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Discovery of pyrazolopyridones as a novel class of noncovalent DprE1 inhibitor with potent anti-mycobacterial activity

Panda, Manoranjan ; Ramachandran, Sreekanth ; Ramachandran, Vasanthi ; Shirude, Pravin S ; Humnabadkar, Vaishali ; Nagalapur, Kavitha ; Sharma, Sreevalli ; Kaur, Parvinder ; Guptha, Supreeth ; Narayan, Ashwini ; Mahadevaswamy, Jyothi ; Ambady, Anisha ; Hegde, Naina ; Rudrapatna, Suresh S ; Hosagrahara, Vinayak P ; Sambandamurthy, Vasan K ; Raichurkar, Anandkumar

Journal of medicinal chemistry, 12 June 2014, Vol.57(11), pp.4761-71 [Peer Reviewed Journal]

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Identification and mitigation of a reactive metabolite liability associated with aminoimidazoles

Srivastava, Abhishek ; Ramachandran, Sreekanth ; Hameed, Shahul P ; Ahuja, Vijaykamal ; Hosagrahara, Vinayak P

Chemical research in toxicology, 15 September 2014, Vol.27(9), pp.1586-97 [Peer Reviewed Journal]

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The Discovery of N-(1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-5-((6- ((methylamino)methyl)pyrimidin-4-yl)oxy)-1H-indole-1-carboxamide (Acrizanib), a VEGFR-2 Inhibitor Specifically Designed for Topical Ocular Delivery, as a Therapy for Neovascular Age-Related Macular Degeneration

Adams, Christopher M ; Anderson, Karen ; Artman, Gerald ; Bizec, Jean-Claude ; Cepeda, Rosemarie ; Elliott, Jason ; Fassbender, Elizabeth ; Ghosh, Malay ; Hanks, Shawn ; Hardegger, Leo A ; Hosagrahara, Vinayak P ; Jaffee, Bruce ; Jendza, Keith ; Ji, Nan ; Johnson, Leland ; Lee, Wendy ; Liu, Donglei ; Liu, Fang ; Long, Debby ; Ma, Fupeng ; Mainolfi, Nello ; Meredith, Erik L ; Miranda, Karl ; Peng, Yao ; Poor, Stephen ; Powers, James ; Qiu, Yubin ; Rao, Chang ; Shen, Siyuan ; Sivak, Jeremy M ; Solovay, Catherine ; Tarsa, Peter ; Woolfenden, Amber ; Zhang, Chun ; Zhang, Yiqin

Journal of medicinal chemistry, 22 February 2018, Vol.61(4), pp.1622-1635 [Peer Reviewed Journal]

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Discovery of Oral VEGFR-2 Inhibitors with Prolonged Ocular Retention That Are Efficacious in Models of Wet Age-Related Macular Degeneration

Meredith, Erik L ; Mainolfi, Nello ; Poor, Stephen ; Qiu, Yubin ; Miranda, Karl ; Powers, James ; Liu, Donglei ; Ma, Fupeng ; Solovay, Catherine ; Rao, Chang ; Johnson, Leland ; Ji, Nan ; Artman, Gerald ; Hardegger, Leo ; Hanks, Shawn ; Shen, Siyuan ; Woolfenden, Amber ; Fassbender, Elizabeth ; Sivak, Jeremy M ; Zhang, Yiqin ; Long, Debby ; Cepeda, Rosemarie ; Liu, Fang ; Hosagrahara, Vinayak P ; Lee, Wendy ; Tarsa, Peter ; Anderson, Karen ; Elliott, Jason ; Jaffee, Bruce

Journal of medicinal chemistry, 10 December 2015, Vol.58(23), pp.9273-86 [Peer Reviewed Journal]

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Evaluation of Pharmaceutical Excipients as Cosolvents in 4-Methyl Umbelliferone Glucuronidation in Human Liver Microsomes: Applications for Compounds with Low Solubility

Argikar, Upendra A ; Liang, Guiqing ; Bushee, Jennifer L ; Hosagrahara, Vinayak P ; Lee, Wendy

Drug Metabolism and Pharmacokinetics, 2011, Vol.26(1), pp.102-106 [Peer Reviewed Journal]

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Effect of repeated dosing on rifampin exposure in BALB/c mice

Hosagrahara, Vinayak ; Reddy, Jitendar ; Ganguly, Samit ; Panduga, Vijender ; Ahuja, Vijaykamal ; Parab, Manish ; Giridhar, Jayashree

