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"It Ain't Over 'til It's Over" (a) -The Search for Treatments and Cures for Alzheimer's Disease

Hargreaves, Richard J

ACS medicinal chemistry letters, 08 November 2012, Vol.3(11), pp.862-6 [Peer Reviewed Journal]

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Translational PET imaging research

Hargreaves, Richard J ; Rabiner, Eugenii A

Neurobiology of Disease, January 2014, Vol.61, pp.32-38 [Peer Reviewed Journal]

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Non-invasive bioluminescence imaging of β-cell function in obese-hyperglycemic ob/ob mice

Patel, Manishkumar ; Gleason, Alexa ; O'Malley, Stacey ; Connolly, Brett ; Suresch, Donna ; Virostko, John ; Phillips, Neil ; Lin, Shu-An ; Chen, Tsing-Bau ; Klimas, Michael ; Hargreaves, Richard J ; Sur, Cyrille ; Williams, David L ; Powers, Alvin C ; Bednar, Bohumil

PloS one, 2014, Vol.9(9), pp.e106693 [Peer Reviewed Journal]

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Evaluation of [18F]MK-0911, a positron emission tomography (PET) tracer for opioid receptor-like 1 (ORL1), in rhesus monkey and human

Hostetler, Eric D ; Sanabria-Bohórquez, Sandra ; Eng, Waisi ; Joshi, Aniket D ; Patel, Shailendra ; Gibson, Raymond E ; O'Malley, Stacey ; Krause, Stephen M ; Ryan, Christine ; Riffel, Kerry ; Bi, Sheng ; Okamoto, Osamu ; Kawamoto, Hiroshi ; Ozaki, Satoshi ; Ohta, Hisashi ; de Groot, Tjibbe ; Bormans, Guy ; Depré, Marleen ; de Hoon, Jan ; De Lepeleire, Inge ; Reynders, Tom ; Cook, Jacquelynn J ; Burns, H. Donald ; Egan, Michael ; Cho, William ; van Laere, Koen ; Hargreaves, Richard J

NeuroImage, March 2013, Vol.68, pp.1-10 [Peer Reviewed Journal]

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Addition of an NK 1 receptor antagonist to an SSRI did not enhance the antidepressant effects of SSRI monotherapy: results from a randomized clinical trial in patients with major depressive disorder

Ball, William A. ; Snavely, Duane B. ; Hargreaves, Richard J. ; Szegedi, Armin ; Lines, Christopher ; Reines, Scott A.

Human Psychopharmacology: Clinical and Experimental, November 2014, Vol.29(6), pp.568-577 [Peer Reviewed Journal]

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10 Years of Rizatriptan

Hargreaves, Richard J.

Headache: The Journal of Head and Face Pain, February 2009, Vol.49, pp.S1-S2 [Peer Reviewed Journal]

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Reducing abuse liability of GABAA/benzodiazepine ligands via selective partial agonist efficacy at alpha1 and alpha2/3 subtypes

Ator, Nancy A ; Atack, John R ; Hargreaves, Richard J ; Burns, H Donald ; Dawson, Gerard R

The Journal of pharmacology and experimental therapeutics, January 2010, Vol.332(1), pp.4-16 [Peer Reviewed Journal]

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A growth hormone secretagogue prevents ischemic-induced mortality independently of the growth hormone pathway in dogs with chronic dilated cardiomyopathy

Shen, You-Tang ; Lynch, Joseph J ; Hargreaves, Richard J ; Gould, Robert J

The Journal of pharmacology and experimental therapeutics, August 2003, Vol.306(2), pp.815-20 [Peer Reviewed Journal]

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Characteristic time courses of cortical and medullary sodium signals measured by noninvasive 23Na‐MRI in rat kidney induced by furosemide

Liu, Haiying ; Zhou, Dan ; Garcia, Maria L. ; Kohler, Martin G. ; Shen, Xiaolan ; Williams, Donald S. ; Klimas, Michael T. ; Hargreaves, Richard J. ; Kaczorowski, Gregory J.

