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Aza-Riley Oxidation of Ugi-Azide and Ugi-3CR Products toward Vicinal Tricarbonyl Amides: Two-Step MCR-Oxidation Methodology Accessing Functionalized α,β-Diketoamides and α,β-Diketotetrazoles

Foley, Christopher ; Shaw, Arthur ; Hulme, Christopher

Organic letters, 02 March 2018, Vol.20(5), pp.1275-1278 [Peer Reviewed Journal]

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A Van Leusen deprotection-cyclization strategy as a fast entry into two imidazoquinoxaline families

De Moliner, Fabio ; Hulme, Christopher

Tetrahedron Letters, 24 October 2012, Vol.53(43), pp.5787-5790 [Peer Reviewed Journal]

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A facile and rapid route for the synthesis of novel 1,5-substituted tetrazole hydantoins and thiohydantoins via a TMSN3-Ugi/RNCX cyclization

Medda, Federico ; Hulme, Christopher

Tetrahedron Letters, 17 October 2012, Vol.53(42), pp.5593-5596 [Peer Reviewed Journal]

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Construction of functionalized tricyclic dihydropyrazino-quinazolinedione chemotypes via an Ugi/N-acyliminium ion cyclization cascade

Gunawan, Steven ; Hulme, Christopher

Tetrahedron Letters, 14 August 2013, Vol.54(33), pp.4467-4470 [Peer Reviewed Journal]

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Exploiting the divalent nature of isonitriles: a novel Pictet–Spengler amidination process

Medda, Federico ; Hulme, Christopher

Tetrahedron Letters, 28 May 2014, Vol.55(22), pp.3328-3331 [Peer Reviewed Journal]

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Concise route to a series of novel 3-(tetrazol-5-yl)quinoxalin-2(1H)-ones

Gunawan, Steven ; Nichol, Gary ; Hulme, Christopher

Tetrahedron Letters, 28 March 2012, Vol.53(13), pp.1664-1667 [Peer Reviewed Journal]

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7
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Novel succinct routes to quinoxalines and 2-benzimidazolylquinoxalines via the Ugi reaction

Ayaz, Muhammad ; Xu, Zhigang ; Hulme, Christopher

Tetrahedron Letters, 04 June 2014, Vol.55(23), pp.3406-3409 [Peer Reviewed Journal]

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A novel route to synthesize libraries of quinoxalines via Petasis methodology in two synthetic operations

Ayaz, Muhammad ; Dietrich, Justin ; Hulme, Christopher

Tetrahedron Letters, 2011, Vol.52(38), pp.4821-4823 [Peer Reviewed Journal]

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9
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Straightforward assembly of phenylimidazoquinoxalines via a one-pot two-step MCR process

De Moliner, Fabio ; Hulme, Christopher

Organic letters, 02 March 2012, Vol.14(5), pp.1354-7 [Peer Reviewed Journal]

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10
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Two-Step Route to Diverse N-Functionalized Peptidomimetic-like Isatins through an Oxidation/Intramolecular Oxidative-Amidation Cascade of Ugi Azide and Ugi Three-Component Reaction Products

Foley, Christopher ; Shaw, Arthur ; Hulme, Christopher

Organic letters, 07 October 2016, Vol.18(19), pp.4904-4907 [Peer Reviewed Journal]

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11
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Oxidative Deaminations and Deisatinylations of Ugi-Azide and Ugi-3CR Products: A Two-Step MCR-Oxidation Protocol toward Functionalized α-Ketoamides and α-Ketotetrazoles

Foley, Christopher ; Shaw, Arthur ; Hulme, Christopher

Organic letters, 05 May 2017, Vol.19(9), pp.2238-2241 [Peer Reviewed Journal]

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12
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A simple one-pot 2-step N-1-alkylation of indoles with α-iminoketones toward the expeditious 3-step synthesis of N-1-quinoxaline-indoles

Martinez-Ariza, Guillermo ; Ayaz, Muhammad ; Hulme, Christopher

Tetrahedron Letters, 04 December 2013, Vol.54(49), pp.6719-6721 [Peer Reviewed Journal]

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13
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Facile and rapid route for the synthesis of novel norstatine analogs via PADAM-cyclization methodology

Shaw, Arthur Y ; Medda, Federico ; Hulme, Christopher

Tetrahedron Letters, 14 March 2012, Vol.53(11), pp.1313-1315 [Peer Reviewed Journal]