European Journal of Pharmaceutical Sciences, 11 April 2013, Vol.49(1), pp.33-38 [Peer Reviewed Journal]

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N-aryl-2-aminobenzimidazoles: novel, efficacious, antimalarial lead compounds

Ramachandran, Sreekanth ; Hameed P, Shahul ; Srivastava, Abhishek ; Shanbhag, Gajanan ; Morayya, Sapna ; Rautela, Nikhil ; Awasthy, Disha ; Kavanagh, Stefan ; Bharath, Sowmya ; Reddy, Jitendar ; Panduga, Vijender ; Prabhakar, K R ; Saralaya, Ramanatha ; Nanduri, Robert ; Raichurkar, Anandkumar ; Menasinakai, Sreenivasaiah ; Achar, Vijayashree ; Jiménez-Díaz, María Belén ; Martínez, María Santos ; Angulo-Barturen, Iñigo ; Ferrer, Santiago ; Sanz, Laura María ; Gamo, Francisco Javier ; Duffy, Sandra ; Avery, Vicky M ; Waterson, David ; Lee, Marcus C S ; Coburn-Flynn, Olivia ; Fidock, David A ; Iyer, Pravin S ; Narayanan, Shridhar ; Hosagrahara, Vinayak ; Sambandamurthy, Vasan K

Journal of medicinal chemistry, 14 August 2014, Vol.57(15), pp.6642-52 [Peer Reviewed Journal]

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Aminoazabenzimidazoles, a novel class of orally active antimalarial agents

Hameed P, Shahul ; Chinnapattu, Murugan ; Shanbag, Gajanan ; Manjrekar, Praveena ; Koushik, Krishna ; Raichurkar, Anandkumar ; Patil, Vikas ; Jatheendranath, Sandesh ; Rudrapatna, Suresh S ; Barde, Shubhada P ; Rautela, Nikhil ; Awasthy, Disha ; Morayya, Sapna ; Narayan, Chandan ; Kavanagh, Stefan ; Saralaya, Ramanatha ; Bharath, Sowmya ; Viswanath, Pavithra ; Mukherjee, Kakoli ; Bandodkar, Balachandra ; Srivastava, Abhishek ; Panduga, Vijender ; Reddy, Jitender ; Prabhakar, K R ; Sinha, Achyut ; Jiménez-Díaz, María Belén ; Martínez, María Santos ; Angulo-Barturen, Iñigo ; Ferrer, Santiago ; Sanz, Laura María ; Gamo, Francisco Javier ; Duffy, Sandra ; Avery, Vicky M ; Magistrado, Pamela A ; Lukens, Amanda K ; Wirth, Dyann F ; Waterson, David ; Balasubramanian, V ; Iyer, Pravin S ; Narayanan, Shridhar ; Hosagrahara, Vinayak ; Sambandamurthy, Vasan K ; Ramachandran, Sreekanth

Journal of medicinal chemistry, 10 July 2014, Vol.57(13), pp.5702-13 [Peer Reviewed Journal]

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Azaindoles: noncovalent DprE1 inhibitors from scaffold morphing efforts, kill Mycobacterium tuberculosis and are efficacious in vivo

Shirude, Pravin S ; Shandil, Radha ; Sadler, Claire ; Naik, Maruti ; Hosagrahara, Vinayak ; Hameed, Shahul ; Shinde, Vikas ; Bathula, Chandramohan ; Humnabadkar, Vaishali ; Kumar, Naveen ; Reddy, Jitendar ; Panduga, Vijender ; Sharma, Sreevalli ; Ambady, Anisha ; Hegde, Naina ; Whiteaker, James ; Mclaughlin, Robert E ; Gardner, Humphrey ; Madhavapeddi, Prashanti ; Ramachandran, Vasanthi ; Kaur, Parvinder ; Narayan, Ashwini ; Guptha, Supreeth ; Awasthy, Disha ; Narayan, Chandan ; Mahadevaswamy, Jyothi ; Vishwas, K G ; Ahuja, Vijaykamal ; Srivastava, Abhishek ; Prabhakar, K R ; Bharath, Sowmya ; Kale, Ramesh ; Ramaiah, Manjunatha ; Choudhury, Nilanjana Roy ; Sambandamurthy, Vasan K ; Solapure, Suresh ; Iyer, Pravin S ; Narayanan, Shridhar ; Chatterji, Monalisa

Journal of medicinal chemistry, 12 December 2013, Vol.56(23), pp.9701-8 [Peer Reviewed Journal]

