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Notch signalling pathway as an oncogenic factor involved in cancer development

Brzozowa-Zasada, Marlena ; Piecuch, Adam ; Dittfeld, Anna ; Mielańczyk, Łukasz ; Michalski, Marek ; Wyrobiec, Grzegorz ; Harabin-Słowińska, Marzena ; Kurek, Józef ; Wojnicz, Romuald

Contemporary Oncology, 2016, Vol.20(4), p.267-272 [Peer Reviewed Journal]

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Acute intravenous glucose load impairs early insulin secretion and insulin content in islet β cells in mice

Yan, Dien ; Zhao, Yinan ; Gao, Xiuying ; Zhou, Yingsheng

Life Sciences, 01 January 2016, Vol.144, pp.148-155 [Peer Reviewed Journal]

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Differential regulation of mouse pancreatic islet insulin secretion and Smad proteins by activin ligands

Wu, Haiya ; Mezghenna, Karima ; Marmol, Patricia ; Guo, Tingqing ; Moliner, Annalena ; Yang, Shao-Nian ; Berggren, Per-Olof ; Ibáñez, Carlos

Diabetologia, 2014, Vol.57(1), pp.148-156 [Peer Reviewed Journal]

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Site location analysis for small hydropower using geo-spatial information system

Yi, Choong-Sung ; Lee, Jin-Hee ; Shim, Myung-Pil

Renewable Energy, April 2010, Vol.35(4), pp.852-861 [Peer Reviewed Journal]

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5
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Innovation and network multiplexity: R&D and the concurrent effects of two collaboration networks in an emerging economy

Andrade Rojas, Mariana Giovanna ; Solis, Edgar Rogelio Ramirez ; Zhu, John Jianjun

Research Policy, July 2018, Vol.47(6), pp.1111-1124 [Peer Reviewed Journal]

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Rapamycin toxicity in MIN6 cells and rat and human islets is mediated by the inhibition of mTOR complex 2 (mTORC2)

Barlow, A. ; Xie, J. ; Moore, C. ; Campbell, S. ; Shaw, J. ; Nicholson, M. ; Herbert, T.

Diabetologia, 2012, Vol.55(5), pp.1355-1365 [Peer Reviewed Journal]

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Regulation of pancreatic β-cell function and mass dynamics by prostaglandin signaling

Carboneau, Bethany A ; Breyer, Richard M ; Gannon, Maureen

Journal of cell communication and signaling, June 2017, Vol.11(2), pp.105-116 [Peer Reviewed Journal]

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Anchored phosphatases modulate glucose homeostasis

Hinke, Simon A ; Navedo, Manuel F ; Ulman, Allison ; Whiting, Jennifer L ; Nygren, Patrick J ; Tian, Geng ; Jiménez Caliani, Antonio Javier ; Langeberg, Lorene K. ; Cirulli, Vincenzo ; Tengholm, Anders ; Dell'Acqua, Mark L ; Santana, L Fernando ; Scott, John D.

EMBO journal: European Molecular Biology Organization, 2012, Issue 20, pp.3991-4004 [Peer Reviewed Journal]

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Anchored phosphatases modulate glucose homeostasis

Hinke, Simon A ; Navedo, Manuel F ; Ulman, Allison ; Whiting, Jennifer L ; Nygren, Patrick J ; Tian, Geng ; Jimenez‐Caliani, Antonio J ; Langeberg, Lorene K ; Cirulli, Vincenzo ; Tengholm, Anders ; Dell' Acqua, Mark L ; Santana, L Fernando ; Scott, John D

EMBO Journal, 17 October 2012, Vol.31(20), pp.3991-4004 [Peer Reviewed Journal]

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10
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PANDER KO mice on high‐fat diet are glucose intolerant yet resistant to fasting hyperglycemia and hyperinsulinemia

Robert - Cooperman, Claudia E. ; Wilson, Camella G. ; Burkhardt, Brant R.

FEBS Letters, 06 May 2011, Vol.585(9), pp.1345-1349 [Peer Reviewed Journal]

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11
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Glicentin‐related pancreatic polypeptide inhibits glucose‐stimulated insulin secretion from the isolated pancreas of adult male rats

Whiting, Lynda ; Stewart, Kevin W. ; Hay, Deborah L. ; Harris, Paul W. ; Choong, Yee S. ; Phillips, Anthony R. J. ; Brimble, Margaret A. ; Cooper, Garth J. S.