Journal of Magnetic Resonance Imaging, June 2015, Vol.41(6), pp.1622-1628 [Peer Reviewed Journal]

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Decision-making using fMRI in clinical drug development: revisiting NK-1 receptor antagonists for pain

Borsook, David ; Upadhyay, Jaymin ; Klimas, Michael ; Schwarz, Adam J ; Coimbra, Alexandre ; Baumgartner, Richard ; George, Edward ; Potter, William Z ; Large, Thomas ; Bleakman, David ; Evelhoch, Jeffrey ; Iyengar, Smriti ; Becerra, Lino ; Hargreaves, Richard J

Drug Discovery Today, September 2012, Vol.17(17-18), pp.964-973 [Peer Reviewed Journal]

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In vivo characterization and dynamic receptor occupancy imaging of TPA023B, an alpha 2/alpha 3/alpha 5 subtype selective gamma-aminobutyric acid-A partial agonist

Van Laere, Koen ; Bormans, Guy ; Sanabria-Bohorquez, Sandra M ; de Hoon, Jan ; de Groot, Tjibbe ; De Lepeleire, Inge ; Dupont, Patrick ; Mortelmans, Luc ; Hargreaves, Richard J ; Atack, John R ; Burns, H. Donald

Biological Psychiatry, 2008-07, Vol.64(2), pp.153-161 [Peer Reviewed Journal]

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In Vivo Characterization and Dynamic Receptor Occupancy Imaging of TPA023B, an α2/α3/α5 Subtype Selective γ-Aminobutyric Acid–A Partial Agonist

Van Laere, Koen ; Bormans, Guy ; Sanabria-Bohórquez, Sandra M ; de Groot, Tjibbe ; Dupont, Patrick ; De Lepeleire, Inge ; de Hoon, Jan ; Mortelmans, Luc ; Hargreaves, Richard J ; Atack, John R ; Burns, H. Donald

Biological Psychiatry, 2008, Vol.64(2), pp.153-161 [Peer Reviewed Journal]

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[ 18F]Fluoroazabenzoxazoles as potential amyloid plaque PET tracers: synthesis and in vivo evaluation in rhesus monkey

Hostetler, Eric D ; Sanabria-Bohórquez, Sandra ; Fan, Hong ; Zeng, Zhizhen ; Gammage, Linda ; Miller, Patricia ; O'Malley, Stacey ; Connolly, Brett ; Mulhearn, James ; Harrison, Scott T ; Wolkenberg, Scott E ; Barrow, James C ; Williams, David L ; Hargreaves, Richard J ; Sur, Cyrille ; Cook, Jacquelynn J

Nuclear Medicine and Biology, 2011, Vol.38(8), pp.1193-1203 [Peer Reviewed Journal]

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Synthesis and Evaluation of 5-Fluoro-2-aryloxazolo5,4-bpyridines as β-Amyloid PET Ligands and Identification of MK-3328

Harrison, Scott T ; Mulhearn, James ; Wolkenberg, Scott E ; Miller, Patricia J ; O'Malley, Stacey S ; Zeng, Zhizhen ; Williams, David L ; Hostetler, Eric D ; Sanabria-Bohórquez, Sandra ; Gammage, Linda ; Fan, Hong ; Sur, Cyrille ; Culberson, J Christopher ; Hargreaves, Richard J ; Cook, Jacquelynn J ; Hartman, George D ; Barrow, James C

ACS medicinal chemistry letters, 14 July 2011, Vol.2(7), pp.498-502 [Peer Reviewed Journal]

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Neurogenic inflammation in the context of migraine

Williamson, David J. ; Hargreaves, Richard J. Fricke, Britta

Microscopy Research and Technique, 01 May 2001, Vol.53(3), pp.167-178 [Peer Reviewed Journal]

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16
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Comparison of lorazepam 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one occupancy of rat brain gamma-aminobutyric acid(A) receptors measured using in vivo 3Hflumazenil (8-fluoro 5,6-dihydro-5-methyl-6-oxo-4H-imidazo1,5-a1,4benzodiazepine-3-carboxylic acid ethyl ester) binding and 11Cflumazenil micro-positron emission tomography

Atack, John R ; Scott-Stevens, Paul ; Beech, John S ; Fryer, Tim D ; Hughes, Jessica L ; Cleij, Marcel C ; Baron, Jean-Claude ; Clark, John C ; Hargreaves, Richard J ; Aigbirhio, Franklin I

The Journal of pharmacology and experimental therapeutics, March 2007, Vol.320(3), pp.1030-7 [Peer Reviewed Journal]

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Benzodiazepine binding site occupancy by the novel GABAA receptor subtype-selective drug 7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo4,3-bpyridazine (TPA023) in rats, primates, and humans

Atack, John R ; Wong, Dean F ; Fryer, Tim D ; Ryan, Christine ; Sanabria, Sandra ; Zhou, Yun ; Dannals, Robert F ; Eng, Wai-Si ; Gibson, Raymond E ; Burns, H Donald ; Vega, Jose M ; Vessy, Laura ; Scott-Stevens, Paul ; Beech, John S ; Baron, Jean-Claude ; Sohal, Bindi ; Schrag, Michael L ; Aigbirhio, Franklin I ; Mckernan, Ruth M ; Hargreaves, Richard J

