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The many roles for fluorine in medicinal chemistry

Hagmann, William K

Journal of medicinal chemistry, 14 August 2008, Vol.51(15), pp.4359-69 [Peer Reviewed Journal]

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Synthesis of β-carbolines from aldehydes and ketones via the α-siloxy α,β-unsaturated esters

He, Shuwen ; Lai, Zhong ; Yang, David X ; Hong, Qingmei ; Reibarkh, Mikhail ; Nargund, Ravi P ; Hagmann, William K

Tetrahedron Letters, 2010, Vol.51(33), pp.4361-4364 [Peer Reviewed Journal]

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GPR40 partial agonist MK-2305 lower fasting glucose in the Goto Kakizaki rat via suppression of endogenous glucose production

Miller, Corin ; Pachanski, Michele J ; Kirkland, Melissa E ; Kosinski, Daniel T ; Mane, Joel ; Bunzel, Michelle ; Cao, Jin ; Souza, Sarah ; Thomas-Fowlkes, Brande ; Di Salvo, Jerry ; Weinglass, Adam B ; Li, Xiaoyan ; Myers, Robert W ; Knagge, Kevin ; Carrington, Paul E ; Hagmann, William K ; Trujillo, Maria E

PloS one, 2017, Vol.12(5), pp.e0176182 [Peer Reviewed Journal]

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A direct functionalization of tertiary alkyl bromides with O-, N-, and C-nucleophiles

Vachal, Petr ; Fletcher, Joan M ; Hagmann, William K

Tetrahedron Letters, 13 August 2007, Vol.48(33), pp.5761-5765 [Peer Reviewed Journal]

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A ‘one-pot’ synthesis of α-1,2,4-oxadiazolo esters from malonic diesters and amidoximes under solvent-free conditions

Du, Wu ; Hagmann, William K ; Hale, Jeffrey J

Tetrahedron Letters, 2006, Vol.47(25), pp.4271-4274 [Peer Reviewed Journal]

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Enantioselective approach to 3-substituted prolines

Kamenecka, Theodore M ; Park, You-Jung ; Lin, Linus S ; Lanza, Thomas ; Hagmann, William K

Tetrahedron Letters, 2001, Vol.42(49), pp.8571-8573 [Peer Reviewed Journal]

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Chiral synthesis of C-carboxyalkyl dipeptide inhibitors of stromelysin-1 (MMP-3)

Ponpipom, Mitree M ; Hagmann, William K

Tetrahedron, 1999, Vol.55(22), pp.6749-6758 [Peer Reviewed Journal]

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QSAR Prediction of Passive Permeability in the LLC‐PK1 Cell Line: Trends in Molecular Properties and Cross‐Prediction of Caco‐2 Permeabilities

Sherer, Edward C. ; Verras, Andreas ; Madeira, Maria ; Hagmann, William K. ; Sheridan, Robert P. ; Roberts, Drew ; Bleasby, Kelly ; Cornell, Wendy D.

Molecular Informatics, April 2012, Vol.31(3‐4), pp.231-245 [Peer Reviewed Journal]

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A highly active catalyst system for the heteroarylation of acetone

Liu, Ping ; Lanza, Thomas J ; Jewell, James P ; Jones, Carrie P ; Hagmann, William K ; Lin, Linus S

Tetrahedron Letters, 2003, Vol.44(49), pp.8869-8871 [Peer Reviewed Journal]

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10
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Similar in vitro pharmacology of human cannabinoid CB 1 receptor variants expressed in CHO cells

Xiao, Jing Chen ; Jewell, James P ; Lin, Linus S ; Hagmann, William K ; Fong, Tung M ; Shen, Chun-Pyn

Brain Research, 2008, Vol.1238, pp.36-43 [Peer Reviewed Journal]

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The Discovery of Taranabant, a Selective Cannabinoid‐1 Receptor Inverse Agonist for the Treatment of Obesity

Hagmann, William K.

