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Highly regioselective palladium-catalyzed direct arylation of oxazole at C-2 or C-5 with aryl bromides, chlorides, and triflates

Strotman, Neil A ; Chobanian, Harry R ; Guo, Yan ; He, Jiafang ; Wilson, Jonathan E

Organic letters, 20 August 2010, Vol.12(16), pp.3578-81 [Peer Reviewed Journal]

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Catalyst-controlled regioselective Suzuki couplings at both positions of dihaloimidazoles, dihalooxazoles, and dihalothiazoles

Strotman, Neil A ; Chobanian, Harry R ; He, Jiafang ; Guo, Yan ; Dormer, Peter G ; Jones, Christina M ; Steves, Janelle E

The Journal of organic chemistry, 05 March 2010, Vol.75(5), pp.1733-9 [Peer Reviewed Journal]

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Omarigliptin (MK-3102): a novel long-acting DPP-4 inhibitor for once-weekly treatment of type 2 diabetes

Biftu, Tesfaye ; Sinha-Roy, Ranabir ; Chen, Ping ; Qian, Xiaoxia ; Feng, Dennis ; Kuethe, Jeffrey T ; Scapin, Giovanna ; Gao, Ying Duo ; Yan, Youwei ; Krueger, Davida ; Bak, Annette ; Eiermann, George ; He, Jiafang ; Cox, Jason ; Hicks, Jacqueline ; Lyons, Kathy ; He, Huaibing ; Salituro, Gino ; Tong, Sharon ; Patel, Sangita ; Doss, George ; Petrov, Aleksandr ; Wu, Joseph ; Xu, Shiyao Sherrie ; Sewall, Charles ; Zhang, Xiaoping ; Zhang, Bei ; Thornberry, Nancy A ; Weber, Ann E

Journal of medicinal chemistry, 24 April 2014, Vol.57(8), pp.3205-12 [Peer Reviewed Journal]

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3-Substituted 3-(4-aryloxyaryl)-propanoic acids as GPR40 agonists

Walsh, Shawn P ; Severino, Alexandra ; Zhou, Changyou ; He, Jiafang ; Liang, Gui-Bai ; Tan, Carina P ; Cao, Jin ; Eiermann, George J ; Xu, Ling ; Salituro, Gino ; Howard, Andrew D ; Mills, Sander G ; Yang, Lihu

Bioorganic & Medicinal Chemistry Letters, 2011, Vol.21(11), pp.3390-3394 [Peer Reviewed Journal]

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Isolation, characterization, and biological evaluation of syn and anti diastereomers of (99m)Tctechnetium depreotide: a somatostatin receptor binding tumor imaging agent

Cyr, John E ; Pearson, Daniel A ; Nelson, Carol A ; Lyons, Barbara A ; Zheng, Yongyong ; Bartis, Judit ; He, Jiafang ; Cantorias, Melchor V ; Howell, Robertha C ; Francesconi, Lynn C

Journal of medicinal chemistry, 06 September 2007, Vol.50(18), pp.4295-303 [Peer Reviewed Journal]

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Discovery and Pharmacology of a Novel Somatostatin Subtype 5 (SSTR5) Antagonist: Synergy with DPP-4 Inhibition

Liu, Weiguo ; Shao, Pengcheng P ; Liang, Gui-Bai ; Bawiec, John ; He, Jiafang ; Aster, Susan D ; Wu, Margaret ; Chicchi, Garry ; Wang, John ; Tsao, Kwei-Lan ; Shang, Jin ; Salituro, Gino ; Zhou, Yun-Ping ; Li, Cai ; Akiyama, Taro E ; Metzger, Daniel E ; Murphy, Beth Ann ; Howard, Andrew D ; Weber, Ann E ; Duffy, Joseph L

ACS medicinal chemistry letters, 08 November 2018, Vol.9(11), pp.1082-1087 [Peer Reviewed Journal]

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Design of a novel pyrrolidine scaffold utilized in the discovery of potent and selective human β 3 adrenergic receptor agonists

Morriello, Gregori J ; Wendt, Harvey R ; Bansal, Alka ; Salvo, Jerry Di ; Feighner, Scott ; He, Jiafang ; Hurley, Amanda L ; Hreniuk, Donna L ; Salituro, Gino M ; Reddy, Marat Vijay ; Galloway, Sheila M ; Mcgettigan, Katherine K ; Laws, George ; Mcknight, Crystal ; Doss, George A ; Tsou, Nancy N ; Black, Regina M ; Morris, Judy ; Ball, Richard G ; Sanfiz, Anthony T ; Streckfuss, Eric ; Struthers, Mary ; Edmondson, Scott D

Bioorganic & Medicinal Chemistry Letters, 2011, Vol.21(6), pp.1865-1870 [Peer Reviewed Journal]

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Heterocyclic acetamide and benzamide derivatives as potent and selective β 3-adrenergic receptor agonists with improved rodent pharmacokinetic profiles

Goble, Stephen D ; Wang, Liping ; Howell, K. Lulu ; Bansal, Alka ; Berger, Richard ; Brockunier, Linda ; Disalvo, Jerry ; Feighner, Scott ; Harper, Bart ; He, Jiafang ; Hurley, Amanda ; Hreniuk, Donna ; Parmee, Emma ; Robbins, Michael ; Salituro, Gino ; Sanfiz, Anthony ; Streckfuss, Eric ; Watkins, Eloisa ; Weber, Ann E ; Struthers, Mary ; Edmondson, Scott D

Bioorganic & Medicinal Chemistry Letters, 2010, Vol.20(6), pp.1895-1899 [Peer Reviewed Journal]