The Journal of pharmacology and experimental therapeutics, January 2010, Vol.332(1), pp.17-25 [Peer Reviewed Journal]

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Human positron emission tomography studies of brain neurokinin 1 receptor occupancy by aprepitant

Bergström, Mats ; Hargreaves, Richard J ; Burns, H.Donald ; Goldberg, Michael R ; Sciberras, David ; Reines, Scott A ; Petty, Kevin J ; Ögren, Mattias ; Antoni, Gunnar ; Långström, Bengt ; Eskola, Olli ; Scheinin, Mika ; Solin, Olof ; Majumdar, Anup K ; Constanzer, Marvin L ; Battisti, Wendy P ; Bradstreet, Thomas E ; Gargano, Cynthia ; Hietala, Jarmo

Biological Psychiatry, 2004, Vol.55(10), pp.1007-1012 [Peer Reviewed Journal]

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19
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The design of novel muscarinic partial agonists that have functional selectivity in pharmacological preparations in vitro and reduced side-effect profile in vivo

Freedman, Stephen B ; Dawson, Gerard R ; Iversen, Leslie L ; Baker, Raymond ; Hargreaves, Richard J

Life Sciences, 1993, Vol.52(5), pp.489-495 [Peer Reviewed Journal]

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20
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18FMK-9470, a positron emission tomography (PET) tracer for in vivo human PET brain imaging of the cannabinoid-1 receptor

Burns, H Donald ; Van Laere, Koen ; Sanabria-Bohórquez, Sandra ; Hamill, Terence G ; Bormans, Guy ; Eng, Wai-Si ; Gibson, Ray ; Ryan, Christine ; Connolly, Brett ; Patel, Shil ; Krause, Stephen ; Vanko, Amy ; Van Hecken, Anne ; Dupont, Patrick ; De Lepeleire, Inge ; Rothenberg, Paul ; Stoch, S Aubrey ; Cote, Josee ; Hagmann, William K ; Jewell, James P ; Lin, Linus S ; Liu, Ping ; Goulet, Mark T ; Gottesdiener, Keith ; Wagner, John A ; De Hoon, Jan ; Mortelmans, Luc ; Fong, Tung M ; Hargreaves, Richard J

Proceedings of the National Academy of Sciences of the United States of America, 05 June 2007, Vol.104(23), pp.9800-5 [Peer Reviewed Journal]

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[18F]MK-9470, a positron emission tomography (PET) tracer for in vivo human PET brain imaging of the cannabinoid-1 receptor

Burns, H Donald ; Van Laere, Koen ; Sanabria-Bohórquez, Sandra ; Hamill, Terence G ; Bormans, Guy ; Eng, Wai-si ; Gibson, Ray ; Ryan, Christine ; Connolly, Brett ; Patel, Shil ; Krause, Stephen ; Vanko, Amy ; Van Hecken, Anne ; Dupont, Patrick ; De Lepeleire, Inge ; Rothenberg, Paul ; Stoch, S Aubrey ; Cote, Josee ; Hagmann, William K ; Jewell, James P ; Lin, Linus S ; Liu, Ping ; Goulet, Mark T ; Gottesdiener, Keith ; Wagner, John A ; de Hoon, Jan ; Mortelmans, Luc ; Fong, Tung M ; Hargreaves, Richard J

Proceedings of the National Academy of Sciences of the United States of America, 2007-06, Vol.104(23), pp.9800-9805 [Peer Reviewed Journal]

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22
An Orally Active, Water-Soluble Neurokinin-1 Receptor Antagonist Suitable for Both Intravenous and Oral Clinical Administration
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An Orally Active, Water-Soluble Neurokinin-1 Receptor Antagonist Suitable for Both Intravenous and Oral Clinical Administration

Harrison, Timothy ; Owens, Andrew P. ; Williams, Brian J. ; Swain, Christopher J. ; Williams, Angela ; Carlson, Emma J. ; Rycroft, Wayne ; Tattersall, F. David ; Cascieri, Margaret A. ; Chicchi, Gary G. ; Sadowski, Sharon ; Rupniak, Nadia M. J. ; Hargreaves, Richard J.

