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32 Results  for Everything (Includes Articles)

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1
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Inhibitor of intramembrane protease RseP blocks the σ response causing lethal accumulation of unfolded outer membrane proteins

Konovalova, Anna ; Grabowicz, Marcin ; Balibar, Carl J ; Malinverni, Juliana C ; Painter, Ronald E ; Riley, Daniel ; Mann, Paul A ; Wang, Hao ; Garlisi, Charles G ; Sherborne, Brad ; Rigel, Nathan W ; Ricci, Dante P ; Black, Todd A ; Roemer, Terry ; Silhavy, Thomas J ; Walker, Scott S

Proceedings of the National Academy of Sciences of the United States of America, 10 July 2018, Vol.115(28), pp.E6614-E6621 [Peer Reviewed Journal]

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Kibdelomycin is a bactericidal broad-spectrum aerobic antibacterial agent

Singh, Sheo B ; Dayananth, Priya ; Balibar, Carl J ; Garlisi, Charles G ; Lu, Jun ; Kishii, Ryuta ; Takei, Masaya ; Fukuda, Yasumichi ; Ha, Sookhee ; Young, Katherine

Antimicrobial agents and chemotherapy, 2015, Vol.59(6), pp.3474-81 [Peer Reviewed Journal]

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Selective small-molecule inhibition of an RNA structural element

Howe, John A ; Wang, Hao ; Fischmann, Thierry O ; Balibar, Carl J ; Xiao, Li ; Galgoci, Andrew M ; Malinverni, Juliana C ; Mayhood, Todd ; Villafania, Artjohn ; Nahvi, Ali ; Murgolo, Nicholas ; Barbieri, Christopher M ; Mann, Paul A ; Carr, Donna ; Xia, Ellen ; Zuck, Paul ; Riley, Dan ; Painter, Ronald E ; Walker, Scott S ; Sherborne

Nature, 29 October 2015, Vol.526(7575), pp.672-7 [Peer Reviewed Journal]

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Can We Make Small Molecules Lean? Optimization of a Highly Lipophilic TarO Inhibitor

Mandal, Mihirbaran ; Tan, Zheng ; Madsen-Duggan, Christina ; Buevich, Alexei V ; Caldwell, John P ; Dejesus, Reynalda ; Flattery, Amy ; Garlisi, Charles G ; Gill, Charles ; Ha, Sookhee Nicole ; Ho, Ginny ; Koseoglu, Sandra ; Labroli, Marc ; Basu, Kallol ; Lee, Sang Ho ; Liang, Lianzhu ; Liu, Jenny ; Mayhood, Todd ; Mcguinness, Debra ; Mclaren

Journal of medicinal chemistry, 11 May 2017, Vol.60(9), pp.3851-3865 [Peer Reviewed Journal]

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Antibacterial small molecules targeting the conserved TOPRIM domain of DNA gyrase

Walker, Scott S ; Labroli, Marc ; Painter, Ronald E ; Wiltsie, Judyann ; Sherborne, Brad ; Murgolo, Nicholas ; Sher, Xinwei ; Mann, Paul ; Zuck, Paul ; Garlisi, Charles G ; Su, Jing ; Kargman, Stacia ; Xiao, Li ; Scapin, Giovanna ; Salowe, Scott ; Devito, Kristine ; Sheth, Payal ; Buist, Nichole ; Tan, Christopher M ; Black

PloS one, 2017, Vol.12(7), pp.e0180965 [Peer Reviewed Journal]

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In Vitro and In Vivo Characterization of the Novel Oxabicyclooctane-Linked Bacterial Topoisomerase Inhibitor AM-8722, a Selective, Potent Inhibitor of Bacterial DNA Gyrase

Tan, Christopher M ; Gill, Charles J ; Wu, Jin ; Toussaint, Nathalie ; Yin, Jingjun ; Tsuchiya, Takayuki ; Garlisi, Charles G ; Kaelin, David ; Meinke, Peter T ; Miesel, Lynn ; Olsen, David B ; Lagrutta, Armando ; Fukuda, Hideyuki ; Kishii, Ryuta ; Takei, Masaya ; Oohata, Kouhei ; Takeuchi, Tomoko ; Shibue, Taku ; Takano, Hisashi ; Nishimura

