guidelines.

Canadian Agency for Drugs and Technologies in Health issuing body

24 April 2015

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Article
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Cooperative interactions of BRAFV600E kinase and CDKN2A locus deficiency in pediatric malignant astrocytoma as a basis for rational therapy

Huillard, Emmanuelle ; Hashizume, Rintaro ; Phillips, Joanna J ; Griveau, Amélie ; Ihrie, Rebecca A ; Aoki, Yasuyuki ; Nicolaides, Theodore ; Perry, Arie ; Waldman, Todd ; Mcmahon, Martin ; Weiss, William A ; Petritsch, Claudia ; James, C David ; Rowitch, David H

Proceedings of the National Academy of Sciences of the United States of America, 29 May 2012, Vol.109(22), pp.8710-5 [Peer Reviewed Journal]

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Mimicking nature by codelivery of stimulant and inhibitor to create temporally stable and spatially restricted angiogenic zones

Yuen, William ; Du, Nan ; Chan, Chun ; Silva, Eduardo ; Mooney, David

Proceedings of the National Academy of Sciences of the United States of America, Oct 19, 2010, Vol.107(42), p.17933 [Peer Reviewed Journal]

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Glucose and Weight Control in Mice with a Designed Ghrelin O-Acyltransferase Inhibitor

Barnett, Brad ; Hwang, Yousang ; Taylor, Martin ; Kirchner, Henriette ; Pfluger, Paul ; Vincent, Bernard ; Yu-Yi, Lin ; Bowers, Erin ; Mukherjee, Chandrani ; Woo-Jin, Song ; Longo, Patti ; Leahy, Daniel ; Hussain, Mehboob ; Tschöp, Matthias ; Boeke, Jef

Science, Dec 17, 2010, Vol.330(6011), pp.1689-1692 [Peer Reviewed Journal]

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Article
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Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

Lamming, Dudley ; Ye, Lan ; Katajisto, Pekka ; Goncalves, Marcus ; Saitoh, Maki ; Stevens, Deanna ; Davis, James ; Salmon, Adam ; Richardson, Arlan ; Ahima, Rexford ; Guertin, David ; Sabatini, David ; Baur, Joseph

Science, Mar 30, 2012, Vol.335(6076), pp.1638-1643 [Peer Reviewed Journal]

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Cancer and Telomeres--An ALTernative to Telomerase

Shay, Jerry ; Reddel, Roger ; Wright, Woodring

Science, Jun 15, 2012, Vol.336(6087), pp.1388-1390 [Peer Reviewed Journal]

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7
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Article
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Molecular Mechanism of Action of Microtubule-Stabilizing Anticancer Agents

Prota, Andrea ; Bargsten, Katja ; Zurwerra, Didier ; Field, Jessica ; Díaz, José ; Altmann, Karl-Heinz ; Steinmetz, Michel

Science, Feb 1, 2013, Vol.339(6119), pp.587-590 [Peer Reviewed Journal]

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Article
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Long-Acting Integrase Inhibitor Protects Macaques from Intrarectal Simian/Human Immunodeficiency Virus

Andrews, Chasity ; Spreen, William ; Mohri, Hiroshi ; Moss, Lee ; Ford, Susan ; Gettie, Agegnehu ; Russell-Lodrigue, Kasi ; Bohm, Rudolf ; Cheng-Mayer, Cecilia ; Hong, Zhi ; Markowitz, Martin ; Ho, David

Science, Mar 7, 2014, Vol.343(6175), pp.1151-1154 [Peer Reviewed Journal]

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9
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Pyrazinamide--Old TB Drug Finds New Target

Cole, Stewart

Science, Sep 16, 2011, Vol.333(6049), pp.1583-1584 [Peer Reviewed Journal]

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Pyrazinamide Inhibits Trans-Translation in Mycobacterium tuberculosis

Shi, Wanliang ; Zhang, Xuelian ; Jiang, Xin ; Yuan, Haiming ; Lee, Jong ; Barry, Clifton ; Wang, Honghai ; Zhang, Wenhong ; Zhang, Ying