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(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(4-1,2,4triazolo1,5-a-pyridin-6-ylphenyl)butanamide: a selective alpha-amino amide dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes

Edmondson, Scott D ; Mastracchio, Anthony ; Mathvink, Robert J ; He, Jiafang ; Harper, Bart ; Park, You-Jung ; Beconi, Maria ; Di Salvo, Jerry ; Eiermann, George J ; He, Huaibing ; Leiting, Barbara ; Leone, Joseph F ; Levorse, Dorothy A ; Lyons, Kathryn ; Patel, Reshma A ; Patel, Sangita B ; Petrov, Aleksandr ; Scapin, Giovanna ; Shang, Jackie ; Roy, Ranabir Sinha ; Smith, Aaron ; Wu, Joseph K ; Xu, Shiyao ; Zhu, Bing ; Thornberry, Nancy A ; Weber, Ann E

Journal of medicinal chemistry, 15 June 2006, Vol.49(12), pp.3614-27 [Peer Reviewed Journal]

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CCDC 787767: Experimental Crystal Structure Determination

Morriello, G.J. ; Wendt, H.R. ; Bansal, A. ; Di Salvo, J. ; Feighner, S. ; He, Jiafang ; Hurley, A.L. ; Hreniuk, D.L. ; Salituro, G.M. ; Reddy, M.V. ; Galloway, S.M. ; McGettigan, K.K. ; Laws, G. ; McKnight, C. ; Doss, G.A. ; Tsou, N.N. ; Black, R.M. ; Morris, J. ; Ball, R.G. ; Sanfiz, A.T. ; Streckfuss, E. ; Struthers, M. ; Edmondson, S.D.

2011

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Discovery of potent and selective phenylalanine based dipeptidyl peptidase IV inhibitors

Xu, Jinyou ; Wei, Lan ; Mathvink, Robert ; He, Jiafang ; Park, You-Jung ; He, Huaibing ; Leiting, Barbara ; Lyons, Kathryn A ; Marsilio, Frank ; Patel, Reshma A ; Wu, Joseph K ; Thornberry, Nancy A ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 16 May 2005, Vol.15(10), pp.2533-2536 [Peer Reviewed Journal]

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Copper and rhenium complexes of abis(aminoethanethiol) ligand

Sukal, Sean ; Bradshaw, Joseph E ; He, Jiafang ; Yap, Glenn P.a ; Rheingold, Arnold L ; Kung, Hank F ; Francesconi, Lynn C

Polyhedron, 1998, Vol.18(1), pp.7-17 [Peer Reviewed Journal]

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4-Amino cyclohexylglycine analogues as potent dipeptidyl peptidase IV inhibitors

Parmee, Emma R ; He, Jiafang ; Mastracchio, Anthony ; Edmondson, Scott D ; Colwell, Larry ; Eiermann, George ; Feeney, William P ; Habulihaz, Bahanu ; He, Huaibing ; Kilburn, Ruth ; Leiting, Barbara ; Lyons, Kathryn ; Marsilio, Frank ; Patel, Reshma A ; Petrov, Aleksandr ; Di Salvo, Jerry ; Wu, Joseph K ; Thornberry, Nancy A ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 2004, Vol.14(1), pp.43-46 [Peer Reviewed Journal]

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Substituted piperazines as novel dipeptidyl peptidase IV inhibitors

Brockunier, Linda L ; He, Jiafang ; Colwell, Lawrence F ; Habulihaz, Bahanu ; He, Huaibing ; Leiting, Barbara ; Lyons, Kathryn A ; Marsilio, Frank ; Patel, Reshma A ; Teffera, Yohannes ; Wu, Joseph K ; Thornberry, Nancy A ; Weber, Ann E ; Parmee, Emma R

Bioorganic & Medicinal Chemistry Letters, 2004, Vol.14(18), pp.4763-4766 [Peer Reviewed Journal]

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Fluoropyrrolidine amides as dipeptidyl peptidase IV inhibitors

Caldwell, Charles G ; Chen, Ping ; He, Jiafang ; Parmee, Emma R ; Leiting, Barbara ; Marsilio, Frank ; Patel, Reshma A ; Wu, Joseph K ; Eiermann, George J ; Petrov, Aleksandr ; He, Huaibing ; Lyons, Kathryn A ; Thornberry, Nancy A ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 08 March 2004, Vol.14(5), pp.1265-1268 [Peer Reviewed Journal]

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Tetrahydroisoquinoline derivatives containing a benzenesulfonamide moiety as potent, selective human β 3 adrenergic receptor agonists

Parmee, Emma R ; Brockunier, Linda L ; He, Jiafang ; Singh, Suresh B ; Candelore, Mari R ; Cascieri, Margaret A ; Deng, Liping ; Liu, Yong ; Tota, Laurie ; Wyvratt, Matthew J ; Fisher, Michael H ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 2000, Vol.10(20), pp.2283-2286 [Peer Reviewed Journal]

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Benzyl vinylogous amide substituted aryldihydropyridazinones and aryldimethylpyrazolones as potent and selective PDE3B inhibitors

Edmondson, Scott D ; Mastracchio, Anthony ; He, Jiafang ; Chung, Christine C ; Forrest, Michael J ; Hofsess, Scott ; Macintyre, Euan ; Metzger, Joseph ; O'Connor, Naphtali ; Patel, Kajal ; Tong, Xinchun ; Tota, Michael R ; Van Der Ploeg, Lex H.T ; Varnerin, Jeff P ; Fisher, Michael H ; Wyvratt, Matthew J ; Weber, Ann E ; Parmee, Emma R

Bioorganic & Medicinal Chemistry Letters, 2003, Vol.13(22), pp.3983-3987 [Peer Reviewed Journal]

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