Antimicrobial agents and chemotherapy, August 2016, Vol.60(8), pp.4830-9 [Peer Reviewed Journal]

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The synthesis of 2,3,6-trisubstituted 1-oxo-1,2-dihydroisoquinolines as potent CRTh2 antagonists

Huang, Xianhai ; Rao, Ashwin ; Zhou, Wei ; Aslanian, Robert ; Nargund, Ravi ; Buevich, Alexei ; Zhang, Li-Kang ; Qiu, Hongchen ; Yang, Xiaoxin ; Garlisi, Charles G ; Correll, Craig ; Palani, Anandan

Bioorganic & Medicinal Chemistry Letters, 01 December 2017, Vol.27(23), pp.5344-5348 [Peer Reviewed Journal]

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Catalytic activity of human ADAM33

Zou, Jun ; Zhu, Feng ; Liu, Jianjun ; Wang, Wenyan ; Zhang, Rumin ; Garlisi, Charles G ; Liu, Yan-Hui ; Wang, Shihong ; Shah, Himanshu ; Wan, Yuntao ; Umland, Shelby P

The Journal of biological chemistry, 12 March 2004, Vol.279(11), pp.9818-30 [Peer Reviewed Journal]

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9
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Discovery of potent wall teichoic acid early stage inhibitors

Labroli, Marc A ; Caldwell, John P ; Yang, Christine ; Lee, Sang Ho ; Wang, Hao ; Koseoglu, Sandra ; Mann, Paul ; Yang, Shu-Wei ; Xiao, Jing ; Garlisi, Charles G ; Tan, Christopher ; Roemer, Terry ; Su, Jing

Bioorganic & Medicinal Chemistry Letters, 15 August 2016, Vol.26(16), pp.3999-4002 [Peer Reviewed Journal]

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10
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Synthesis and SAR development of novel P2X 7 receptor antagonists for the treatment of pain: Part 1

Matasi, Julius J ; Brumfield, Stephanie ; Tulshian, Deen ; Czarnecki, Michael ; Greenlee, William ; Garlisi, Charles G ; Qiu, Hongchen ; Devito, Kristine ; Chen, Shu-Cheng ; Sun, Youngliang ; Bertorelli, Rosalia ; Geiss, William ; Le, Van-Duc ; Martin, Gregory S ; Vellekoop, Samuel A ; Haber, James ; Allard, Melissa L

Bioorganic & Medicinal Chemistry Letters, 2011, Vol.21(12), pp.3805-3808 [Peer Reviewed Journal]

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11
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Quality by design (QbD) of amide isosteres: 5,5-Disubstituted isoxazolines as potent CRTh2 antagonists with favorable pharmacokinetic and drug-like properties

Xiao, Dong ; Zhu, Xiaohong ; Yu, Younong ; Shao, Ning ; Wu, Jie ; Mccormick, Kevin D ; Dhondi, Pawan ; Qin, Jun ; Mazzola, Robert ; Tang, Haiqun ; Rao, Ashwin ; Siliphaivanh, Phieng ; Qiu, Hongchen ; Yang, Xiaoxin ; Rivelli, Maria ; Garlisi, Charles G ; Eckel, Steve ; Mukhopadhyay, Gitali ; Correll, Craig ; Rindgen, Diane

Bioorganic & Medicinal Chemistry Letters, 15 March 2014, Vol.24(6), pp.1615-1620 [Peer Reviewed Journal]

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12
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Discovery and Structure Enabled Synthesis of 2,6-Diaminopyrimidin-4-one IRAK4 Inhibitors

Seganish, W. Michael ; Fischmann, Thierry O ; Sherborne, Brad ; Matasi, Julius ; Lavey, Brian ; Mcelroy, William T ; Tulshian, Deen ; Tata, James ; Sondey, Christopher ; Garlisi, Charles G ; Devito, Kristine ; Fossetta, James ; Lundell, Daniel ; Niu, Xiaoda Argonne National Lab. (Anl), Argonne, Il (United States). Advanced Photon Source (APS) (Corporate Author)