Science, Sep 16, 2011, Vol.333(6049), pp.1630-1632 [Peer Reviewed Journal]

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Preparation of tetrasubstituted pyrimido[4,5-d]pyrimidine diones

Wang, Hui ; Wang, Chao ; Bannister, Thomas D

Tetrahedron Letters, 08 April 2015, Vol.56(15), pp.1949-1952 [Peer Reviewed Journal]

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12
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Exploring the mechanism of inhibition of human telomerase by cysteine‐reactive compounds

Kellermann, Guillaume ; Dingli, Florent ; Masson, Vanessa ; Dauzonne, Daniel ; Ségal‐Bendirdjian, Evelyne ; Teulade‐Fichou, Marie‐Paule ; Loew, Damarys ; Bombard, Sophie

FEBS Letters, March 2017, Vol.591(6), pp.863-874 [Peer Reviewed Journal]

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108 The Observational HDL Hypothesis: A Useful Therapeutic Target? a Meta Analysis of 117,411 Patients in Randomised Controlled Trials

Keene, Daniel ; Shun-Shin, Matthew ; Price, Clare ; Francis, Darrel

Heart, Jun 2014, Vol.100, p.A62 [Peer Reviewed Journal]

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Mechanism-Based Covalent Neuraminidase Inhibitors with Broad-Spectrum Influenza Antiviral Activity

Jin-Hyo, Kim ; Resende, Ricardo ; Wennekes, Tom ; Hong-Ming, Chen ; Bance, Nicole ; Buchini, Sabrina ; Watts, Andrew ; Pilling, Pat ; Streltsov, Victor ; Petric, Martin ; Liggins, Richard ; Barrett, Susan ; Mckimm-Breschkin, Jennifer ; Niikura, Masahiro ; Withers, Stephen

Science, Apr 5, 2013, Vol.340(6128), pp.71-75 [Peer Reviewed Journal]

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Spiroindolones, a Potent Compound Class for the Treatment of Malaria

Rottmann, Matthias ; Mcnamara, Case ; Yeung, Bryan ; Lee, Marcus

Science, Sep 03, 2010, Vol.329(5996), pp.1175-1180 [Peer Reviewed Journal]

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Activity of anti-cancer protein kinase inhibitors against Leishmania spp

Sanderson, Lisa ; Yardley, Vanessa ; Croft, Simon

The Journal of Antimicrobial Chemotherapy, Jul 2014, Vol.69(7), p.1888 [Peer Reviewed Journal]

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17
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PF-06463922 is a potent and selective next-generation ROS1/ALK inhibitor capable of blocking crizotinib-resistant ROS1 mutations

Zou, Helen Y ; Li, Qiuhua ; Engstrom, Lars D ; West, Melissa ; Appleman, Vicky ; Wong, Katy A ; Mctigue, Michele ; Deng, Ya-Li ; Liu, Wei ; Brooun, Alexei ; Timofeevski, Sergei ; Mcdonnell, Scott R P ; Jiang, Ping ; Falk, Matthew D ; Lappin, Patrick B ; Affolter, Timothy ; Nichols, Tim ; Hu, Wenyue ; Lam, Justine ; Johnson, Ted W ; Smeal, Tod ; Charest, Al ; Fantin, Valeria R

Proceedings of the National Academy of Sciences of the United States of America, 17 March 2015, Vol.112(11), pp.3493-8 [Peer Reviewed Journal]

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18
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Cross-resistance mechanism of respiratory syncytial virus against structurally diverse entry inhibitors

Yan, Dan ; Lee, Sujin ; Thakkar, Vidhi ; Luo, Ming ; Moore, Martin ; Plemper, Richard

Proceedings of the National Academy of Sciences of the United States of America, Aug 19, 2014, Vol.111(33), p.E3441 [Peer Reviewed Journal]

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19
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Biomimetic model to reconstitute angiogenic sprouting morphogenesis in vitro