Physiological Reports, December 2015, Vol.3(12), pp.n/a-n/a [Peer Reviewed Journal]

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12
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Block of K v 1.7 potassium currents increases glucose‐stimulated insulin secretion

Finol‐Urdaneta, Rocio K. ; Remedi, Maria S. ; Raasch, Walter ; Becker, Stefan ; Clark, Robert B. ; Strüver, Nina ; Pavlov, Evgeny ; Nichols, Colin G. ; French, Robert J. ; Terlau, Heinrich

EMBO Molecular Medicine, May 2012, Vol.4(5), pp.424-434 [Peer Reviewed Journal]

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13
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Discovery of novel benzo[b]thiophene tetrazoles as non-carboxylate GPR40 agonists

Huang, Hui ; Winters, Michael P ; Meegalla, Sanath K ; Arnoult, Eric ; Paul Lee, S ; Zhao, Shuyuan ; Martin, Tonya ; Rady, Brian ; Liu, Jianying ; Towers, Meghan ; Otieno, Monicah ; Xu, Fran ; Lim, Heng Keang ; Silva, Jose ; Pocai, Alessandro ; Player, Mark R

Bioorganic & Medicinal Chemistry Letters, 01 February 2018, Vol.28(3), pp.429-436 [Peer Reviewed Journal]

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The expression of dominant negative TCF7L2 in pancreatic beta cells during the embryonic stage causes impaired glucose homeostasis

Shao, Weijuan ; Xiong, Xiaoquan ; Ip, Wilfred ; Xu, Fenghao ; Song, Zhuolun ; Zeng, Kejing ; Hernandez, Marcela ; Liang, Tao ; Weng, Jianping ; Gaisano, Herbert ; Nostro, M. Cristina ; Jin, Tianru

Molecular Metabolism, April 2015, Vol.4(4), pp.344-352 [Peer Reviewed Journal]

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Hypothalamic AMP-Activated Protein Kinase Regulates Biphasic Insulin Secretion from Pancreatic β Cells during Fasting and in Type 2 Diabetes

Kume, Shinji ; Kondo, Motoyuki ; Maeda, Shiro ; Nishio, Yoshihiko ; Yanagimachi, Tsuyoshi ; Fujita, Yukihiro ; Haneda, Masakazu ; Kondo, Keiko ; Sekine, Akihiro ; Araki, Shin-Ich ; Araki, Hisazumi ; Chin-Kanasaki, Masami ; Ugi, Satoshi ; Koya, Daisuke ; Kitahara, Sawako ; Maeda, Kiyosumi ; Kashiwagi, Atsunori ; Uzu, Takashi ; Maegawa, Hiroshi

EBioMedicine, November 2016, Vol.13, pp.168-180 [Peer Reviewed Journal]

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16
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Reactive oxygen species and uncoupling protein 2 in pancreatic β‐cell function

Pi, J. ; Collins, S.

Diabetes, Obesity and Metabolism, October 2010, Vol.12, pp.141-148 [Peer Reviewed Journal]

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17
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Discovery of TAK-875: A Potent, Selective, and Orally Bioavailable GPR40 Agonist

Negoro, Nobuyuki ; Sasaki, Shinobu ; Mikami, Satoshi ; Ito, Masahiro ; Suzuki, Masami ; Tsujihata, Yoshiyuki ; Ito, Ryo ; Harada, Ayako ; Takeuchi, Koji ; Suzuki, Nobuhiro ; Miyazaki, Junichi ; Santou, Takashi ; Odani, Tomoyuki ; Kanzaki, Naoyuki ; Funami, Miyuki ; Tanaka, Toshimasa ; Kogame, Akifumi ; Matsunaga, Shinichiro ; Yasuma, Tsuneo ; Momose, Yu

ACS medicinal chemistry letters, 09 September 2010, Vol.1(6), pp.290-4 [Peer Reviewed Journal]

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18
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Sauchinone protects pancreatic β cells against cytokine-mediated toxicity

Jeong, Gil-Saeng ; Lee, Dong-Sung ; Park, Byung-Hyun ; Kwon, Kang-Beom ; Kim, Youn-Chul

Toxicology in Vitro, March 2011, Vol.25(2), pp.505-512 [Peer Reviewed Journal]

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19
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Synthesis and glucose-stimulate insulin secretion (GSIS) evaluation of vindoline derivatives

Xiao, Chengqian ; Tian, Yunan ; Lei, Min ; Chen, Fanglei ; Gan, Xianwen ; Yao, Xingang ; Shen, Xu ; Chen, Jing ; Hu, Lihong

Bioorganic & Medicinal Chemistry Letters, 01 March 2017, Vol.27(5), pp.1316-1318 [Peer Reviewed Journal]

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20
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Comparison of approximate assessments of the harmfulness of mining shocks using ground and building foundation vibrations

Krystyna Kuzniar ; Krystyna Stec ; Tadeusz Tatara

Journal of Measurements in Engineering, 01 December 2018, Vol.6(4), pp.218-225 [Peer Reviewed Journal]