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14
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Ugi/Robinson–Gabriel reactions directed toward the synthesis of 2,4,5-trisubstituted oxazoles

Shaw, Arthur Y ; Xu, Zhigang ; Hulme, Christopher

Tetrahedron Letters, 11 April 2012, Vol.53(15), pp.1998-2000 [Peer Reviewed Journal]

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15
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Ugi/Robinson-Gabriel reactions directed toward the synthesis of 2,4,5-trisubstituted oxazoles

Shaw, Arthur Y ; Xu, Zhigang ; Hulme, Christopher

Tetrahedron letters, 11 April 2012, Vol.53(15), pp.1998-2000 [Peer Reviewed Journal]

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16
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Selenium dioxide-mediated synthesis of α-ketoamides from arylglyoxals and secondary amines

Shaw, Arthur Y ; Denning, Christine R ; Hulme, Christopher

Tetrahedron Letters, 08 August 2012, Vol.53(32), pp.4151-4153 [Peer Reviewed Journal]

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17
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A facile and concise route toward the synthesis of novel imidazo-tetrazolodiazepinones via post-condensation modifications of the Ugi-azide adduct

Medda, Federico ; Martinez-Ariza, Guillermo ; Hulme, Christopher

Tetrahedron Letters, 16 September 2015, Vol.56(38), pp.5295-5298 [Peer Reviewed Journal]

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18
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One-Pot Two-Step Multicomponent Process of Indole and Other Nitrogenous Heterocycles or Amines toward α-Oxo-acetamidines

Martinez-Ariza, Guillermo ; Mcconnell, Nicholas ; Hulme, Christopher

Organic letters, 15 April 2016, Vol.18(8), pp.1864-7 [Peer Reviewed Journal]

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19
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Hydrazine-mediated cyclization of Ugi products to synthesize novel 3-hydroxypyrazoles

Shaw, Arthur Y ; Mclaren, Jonathan A ; Nichol, Gary S ; Hulme, Christopher

Tetrahedron Letters, 23 May 2012, Vol.53(21), pp.2592-2594 [Peer Reviewed Journal]

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20
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Acetyl cyanide as a cyanide source in a tandem catalyst-free modified Groebke–Blackburn–Bienaymé [4+1]-cycloaddition-Strecker cascade

Martinez-Ariza, Guillermo ; Nunez-Rios, Jose ; Lee, Yeon-Sun ; Hulme, Christopher

Tetrahedron Letters, 18 February 2015, Vol.56(8), pp.1038-1040 [Peer Reviewed Journal]

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21
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Synthesis of diverse nitrogen-enriched heterocyclic scaffolds using a suite of tunable one-pot multicomponent reactions

Martinez-Ariza, Guillermo ; Ayaz, Muhammad ; Medda, Federico ; Hulme, Christopher

The Journal of organic chemistry, 06 June 2014, Vol.79(11), pp.5153-62 [Peer Reviewed Journal]

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22
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The design, synthesis, and evaluation of 8 hybrid DFG-out allosteric kinase inhibitors: A structural analysis of the binding interactions of Gleevec®, Nexavar®, and BIRB-796

Dietrich, Justin ; Hulme, Christopher ; Hurley, Laurence H

Bioorganic & Medicinal Chemistry, 01 August 2010, Vol.18(15), pp.5738-5748 [Peer Reviewed Journal]

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23
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Ugi/Aldol Sequence: Expeditious Entry to Several Families of Densely Substituted Nitrogen Heterocycles

Xu, Zhigang ; De Moliner, Fabio ; Cappelli, Alexandra P. ; Hulme, Christopher

Angewandte Chemie International Edition, 06 August 2012, Vol.51(32), pp.8037-8040 [Peer Reviewed Journal]

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24
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MCRs reshaped into a switchable microwave-assisted protocol toward 5-aminoimidazoles and dihydrotriazines

Bell, Christan E ; Shaw, Arthur Y ; De Moliner, Fabio ; Hulme, Christopher

Tetrahedron, 07 January 2014, Vol.70(1), pp.54-59 [Peer Reviewed Journal]

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25
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Aldol reactions in multicomponent reaction based domino pathways: a multipurpose enabling tool in heterocyclic chemistry

Xu, Zhigang ; De Moliner, Fabio ; Cappelli, Alexandra P ; Hulme, Christopher

Organic letters, 07 June 2013, Vol.15(11), pp.2738-41 [Peer Reviewed Journal]

