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Maternal obesity increases hypothalamic leptin receptor expression and sensitivity in juvenile obesity-prone rats

Gorski, Judith N ; Dunn-Meynell, Ambrose A ; Levin, Barry E

American journal of physiology. Regulatory, integrative and comparative physiology, May 2007, Vol.292(5), pp.R1782-91 [Peer Reviewed Journal]

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Pharmacological inhibition of diacylglycerol acyltransferase 1 reduces body weight and modulates gut peptide release—Potential insight into mechanism of action

Liu, Jinqi ; Gorski, Judith N. ; Gold, Stephen J. ; Chen, Dunlu ; Chen, Shirley ; Forrest, Gail ; Itoh, Yoshiki ; Marsh, Donald J. ; Mclaren, David G. ; Shen, Zhu ; Sonatore, Lisa ; Carballo‐Jane, Ester ; Craw, Stephanie ; Guan, Xiaoming ; Karanam, Bindhu ; Sakaki, Junichi ; Szeto, Daphne ; Tong, Xinchun ; Xiao, Jianying ; Yoshimoto, Ryo ; Yu, Hong ; Roddy, Thomas P. ; Balkovec, James ; Pinto, Shirly

Obesity, July 2013, Vol.21(7), pp.1406-1415 [Peer Reviewed Journal]

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The design and synthesis of potent, selective benzodiazepine sulfonamide bombesin receptor subtype 3 (BRS-3) agonists with an increased barrier of atropisomerization

Chobanian, Harry R ; Guo, Yan ; Liu, Ping ; Lanza, Thomas J ; Chioda, Marc ; Chang, Linda ; Kelly, Theresa M ; Kan, Yanqing ; Palyha, Oksana ; Guan, Xiao-Ming ; Marsh, Donald J ; Metzger, Joseph M ; Raustad, Katie ; Wang, Sheng-Ping ; Strack, Alison M ; Gorski, Judith N ; Miller, Randy ; Pang, Jianmei ; Lyons, Kathy ; Dragovic, Jasminka ; Ning, Jian G ; Schafer, Wes A ; Welch, Christopher J ; Gong, Xiaoyi ; Gao, Ying-Duo ; Hornak, Viktor ; Reitman, Marc L ; Nargund, Ravi P ; Lin, Linus S

Bioorganic & Medicinal Chemistry, 01 May 2012, Vol.20(9), pp.2845-2849 [Peer Reviewed Journal]

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GPR40 reduces food intake and body weight through GLP-1

Gorski, Judith N ; Pachanski, Michele J ; Mane, Joel ; Plummer, Christopher W ; Souza, Sarah ; Thomas-Fowlkes, Brande S ; Ogawa, Aimie M ; Weinglass, Adam B ; Di Salvo, Jerry ; Cheewatrakoolpong, Boonlert ; Howard, Andrew D ; Colletti, Steven L ; Trujillo, Maria E

American journal of physiology. Endocrinology and metabolism, 01 July 2017, Vol.313(1), pp.E37-E47 [Peer Reviewed Journal]

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Discovery of benzodihydroisofurans as novel, potent, bioavailable and brain-penetrant prolylcarboxypeptidase inhibitors

Shen, Hong C ; Ding, Fa-Xiang ; Jiang, Jinlong ; Verras, Andreas ; Chabin, Renee M ; Xu, Suoyu ; Tong, Xinchun ; Chen, Qing ; Xie, Dan ; Lassman, Mike E ; Bhatt, Urmi R ; Garcia-Calvo, Margarita M ; Geissler, Wayne ; Shen, Zhu ; Murphy, Beth Ann ; Gorski, Judith N ; Wiltsie, Judyann ; Sinharoy, Ranabir ; Hale, Jeffrey J ; Pinto, Shirly ; Shen, Dong-Ming

Bioorganic & Medicinal Chemistry Letters, 15 February 2012, Vol.22(4), pp.1550-1556 [Peer Reviewed Journal]

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A new class of prolylcarboxypeptidase inhibitors, Part 2: The aminocyclopentanes

Graham, Thomas H ; Liu, Wensheng ; Verras, Andreas ; Reibarkh, Mikhail ; Bleasby, Kelly ; Bhatt, Urmi R ; Chen, Qing ; Garcia-Calvo, Margarita ; Geissler, Wayne M ; Gorski, Judith N ; He, Huaibing ; Lassman, Michael E ; Lisnock, Jeanmarie ; Li, Xiaohua ; Shen, Zhu ; Tong, Xinchun ; Tung, Elaine C ; Wiltsie, Judyann ; Xie, Dan ; Xu, Suoyu ; Xiao, Jianying ; Hale, Jeffrey J ; Pinto, Shirly ; Shen, Dong-Ming

Bioorganic & Medicinal Chemistry Letters, 15 April 2012, Vol.22(8), pp.2818-2822 [Peer Reviewed Journal]