ACS Medicinal Chemistry Letters, 13 August 2015, Vol.6(8) [Peer Reviewed Journal]

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13
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Initial optimization and series evolution of diaminopyrimidine inhibitors of interleukin-1 receptor associated kinase 4

Seganish, W. Michael ; Mcelroy, William T ; Herr, R. Jason ; Brumfield, Stephanie ; Greenlee, William J ; Harding, James ; Komanduri, Venukrishnan ; Matasi, Julius ; Prakash, Koraboina Chandra ; Tulshian, Deen ; Yang, Jinhai ; Yet, Larry ; Devito, Kristine ; Fossetta, James ; Garlisi, Charles G ; Lundell, Daniel ; Niu, Xiaoda ; Sondey, Christopher

Bioorganic & Medicinal Chemistry Letters, 15 August 2015, Vol.25(16), pp.3203-3207 [Peer Reviewed Journal]

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14
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Benzimidazole analogs as WTA biosynthesis inhibitors targeting methicillin resistant Staphylococcus aureus

Yang, Shu-Wei ; Pan, Jianping ; Yang, Christine ; Labroli, Marc ; Pan, Weidong ; Caldwell, John ; Ha, Sookhee ; Koseoglu, Sandra ; Xiao, Jing C ; Mayhood, Todd ; Sheth, Payal R ; Garlisi, Charles G ; Wu, Jin ; Lee, Sang Ho ; Wang, Hao ; Tan, Christopher M ; Roemer, Terry ; Su, Jing

Bioorganic & Medicinal Chemistry Letters, 01 October 2016, Vol.26(19), pp.4743-4747 [Peer Reviewed Journal]

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15
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Efforts towards the optimization of a bi-aryl class of potent IRAK4 inhibitors

Hanisak, Jennifer ; Seganish, W. Michael ; Mcelroy, William T ; Tang, Haiquin ; Zhang, Rui ; Tsui, Hon-Chung ; Fischmann, Theirry ; Tulshian, Deen ; Tata, James ; Sondey, Christopher ; Devito, Kristine ; Fossetta, James ; Garlisi, Charles G ; Lundell, Daniel ; Niu, Xiaoda

Bioorganic & Medicinal Chemistry Letters, 01 September 2016, Vol.26(17), pp.4250-4255 [Peer Reviewed Journal]

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16
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Potent and Selective Amidopyrazole Inhibitors of IRAK4 That Are Efficacious in a Rodent Model of Inflammation

Mcelroy, William T ; Tan, Zheng ; Ho, Ginny ; Paliwal, Sunil ; Li, Guoqing ; Seganish, W. Michael ; Tulshian, Deen ; Tata, James ; Fischmann, Thierry O ; Sondey, Christopher ; Bian, Hong ; Bober, Loretta ; Jackson, James ; Garlisi, Charles G ; Devito, Kristine ; Fossetta, James ; Lundell, Daniel ; Niu, Xiaoda Argonne National Lab. (Anl), Argonne, Il (United States). Advanced Photon Source (APS) (Corporate Author)

ACS Medicinal Chemistry Letters, 11 June 2015, Vol.6(6) [Peer Reviewed Journal]

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17
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Discovery of novel BTK inhibitors with carboxylic acids

Gao, Xiaolei ; Wang, James ; Liu, Jian ; Guiadeen, Deodial ; Krikorian, Arto ; Boga, Sobhana Babu ; Alhassan, Abdul-Basit ; Selyutin, Oleg ; Yu, Wensheng ; Yu, Younong ; Anand, Rajan ; Liu, Shilan ; Yang, Chundao ; Wu, Hao ; Cai, Jiaqiang ; Cooper, Alan ; Zhu, Hugh ; Maloney, Kevin ; Gao, Ying-Duo ; Fischmann

Bioorganic & medicinal chemistry letters, 15 March 2017, Vol.27(6), pp.1471-1477 [Peer Reviewed Journal]

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18
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Discovery of 3-morpholino-imidazole1,5-apyrazine BTK inhibitors for rheumatoid arthritis

