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32 Results  for Everything (Includes Articles)

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1
Material Type:
Review
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Potassium channels: from scorpion venoms to high-resolution structure

Garcia, M.L ; Gao, Ying-Duo ; Mcmanus, O.B ; Kaczorowski, G.J

Toxicon, 2001, Vol.39(6), pp.739-748 [Peer Reviewed Journal]

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2
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Article
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Omarigliptin (MK-3102): a novel long-acting DPP-4 inhibitor for once-weekly treatment of type 2 diabetes

Biftu, Tesfaye ; Sinha-Roy, Ranabir ; Chen, Ping ; Qian, Xiaoxia ; Feng, Dennis ; Kuethe, Jeffrey T ; Scapin, Giovanna ; Gao, Ying Duo ; Yan, Youwei ; Krueger, Davida ; Bak, Annette ; Eiermann, George ; He, Jiafang ; Cox, Jason ; Hicks, Jacqueline ; Lyons, Kathy ; He, Huaibing ; Salituro, Gino ; Tong, Sharon ; Patel

Journal of medicinal chemistry, 24 April 2014, Vol.57(8), pp.3205-12 [Peer Reviewed Journal]

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3
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Article
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Drug-like density: a method of quantifying the "bindability" of a protein target based on a very large set of pockets and drug-like ligands from the Protein Data Bank

Sheridan, Robert P ; Maiorov, Vladimir N ; Holloway, M Katharine ; Cornell, Wendy D ; Gao, Ying-Duo

Journal of chemical information and modeling, 22 November 2010, Vol.50(11), pp.2029-40 [Peer Reviewed Journal]

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4
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Article
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The design and synthesis of potent, selective benzodiazepine sulfonamide bombesin receptor subtype 3 (BRS-3) agonists with an increased barrier of atropisomerization

Chobanian, Harry R ; Guo, Yan ; Liu, Ping ; Lanza, Thomas J ; Chioda, Marc ; Chang, Linda ; Kelly, Theresa M ; Kan, Yanqing ; Palyha, Oksana ; Guan, Xiao-Ming ; Marsh, Donald J ; Metzger, Joseph M ; Raustad, Katie ; Wang, Sheng-Ping ; Strack, Alison M ; Gorski, Judith N ; Miller, Randy ; Pang, Jianmei ; Lyons, Kathy ; Dragovic

Bioorganic & medicinal chemistry, 01 May 2012, Vol.20(9), pp.2845-9 [Peer Reviewed Journal]

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5
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Article
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Resiniferatoxin binds to the capsaicin receptor (TRPV1) near the extracellular side of the S4 transmembrane domain

Chou, Margaret Z ; Mtui, Tecla ; Gao, Ying-Duo ; Kohler, Martin ; Middleton, Richard E

Biochemistry, 09 March 2004, Vol.43(9), pp.2501-11 [Peer Reviewed Journal]

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6
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Article
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The discovery of novel 5,6,5- and 5,5,6-tricyclic pyrrolidines as potent and selective DPP-4 inhibitors

Cox, Jason M ; Chu, Hong D ; Kuethe, Jeffrey T ; Gao, Ying-Duo ; Scapin, Giovanna ; Eiermann, George ; He, Huaibing ; Li, Xiaohua ; Lyons, Kathryn A ; Metzger, Joseph ; Petrov, Aleksandr ; Wu, Joseph K ; Xu, Shiyao ; Sinha-Roy, Ranabir ; Weber, Ann E ; Biftu, Tesfaye

Bioorganic & Medicinal Chemistry Letters, 01 June 2016, Vol.26(11), pp.2622-2626 [Peer Reviewed Journal]

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7
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Article
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Discovery of novel BTK inhibitors with carboxylic acids

Gao, Xiaolei ; Wang, James ; Liu, Jian ; Guiadeen, Deodial ; Krikorian, Arto ; Boga, Sobhana Babu ; Alhassan, Abdul-Basit ; Selyutin, Oleg ; Yu, Wensheng ; Yu, Younong ; Anand, Rajan ; Liu, Shilan ; Yang, Chundao ; Wu, Hao ; Cai, Jiaqiang ; Cooper, Alan ; Zhu, Hugh ; Maloney, Kevin ; Gao, Ying-Duo ; Fischmann, Thierry O

Bioorganic & Medicinal Chemistry Letters, 15 March 2017, Vol.27(6), pp.1471-1477 [Peer Reviewed Journal]