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Discovery of MK-7725, A Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity

Chobanian, Harry R ; Guo, Yan ; Liu, Ping ; Chioda, Marc ; Lanza, Thomas J ; Chang, Linda ; Kelly, Theresa M ; Kan, Yanqing ; Palyha, Oksana ; Guan, Xiao-Ming ; Marsh, Donald J ; Metzger, Joseph M ; Gorski, Judith N ; Raustad, Kate ; Wang, Sheng-Ping ; Strack, Alison M ; Miller, Randy ; Pang, Jianmei ; Madeira, Maria ; Lyons, Kathy ; Dragovic, Jasminka ; Reitman, Marc L ; Nargund, Ravi P ; Lin, Linus S

ACS medicinal chemistry letters, 08 March 2012, Vol.3(3), pp.252-6 [Peer Reviewed Journal]

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A new class of prolylcarboxypeptidase inhibitors, Part 1: Discovery and evaluation

Graham, Thomas H ; Liu, Wensheng ; Verras, Andreas ; Sebhat, Iyassu K ; Xiong, Yusheng ; Bleasby, Kelly ; Bhatt, Urmi R ; Chen, Qing ; Garcia-Calvo, Margarita ; Geissler, Wayne M ; Gorski, Judith N ; He, Huaibing ; Lassman, Michael E ; Lisnock, Jeanmarie ; Li, Xiaohua ; Shen, Zhu ; Tong, Xinchun ; Tung, Elaine C ; Wiltsie, Judyann ; Xiao, Jianying ; Xie, Dan ; Xu, Suoyu ; Hale, Jeffrey J ; Pinto, Shirly ; Shen, Dong-Ming

Bioorganic & Medicinal Chemistry Letters, 15 April 2012, Vol.22(8), pp.2811-2817 [Peer Reviewed Journal]

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Potent DGAT1 Inhibitors in the Benzimidazole Class with a Pyridyl-oxy-cyclohexanecarboxylic Acid Moiety

He, Shuwen ; Hong, Qingmei ; Lai, Zhong ; Wu, Zhicai ; Yu, Yang ; Kim, David W ; Ting, Pauline C ; Kuethe, Jeffrey T ; Yang, Ginger X ; Jian, Tianying ; Liu, Jian ; Guiadeen, Deodial ; Krikorian, Arto D ; Sperbeck, Donald M ; Sonatore, Lisa M ; Wiltsie, Judyann ; Chung, Christine C ; Gibson, Jack T ; Lisnock, Jeanmarie ; Murphy, Beth A ; Gorski, Judith N ; Liu, Jinqi ; Chen, Dunlu ; Chen, Xiaoli ; Wolff, Michael ; Tong, Sharon X ; Madeira, Maria ; Karanam, Bindhu V ; Shen, Dong-Ming ; Balkovec, James M ; Pinto, Shirly ; Nargund, Ravi P ; Devita, Robert J

ACS medicinal chemistry letters, 08 August 2013, Vol.4(8), pp.773-8 [Peer Reviewed Journal]

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10
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Discovery of a Potent and Selective DGAT1 Inhibitor with a Piperidinyl-oxy-cyclohexanecarboxylic Acid Moiety

He, Shuwen ; Hong, Qingmei ; Lai, Zhong ; Yang, David X ; Ting, Pauline C ; Kuethe, Jeffrey T ; Cernak, Timothy A ; Dykstra, Kevin D ; Sperbeck, Donald M ; Wu, Zhicai ; Yu, Yang ; Yang, Ginger X ; Jian, Tianying ; Liu, Jian ; Guiadeen, Deodial ; Krikorian, Arto D ; Sonatore, Lisa M ; Wiltsie, Judyann ; Liu, Jinqi ; Gorski, Judith N ; Chung, Christine C ; Gibson, Jack T ; Lisnock, Jeanmarie ; Xiao, Jianying ; Wolff, Michael ; Tong, Sharon X ; Madeira, Maria ; Karanam, Bindhu V ; Shen, Dong-Ming ; Balkovec, James M ; Pinto, Shirly ; Nargund, Ravi P ; Devita, Robert J

ACS medicinal chemistry letters, 09 October 2014, Vol.5(10), pp.1082-7 [Peer Reviewed Journal]

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11
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Plasma lipid profiling across species for the identification of optimal animal models of human dyslipidemia