Archiv der Pharmazie, July 2008, Vol.341(7), pp.405-411 [Peer Reviewed Journal]

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A one-pot synthesis of 3-substituted-5-carbonylmethyl-1,2,4-oxadiazoles from β-keto esters and amidoximes under solvent-free conditions

Du, Wu ; Truong, Quang ; Qi, Hongbo ; Guo, Yan ; Chobanian, Harry R ; Hagmann, William K ; Hale, Jeffrey J

Tetrahedron Letters, 2007, Vol.48(13), pp.2231-2235 [Peer Reviewed Journal]

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13
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Discovery and development of benzo-[1,2,4]-triazolo-[1,4]-oxazepine GPR142 agonists for the treatment of diabetes

Wilson, Jonathan E ; Kurukulasuriya, Ravi ; Sinz, Christopher ; Lombardo, Matthew ; Bender, Kate ; Parker, Dann ; Sherer, Edward C ; Costa, Melissa ; Dingley, Karen ; Li, Xiaofang ; Mitelman, Stanley ; Tong, Sharon ; Bugianesi, Randal ; Ehrhardt, Anka ; Priest, Birgit ; Ratliff, Kevin ; Ujjainwalla, Feroze ; Nargund, Ravi ; Hagmann, William K ; Edmondson, Scott

Bioorganic & Medicinal Chemistry Letters, 15 June 2016, Vol.26(12), pp.2947-2951 [Peer Reviewed Journal]

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Discovery of substituted (4-phenyl-1H-imidazol-2-yl)methanamine as potent somatostatin receptor 3 agonists

Lai, Zhong ; He, Shuwen ; Sherer, Edward C ; Wu, Zhicai ; Yu, Yang ; Ball, Richard ; Hong, Qingmei ; Yang, David X ; Guo, Liangqing ; Li, Derun ; Tuang, Quang ; Chicchi, Gary G ; Trusca, Dorina ; Tsao, Kwei-Lan ; Zhou, Yun-Ping ; Howard, Andrew D ; Nargund, Ravi P ; Hagmann, William K

Bioorganic & Medicinal Chemistry Letters, 01 September 2015, Vol.25(17), pp.3520-3525 [Peer Reviewed Journal]

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15
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Deprotection of N- tert-butoxycarbonyl (Boc) groups in the presence of tert-butyl esters

Lin, Linus S ; Lanza, Thomas ; de Laszlo, Stephen E ; Truong, Quang ; Kamenecka, Theodore ; Hagmann, William K

Tetrahedron Letters, 2000, Vol.41(36), pp.7013-7016 [Peer Reviewed Journal]

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Synthesis and cannabinoid-1 receptor binding affinity of conformationally constrained analogs of taranabant

Kopka, Ihor E ; Lin, Linus S ; Jewell, James P ; Lanza, Thomas J ; Fong, Tung M ; Shen, Chun-Pyn ; Lao, Zhege J ; Ha, Sookhee ; Castonguay, Laurie G ; Van Der Ploeg, Lex ; Goulet, Mark T ; Hagmann, William K

Bioorganic & Medicinal Chemistry Letters, 2010, Vol.20(16), pp.4757-4761 [Peer Reviewed Journal]

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VLA-4 antagonists: Potent inhibitors of lymphocyte migration
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VLA-4 antagonists: Potent inhibitors of lymphocyte migration

Yang, Ginger X. ; Hagmann, William K.

Medicinal Research Reviews, 05/2003, Vol.23(3), pp.369-392 [Peer Reviewed Journal]

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18
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Conformational analysis and receptor docking of N-(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl-2-methyl-2-{5-(trifluoromethyl)pyridin-2-yloxy}propanamide (taranabant, MK-0364), a novel, acyclic cannabinoid-1 receptor inverse agonist

Lin, Linus S ; Ha, Sookhee ; Ball, Richard G ; Tsou, Nancy N ; Castonguay, Laurie A ; Doss, George A ; Fong, Tung M ; Shen, Chun-Pyn ; Xiao, Jing Chen ; Goulet, Mark T ; Hagmann, William K

Journal of medicinal chemistry, 10 April 2008, Vol.51(7), pp.2108-14 [Peer Reviewed Journal]

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19
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Design and Synthesis of Novel, Selective GPR40 AgoPAMs

Plummer, Christopher W ; Clements, Matthew J ; Chen, Helen ; Rajagopalan, Murali ; Josien, Hubert ; Hagmann, William K ; Miller, Michael ; Trujillo, Maria E ; Kirkland, Melissa ; Kosinski, Daniel ; Mane, Joel ; Pachanski, Michele ; Cheewatrakoolpong, Boonlert ; Nolting, Andrew F ; Orr, Robert ; Christensen, Melodie ; Campeau, Louis-Charles ; Wright, Michael J ; Bugianesi, Randal ; Souza, Sarah ; Zhang, Xiaoping ; Di Salvo, Jerry ; Weinglass, Adam B ; Tschirret-Guth, Richard ; Nargund, Ravi ; Howard, Andrew D ; Colletti, Steven L