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21
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Structure characterization of an arabinogalactan from green tea and its anti-diabetic effect

Wang, Huijun ; Shi, Songshan ; Bao, Bin ; Li, Xiaojun ; Wang, Shunchun

Carbohydrate Polymers, 25 June 2015, Vol.124, pp.98-108 [Peer Reviewed Journal]

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22
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Discovery and Optimization of a Novel Triazole Series of GPR142 Agonists for the Treatment of Type 2 Diabetes

Guo, Liangqin ; Parker, Dann L ; Zang, Yi ; Sweis, Ramzi F ; Liu, Weiguo ; Sherer, Edward C ; Buist, Nicole ; Terebetski, Jenna ; Kelly, Terri ; Bugianesi, Randal ; Priest, Birgit T ; Dingley, Karen H ; Li, Xiaofang ; Mitelman, Stan ; Salituro, Gino ; Trujillo, Maria E ; Pachanski, Michele ; Kirkland, Melissa ; Powles, Mary Ann ; Eiermann, George J ; Feng, Yue ; Shang, Jin ; Howard, Andrew D ; Ujjainwalla, Feroze ; Sinz, Christopher J ; Debenham, John S ; Edmondson, Scott D ; Nargund, Ravi P ; Hagmann, William K ; Li, Derun

ACS medicinal chemistry letters, 08 December 2016, Vol.7(12), pp.1107-1111 [Peer Reviewed Journal]

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23
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The VGF-derived peptide TLQP-62 modulates insulin secretion and glucose homeostasis

Petrocchi-Passeri, Pamela ; Cero, Cheryl ; Cutarelli, Alessandro ; Frank, Claudio ; Severini, Cinzia ; Bartolomucci, Alessandro ; Possenti, Roberta

Journal of molecular endocrinology, June 2015, Vol.54(3), pp.227-39 [Peer Reviewed Journal]

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24
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Uncoupling and reactive oxygen species (ROS) – A double-edged sword for β-cell function? “Moderation in all things”

Collins, Sheila ; Pi, Jingbo ; Yehuda-Shnaidman, Einav

Best Practice & Research Clinical Endocrinology & Metabolism, December 2012, Vol.26(6), pp.753-758 [Peer Reviewed Journal]

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25
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Discovery of novel potent imidazo[1,2-b]pyridazine PDE10a inhibitors

Meegalla, Sanath K ; Huang, Hui ; Illig, Carl R ; Parks, Daniel J ; Chen, Jinsheng ; Lee, Yu-Kai ; Wilson, Kenneth J ; Patel, Sharmila K ; Cheung, Wing S ; Lu, Tianbao ; Kirchner, Thomas ; Askari, Hossein B ; Geisler, John ; Patch, Raymond J ; Gibbs, Alan C ; Rady, Brian ; Connelly, Margery ; Player, Mark R

Bioorganic & Medicinal Chemistry Letters, 01 September 2016, Vol.26(17), pp.4216-4222 [Peer Reviewed Journal]

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26
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Discovery of a novel potent GPR40 full agonist

Meegalla, Sanath K ; Huang, Hui ; Martin, Tonya ; Xu, June ; Zhao, Shuyuan ; Liu, Jianying ; Hall, Meghan ; Gunnet, Joe ; Wang, Yuanping ; Rady, Brian ; Silva, Jose ; Otieno, Monicah ; Arnoult, Eric ; Paul Lee, S ; Pocai, Alessandro ; Player, Mark R

Bioorganic & Medicinal Chemistry Letters, 15 February 2018, Vol.28(4), pp.720-726 [Peer Reviewed Journal]

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27
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Fasiglifam (TAK‐875) has dual potentiating mechanisms via Gαq‐GPR40/FFAR1 signaling branches on glucose‐dependent insulin secretion

Sakuma, Kensuke ; Yabuki, Chiori ; Maruyama, Minoru ; Abiru, Akiko ; Komatsu, Hidetoshi ; Negoro, Nobuyuki ; Tsujihata, Yoshiyuki ; Takeuchi, Koji ; Habata, Yugo ; Mori, Masaaki

Pharmacology Research & Perspectives, June 2016, Vol.4(3), pp.n/a-n/a [Peer Reviewed Journal]

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28
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Chromanol 293B, an inhibitor of KCNQ1 channels, enhances glucose-stimulated insulin secretion and increases glucagon-like peptide-1 level in mice

Liu, Lijie ; Wang, Fanfan ; Lu, Haiying ; Ren, Xiaomei ; Zou, Jihong

Islets, 04 July 2014, Vol.6(4) [Peer Reviewed Journal]