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4-aminoquinolone piperidine amides: noncovalent inhibitors of DprE1 with long residence time and potent antimycobacterial activity

Naik, Maruti ; Humnabadkar, Vaishali ; Tantry, Subramanyam J ; Panda, Manoranjan ; Narayan, Ashwini ; Guptha, Supreeth ; Panduga, Vijender ; Manjrekar, Praveena ; Jena, Lalit Kumar ; Koushik, Krishna ; Shanbhag, Gajanan ; Jatheendranath, Sandesh ; Manjunatha, M R ; Gorai, Gopinath ; Bathula, Chandramohan ; Rudrapatna, Suresh ; Achar, Vijayashree ; Sharma, Sreevalli ; Ambady, Anisha ; Hegde, Naina ; Mahadevaswamy, Jyothi ; Kaur, Parvinder ; Sambandamurthy, Vasan K ; Awasthy, Disha ; Narayan, Chandan ; Ravishankar, Sudha ; Madhavapeddi, Prashanti ; Reddy, Jitendar ; Prabhakar, Kr ; Saralaya, Ramanatha ; Chatterji, Monalisa ; Whiteaker, James ; Mclaughlin, Bob ; Chiarelli, Laurent R ; Riccardi, Giovanna ; Pasca, Maria Rosalia ; Binda, Claudia ; Neres, João ; Dhar, Neeraj ; Signorino-Gelo, François ; Mckinney, John D ; Ramachandran, Vasanthi ; Shandil, Radha ; Tommasi, Ruben ; Iyer, Pravin S ; Narayanan, Shridhar ; Hosagrahara, Vinayak ; Kavanagh, Stefan ; Dinesh, Neela ; Ghorpade, Sandeep R

Journal of medicinal chemistry, 26 June 2014, Vol.57(12), pp.5419-34 [Peer Reviewed Journal]

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Identification of potent and selective amidobipyridyl inhibitors of protein kinase D

Meredith, Erik L ; Beattie, Kimberly ; Burgis, Robin ; Capparelli, Michael ; Chapo, Joseph ; Dipietro, Lucian ; Gamber, Gabriel ; Enyedy, Istvan ; Hood, David B ; Hosagrahara, Vinayak ; Jewell, Charles ; Koch, Keith A ; Lee, Wendy ; Lemon, Douglas D ; Mckinsey, Timothy A ; Miranda, Karl ; Pagratis, Nikos ; Phan, Dillon ; Plato, Craig ; Rao, Chang ; Rozhitskaya, Olga ; Soldermann, Nicolas ; Springer, Clayton ; Van Eis, Maurice ; Vega, Richard B ; Yan, Wanlin ; Zhu, Qingming ; Monovich, Lauren G

Journal of medicinal chemistry, 12 August 2010, Vol.53(15), pp.5422-38 [Peer Reviewed Journal]

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Single-Dose Pharmacokinetics, Excretion, and Metabolism of Zoliflodacin, a Novel Spiropyrimidinetrione Antibiotic, in Healthy Volunteers

O'Donnell, John ; Lawrence, Ken ; Vishwanathan, Karthick ; Hosagrahara, Vinayak ; Mueller, John P

Antimicrobial agents and chemotherapy, January 2019, Vol.63(1) [Peer Reviewed Journal]

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13
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Discovery of Imidazo1,2-apyridine Ethers and Squaramides as Selective and Potent Inhibitors of Mycobacterial Adenosine Triphosphate (ATP) Synthesis

Tantry, Subramanyam J ; Markad, Shankar D ; Shinde, Vikas ; Bhat, Jyothi ; Balakrishnan, Gayathri ; Gupta, Amit K ; Ambady, Anisha ; Raichurkar, Anandkumar ; Kedari, Chaitanyakumar ; Sharma, Sreevalli ; Mudugal, Naina V ; Narayan, Ashwini ; Naveen Kumar, C N ; Nanduri, Robert ; Bharath, Sowmya ; Reddy, Jitendar ; Panduga, Vijender ; Prabhakar, K R ; Kandaswamy, Karthikeyan ; Saralaya, Ramanatha ; Kaur, Parvinder ; Dinesh, Neela ; Guptha, Supreeth ; Rich, Kirsty ; Murray, David ; Plant, Helen ; Preston, Marian ; Ashton, Helen ; Plant, Darren ; Walsh, Jarrod ; Alcock, Peter ; Naylor, Kathryn ; Collier, Matthew ; Whiteaker, James ; Mclaughlin, Robert E ; Mallya, Meenakshi ; Panda, Manoranjan ; Rudrapatna, Suresh ; Ramachandran, Vasanthi ; Shandil, Radha ; Sambandamurthy, Vasan K ; Mdluli, Khisi ; Cooper, Christopher B ; Rubin, Harvey ; Yano, Takahiro ; Iyer, Pravin ; Narayanan, Shridhar ; Kavanagh, Stefan ; Mukherjee, Kakoli ; Balasubramanian, V ; Hosagrahara, Vinayak P ; Solapure, Suresh ; Ravishankar, Sudha ; Hameed P, Shahul