Boga, Sobhana Babu ; Alhassan, Abdul-Basit ; Liu, Jian ; Guiadeen, Deodial ; Krikorian, Arto ; Gao, Xiaolei ; Wang, James ; Yu, Younong ; Anand, Rajan ; Liu, Shilan ; Yang, Chundao ; Wu, Hao ; Cai, Jiaqiang ; Zhu, Hugh ; Desai, Jagdish ; Maloney, Kevin ; Gao, Ying-Duo ; Fischmann, Thierry O ; Presland, Jeremy ; Mansueto

Bioorganic & medicinal chemistry letters, 15 August 2017, Vol.27(16), pp.3939-3943 [Peer Reviewed Journal]

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19
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Identification of full, partial and inverse CC chemokine receptor 3 agonists using [ 35S]GTPγS binding

Wan, Yuntao ; Jakway, James P ; Qiu, Hongchen ; Shah, Himanshu ; Garlisi, Charles G ; Tian, Fang ; Ting, Pauline ; Hesk, David ; Egan, R.W ; Billah, M.Motasim ; Umland, Shelby P

European Journal of Pharmacology, 2002, Vol.456(1), pp.1-10 [Peer Reviewed Journal]

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20
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Chemical Genomics-Based Antifungal Drug Discovery: Targeting Glycosylphosphatidylinositol (GPI) Precursor Biosynthesis

Mann, Paul A ; Mclellan, Catherine A ; Koseoglu, Sandra ; Si, Qian ; Kuzmin, Elena ; Flattery, Amy ; Harris, Guy ; Sher, Xinwei ; Murgolo, Nicholas ; Wang, Hao ; Devito, Kristine ; De Pedro, Nuria ; Genilloud, Olga ; Kahn, Jennifer Nielsen ; Jiang, Bo ; Costanzo, Michael ; Boone, Charlie ; Garlisi, Charles G ; Lindquist, Susan ; Roemer

ACS infectious diseases, 09 January 2015, Vol.1(1), pp.59-72

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21
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Discovery of 8-Amino-imidazo[1,5- a ]pyrazines as Reversible BTK Inhibitors for the Treatment of Rheumatoid Arthritis

Liu, Jian ; Guiadeen, Deodial ; Krikorian, Arto ; Gao, Xiaolei ; Wang, James ; Boga, Sobhana Babu ; Alhassan, Abdul-Basit ; Yu, Younong ; Vaccaro, Henry ; Liu, Shilan ; Yang, Chundao ; Wu, Hao ; Cooper, Alan ; de Man, Jos ; Kaptein, Allard ; Maloney, Kevin ; Hornak, Viktor ; Gao, Ying-Duo ; Fischmann, Thierry O ; Raaijmakers, Hans ; Vu-Pham, Diep ; Presland, Jeremy ; Mansueto, My ; Xu, Zangwei ; Leccese, Erica ; Zhang-Hoover, Jie ; Knemeyer, Ian ; Garlisi, Charles G ; Bays, Nathan ; Stivers, Peter ; Brandish, Philip E ; Hicks, Alexandra ; Kim, Ronald ; Kozlowski, Joseph A Argonne National Lab. (Anl), Argonne, Il (United States). Advanced Photon Source (APS) (Corporate Author)

ACS Medicinal Chemistry Letters, 11 February 2016, Vol.7(2) [Peer Reviewed Journal]

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22
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Production of interleukin-2 mRNA by bovine lymph node lymphocytes in response to concanavalin A, 12-O-tetradecanoylphorbol-13-acetate, and ionomycin

Garlisi, Charles G ; Mastro, Andrea M

Veterinary Immunology and Immunopathology, 1992, Vol.30(4), pp.359-372 [Peer Reviewed Journal]

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23
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Mouse ADAM33: two splice variants differ in protein maturation and localization

Umland, Shelby P ; Wan, Yuntao ; Shah, Himanshu ; Garlisi, Charles G ; Devito, Kristine E ; Braunschweiger, Karen ; Gheyas, Ferdous ; Del Mastro, Richard

American journal of respiratory cell and molecular biology, April 2004, Vol.30(4), pp.530-9 [Peer Reviewed Journal]

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24
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Human ADAM33 messenger RNA expression profile and post-transcriptional regulation

