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22 Results  for Everything (Includes Articles)

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1
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Enzymatic preparation of high-specific-activity β- d-[6,6′- 3H]fructose-2,6-bisphosphate: Application to a sensitive assay for fructose-2,6-bisphosphatase

Myers, Robert W ; Baginsky, Walter F ; Gattermeir, David J ; Geissler, Wayne M ; Harris, Georgianna

Analytical Biochemistry, 2010, Vol.406(2), pp.97-104 [Peer Reviewed Journal]

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2
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Allosteric effects of dexamethasone and RU486 on glucocorticoid receptor-DNA interactions

Pandit, Shilpa ; Geissler, Wayne ; Harris, Georgianna ; Sitlani, Ayesha

The Journal of biological chemistry, 11 January 2002, Vol.277(2), pp.1538-43 [Peer Reviewed Journal]

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3
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Colorimetric Detection of Glutamine Synthetase-Catalyzed Transferase Activity in Glucocorticoid-Treated Skeletal Muscle Cells

Santoro, Joseph C ; Harris, Georgianna ; Sitlani, Ayesha

Analytical Biochemistry, 01 February 2001, Vol.289(1), pp.18-25 [Peer Reviewed Journal]

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Identification and selective inhibition of an isozyme of steroid 5(alpha)-reductase in human scalp

Harris, Georgianna ; Azzolina, Barbara ; Baginsky, Walter ; Cimis, George

Proceedings of the National Academy of Sciences of the United States of America, Nov 15, 1992, Vol.89(22), p.10787 [Peer Reviewed Journal]

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5
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Novel pyrazolo3,4-dpyrimidine-based inhibitors of Staphlococcus aureus DNA polymerase III: design, synthesis, and biological evaluation

Ali, Amjad ; Taylor, Gayle E ; Ellsworth, Ken ; Harris, Georgianna ; Painter, Ronald ; Silver, Lynn L ; Young, Katherine

Journal of medicinal chemistry, 08 May 2003, Vol.46(10), pp.1824-30 [Peer Reviewed Journal]

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6
Mechanism-Based Inhibition of Human Steroid 5α-Reductase by Finasteride:  Enzyme-Catalyzed Formation of NADP−Dihydrofinasteride, a Potent Bisubstrate Analog Inhibitor
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Mechanism-Based Inhibition of Human Steroid 5α-Reductase by Finasteride:  Enzyme-Catalyzed Formation of NADP−Dihydrofinasteride, a Potent Bisubstrate Analog Inhibitor

Bull, Herbert G. ; Garcia-Calvo, Margarita ; Andersson, Stefan ; Baginsky, Walter F. ; Chan, H. Karen ; Ellsworth, Dina E. ; Miller, Randall R. ; Stearns, Ralph A. ; Bakshi, Raman K. ; Rasmusson, Gary H. ; Tolman, Richard L. ; Myers, Robert W. ; Kozarich, John W. ; Harris, Georgianna S.

Journal of the American Chemical Society, 01/1996, Vol.118(10), pp.2359-2365 [Peer Reviewed Journal]

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Discovery of betamethasone 17α-carbamates as dissociated glucocorticoid receptor modulators in the rat

Ali, Amjad ; Balkovec, James M ; Greenlee, Mark ; Hammond, Milton L ; Rouen, Greg ; Taylor, Gayle ; Einstein, Monica ; Ge, Lan ; Harris, Georgianna ; Kelly, Terri M ; Mazur, Paul ; Pandit, Shilpa ; Santoro, Joseph ; Sitlani, Ayesha ; Wang, Chuanlin ; Williamson, Joann ; Forrest, Michael J ; Carballo-Jane, Ester ; Luell, Silvi ; Lowitz, Karen

Bioorganic & Medicinal Chemistry, 2008, Vol.16(16), pp.7535-7542 [Peer Reviewed Journal]

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8
4-Aza-3-oxo-5α-androst-1-ene-17β- N -arylcarboxamides as Dual Inhibitors of Human Type 1 and Type 2 Steroid 5α-Reductases. Dramatic Effect of N -Aryl Substituents on Type 1 and Type 2 5α-Reductase Inhibitory Potency
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4-Aza-3-oxo-5α-androst-1-ene-17β- N -arylcarboxamides as Dual Inhibitors of Human Type 1 and Type 2 Steroid 5α-Reductases. Dramatic Effect of N -Aryl Substituents on Type 1 and Type 2 5α-Reductase Inhibitory Potency

Bakshi, Raman K. ; Rasmusson, Gary H. ; Patel, Gool F. ; Mosley, Ralph T. ; Chang, Benedict ; Ellsworth, Kenneth ; Harris, Georgianna S. ; Tolman, Richard L.