Journal of Medicinal Chemistry, 11/2001, Vol.44(24), pp.4296-4299 [Peer Reviewed Journal]

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23
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(11)CMK-4232: The First Positron Emission Tomography Tracer for the Calcitonin Gene-Related Peptide Receptor

Bell, Ian M ; Gallicchio, Steven N ; Stump, Craig A ; Bruno, Joseph G ; Fan, Hong ; Gantert, Liza T ; Hostetler, Eric D ; Kemmerer, Amanda L ; Mcwherter, Melody ; Moore, Eric L ; Mosser, Scott D ; Purcell, Mona L ; Riffel, Kerry ; Salvatore, Christopher A ; Sanabria-Bohórquez, Sandra ; Staas, Donnette D ; White, Rebecca B ; Williams, Mangay ; Zartman, C Blair ; Cook, Jacquelynn J ; Hargreaves, Richard J ; Kane, Stefanie A ; Graham, Samuel L ; Selnick, Harold G

ACS medicinal chemistry letters, 12 September 2013, Vol.4(9), pp.863-8 [Peer Reviewed Journal]

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In vivo quantification of calcitonin gene-related peptide receptor occupancy by telcagepant in rhesus monkey and human brain using the positron emission tomography tracer 11CMK-4232

Hostetler, Eric D ; Joshi, Aniket D ; Sanabria-Bohórquez, Sandra ; Fan, Hong ; Zeng, Zhizhen ; Purcell, Mona ; Gantert, Liza ; Riffel, Kerry ; Williams, Mangay ; O'Malley, Stacey ; Miller, Patricia ; Selnick, Harold G ; Gallicchio, Steven N ; Bell, Ian M ; Salvatore, Christopher A ; Kane, Stefanie A ; Li, Chi-Chung ; Hargreaves, Richard J ; De Groot, Tjibbe ; Bormans, Guy ; Van Hecken, Anne ; Derdelinckx, Inge ; De Hoon, Jan ; Reynders, Tom ; Declercq, Ruben ; De Lepeleire, Inge ; Kennedy, W P ; Blanchard, Rebecca ; Marcantonio, Eugene E ; Sur, Cyrille ; Cook, Jacquelynn J ; Van Laere, Koen ; Evelhoch, Jeffrey L

The Journal of pharmacology and experimental therapeutics, November 2013, Vol.347(2), pp.478-86 [Peer Reviewed Journal]

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25
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The anti‐migraine 5‐HT 1B/1D agonist rizatriptan inhibits neurogenic dural vasodilation in anaesthetized guinea‐pigs

Williamson, David J ; Hill, Raymond G ; Shepheard, Sara L ; Hargreaves, Richard J

British Journal of Pharmacology, August 2001, Vol.133(7), pp.1029-1034 [Peer Reviewed Journal]

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26
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Ten Years of Rizatriptan: From Development to Clinical Science and Future Directions

Hargreaves, Richard J. ; Lines, Chris R. ; Rapoport, Alan M. ; Ho, Tony W. ; Sheftell, Fred D.

Headache: The Journal of Head and Face Pain, February 2009, Vol.49, pp.S3-S20 [Peer Reviewed Journal]

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27
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The plasma–occupancy relationship of the novel GABA A receptor benzodiazepine site ligand, α5IA, is similar in rats and primates

Atack, John R ; Eng, Wai‐Si ; Gibson, Ray E ; Ryan, Christine ; Francis, Barbara ; Sohal, Bindi ; Dawson, Gerard R ; Hargreaves, Richard J ; Burns, H Donald

British Journal of Pharmacology, July 2009, Vol.157(5), pp.796-803 [Peer Reviewed Journal]

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28
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The non‐peptide neurokinin1 receptor antagonist, RP 67580, blocks neurogenic plasma extravasation in the dura mater of rats

Shepheard, Sara L. ; Williamson, David J. ; Hill, Raymond G. ; Hargreaves, Richard J.

British Journal of Pharmacology, January 1993, Vol.108(1), pp.11-12 [Peer Reviewed Journal]

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29
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PET imaging of neurokinin‐1 receptors with [ 18 F]SPA‐RQ in human subjects: Assessment of reference tissue models and their test–retest reproducibility

Yasuno, Fumihiko ; Sanabria, Sandra M. ; Burns, Donald ; Hargreaves, Richard J. ; Ghose, Subroto ; Ichise, Masanori ; Chin, Frederick T. ; Morse, Cheryl L. ; Pike, Victor W. ; Innis, Robert B.