Journal of medicinal chemistry, 23 February 2017, Vol.60(4), pp.1379-1399 [Peer Reviewed Journal]

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14
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3,5-Diarylazoles as novel and selective inhibitors of protein kinase D

Gamber, Gabriel G ; Meredith, Erik ; Zhu, Qingming ; Yan, Wanlin ; Rao, Chang ; Capparelli, Michael ; Burgis, Robin ; Enyedy, Istvan ; Zhang, Ji-Hu ; Soldermann, Nicolas ; Beattie, Kimberley ; Rozhitskaya, Olga ; Koch, Keith A ; Pagratis, Nikos ; Hosagrahara, Vinayak ; Vega, Richard B ; Mckinsey, Timothy A ; Monovich, Lauren

Bioorganic & Medicinal Chemistry Letters, 2011, Vol.21(5), pp.1447-1451 [Peer Reviewed Journal]

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15
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Identification of orally available naphthyridine protein kinase D inhibitors

Meredith, Erik L ; Ardayfio, Ophelia ; Beattie, Kimberly ; Dobler, Markus R ; Enyedy, Istvan ; Gaul, Christoph ; Hosagrahara, Vinayak ; Jewell, Charles ; Koch, Keith ; Lee, Wendy ; Lehmann, Hansjoerg ; Mckinsey, Timothy A ; Miranda, Karl ; Pagratis, Nikos ; Pancost, Margaret ; Patnaik, Anup ; Phan, Dillon ; Plato, Craig ; Qian, Ming ; Rajaraman, Vasumathy ; Rao, Chang ; Rozhitskaya, Olga ; Ruppen, Thomas ; Shi, Jie ; Siska, Sarah J ; Springer, Clayton ; Van Eis, Maurice ; Vega, Richard B ; Von Matt, Anette ; Yang, Lihua ; Yoon, Taeyoung ; Zhang, Ji-Hu ; Zhu, Na ; Monovich, Lauren G

Journal of medicinal chemistry, 12 August 2010, Vol.53(15), pp.5400-21 [Peer Reviewed Journal]

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16
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Discovery of an oxybenzylglycine based peroxisome proliferator activated receptor alpha selective agonist 2-((3-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)(methoxycarbonyl)amino)acetic acid (BMS-687453)

Li, Jun ; Kennedy, Lawrence J ; Shi, Yan ; Tao, Shiwei ; Ye, Xiang-Yang ; Chen, Stephanie Y ; Wang, Ying ; Hernández, Andrés S ; Wang, Wei ; Devasthale, Pratik V ; Chen, Sean ; Lai, Zhi ; Zhang, Hao ; Wu, Shung ; Smirk, Rebecca A ; Bolton, Scott A ; Ryono, Denis E ; Zhang, Huiping ; Lim, Ngiap-Kie ; Chen, Bang-Chi ; Locke, Kenneth T ; O'Malley, Kevin M ; Zhang, Litao ; Srivastava, Rai Ajit ; Miao, Bowman ; Meyers, Daniel S ; Monshizadegan, Hossain ; Search, Debra ; Grimm, Denise ; Zhang, Rongan ; Harrity, Thomas ; Kunselman, Lori K ; Cap, Michael ; Kadiyala, Pathanjali ; Hosagrahara, Vinayak ; Zhang, Lisa ; Xu, Carrie ; Li, Yi-Xin ; Muckelbauer, Jodi K ; Chang, Chiehying ; An, Yongmi ; Krystek, Stanley R ; Blanar, Michael A ; Zahler, Robert ; Mukherjee, Ranjan ; Cheng, Peter T W ; Tino, Joseph A

Journal of medicinal chemistry, 08 April 2010, Vol.53(7), pp.2854-64 [Peer Reviewed Journal]

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17
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Synthesis and biological evaluation of novel pyrrolidine acid analogs as potent dual PPARα/γ agonists