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8
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Article
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Corrigendum to “Novel tetrahydropyran analogs as dipeptidyl peptidase IV inhibitors: Profile of clinical candidate (2R,3S,5R)-2-(2,5-difluorophenyl)-5-(4,6-dihydropyrrolo[3,4-c]pyrazol-5-(1H)-yl)tetrahydro-2H-pyran-3-amine (23)” [Bioorg. Med. Chem. Lett. 23 (2013) 5361–5366]

Biftu, Tesfaye ; Qian, Xiaoxia ; Chen, Ping ; Feng, Dennis ; Scapin, Giovanna ; Gao, Ying-Duo ; Cox, Jason ; Roy, Ranabir Sinha ; Eiermann, George ; He, Huabing ; Lyons, Kathy ; Salituro, Gino ; Patel, Sangita ; Petrov, Alexander ; Xu, Feng ; Xu, Shiyao Sherrie ; Zhang, Bei ; Caldwell, Charles ; Wu, Joseph K ; Lyons, Kathy

Bioorganic & Medicinal Chemistry Letters, 01 June 2014, Vol.24(11), pp.2590-2590 [Peer Reviewed Journal]

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9
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Article
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Novel tetrahydropyran analogs as dipeptidyl peptidase IV inhibitors: Profile of clinical candidate (2R,3S,5R)-2-(2,5-difluorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]tetrahydro-2H-pyran-3-amine (23)

Biftu, Tesfaye ; Qian, Xiaoxia ; Chen, Ping ; Feng, Dennis ; Scapin, Giovanna ; Gao, Ying-Duo ; Cox, Jason ; Sinha Roy, Ranabir ; Eiermann, George ; He, Huabing ; Lyons, Kathy ; Salituro, Gino ; Patel, Sangita ; Petrov, Alexander ; Xu, Feng ; Xu, Shiyao Sherrie ; Zhang, Bei ; Caldwell, Charles ; Wu, Joseph K ; Lyons, Kathy

Bioorganic & Medicinal Chemistry Letters, 01 October 2013, Vol.23(19), pp.5361-5366 [Peer Reviewed Journal]

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10
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Article
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Discovery of 3-morpholino-imidazole[1,5-a]pyrazine BTK inhibitors for rheumatoid arthritis

Boga, Sobhana Babu ; Alhassan, Abdul-Basit ; Liu, Jian ; Guiadeen, Deodial ; Krikorian, Arto ; Gao, Xiaolei ; Wang, James ; Yu, Younong ; Anand, Rajan ; Liu, Shilan ; Yang, Chundao ; Wu, Hao ; Cai, Jiaqiang ; Zhu, Hugh ; Desai, Jagdish ; Maloney, Kevin ; Gao, Ying-Duo ; Fischmann, Thierry O ; Presland, Jeremy ; Mansueto, My

Bioorganic & Medicinal Chemistry Letters, 15 August 2017, Vol.27(16), pp.3939-3943 [Peer Reviewed Journal]

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11
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Article
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Discovery of Novel Tricyclic Heterocycles as Potent and Selective DPP-4 Inhibitors for the Treatment of Type 2 Diabetes

Wu, Wen-Lian ; Hao, Jinsong ; Domalski, Martin ; Burnett, Duane A ; Pissarnitski, Dmitri ; Zhao, Zhiqiang ; Stamford, Andrew ; Scapin, Giovanna ; Gao, Ying-Duo ; Soriano, Aileen ; Kelly, Terri M ; Yao, Zuliang ; Powles, Mary Ann ; Chen, Shiying ; Mei, Hong ; Hwa, Joyce Argonne National Lab. (Anl), Argonne, Il (United States). Advanced Photon Source (APS) (Corporate Author)

ACS Medicinal Chemistry Letters, 12 May 2016, Vol.7(5) [Peer Reviewed Journal]

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12
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Article
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Glycine 30 in iberiotoxin is a critical determinant of its specificity for maxi‐K versus KV channels

Schroeder, Nathan ; Mullmann, Theodore J ; Schmalhofer, W. A ; Gao, Ying - Duo ; Garcia, Maria L ; Giangiacomo, Kathleen M

FEBS Letters, 11 September 2002, Vol.527(1-3), pp.298-302 [Peer Reviewed Journal]

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13
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Article
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A comparative study of the binding properties, dipeptidyl peptidase‐4 (DPP‐4) inhibitory activity and glucose‐lowering efficacy of the DPP‐4 inhibitors alogliptin, linagliptin, saxagliptin, sitagliptin and vildagliptin in mice

Berger, Joel P. ; Sinharoy, Ranabir ; Pocai, Alessandro ; Kelly, Theresa M. ; Scapin, Giovanna ; Gao, YingDuo ; Pryor, Kelly Ann D. ; Wu, Joseph K. ; Eiermann, George J. ; Xu, Shiyao S. ; Zhang, Xiaoping ; Tatosian, Daniel A. ; Weber, Ann E. ; Thornberry, Nancy A. ; Carr, Richard D.