Synapse, April 2007, Vol.61(4), pp.242-251 [Peer Reviewed Journal]

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30
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Investigation of the species selectivity of a nonpeptide CGRP receptor antagonist using a novel pharmacodynamic assay

Hershey, James C ; Corcoran, Halea A ; Baskin, Elizabeth P ; Salvatore, Christopher A ; Mosser, Scott ; Williams, Theresa M ; Koblan, Kenneth S ; Hargreaves, Richard J ; Kane, Stefanie A

Regulatory Peptides, 2005, Vol.127(1), pp.71-77 [Peer Reviewed Journal]

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31
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Comparison of the effects of ascorbyl palmitate and L-ascorbic acid on paracetamol-induced hepatotoxicity in the mouse

Jonker, Diana ; Lee, Victoria S ; Hargreaves, Richard J ; Lake, Brian G

Toxicology, 1988, Vol.52(3), pp.287-295 [Peer Reviewed Journal]

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32
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Studies on the effects of l-ascorbic acid on acetaminophen-induced hepatotoxicity : II. An in vivo assessment in mice of the protection afforded by various dosage forms of ascorbate

Hargreaves, Richard J ; Evans, John G ; Pelling, David ; Butterworth, Kenneth R

Toxicology and Applied Pharmacology, 1982, Vol.64(3), pp.380-392 [Peer Reviewed Journal]

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33
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Whole-body biodistribution and radiation dosimetry of the human cannabinoid type-1 receptor ligand F-18-MK-9470 in healthy subjects

Van Laere, Koen ; Koole, Michel ; Bohorquez, Sandra M. Sanabria ; Goffin, Karolien ; Bormans, Guy ; Guenther, Ilonka ; Cote, Josee ; Belanger, Marie J ; Rothenberg, Paul ; De Lepeleire, Inge ; Grache, Igor D ; HargreaveS, Richard J ; Burns, H. Donald

Journal of Nuclear Medicine, 2008-03, Vol.49(3), pp.439-445 [Peer Reviewed Journal]

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34
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Whole-body biodistribution and radiation dosimetry of the human cannabinoid type-1 receptor ligand 18F-MK-9470 in healthy subjects

Van Laere, Koen ; Koole, Michel ; Sanabria Bohorquez, Sandra M ; Goffin, Karolien ; Guenther, Ilonka ; Belanger, Marie J ; Cote, Josee ; Rothenberg, Paul ; De Lepeleire, Inge ; Grachev, Igor D ; Hargreaves, Richard J ; Bormans, Guy ; Burns, H Donald

Journal of nuclear medicine : official publication, Society of Nuclear Medicine, March 2008, Vol.49(3), pp.439-45 [Peer Reviewed Journal]

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35
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The discovery of potent, selective, and orally bioavailable hNK 1 antagonists derived from pyrrolidine

Lin, Peter ; Chang, Lehua ; Devita, Robert J ; Young, Jonathan R ; Eid, Ronsar ; Tong, Xinchun ; Zheng, Song ; Ball, Richard G ; Tsou, Nancy N ; Chicchi, Gary G ; Kurtz, Marc M ; Tsao, Kwei-Lan C ; Wheeldon, Alan ; Carlson, Emma J ; Eng, Waisi ; Burns, H. Donald ; Hargreaves, Richard J ; Mills, Sander G

Bioorganic & Medicinal Chemistry Letters, 2007, Vol.17(18), pp.5191-5198 [Peer Reviewed Journal]

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36
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The effect of chronic low level lead exposure on blood-brain barrier function in the developing rat

Moorhouse, Stephen R ; Carden, Susanne ; Drewitt, Philip N ; Eley, Brenda P ; Hargreaves, Richard J ; Pelling, David

Biochemical Pharmacology, 1988, Vol.37(23), pp.4539-4547 [Peer Reviewed Journal]

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37
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In vitro and in vivo properties of 3-tert-butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy)-pyrazolo1,5-d-1,2,4triazine (MRK-016), a GABAA receptor alpha5 subtype-selective inverse agonist

Atack, John R ; Maubach, Karen A ; Wafford, Keith A ; O'Connor, Desmond ; Rodrigues, A David ; Evans, David C ; Tattersall, F David ; Chambers, Mark S ; Macleod, Angus M ; Eng, Wai-Si ; Ryan, Christine ; Hostetler, Eric ; Sanabria, Sandra M ; Gibson, Raymond E ; Krause, Stephen ; Burns, H Donald ; Hargreaves, Richard J ; Agrawal, Nancy G B ; Mckernan, Ruth M ; Murphy, M Gail ; Gingrich, Kevin ; Dawson, Gerard R ; Musson, Donald G ; Petty, Kevin J

The Journal of pharmacology and experimental therapeutics, November 2009, Vol.331(2), pp.470-84 [Peer Reviewed Journal]

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