Zhang, Hao ; Ding, Charles Z ; Lai, Zhi ; Chen, Sean S ; Devasthale, Pratik ; Herpin, Tim ; Morton, George ; Qu, Fucheng ; Ryono, Denis ; Smirk, Rebecca ; Wang, Wei ; Wu, Shung ; Ye, Xiang-Xang ; Li, Yi-Xin ; Apedo, Atsu ; Farrelly, Dennis ; Wang, Tao ; Gu, Liqun ; Morgan, Nathan ; Flynn, Neil ; Chu, Cuixia ; Kunselman, Lori ; Lippy, Jonathan ; Locke, Kenneth ; O’malley, Kevin ; Harrity, Thomas ; Cap, Michael ; Zhang, Lisa ; Hosagrahara, Vinayak ; Kadiyala, Pathanjali ; Xu, Carrie ; Doweyko, Arthur M ; Zahler, Robert ; Hariharan, Narayanan ; Cheng, Peter T.W

Bioorganic & Medicinal Chemistry Letters, 15 March 2015, Vol.25(6), pp.1196-1205 [Peer Reviewed Journal]

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18
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Synthesis and structure–activity relationships of 2-aryl-4-oxazolylmethoxy benzylglycines and 2-aryl-4-thiazolylmethoxy benzylglycines as novel, potent PPARα selective activators- PPARα and PPARγ selectivity modulation

Ye, Xiang-Yang ; Chen, Stephanie ; Zhang, Hao ; Locke, Kenneth T ; O’malley, Kevin ; Zhang, Litao ; Srivastava, Raijit ; Miao, Bowman ; Meyers, Daniel ; Monshizadegan, Hossain ; Search, Debra ; Grimm, Denise ; Zhang, Rongan ; Lippy, Jonathan ; Twamley, Celeste ; Muckelbauer, Jodi K ; Chang, Chiehying ; An, Yongmi ; Hosagrahara, Vinayak ; Zhang, Lisa ; Yang, T.-J ; Mukherjee, Ranjan ; Cheng, Peter T.W ; Tino, Joseph A

Bioorganic & Medicinal Chemistry Letters, 2010, Vol.20(9), pp.2933-2937 [Peer Reviewed Journal]

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19
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Discovery and Preclinical Evaluation of BMS-711939, an Oxybenzylglycine Based PPARα Selective Agonist

Shi, Yan ; Li, Jun ; Kennedy, Lawrence J ; Tao, Shiwei ; Hernández, Andrés S ; Lai, Zhi ; Chen, Sean ; Wong, Henry ; Zhu, Juliang ; Trehan, Ashok ; Lim, Ngiap-Kie ; Zhang, Huiping ; Chen, Bang-Chi ; Locke, Kenneth T ; O'Malley, Kevin M ; Zhang, Litao ; Srivastava, Rai Ajit ; Miao, Bowman ; Meyers, Daniel S ; Monshizadegan, Hossain ; Search, Debra ; Grimm, Denise ; Zhang, Rongan ; Harrity, Thomas ; Kunselman, Lori K ; Cap, Michael ; Muckelbauer, Jodi ; Chang, Chiehying ; Krystek, Stanley R ; Li, Yi-Xin ; Hosagrahara, Vinayak ; Zhang, Lisa ; Kadiyala, Pathanjali ; Xu, Carrie ; Blanar, Michael A ; Zahler, Robert ; Mukherjee, Ranjan ; Cheng, Peter T W ; Tino, Joseph A

ACS medicinal chemistry letters, 09 June 2016, Vol.7(6), pp.590-4 [Peer Reviewed Journal]

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20
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Functional analysis of human microsomal epoxide hydrolase genetic variants

Hosagrahara, Vinayak P ; Rettie, Allan E ; Hassett, Christopher ; Omiecinski, Curtis J

Chemico-Biological Interactions, 2004, Vol.150(2), pp.149-159 [Peer Reviewed Journal]

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21
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Epoxide hydrolase — polymorphism and role in toxicology

Omiecinski, Curtis J ; Hassett, Christopher ; Hosagrahara, Vinayak

Toxicology Letters, 2000, Vol.112, pp.365-370 [Peer Reviewed Journal]

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22
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Triaminopyrimidine is a fast-killing and long-acting antimalarial clinical candidate