Journal of Medicinal Chemistry, 01/1996, Vol.39(5), pp.1192-1192 [Peer Reviewed Journal]

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Steroid 5α-reductase inhibitors in androgen-dependent disorders

Harris, Georgianna S ; Kozarich, John W

Current Opinion in Chemical Biology, 1997, Vol.1(2), pp.254-259 [Peer Reviewed Journal]

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10
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Novel N-arylpyrazolo3,2-c-based ligands for the glucocorticoid receptor: receptor binding and in vivo activity

Ali, Amjad ; Thompson, Christopher F ; Balkovec, James M ; Graham, Donald W ; Hammond, Milton L ; Quraishi, Nazia ; Tata, James R ; Einstein, Monica ; Ge, Lan ; Harris, Georgianna ; Kelly, Terri M ; Mazur, Paul ; Pandit, Shilpa ; Santoro, Joseph ; Sitlani, Ayesha ; Wang, Chuanlin ; Williamson, Joanne ; Miller, Douglas K ; Thompson, Chris M ; Zaller

Journal of medicinal chemistry, 06 May 2004, Vol.47(10), pp.2441-52 [Peer Reviewed Journal]

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11
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Skeletal muscle: a dual system to measure glucocorticoid-dependent transactivation and transrepression of gene regulation

Carballo-Jane, Ester ; Pandit, Shilpa ; Santoro, Joseph C ; Freund, Concetta ; Luell, Silvi ; Harris, Georgianna ; Forrest, Michael J ; Sitlani, Ayesha

Journal of Steroid Biochemistry and Molecular Biology, 2004, Vol.88(2), pp.191-201 [Peer Reviewed Journal]

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12
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Steroid 5α-Reductase: Comparative Study of Mechanism of Inhibition by Nonsteroids ONO-3805 and LY191704

Harris, Georgianna S ; Ellsworth, Kenneth ; Witzel, Bruce E ; Tolman, Richard L

Bioorganic Chemistry, December 1996, Vol.24(4), pp.386-400 [Peer Reviewed Journal]

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13
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Glucose-lowering in a db/db mouse model by dihydropyridine diacid glycogen phosphorylase inhibitors

Ogawa, Anthony K ; Willoughby, Chris A ; Bergeron, Raynald ; Ellsworth, Kenneth P ; Geissler, Wayne M ; Myers, Robert W ; Yao, Jun ; Harris, Georgianna ; Chapman, Kevin T

Bioorganic & medicinal chemistry letters, 20 October 2003, Vol.13(20), pp.3405-8 [Peer Reviewed Journal]

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14
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Modeling aided design of potent glycogen phosphorylase inhibitors

Deng, Qiaolin ; Lu, Zhijian ; Bohn, Joann ; Ellsworth, Kenneth P ; Myers, Robert W ; Geissler, Wayne M ; Harris, Georgianna ; Willoughby, Christopher A ; Chapman, Kevin ; Mckeever, Brian ; Mosley, Ralph

Journal of Molecular Graphics and Modelling, 2005, Vol.23(5), pp.457-464 [Peer Reviewed Journal]

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15
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A new class of glycogen phosphorylase inhibitors

Lu, Zhijian ; Bohn, Joann ; Bergeron, Raynald ; Deng, Qiaolin ; Ellsworth, Kenneth P ; Geissler, Wayne M ; Harris, Georgianna ; Mccann, Peggy E ; Mckeever, Brian ; Myers, Robert W ; Saperstein, Richard ; Willoughby, Christopher A ; Yao, Jun ; Chapman, Kevin

Bioorganic & Medicinal Chemistry Letters, 2003, Vol.13(22), pp.4125-4128 [Peer Reviewed Journal]

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16
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Design and synthesis of novel antibacterial agents with inhibitory activity against DNA polymerase III

Ali, Amjad ; Aster, Susan D ; Graham, Donald W ; Patel, Gool F ; Taylor, Gayle E ; Tolman, Richard L ; Painter, Ronald E ; Silver, Lynn L ; Young, Katherine ; Ellsworth, Kenneth ; Geissler, Wayne ; Harris, Georgianna S

Bioorganic & Medicinal Chemistry Letters, 2001, Vol.11(16), pp.2185-2188 [Peer Reviewed Journal]