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29
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Identification of microRNAs with a role in glucose stimulated insulin secretion by expression profiling of MIN6 cells

Hennessy, Erica ; Clynes, Martin ; Jeppesen, Per Bendix ; O’driscoll, Lorraine

Biochemical and Biophysical Research Communications, 2010, Vol.396(2), pp.457-462 [Peer Reviewed Journal]

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30
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Geniposide protects pancreatic β cells from high glucose‐mediated injury by activation of AMP‐activated protein kinase

Liu, Chunyan ; Hao, Yanan ; Yin, Fei ; Zhang, Yonglan ; Liu, Jianhui

Cell Biology International, May 2017, Vol.41(5), pp.544-554 [Peer Reviewed Journal]

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31
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2-OMe-lysophosphatidylcholine analogues are GPR119 ligands and activate insulin secretion from βTC-3 pancreatic cells: Evaluation of structure-dependent biological activity

Drzazga, Anna ; Sowińska, Agata ; Krzemińska, Agnieszka ; Okruszek, Andrzej ; Paneth, Piotr ; Koziołkiewicz, Maria ; Gendaszewska-Darmach, Edyta

BBA - Molecular and Cell Biology of Lipids, January 2018, Vol.1863(1), pp.91-103 [Peer Reviewed Journal]

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32
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Perspectives on geospatial information science education: an example of urban planners in Southern Africa

Walter Musakwa

Geo-spatial Information Science, 01 April 2017, Vol.20(2), pp.201-208 [Peer Reviewed Journal]

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33
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Secretase inhibitors for the treatment of Alzheimer's disease: Long road ahead

Kumar, Devendra ; Ganeshpurkar, Ankit ; Kumar, Dileep ; Modi, Gyan ; Gupta, Sanjeev Kumar ; Singh, Sushil Kumar

European Journal of Medicinal Chemistry, 25 March 2018, Vol.148, pp.436-452 [Peer Reviewed Journal]

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34
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Prostaglandin E 2 regulates Foxo activity via the Akt pathway: implications for pancreatic islet beta cell dysfunction

Meng, Z. ; Sun, J. ; Ling, J. ; Lv, J. ; Zhu, D. ; Chen, Q. ; Sun, Y. ; Han, X.

Diabetologia, 2006, Vol.49(12), pp.2959-2968 [Peer Reviewed Journal]

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35
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Ghrelin inhibits insulin secretion through the AMPK–UCP2 pathway in β cells

Wang, Ying ; Nishi, Masahiro ; Doi, Asako ; Shono, Takeshi ; Furukawa, Yasushi ; Shimada, Takeshi ; Furuta, Hiroto ; Sasaki, Hideyuki ; Nanjo, Kishio

FEBS Letters, 16 April 2010, Vol.584(8), pp.1503-1508 [Peer Reviewed Journal]

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36
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The nuclear receptor FXR is expressed in pancreatic β‐cells and protects human islets from lipotoxicity

Popescu, Iuliana Ristea ; Helleboid - Chapman, Audrey ; Lucas, Anthony ; Vandewalle, Brigitte ; Dumont, Julie ; Bouchaert, Emmanuel ; Derudas, Bruno ; Kerr - Conte, Julie ; Caron, Sandrine ; Pattou, François ; Staels, Bart

FEBS Letters, 02 July 2010, Vol.584(13), pp.2845-2851 [Peer Reviewed Journal]

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37
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Discovery of 5-aryloxy-2,4-thiazolidinediones as potent GPR40 agonists

Zhou, Changyou ; Tang, Cheng ; Chang, Eric ; Ge, Min ; Lin, Songnian ; Cline, Eric ; Tan, Carina P ; Feng, Yue ; Zhou, Yun-Ping ; Eiermann, George J ; Petrov, Aleksandr ; Salituro, Gino ; Meinke, Peter ; Mosley, Ralph ; Akiyama, Taro E ; Einstein, Monica ; Kumar, Sanjeev ; Berger, Joel ; Howard, Andrew D ; Thornberry, Nancy ; Mills, Sander G ; Yang, Lihu

Bioorganic & Medicinal Chemistry Letters, 2010, Vol.20(3), pp.1298-1301 [Peer Reviewed Journal]

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38
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Metformin prevents glucotoxicity by alleviating oxidative and ER stress-induced CD36 expression in pancreatic beta cells

Moon, Jun ; Karunakaran, Udayakumar ; Elumalai, Suma ; Lee, In-Kyu ; Lee, Hyoung ; Kim, Yong-Woon ; Won, Kyu

Journal of Diabetes and its Complications, Jan 01, 2017, Vol.31(1), pp.21-30 [Peer Reviewed Journal]

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