ACS medicinal chemistry letters, 09 February 2017, Vol.8(2), pp.221-226 [Peer Reviewed Journal]

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20
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Diamine Derivatives as Novel Small-Molecule, Potent, and Subtype-Selective Somatostatin SST3 Receptor Agonists

Li, Derun ; Wu, Zhicai ; Yu, Yang ; Ball, Richard G ; Guo, Liangqin ; Sherer, Edward ; He, Shuwen ; Hong, Qingmei ; Lai, Zhong ; Qi, Hongbo ; Truong, Quang ; Yang, David X ; Chicchi, Gary G ; Tsao, Kwei-Lan ; Trusca, Dorina ; Trujillo, Maria ; Pachanski, Michele ; Eiermann, George J ; Howard, Andrew D ; Zhou, Yun-Ping ; Zhang, Bei B ; Nargund, Ravi P ; Hagmann, William K

ACS medicinal chemistry letters, 12 June 2014, Vol.5(6), pp.690-5 [Peer Reviewed Journal]

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Discovery of N-{N-(3-cyanophenyl)sulfonyl-4(R)-cyclobutylamino-(L)-prolyl}-4-(3',5'-dichloroisonicotinoyl) amino-(L)-phenylalanine (MK-0668), an extremely potent and orally active antagonist of very late antigen-4

Lin, Linus S ; Lanza, Thomas ; Jewell, James P ; Liu, Ping ; Jones, Carrie ; Kieczykowski, Gerard R ; Treonze, Kelly ; Si, Qian ; Manior, Salony ; Koo, Gloria ; Tong, Xinchun ; Wang, Junying ; Schuelke, Anne ; Pivnichny, James ; Wang, Regina ; Raab, Conrad ; Vincent, Stella ; Davies, Philip ; Maccoss, Malcolm ; Mumford, Richard A ; Hagmann, William K

Journal of medicinal chemistry, 11 June 2009, Vol.52(11), pp.3449-52 [Peer Reviewed Journal]

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22
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Comparative assessment of the ligand and metal ion binding properties of integrins alpha9beta1 and alpha4beta1

Pepinsky, R Blake ; Mumford, Richard A ; Chen, Ling Ling ; Leone, Diane ; Amo, Suzanne E ; Riper, Gail Van ; Whitty, Adrian ; Dolinski, Brian ; Lobb, Roy R ; Dean, Dennis C ; Chang, Linda L ; Raab, Conrad E ; Si, Qian ; Hagmann, William K ; Lingham, Russell B

Biochemistry, 04 June 2002, Vol.41(22), pp.7125-41 [Peer Reviewed Journal]

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23
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18FMK-9470, a positron emission tomography (PET) tracer for in vivo human PET brain imaging of the cannabinoid-1 receptor

Burns, H Donald ; Van Laere, Koen ; Sanabria-Bohórquez, Sandra ; Hamill, Terence G ; Bormans, Guy ; Eng, Wai-Si ; Gibson, Ray ; Ryan, Christine ; Connolly, Brett ; Patel, Shil ; Krause, Stephen ; Vanko, Amy ; Van Hecken, Anne ; Dupont, Patrick ; De Lepeleire, Inge ; Rothenberg, Paul ; Stoch, S Aubrey ; Cote, Josee ; Hagmann, William K ; Jewell, James P ; Lin, Linus S ; Liu, Ping ; Goulet, Mark T ; Gottesdiener, Keith ; Wagner, John A ; De Hoon, Jan ; Mortelmans, Luc ; Fong, Tung M ; Hargreaves, Richard J

Proceedings of the National Academy of Sciences of the United States of America, 05 June 2007, Vol.104(23), pp.9800-5 [Peer Reviewed Journal]

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24
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[18F]MK-9470, a positron emission tomography (PET) tracer for in vivo human PET brain imaging of the cannabinoid-1 receptor