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17
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Novel 3,4-dihydroquinolin-2(1H)-one inhibitors of human glycogen phosphorylase a

Rosauer, Keith G ; Ogawa, Anthony K ; Willoughby, Chris A ; Ellsworth, Kenneth P ; Geissler, Wayne M ; Myers, Robert W ; Deng, Qiaolin ; Chapman, Kevin T ; Harris, Georgianna ; Moller, David E

Bioorganic & medicinal chemistry letters, 15 December 2003, Vol.13(24), pp.4385-8 [Peer Reviewed Journal]

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18
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4-Methyl-3-oxo-4-aza-5α-androst-1-ene-17β-N-aryl-carboxamides: an approach to combined androgen blockade [5α-reductase inhibition with androgen receptor binding in vitro]

Tolman, Richard L ; Sahoo, Soumya P ; Bakshi, Raman K ; Gratale, Dominick ; Patel, Gool ; Patel, Sushma ; Toney, Jeffrey ; Chang, Benedict ; Harris, Georgianna S

Journal of Steroid Biochemistry and Molecular Biology, 1997, Vol.60(5), pp.303-309 [Peer Reviewed Journal]

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19
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Novel glucocorticoids containing a 6,5-bicyclic core fused to a pyrazole ring: Synthesis, in vitro profile, molecular modeling studies, and in vivo experiments

Thompson, Christopher F ; Quraishi, Nazia ; Ali, Amjad ; Mosley, Ralph T ; Tata, James R ; Hammond, Milton L ; Balkovec, James M ; Einstein, Monica ; Ge, Lan ; Harris, Georgianna ; Kelly, Terri M ; Mazur, Paul ; Pandit, Shilpa ; Santoro, Joseph ; Sitlani, Ayesha ; Wang, Chuanlin ; Williamson, Joanne ; Miller, Douglas K ; Yamin, Ting-Ting D ; Thompson, Chris M

Bioorganic & Medicinal Chemistry Letters, 2007, Vol.17(12), pp.3354-3361 [Peer Reviewed Journal]

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20
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Selective glucocorticoid receptor nonsteroidal ligands completely antagonize the dexamethasone mediated induction of enzymes involved in gluconeogenesis and glutamine metabolism

Einstein, Monica ; Greenlee, Mark ; Rouen, Greg ; Sitlani, Ayesha ; Santoro, Joe ; Wang, Chuanlin ; Pandit, Shilpa ; Mazur, Paul ; Smalera, Isabella ; Weaver, Alehna Pm ; Zeng, Ying Ying ; Ge, Lan ; Kelly, Theresa ; Paiva, Tony ; Geissler, Wayne ; Mosley, Ralph T ; Williamson, Joanne ; Ali, Amjad ; Balkovec, Jim ; Harris, Georgianna

Journal of Steroid Biochemistry and Molecular Biology, 2004, Vol.92(5), pp.345-356 [Peer Reviewed Journal]

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21
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Novel ketal ligands for the glucocorticoid receptor: in vitro and in vivo activity

Smith, Cameron J ; Ali, Amjad ; Balkovec, James M ; Graham, Donald W ; Hammond, Milton L ; Patel, Gool F ; Rouen, Gregory P ; Smith, Scott K ; Tata, James R ; Einstein, Monica ; Ge, Lan ; Harris, Georgianna S ; Kelly, Theresa M ; Mazur, Paul ; Thompson, Chris M ; Wang, Chuanlin F ; Williamson, Joanne M ; Miller, Douglas K ; Pandit, Shilpa ; Santoro, Joseph C

Bioorganic & Medicinal Chemistry Letters, 2005, Vol.15(11), pp.2926-2931 [Peer Reviewed Journal]

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22
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Novel heterocyclic glucocorticoids: in vitro profile and in vivo efficacy

Thompson, Christopher F ; Quraishi, Nazia ; Ali, Amjad ; Tata, James R ; Hammond, Milton L ; Balkovec, James M ; Einstein, Monica ; Ge, Lan ; Harris, Georgianna ; Kelly, Theresa M ; Mazur, Paul ; Pandit, Shilpa ; Santoro, Joseph ; Sitlani, Ayesha ; Wang, Chuanlin ; Williamson, Joanne ; Miller, Douglas K ; Yamin, Ting-Ting D ; Thompson, Chris M ; O’neill, Edward A

Bioorganic & Medicinal Chemistry Letters, 2005, Vol.15(8), pp.2163-2167 [Peer Reviewed Journal]

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