Endocrinology, Diabetes & Metabolism, January 2018, Vol.1(1), pp.n/a-n/a [Peer Reviewed Journal]

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14
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Article
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Discovery of 8-Amino-imidazo[1,5- a ]pyrazines as Reversible BTK Inhibitors for the Treatment of Rheumatoid Arthritis

Liu, Jian ; Guiadeen, Deodial ; Krikorian, Arto ; Gao, Xiaolei ; Wang, James ; Boga, Sobhana Babu ; Alhassan, Abdul-Basit ; Yu, Younong ; Vaccaro, Henry ; Liu, Shilan ; Yang, Chundao ; Wu, Hao ; Cooper, Alan ; de Man, Jos ; Kaptein, Allard ; Maloney, Kevin ; Hornak, Viktor ; Gao, Ying-Duo ; Fischmann, Thierry O ; Raaijmakers, Hans ; Vu-Pham, Diep ; Presland, Jeremy ; Mansueto, My ; Xu, Zangwei ; Leccese, Erica ; Zhang-Hoover, Jie ; Knemeyer, Ian ; Garlisi, Charles G ; Bays, Nathan ; Stivers, Peter ; Brandish, Philip E ; Hicks, Alexandra ; Kim, Ronald ; Kozlowski, Joseph A Argonne National Lab. (Anl), Argonne, Il (United States). Advanced Photon Source (APS) (Corporate Author)

ACS Medicinal Chemistry Letters, 11 February 2016, Vol.7(2) [Peer Reviewed Journal]

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15
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Article
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Structure–activity-relationship of amide and sulfonamide analogs of omarigliptin

Chen, Ping ; Feng, Dennis ; Qian, Xiaoxia ; Apgar, James ; Wilkening, Robert ; Kuethe, Jeffrey T ; Gao, Ying-Duo ; Scapin, Giovanna ; Cox, Jason ; Doss, George ; Eiermann, George ; He, Huaibing ; Li, Xiaohua ; Lyons, Kathryn A ; Metzger, Joseph ; Petrov, Aleksandr ; Wu, Joseph K ; Xu, Shiyao ; Weber, Ann E ; Yan, Youwei

Bioorganic & Medicinal Chemistry Letters, 15 December 2015, Vol.25(24), pp.5767-5771 [Peer Reviewed Journal]

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16
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Article
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Interaction of agitoxin2, charybdotoxin, and iberiotoxin with potassium channels: Selectivity between voltage‐gated and Maxi‐K channels

Gao, YingDuo ; Garcia, Maria L.

Proteins: Structure, Function, and Bioinformatics, 01 August 2003, Vol.52(2), pp.146-154 [Peer Reviewed Journal]

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17
Binding of Correolide to the K v 1.3 Potassium Channel:  Characterization of the Binding Domain by Site-Directed Mutagenesis †
Material Type:
Article
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Binding of Correolide to the K v 1.3 Potassium Channel:  Characterization of the Binding Domain by Site-Directed Mutagenesis †

Hanner, Markus ; Green, Brian ; Gao, Ying-Duo ; Schmalhofer, William A. ; Matyskiela, Mary ; Durand, Daniel J. ; Felix, John P. ; Linde, Ana-Rosa ; Bordallo, Carmen ; Kaczorowski, Gregory J. ; Kohler, Martin ; Garcia, Maria L.