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26
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Concise two-step solution phase syntheses of four novel dihydroquinazoline scaffolds

Dietrich, Justin ; Kaiser, Christine ; Meurice, Nathalie ; Hulme, Christopher

Tetrahedron Letters, 2010, Vol.51(30), pp.3951-3955 [Peer Reviewed Journal]

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27
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Two-step syntheses of fused quinoxaline-benzodiazepines and bis-benzodiazepines

Xu, Zhigang ; Dietrich, Justin ; Shaw, Arthur Y ; Hulme, Christopher

Tetrahedron Letters, 2010, Vol.51(34), pp.4566-4569 [Peer Reviewed Journal]

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28
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Concise preparation of novel tricyclic chemotypes: fused hydantoin–benzodiazepines

Gunawan, Steven ; Nichol, Gary S ; Chappeta, Shashi ; Dietrich, Justin ; Hulme, Christopher

Tetrahedron Letters, 2010, Vol.51(36), pp.4689-4692 [Peer Reviewed Journal]

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29
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(Z)-Stereoselective Synthesis of Mono- and Bis-heterocyclic Benzimidazol-2-ones via Cascade Processes Coupled with the Ugi Multicomponent Reaction

Xu, Zhigang ; Martinez-Ariza, Guillermo ; Cappelli, Alexandra P ; Roberts, Sue A ; Hulme, Christopher

The Journal of organic chemistry, 18 September 2015, Vol.80(18), pp.9007-15 [Peer Reviewed Journal]

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30
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Synthesis of tetrazolo-fused benzodiazepines and benzodiazepinones by a two-step protocol using an Ugi-azide reaction for initial diversity generation

Gunawan, Steven ; Ayaz, Muhammad ; De Moliner, Fabio ; Frett, Brendan ; Kaiser, Christine ; Patrick, Nina ; Xu, Zhigang ; Hulme, Christopher

Tetrahedron, 08 July 2012, Vol.68(27-28), pp.5606-5611 [Peer Reviewed Journal]

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31
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Computational study of organo-cesium complexes and the possibility of lanthanide/actinide ions substitution

Rabanal-León, Walter A ; Martinez-Ariza, Guillermo ; Roberts, Sue A ; Hulme, Christopher ; Arratia-Pérez, Ramiro

Chemical Physics Letters, 16 November 2015, Vol.641, pp.181-186 [Peer Reviewed Journal]

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32
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The Synthesis of Stable, Complex Organocesium Tetramic Acids through the Ugi Reaction and Cesium‐Carbonate‐Promoted Cascades

Martinez‐Ariza, Guillermo ; Ayaz, Muhammad ; Roberts, Sue A. ; Rabanal‐León, Walter A. ; Arratia‐Pérez, Ramiro ; Hulme, Christopher

Angewandte Chemie International Edition, 28 September 2015, Vol.54(40), pp.11672-11676 [Peer Reviewed Journal]

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33
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Unique one step, multicomponent α,β,β-oxidations of carbamates with Willgerodt-like hypervalent iodine reagents—an example of triple C–H bond activation

Salamant, Walter ; Hulme, Christopher

Tetrahedron Letters, 2006, Vol.47(4), pp.605-609 [Peer Reviewed Journal]

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34
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Structural conservation in band 4.1, ezrin, radixin, moesin (FERM) domains as a guide to identify inhibitors of the proline-rich tyrosine kinase 2

Meurice, Nathalie ; Wang, Lei ; Lipinski, Christopher A ; Yang, Zhongbo ; Hulme, Christopher ; Loftus, Joseph C

Journal of medicinal chemistry, 28 January 2010, Vol.53(2), pp.669-77 [Peer Reviewed Journal]

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35
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Rapid generation of cis-constrained norstatine analogs using a TMSN 3-modified Passerini MCC/ N-capping strategy

Nixey, Thomas ; Hulme, Christopher

Tetrahedron Letters, 2002, Vol.43(38), pp.6833-6835 [Peer Reviewed Journal]

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36
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A simple, cheap alternative to ‘designer convertible isonitriles’ expedited with microwaves

Hulme, Christopher ; Chappeta, Shashi ; Dietrich, Justin

Tetrahedron Letters, 2009, Vol.50(28), pp.4054-4057 [Peer Reviewed Journal]

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