Umland, Shelby P ; Garlisi, Charles G ; Shah, Himanshu ; Wan, Yuntao ; Zou, Jun ; Devito, Kristine E ; Huang, Whei-Mei ; Gustafson, Eric L ; Ralston, Robert

American journal of respiratory cell and molecular biology, November 2003, Vol.29(5), pp.571-82 [Peer Reviewed Journal]

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25
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The Kaposi's Sarcoma–related Herpesvirus (KSHV)-encoded Chemokine vMIP-I is a Specific Agonist for the CC Chemokine Receptor (CCR)8

Endres, Michael J ; Garlisi, Charles G ; Xiao, Hong ; Shan, Lixin ; Hedrick, Joseph A

The Journal of Experimental Medicine, 1999, Vol.189(12), p.1993-1998 [Peer Reviewed Journal]

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26
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The synthesis of substituted bipiperidine amide compounds as CCR3 ligands: Antagonists versus agonists

Ting, Pauline C ; Umland, Shelby P ; Aslanian, Robert ; Cao, Jianhua ; Garlisi, Charles G ; Huang, Ying ; Jakway, James ; Liu, Zhidan ; Shah, Himanshu ; Tian, Fang ; Wan, Yuntao ; Shih, Neng-Yang

Bioorganic & Medicinal Chemistry Letters, 2005, Vol.15(12), pp.3020-3023 [Peer Reviewed Journal]

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27
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Human ADAM33: protein maturation and localization

Garlisi, Charles G ; Zou, Jun ; Devito, Kristine E ; Tian, Fang ; Zhu, Feng X ; Liu, Jianjun ; Shah, Himanshu ; Wan, Yuntao ; Motasim Billah, M ; Egan, Robert W ; Umland, Shelby P

Biochemical and Biophysical Research Communications, 2003, Vol.301(1), pp.35-43 [Peer Reviewed Journal]

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28
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IL-2 mRNA levels and degradation rates change with mode of stimulation and phorbol ester treatment of lymphocytes

Bill, Olga ; Garlisi, Charles G ; Grove, Deborah S ; Holt, Gregory E ; Mastro, Andrea M

Cytokine, 1994, Vol.6(1), pp.102-110 [Peer Reviewed Journal]

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29
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Cytokine gene expression in mice undergoing chronic graft-versus-host disease

Garlisi, Charles G ; Pennline, Kenneth J ; Smith, Sidney R ; Siegel, Marvin I ; Umland, Shelby P

Molecular Immunology, 1993, Vol.30(7), pp.669-677 [Peer Reviewed Journal]

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30
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The assignment of chemokine‐chemokine receptor pairs: TARC and MIP‐1β are not ligands for human CC‐chemokine receptor 8

Garlisi, Charles G. ; Xiao, Hong ; Tian, Fang ; Hedrick, Joseph A. ; Billah, M. Motasim ; Egan, Robert W. ; Umland, Shelby P.

European Journal of Immunology, October 1999, Vol.29(10), pp.3210-3215 [Peer Reviewed Journal]

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31
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The synthesis of substituted bipiperidine amide compounds as CCR3 antagonists

Ting, Pauline C ; Lee, Joe F ; Wu, Jie ; Umland, Shelby P ; Aslanian, Robert ; Cao, Jianhua ; Dong, Youhao ; Garlisi, Charles G ; Gilbert, Eric J ; Huang, Ying ; Jakway, James ; Kelly, Joseph ; Liu, Zhidan ; Mccombie, Stuart ; Shah, Himanshu ; Tian, Fang ; Wan, Yuntao ; Shih, Neng-Yang

Bioorganic & Medicinal Chemistry Letters, 2005, Vol.15(5), pp.1375-1378 [Peer Reviewed Journal]

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32
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T Cells Are Necessary for Th 2 Cytokine Production and Eosinophil Accumulation in Airways of Antigen-Challenged Allergic Mice

Garlisi, Charles G ; Falcone, Angela ; Kung, Ted T ; Stelts, Dawn ; Pennline, Kenneth J ; Beavis, Andrew J ; Smith, Sidney R ; Egan, Robert W ; Umland, Shelby P

Clinical Immunology and Immunopathology, 1995, Vol.75(1), pp.75-83 [Peer Reviewed Journal]

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