Biochemistry, 10/2001, Vol.40(39), pp.11687-11697 [Peer Reviewed Journal]

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18
Material Type:
Article
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Two tarantula peptides inhibit activation of multiple sodium channels

Middleton, Richard E ; Warren, Vivien A ; Kraus, Richard L ; Hwang, Jeremy C ; Liu, Chou J ; Dai, Ge ; Brochu, Richard M ; Kohler, Martin G ; Gao, Ying-Duo ; Garsky, Victor M ; Bogusky, Michael J ; Mehl, John T ; Cohen, Charles J ; Smith, Mchardy M

Biochemistry, 17 December 2002, Vol.41(50), pp.14734-47 [Peer Reviewed Journal]

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19
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Article
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Discovery of benzodiazepine sulfonamide-based bombesin receptor subtype 3 agonists and their unusual chirality

Liu, Ping ; Lanza, Thomas J ; Chioda, Marc ; Jones, Carrie ; Chobanian, Harry R ; Guo, Yan ; Chang, Linda ; Kelly, Theresa M ; Kan, Yanqing ; Palyha, Oksana ; Guan, Xiao-Ming ; Marsh, Donald J ; Metzger, Joseph M ; Ramsay, Katie ; Wang, Sheng-Ping ; Strack, Alison M ; Miller, Randy ; Pang, Jianmei ; Lyons, Kathy ; Dragovic

ACS medicinal chemistry letters, 08 December 2011, Vol.2(12), pp.933-7 [Peer Reviewed Journal]

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20
Material Type:
Article
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1 H NMR structural analysis of human ghrelin and its six truncated analogs

Silva Elipe, Maria Victoria ; Bednarek, Maria A. ; Gao, YingDuo

Biopolymers, December 2001, Vol.59(7), pp.489-501 [Peer Reviewed Journal]

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21
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Article
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Analysis of the π-electronic structure of infinitely large networks: Part III. Branched polyenes with bond alternation

Gao, Ying-Duo ; Hosoya, Haruo

Journal of Molecular Structure: THEOCHEM, 1990, Vol.206(1), pp.153-172 [Peer Reviewed Journal]

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22
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Article
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Synthesis of 13 C‐Labeled Pyrazinone Thrombin Inhibitors and Elucidation of Metabolic Activation Pathways

Ho, Jonathan Z. ; Braun, Matthew P. ; Subramanian, Raju ; Gao, YingDuo ; Dean, Dennis C. ; Melillo, David G.

Helvetica Chimica Acta, March 2004, Vol.87(3), pp.674-681 [Peer Reviewed Journal]

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23
Material Type:
Article
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Functional mapping of the transient receptor potential vanilloid 1 intracellular binding site

Johnson, Daniel M ; Garrett, Elizabeth M ; Rutter, Richard ; Bonnert, Timothy P ; Gao, Ying-Duo ; Middleton, Richard E ; Sutton, Kathy G

Molecular Pharmacology, 2006-09, Vol.70(3), pp.1005-12 [Peer Reviewed Journal]

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24
Material Type:
Article
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Functional mapping of the transient receptor potential vanilloid 1 intracellular binding site

Johnson, Daniel M ; Garrett, Elizabeth M ; Rutter, Richard ; Bonnert, Timothy P ; Gao, Ying-Duo ; Middleton, Richard E ; Sutton, Kathy G

Molecular pharmacology, September 2006, Vol.70(3), pp.1005-12 [Peer Reviewed Journal]

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25
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Article
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Identification of novel and orally active spiroindoline NPY Y5 receptor antagonists

Sakamoto, Toshihiro ; Moriya, Minoru ; Haga, Yuji ; Takahashi, Toshiyuki ; Shibata, Takunobu ; Okamoto, Osamu ; Nonoshita, Katsumasa ; Kitazawa, Hidefumi ; Hidaka, Masayasu ; Gomori, Akira ; Iwaasa, Hisashi ; Ishihara, Akane ; Kanatani, Akio ; Fukami, Takehiro ; Gao, Ying-Duo ; Macneil, Douglas J ; Yang, Lihu

Bioorganic & medicinal chemistry letters, 15 March 2009, Vol.19(6), pp.1564-8 [Peer Reviewed Journal]

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26
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Article
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Discovery of new binding elements in DPP-4 inhibition and their applications in novel DPP-4 inhibitor design

Liang, Gui-Bai ; Qian, Xiaoxia ; Biftu, Tesfaye ; Singh, Suresh ; Gao, Ying-Duo ; Scapin, Giovanna ; Patel, Sangita ; Leiting, Barbara ; Patel, Reshma ; Wu, Joseph ; Zhang, Xiaoping ; Thornberry, Nancy A ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 2008, Vol.18(13), pp.3706-3710 [Peer Reviewed Journal]

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27
Material Type:
Research Dataset
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CCDC 841543: Experimental Crystal Structure Determination