Burns, H Donald ; Van Laere, Koen ; Sanabria-Bohórquez, Sandra ; Hamill, Terence G ; Bormans, Guy ; Eng, Wai-si ; Gibson, Ray ; Ryan, Christine ; Connolly, Brett ; Patel, Shil ; Krause, Stephen ; Vanko, Amy ; Van Hecken, Anne ; Dupont, Patrick ; De Lepeleire, Inge ; Rothenberg, Paul ; Stoch, S Aubrey ; Cote, Josee ; Hagmann, William K ; Jewell, James P ; Lin, Linus S ; Liu, Ping ; Goulet, Mark T ; Gottesdiener, Keith ; Wagner, John A ; de Hoon, Jan ; Mortelmans, Luc ; Fong, Tung M ; Hargreaves, Richard J

Proceedings of the National Academy of Sciences of the United States of America, 2007-06, Vol.104(23), pp.9800-9805 [Peer Reviewed Journal]

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25
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Investigation of Cardiovascular Effects of Tetrahydro-β-carboline sstr3 antagonists

He, Shuwen ; Lai, Zhong ; Ye, Zhixiong ; Dobbelaar, Peter H ; Shah, Shrenik K ; Truong, Quang ; Du, Wu ; Guo, Liangqin ; Liu, Jian ; Jian, Tianying ; Qi, Hongbo ; Bakshi, Raman K ; Hong, Qingmei ; Dellureficio, James ; Reibarkh, Mikhail ; Samuel, Koppara ; Reddy, Vijay B ; Mitelman, Stan ; Tong, Sharon X ; Chicchi, Gary G ; Tsao, Kwei-Lan ; Trusca, Dorina ; Wu, Margaret ; Shao, Qing ; Trujillo, Maria E ; Fernandez, Guillermo ; Nelson, Donald ; Bunting, Patricia ; Kerr, Janet ; Fitzgerald, Patrick ; Morissette, Pierre ; Volksdorf, Sylvia ; Eiermann, George J ; Li, Cai ; Zhang, Bei ; Howard, Andrew D ; Zhou, Yun-Ping ; Nargund, Ravi P ; Hagmann, William K

ACS medicinal chemistry letters, 10 July 2014, Vol.5(7), pp.748-53 [Peer Reviewed Journal]

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26
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Discovery and Optimization of a Novel Triazole Series of GPR142 Agonists for the Treatment of Type 2 Diabetes

Guo, Liangqin ; Parker, Dann L ; Zang, Yi ; Sweis, Ramzi F ; Liu, Weiguo ; Sherer, Edward C ; Buist, Nicole ; Terebetski, Jenna ; Kelly, Terri ; Bugianesi, Randal ; Priest, Birgit T ; Dingley, Karen H ; Li, Xiaofang ; Mitelman, Stan ; Salituro, Gino ; Trujillo, Maria E ; Pachanski, Michele ; Kirkland, Melissa ; Powles, Mary Ann ; Eiermann, George J ; Feng, Yue ; Shang, Jin ; Howard, Andrew D ; Ujjainwalla, Feroze ; Sinz, Christopher J ; Debenham, John S ; Edmondson, Scott D ; Nargund, Ravi P ; Hagmann, William K ; Li, Derun

ACS medicinal chemistry letters, 08 December 2016, Vol.7(12), pp.1107-1111 [Peer Reviewed Journal]

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27
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SAR exploration at the C-3 position of tetrahydro-β-carboline sstr3 antagonists

He, Shuwen ; Dobbelaar, Peter H ; Guo, Liangqin ; Ye, Zhixiong ; Liu, Jian ; Jian, Tianying ; Truong, Quang ; Shah, Shrenik K ; Du, Wu ; Qi, Hongbo ; Bakshi, Raman K ; Hong, Qingmei ; Dellureficio, James D ; Sherer, Edward ; Pasternak, Alexander ; Feng, Zhe ; Reibarkh, Mikhail ; Lin, Melissa ; Samuel, Koppara ; Reddy, Vijay B ; Mitelman, Stan ; Tong, Sharon X ; Chicchi, Gary G ; Tsao, Kwei-Lan ; Trusca, Dorina ; Wu, Margaret ; Shao, Qing ; Trujillo, Maria E ; Fernandez, Guillermo ; Nelson, Donald ; Bunting, Patricia ; Kerr, Janet ; Fitzgerald, Patrick ; Morissette, Pierre ; Volksdorf, Sylvia ; Eiermann, George J ; Li, Cai ; Zhang, Bei B ; Howard, Andrew D ; Zhou, Yun-Ping ; Nargund, Ravi P ; Hagmann, William K

Bioorganic & Medicinal Chemistry Letters, 15 March 2016, Vol.26(6), pp.1529-1535 [Peer Reviewed Journal]