Nguyen, Duc-Huy ; Stapleton, Sarah ; Yang, Michael ; Cha, Susie ; Choi, Colin ; Galie, Peter ; Chen, Christopher

Proceedings of the National Academy of Sciences of the United States of America, Apr 23, 2013, Vol.110(17), p.6712 [Peer Reviewed Journal]

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Structures and characterization of digoxin- and bufalin-bound Na+,K+-ATPase compared with the ouabain-bound complex

Laursen, Mette ; Gregersen, Jonas Lindholt ; Yatime, Laure ; Nissen, Poul ; Fedosova, Natalya U

Proceedings of the National Academy of Sciences of the United States of America, 10 February 2015, Vol.112(6), pp.1755-60 [Peer Reviewed Journal]

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21
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On the role of water density fluctuations in the inhibition of a proton channel

Gianti, Eleonora ; Delemotte, Lucie ; Klein, Michael ; Carnevale, Vincenzo

Proceedings of the National Academy of Sciences of the United States of America, Dec 27, 2016, Vol.113(52), p.E8359 [Peer Reviewed Journal]

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22
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Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974

Liu, Jun ; Pan, Shifeng ; Hsieh, Mindy ; Ng, Nicholas ; Sun, Fangxian ; Wang, Tao ; Kasibhatla, Shailaja ; Schuller, Alwin ; Li, Allen ; Cheng, Dai ; Li, Jie ; Tompkins, Celin ; Pferdekamper, Annemarie ; Steffy, Auzon ; Cheng, Jane ; Kowal, Colleen ; Phung, Van ; Guo, Guirong ; Wang, Yan ; Graham, Martin ; Flynn, Shannon ; Brenner, J ; Li, Chun ; Villarroel, M ; Schultz, Peter ; Wu, Xu ; Mcnamara, Peter ; Sellers, William ; Petruzzelli, Lilli ; Boral, Anthony ; Seidel, H ; Mclaughlin, Margaret ; Che, Jianwei ; Carey, Thomas ; Vanasse, Gary ; Harris, Jennifer

Proceedings of the National Academy of Sciences of the United States of America, Dec 10, 2013, Vol.110(50), p.20224 [Peer Reviewed Journal]

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23
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Lithocholic acid is an endogenous inhibitor of MDM4 and MDM2

Vogel, Simon ; Bauer, Matthias ; Joerger, Andreas ; Wilcken, Rainer ; Brandt, Tobias ; Veprintsev, Dmitry ; Rutherford, Trevor ; Fersht, Alan ; Boeckler, Frank

Proceedings of the National Academy of Sciences of the United States of America, Oct 16, 2012, Vol.109(42), p.16906 [Peer Reviewed Journal]

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24
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Azidoblebbistatin, a photoreactive myosin inhibitor

Képiró, Miklós ; Várkuti, Boglárka ; Bodor, Andrea ; Hegyi, György ; Drahos, László ; Kovács, Mihály ; Málnási-Csizmadia, András

Proceedings of the National Academy of Sciences of the United States of America, Jun 12, 2012, Vol.109(24), p.9402 [Peer Reviewed Journal]

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25
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Synergistic antileukemic therapies in NOTCH1-induced T-ALL

Sanchez-Martin, Marta ; Ambesi-Impiombato, Alberto ; Qin, Yue ; Herranz, Daniel ; Bansal, Mukesh ; Girardi, Tiziana ; Paietta, Elisabeth ; Tallman, Martin ; Rowe, Jacob ; De Keersmaecker, Kim ; Califano, Andrea ; Ferrando, Adolfo

Proceedings of the National Academy of Sciences of the United States of America, Feb 21, 2017, Vol.114(8), p.2006 [Peer Reviewed Journal]

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26
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Active-site MMP-selective antibody inhibitors discovered from convex paratope synthetic libraries

Nam, Dong ; Rodriguez, Carlos ; Remacle, Albert ; Strongin, Alex ; Ge, Xin

Proceedings of the National Academy of Sciences of the United States of America, Dec 27, 2016, Vol.113(52), p.14970 [Peer Reviewed Journal]