Hameed P., Shahul ; Solapure, Suresh ; Patil, Vikas ; Henrich, Philipp P. ; Magistrado, Pamela A. ; Bharath, Sowmya ; Murugan, Kannan ; Viswanath, Pavithra ; Puttur, Jayashree ; Srivastava, Abhishek ; Bellale, Eknath ; Panduga, Vijender ; Shanbag, Gajanan ; Awasthy, Disha ; Landge, Sudhir ; Morayya, Sapna ; Koushik, Krishna ; Saralaya, Ramanatha ; Raichurkar, Anandkumar ; Rautela, Nikhil ; Roy Choudhury, Nilanjana ; Ambady, Anisha ; Nandishaiah, Radha ; Reddy, Jitendar ; Prabhakar, K. R. ; Menasinakai, Sreenivasaiah ; Rudrapatna, Suresh ; Chatterji, Monalisa ; Jiménez-Díaz, María Belén ; Martínez, María Santos ; Sanz, Laura María ; Coburn-Flynn, Olivia ; Fidock, David A. ; Lukens, Amanda K. ; Wirth, Dyann F. ; Bandodkar, Balachandra ; Mukherjee, Kakoli ; Mclaughlin, Robert E. ; Waterson, David ; Rosenbrier-Ribeiro, Lyn ; Hickling, Kevin ; Balasubramanian, V. ; Warner, Peter ; Hosagrahara, Vinayak ; Dudley, Adam ; Iyer, Pravin S. ; Narayanan, Shridhar ; Kavanagh, Stefan ; Sambandamurthy, Vasan K.

Hameed P., S., S. Solapure, V. Patil, P. P. Henrich, P. A. Magistrado, S. Bharath, K. Murugan, et al. 2015. “Triaminopyrimidine is a fast-killing and long-acting antimalarial clinical candidate.” Nature Communications 6 (1): 6715. doi:10.1038/ncomms7715. http://dx.doi.org/10.1038/ncomms7715. [Peer Reviewed Journal]

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23
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Raising HDL cholesterol without inducing hepatic steatosis and hypertriglyceridemia by a selective LXR modulator

Miao, Bowman ; Zondlo, Susan ; Gibbs, Sandy ; Cromley, Debra ; Hosagrahara, Vinayak P ; Kirchgessner, Todd G ; Billheimer, Jeffrey ; Mukherjee, Ranjan

Journal of lipid research, August 2004, Vol.45(8), pp.1410-7 [Peer Reviewed Journal]

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Evaluation of the effect of culture matrices on induction of CYP3A isoforms in cultured porcine hepatocytes

Hosagrahara, Vinayak P ; Hansen, Linda K ; Beilman, Gregory J ; Remmel, Rory P

Chemico-Biological Interactions, 2000, Vol.127(1), pp.91-106 [Peer Reviewed Journal]

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25
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Design, synthesis and structure–activity relationships of azole acids as novel, potent dual PPAR α/γ agonists

Zhang, Hao ; Ryono, Denis E ; Devasthale, Pratik ; Wang, Wei ; O’malley, Kevin ; Farrelly, Dennis ; Gu, Liqun ; Harrity, Thomas ; Cap, Michael ; Chu, Cuixia ; Locke, Kenneth ; Zhang, Litao ; Lippy, Jonathan ; Kunselman, Lori ; Morgan, Nathan ; Flynn, Neil ; Moore, Lisa ; Hosagrahara, Vinayak ; Zhang, Lisa ; Kadiyala, Pathanjali ; Xu, Carrie ; Doweyko, Arthur M ; Bell, Aneka ; Chang, Chiehying ; Muckelbauer, Jodi ; Zahler, Robert ; Hariharan, Narayanan ; Cheng, Peter T.W

Bioorganic & Medicinal Chemistry Letters, 2009, Vol.19(5), pp.1451-1456 [Peer Reviewed Journal]

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26
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Discovery of azetidinone acids as conformationally-constrained dual PPARα/γ agonists

Wang, Wei ; Devasthale, Pratik ; Farrelly, Dennis ; Gu, Liqun ; Harrity, Thomas ; Cap, Michael ; Chu, Cuixia ; Kunselman, Lori ; Morgan, Nathan ; Ponticiello, Randy ; Zebo, Rachel ; Zhang, Litao ; Locke, Kenneth ; Lippy, Jonathan ; O’malley, Kevin ; Hosagrahara, Vinayak ; Zhang, Lisa ; Kadiyala, Pathanjali ; Chang, Chiehying ; Muckelbauer, Jodi ; Doweyko, Arthur M ; Zahler, Robert ; Ryono, Denis ; Hariharan, Narayanan ; Cheng, Peter T.W

Bioorganic & Medicinal Chemistry Letters, 2008, Vol.18(6), pp.1939-1944 [Peer Reviewed Journal]

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