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28
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1-Sulfonyl-4-acylpiperazines as selective cannabinoid-1 receptor (CB1R) inverse agonists for the treatment of obesity

Vachal, Petr ; Fletcher, Joan M ; Fong, Tung M ; Huang, Cathy C R-R ; Lao, Julie ; Xiao, Jing C ; Shen, Chun-Pyn ; Strack, Alison M ; Shearman, Lauren ; Stribling, Sloan ; Chen, Richard Z ; Frassetto, Andrea ; Tong, Xinchun ; Wang, Junying ; Ball, Richard G ; Tsou, Nancy N ; Hickey, Gerard J ; Thompson, Donald F ; Faidley, Terry D ; Nicolich, Susan ; Achanfuo-Yeboah, Joana ; Hora, Donald F ; Hale, Jeffrey J ; Hagmann, William K

Journal of medicinal chemistry, 23 April 2009, Vol.52(8), pp.2550-8 [Peer Reviewed Journal]

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29
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Alpha(4)beta(7)/alpha(4)beta(1) dual integrin antagonists block alpha(4)beta(7)-dependent adhesion under shear flow

Egger, Linda A ; Kidambi, Usha ; Cao, Jin ; Van Riper, Gail ; Mccauley, Ermengilda ; Mumford, Richard A ; Amo, Suzanne ; Lingham, Russell ; Lanza, Thomas ; Lin, Linus S ; De Laszlo, Stephen E ; Young, David N ; Kopka, Ihor E ; Tong, Sharon ; Pikounis, Bill ; Benson, Evelyn ; Warwood, Sarah ; Bargatze, Robert F ; Hagmann, William K ; Schmidt, John A ; Detmers, Patricia A

The Journal of pharmacology and experimental therapeutics, July 2002, Vol.302(1), pp.153-62 [Peer Reviewed Journal]

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Constraining the amide bond in N-Sulfonylated dipeptide VLA-4 antagonists

Chang, Linda L ; Yang, Ginger X ; Mccauley, Ermengilda ; Mumford, Richard A ; Schmidt, John A ; Hagmann, William K

Bioorganic & Medicinal Chemistry Letters, 2008, Vol.18(5), pp.1688-1691 [Peer Reviewed Journal]

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Characterization of a novel and selective cannabinoid CB 1 receptor inverse agonist, Imidazole 24b, in rodents

Shearman, Lauren P ; Stribling, D. Sloan ; Camacho, Ramon E ; Rosko, Kimberly M ; Wang, Junying ; Tong, Sharon ; Feng, Yue ; Marsh, Donald J ; Yu, Hong ; Guan, Xiaoming ; Spann, Stephanie K ; Macneil, Douglas J ; Fong, Tung M ; Metzger, Joseph M ; Goulet, Mark T ; Hagmann, William K ; Plummer, Christopher W ; Finke, Paul E ; Mills, Sander G ; Shah, Shrenik K ; Truong, Quang ; Van Der Ploeg, L.H.T ; Macintyre, D. Euan ; Strack, Alison M

European Journal of Pharmacology, 2008, Vol.579(1), pp.215-224 [Peer Reviewed Journal]

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Discovery of N-{(1S,2S)-2-(3-cyanophenyl)- 3-4-(2-18Ffluoroethoxy)phenyl-1-methylpropyl}- 2-methyl-2-(5-methylpyridin-2-yl)oxypropanamide, a cannabinoid-1 receptor positron emission tomography tracer suitable for clinical use

Liu, Ping ; Lin, Linus S ; Hamill, Terence G ; Jewell, James P ; Lanza, Thomas J ; Gibson, Raymond E ; Krause, Stephen M ; Ryan, Christine ; Eng, Waisi ; Sanabria, Sandra ; Tong, Xinchun ; Wang, Junying ; Levorse, Dorothy A ; Owens, Karen A ; Fong, Tung M ; Shen, Chun-Pyn ; Lao, Julie ; Kumar, Sanjeev ; Yin, Wenji ; Payack, Joseph F ; Springfield, Shawn A ; Hargreaves, Richard ; Burns, H Donald ; Goulet, Mark T ; Hagmann, William K

Journal of medicinal chemistry, 26 July 2007, Vol.50(15), pp.3427-30 [Peer Reviewed Journal]