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27
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Revival of the abandoned therapeutic wortmannin by nanoparticle drug delivery

Karve, Shrirang ; Werner, Michael ; Sukumar, Rohit ; Cummings, Natalie ; Copp, Jonathan ; Wang, Edina ; Li, Chenxi ; Sethi, Manish ; Chen, Ronald ; Pacold, Michael ; Wang, Andrew

Proceedings of the National Academy of Sciences of the United States of America, May 22, 2012, Vol.109(21), p.8230 [Peer Reviewed Journal]

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28
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Harnessing evolutionary fitness in Plasmodium falciparum for drug discovery and suppressing resistance

Lukens, Amanda ; Ross, Leila ; Heidebrecht, Richard ; Gamo, Francisco ; Lafuente-Monasterio, Maria ; Booker, Michael ; Hartl, Daniel ; Wiegand, Roger ; Wirth, Dyann

Proceedings of the National Academy of Sciences of the United States of America, Jan 14, 2014, Vol.111(2), p.799 [Peer Reviewed Journal]

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29
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Network pharmacology of JAK inhibitors

Moodley, Devapregasan ; Yoshida, Hideyuki ; Mostafavi, Sara ; Asinovski, Natasha ; Ortiz-Lopez, Adriana ; Symanowicz, Peter ; Telliez, Jean-Baptiste ; Hegen, Martin ; Clark, James D ; Mathis, Diane ; Benoist, Christophe

Proceedings of the National Academy of Sciences of the United States of America, 30 August 2016, Vol.113(35), pp.9852-7 [Peer Reviewed Journal]

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30
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Structural insight into selectivity and resistance profiles of ROS1 tyrosine kinase inhibitors

Davare, Monika A ; Vellore, Nadeem A ; Wagner, Jacob P ; Eide, Christopher A ; Goodman, James R ; Drilon, Alexander ; Deininger, Michael W ; O'Hare, Thomas ; Druker, Brian J

Proceedings of the National Academy of Sciences of the United States of America, 29 September 2015, Vol.112(39), pp.E5381-90 [Peer Reviewed Journal]

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31
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Intact sphingomyelin biosynthetic pathway is essential for intracellular transport of influenza virus glycoproteins

Tafesse, Fikadu ; Sanyal, Sumana ; Ashour, Joseph ; Guimaraes, Carla ; Hermansson, Martin ; Somerharju, Pentti ; Ploegh, Hidde

Proceedings of the National Academy of Sciences of the United States of America, Apr 16, 2013, Vol.110(16), p.6406 [Peer Reviewed Journal]

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32
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Eliminating hepatitis B by antagonizing cellular inhibitors of apoptosis

Ebert, Gregor ; Allison, Cody ; Preston, Simon ; Cooney, James ; Toe, Jesse G ; Stutz, Michael D ; Ojaimi, Samar ; Baschuk, Nikola ; Nachbur, Ueli ; Torresi, Joseph ; Silke, John ; Begley, C Glenn ; Pellegrini, Marc

Proceedings of the National Academy of Sciences of the United States of America, 05 May 2015, Vol.112(18), pp.5803-8 [Peer Reviewed Journal]

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Design of donecopride, a dual serotonin subtype 4 receptor agonist/acetylcholinesterase inhibitor with potential interest for Alzheimer's disease treatment

Lecoutey, Cédric ; Hedou, Damien ; Freret, Thomas ; Giannoni, Patrizia ; Gaven, Florence ; Since, Marc ; Bouet, Valentine ; Ballandonne, Céline ; Corvaisier, Sophie ; Fréon, Aurélie ; Mignani, Serge ; Cresteil, Thierry ; Boulouard, Michel ; Claeysen, Sylvie ; Rochais, Christophe ; Dallemagne, Patrick

Proceedings of the National Academy of Sciences of the United States of America, Sep 9, 2014, Vol.111(36), p.E3825 [Peer Reviewed Journal]

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34