Yin, Wu ; Carballo-Jane, Ester ; Mclaren, David G ; Mendoza, Vivienne H ; Gagen, Karen ; Geoghagen, Neil S ; Mcnamara, Lesley Ann ; Gorski, Judith N ; Eiermann, George J ; Petrov, Aleksandr ; Wolff, Michael ; Tong, Xinchun ; Wilsie, Larissa C ; Akiyama, Taro E ; Chen, Jing ; Thankappan, Anil ; Xue, Jiyan ; Ping, Xiaoli ; Andrews, Genevieve ; Wickham, L Alexandra ; Gai, Cesaire L ; Trinh, Tu ; Kulick, Alison A ; Donnelly, Marcie J ; Voronin, Gregory O ; Rosa, Ray ; Cumiskey, Anne-Marie ; Bekkari, Kavitha ; Mitnaul, Lyndon J ; Puig, Oscar ; Chen, Fabian ; Raubertas, Richard ; Wong, Peggy H ; Hansen, Barbara C ; Koblan, Ken S ; Roddy, Thomas P ; Hubbard, Brian K ; Strack, Alison M

Journal of lipid research, January 2012, Vol.53(1), pp.51-65 [Peer Reviewed Journal]

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Postnatal environment overrides genetic and prenatal factors influencing offspring obesity and insulin resistance

Gorski, Judith N ; Dunn-Meynell, Ambrose A ; Hartman, Thomas G ; Levin, Barry E

American journal of physiology. Regulatory, integrative and comparative physiology, September 2006, Vol.291(3), pp.R768-78 [Peer Reviewed Journal]

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13
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Pharmacological AMPK activation induces transcriptional responses congruent to exercise in skeletal and cardiac muscle, adipose tissues and liver

Muise, Eric S ; Guan, Hong-Ping ; Liu, Jinqi ; Nawrocki, Andrea R ; Yang, Xiaodong ; Wang, Chuanlin ; Rodríguez, Carlos G ; Zhou, Dan ; Gorski, Judith N ; Kurtz, Marc M ; Feng, Danqing ; Leavitt, Kenneth J ; Wei, Lan ; Wilkening, Robert R ; Apgar, James M ; Xu, Shiyao ; Lu, Ku ; Feng, Wen ; Li, Ying ; He, Huaibing ; Previs, Stephen F ; Shen, Xiaolan ; Van Heek, Margaret ; Souza, Sandra C ; Rosenbach, Mark J ; Biftu, Tesfaye ; Erion, Mark D ; Kelley, David E ; Kemp, Daniel M ; Myers, Robert W ; Sebhat, Iyassu K

PloS one, 2019, Vol.14(2), pp.e0211568 [Peer Reviewed Journal]

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Regulation of body weight and carcass composition by sibutramine in rats

Strack, Alison M ; Shu, Joanne ; Camacho, Ramon ; Gorski, Judith N ; Murphy, Beth ; Macintyre, D Evan ; Hickey, Gerard J

Obesity research, March 2002, Vol.10(3), pp.173-81

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Accelerating the discovery of DGAT1 inhibitors through the application of parallel medicinal chemistry (PMC)

Yu, Yang ; Wu, Zhicai ; Shi, Zhi-Cai ; He, Shuwen ; Lai, Zhong ; Cernak, Timothy A ; Vachal, Petr ; Liu, Min ; Liu, Jian ; Hong, Qingmei ; Jian, Tianying ; Guiadeen, Deodial ; Krikorian, Arto ; Sperbeck, Donald M ; Verras, Andreas ; Sonatore, Lisa M ; Murphy, Beth A ; Wiltsie, Judyann ; Chung, Christine C ; Gorski, Judith N ; Liu, Jinqi ; Xiao, Jianying ; Wolff, Michael ; Tong, Sharon X ; Madeira, Maria ; Karanam, Bindhu V ; Shen, Dong-Ming ; Balkovec, James M ; De Vita, Robert J ; Pinto, Shirly ; Nargund, Ravi P

Bioorganic & Medicinal Chemistry Letters, 01 June 2019, Vol.29(11), pp.1380-1385 [Peer Reviewed Journal]

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Benzimidazole-based DGAT1 inhibitors with a [3.1.0] bicyclohexane carboxylic acid moiety

He, Shuwen ; Lai, Zhong ; Hong, Qingmei ; Shang, Jackie ; Reibarkh, Mikhail ; Kuethe, Jeffrey T ; Liu, Jian ; Guiadeen, Deodial ; Krikorian, Arto D ; Cernak, Timothy A ; Dykstra, Kevin D ; Sperbeck, Donald M ; Wu, Zhicai ; Yu, Yang ; Yang, Ginger X ; Jian, Tianying ; Verras, Andreas ; Sonatore, Lisa M ; Wiltsie, Judyann ; Chung, Christine C ; Murphy, Beth A ; Gorski, Judith N ; Liu, Jinqi ; Xiao, Jianying ; Wolff, Michael ; Tong, Sharon X ; Madeira, Maria ; Karanam, Bindhu V ; Shen, Dong-Ming ; Balkovec, James M ; Pinto, Shirly ; Nargund, Ravi P ; Devita, Robert J

Bioorganic & Medicinal Chemistry Letters, 15 May 2019, Vol.29(10), pp.1182-1186 [Peer Reviewed Journal]

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