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Discovery of N-(1S,2S)-3-(4-Chlorophenyl)-2- (3-cyanophenyl)-1-methylpropyl-2-methyl-2- {5-(trifluoromethyl)pyridin-2-yloxy}propanamide (MK-0364), a novel, acyclic cannabinoid-1 receptor inverse agonist for the treatment of obesity

Lin, Linus S ; Lanza, Thomas J ; Jewell, James P ; Liu, Ping ; Shah, Shrenik K ; Qi, Hongbo ; Tong, Xinchun ; Wang, Junying ; Xu, Suoyu S ; Fong, Tung M ; Shen, Chun-Pyn ; Lao, Julie ; Xiao, Jing Chen ; Shearman, Lauren P ; Stribling, D Sloan ; Rosko, Kimberly ; Strack, Alison ; Marsh, Donald J ; Feng, Yue ; Kumar, Sanjeev ; Samuel, Koppara ; Yin, Wenji ; Van Der Ploeg, Lex H T ; Goulet, Mark T ; Hagmann, William K

Journal of medicinal chemistry, 28 December 2006, Vol.49(26), pp.7584-7 [Peer Reviewed Journal]

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Discovery of MK-1421, a Potent, Selective sstr3 Antagonist, as a Development Candidate for Type 2 Diabetes

Shah, Shrenik K ; He, Shuwen ; Guo, Liangqin ; Truong, Quang ; Qi, Hongbo ; Du, Wu ; Lai, Zhong ; Liu, Jian ; Jian, Tianying ; Hong, Qingmei ; Dobbelaar, Peter ; Ye, Zhixiong ; Sherer, Edward ; Feng, Zhe ; Yu, Yang ; Wong, Frederick ; Samuel, Koppara ; Madiera, Maria ; Karanam, Bindhu V ; Reddy, Vijay B ; Mitelman, Stan ; Tong, Sharon X ; Chicchi, Gary G ; Tsao, Kwei-Lan ; Trusca, Dorina ; Feng, Yue ; Wu, Margaret ; Shao, Qing ; Trujillo, Maria E ; Eiermann, George J ; Li, Cai ; Pachanski, Michele ; Fernandez, Guillermo ; Nelson, Donald ; Bunting, Patricia ; Morissette, Pierre ; Volksdorf, Sylvia ; Kerr, Janet ; Zhang, Bei B ; Howard, Andrew D ; Zhou, Yun-Ping ; Pasternak, Alexander ; Nargund, Ravi P ; Hagmann, William K

ACS medicinal chemistry letters, 14 May 2015, Vol.6(5), pp.513-7 [Peer Reviewed Journal]

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The Discovery of MK-4256, a Potent SSTR3 Antagonist as a Potential Treatment of Type 2 Diabetes

He, Shuwen ; Ye, Zhixiong ; Truong, Quang ; Shah, Shrenik ; Du, Wu ; Guo, Liangqin ; Dobbelaar, Peter H ; Lai, Zhong ; Liu, Jian ; Jian, Tianying ; Qi, Hongbo ; Bakshi, Raman K ; Hong, Qingmei ; Dellureficio, James ; Pasternak, Alexander ; Feng, Zhe ; Dejesus, Reynalda ; Yang, Lihu ; Reibarkh, Mikhail ; Bradley, Scott A ; Holmes, Mark A ; Ball, Richard G ; Ruck, Rebecca T ; Huffman, Mark A ; Wong, Frederick ; Samuel, Koppara ; Reddy, Vijay B ; Mitelman, Stan ; Tong, Sharon X ; Chicchi, Gary G ; Tsao, Kwei-Lan ; Trusca, Dorina ; Wu, Margaret ; Shao, Qing ; Trujillo, Maria E ; Eiermann, George J ; Li, Cai ; Zhang, Bei B ; Howard, Andrew D ; Zhou, Yun-Ping ; Nargund, Ravi P ; Hagmann, William K

ACS medicinal chemistry letters, 14 June 2012, Vol.3(6), pp.484-9 [Peer Reviewed Journal]

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N-Aryl 2,6-Dimethoxybiphenylalanine Analogues as VLA-4 Antagonists

Doherty, George A ; Kamenecka, Theodore ; Mccauley, Ermenegilda ; Van Riper, Gail ; Mumford, Richard A ; Tong, Sharon ; Hagmann, William K

Bioorganic & Medicinal Chemistry Letters, 2002, Vol.12(5), pp.729-731 [Peer Reviewed Journal]

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