Liu, Ping ; Lanza Junior, T.J. ; Chioda, M. ; Jones, C. ; Chobanian, H.R. ; Guo, Yan ; Chang, Linda ; Kelly, T.M. ; Kan, Yanqing ; Palyha, O. ; Guan, Xiao-Ming ; Marsh, D.J. ; Metzger, J.M. ; Ramsay, K. ; Wang, Sheng-Ping ; Strack, A.M. ; Miller, R. ; Pang, Jianmei ; Lyons, K. ; Dragovic, J. ; Ning, J.G. ; Schafer, W.A. ; Welch, C.J. ; Gong, Xiaoyi ; Gao, Ying-Duo ; Hornak, V. ; Ball, R.G. ; Tsou, N. ; Reitman, M.L. ; Wyvratt, M.J. ; Nargund, R.P. ; Lin, L.S.

2012

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28
Material Type:
Research Dataset
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CCDC 841544: Experimental Crystal Structure Determination

Liu, Ping ; Lanza Junior, T.J. ; Chioda, M. ; Jones, C. ; Chobanian, H.R. ; Guo, Yan ; Chang, Linda ; Kelly, T.M. ; Kan, Yanqing ; Palyha, O. ; Guan, Xiao-Ming ; Marsh, D.J. ; Metzger, J.M. ; Ramsay, K. ; Wang, Sheng-Ping ; Strack, A.M. ; Miller, R. ; Pang, Jianmei ; Lyons, K. ; Dragovic, J. ; Ning, J.G. ; Schafer, W.A. ; Welch, C.J. ; Gong, Xiaoyi ; Gao, Ying-Duo ; Hornak, V. ; Ball, R.G. ; Tsou, N. ; Reitman, M.L. ; Wyvratt, M.J. ; Nargund, R.P. ; Lin, L.S.

2012

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29
Material Type:
Article
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Modeling assisted rational design of novel, potent, and selective pyrrolopyrimidine DPP-4 inhibitors

Gao, Ying-Duo ; Feng, Dennis ; Sheridan, Robert P ; Scapin, Giovanna ; Patel, Sangita B ; Wu, Joseph K ; Zhang, Xiaoping ; Sinha-Roy, Ranabir ; Thornberry, Nancy A ; Weber, Ann E ; Biftu, Tesfaye

Bioorganic & Medicinal Chemistry Letters, 2007, Vol.17(14), pp.3877-3879 [Peer Reviewed Journal]

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30
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Article
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Discovery of a novel class of isoxazoline voltage gated sodium channel blockers

Shao, Pengcheng P ; Ye, Feng ; Weber, Ann E ; Li, Xiaohua ; Lyons, Kathryn A ; Parsons, William H ; Garcia, Maria L ; Priest, Birgit T ; Smith, Mchardy M ; Felix, John P ; Williams, Brande S ; Kaczorowski, Gregory J ; Mcgowan, Erin ; Abbadie, Catherine ; Martin, William J ; Mcmasters, Daniel R ; Gao, Ying-Duo

Bioorganic & Medicinal Chemistry Letters, 2009, Vol.19(18), pp.5329-5333 [Peer Reviewed Journal]

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31
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Article
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Discovery of isoxazole voltage gated sodium channel blockers for treatment of chronic pain

Shao, Pengcheng P ; Ye, Feng ; Weber, Ann E ; Li, Xiaohua ; Lyons, Kathryn A ; Parsons, William H ; Garcia, Maria L ; Priest, Birgit T ; Smith, Mchardy M ; Felix, John P ; Williams, Brande S ; Kaczorowski, Gregory J ; Mcgowan, Erin ; Abbadie, Catherine ; Martin, William J ; Mcmasters, Daniel R ; Gao, Ying-Duo

Bioorganic & Medicinal Chemistry Letters, 2009, Vol.19(18), pp.5334-5338 [Peer Reviewed Journal]

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32
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Article
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(3 R)-4-[(3 R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one, a selective dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes

Biftu, Tesfaye ; Feng, Dennis ; Qian, Xiaoxia ; Liang, Gui-Bai ; Kieczykowski, Gerard ; Eiermann, George ; He, Huaibing ; Leiting, Barbara ; Lyons, Kathy ; Petrov, Aleksandr ; Sinha-Roy, Ranabir ; Zhang, Bei ; Scapin, Giovanna ; Patel, Sangita ; Gao, Ying-Duo ; Singh, Suresh ; Wu, Joseph ; Zhang, Xiaoping ; Thornberry, Nancy A ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 2007, Vol.17(1), pp.49-52 [Peer Reviewed Journal]

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