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32 Results  for Everything (Includes Articles)

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A pharmacological and histological examination of the microcirculation of the rat subcutaneous air-pouch: microcirculation of the rat air-pouch

Takagi, Toshitaka ; Forrest, Michael J ; Brooks, Peter M

Pathology, 1987, Vol.19(3), pp.294-298 [Peer Reviewed Journal]

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On-and Off-Target Pharmacology of Torcetrapib

Johns, Douglas ; Duffy, Joseph ; Fisher, Timothy ; Hubbard, Brian ; Forrest, Michael

Drugs, 2012, Vol.72(4), pp.491-507 [Peer Reviewed Journal]

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Impaired neuropathic pain responses in mice lacking the chemokine receptor CCR2

Abbadie, Catherine ; Lindia, Jill A ; Cumiskey, Anne Marie ; Peterson, Larry B ; Mudgett, John S ; Bayne, Ellen K ; Demartino, Julie A ; Macintyre, D Euan ; Forrest, Michael J

Proceedings of the National Academy of Sciences of the United States of America, 24 June 2003, Vol.100(13), pp.7947-52 [Peer Reviewed Journal]

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Discovery of a biaryl cyclohexene carboxylic acid (MK-6892): a potent and selective high affinity niacin receptor full agonist with reduced flushing profiles in animals as a preclinical candidate

Shen, Hong C ; Ding, Fa-Xiang ; Raghavan, Subharekha ; Deng, Qiaolin ; Luell, Silvi ; Forrest, Michael J ; Carballo-Jane, Ester ; Wilsie, Larissa C ; Krsmanovic, Mihajlo L ; Taggart, Andrew K ; Wu, Kenneth K ; Wu, Tsuei-Ju ; Cheng, Kang ; Ren, Ning ; Cai, Tian-Quan ; Chen, Qing ; Wang, Junying ; Wolff, Michael S ; Tong, Xinchun ; Holt

Journal of medicinal chemistry, 25 March 2010, Vol.53(6), pp.2666-70 [Peer Reviewed Journal]

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Sphingosine-1-phosphate receptor agonism impairs the efficiency of the local immune response by altering trafficking of naive and antigen-activated CD4+ T cells

Xie, Jenny H ; Nomura, Naomi ; Koprak, Sam L ; Quackenbush, Elizabeth J ; Forrest, Michael J ; Rosen, Hugh

Journal of immunology (Baltimore, Md. : 1950), 01 April 2003, Vol.170(7), pp.3662-70 [Peer Reviewed Journal]

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Acute hemodynamic and renal effects of glucagon-like peptide 1 analog and dipeptidyl peptidase-4 inhibitor in rats

Zhou, Xiaoyan ; Huang, Chin-Hu ; Lao, Julie ; Pocai, Alessandro ; Forrest, Gail ; Price, Olga ; Roy, Sophie ; Kelley, David E ; Sullivan, Kathleen A ; Forrest, Michael J

Cardiovascular diabetology, 07 March 2015, Vol.14, pp.29 [Peer Reviewed Journal]

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Sphingosine-1-phosphate agonists increase macrophage homing, lymphocyte contacts, and endothelial junctional complex formation in murine lymph nodes

Singer, Irwin I ; Tian, Min ; Wickham, L Alexandra ; Lin, Jeffrey ; Matheravidathu, Scaria S ; Forrest, Michael J ; Mandala, Suzanne ; Quackenbush, Elizabeth J

Journal of immunology (Baltimore, Md. : 1950), 01 December 2005, Vol.175(11), pp.7151-61 [Peer Reviewed Journal]

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Discovery of a novel series of peroxisome proliferator-activated receptor alpha/gamma dual agonists for the treatment of type 2 diabetes and dyslipidemia

Liu, Kun ; Xu, Libo ; Berger, Joel P ; Macnaul, Karen L ; Zhou, Gauchao ; Doebber, Thomas W ; Forrest, Michael J ; Moller, David E ; Jones, A Brian

Journal of medicinal chemistry, 07 April 2005, Vol.48(7), pp.2262-5 [Peer Reviewed Journal]

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A potent and selective indole N-type calcium channel (Ca v2.2) blocker for the treatment of pain

Tyagarajan, Sriram ; Chakravarty, Prasun K ; Park, Min ; Zhou, Bishan ; Herrington, James B ; Ratliff, Kevin ; Bugianesi, Randall M ; Williams, Brande ; Haedo, Rodolfo J ; Swensen, Andrew M ; Warren, Vivien A ; Smith, Mchardy ; Garcia, Maria ; Kaczorowski, Gregory J ; Mcmanus, Owen B ; Lyons, Kathryn A ; Li, Xiaohua ; Madeira, Maria ; Karanam, Bindhu ; Green, Mitchell

Bioorganic & Medicinal Chemistry Letters, 2011, Vol.21(2), pp.869-873 [Peer Reviewed Journal]

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Discovery of betamethasone 17α-carbamates as dissociated glucocorticoid receptor modulators in the rat

Ali, Amjad ; Balkovec, James M ; Greenlee, Mark ; Hammond, Milton L ; Rouen, Greg ; Taylor, Gayle ; Einstein, Monica ; Ge, Lan ; Harris, Georgianna ; Kelly, Terri M ; Mazur, Paul ; Pandit, Shilpa ; Santoro, Joseph ; Sitlani, Ayesha ; Wang, Chuanlin ; Williamson, Joann ; Forrest, Michael J ; Carballo-Jane, Ester ; Luell, Silvi ; Lowitz, Karen

Bioorganic & Medicinal Chemistry, 2008, Vol.16(16), pp.7535-7542 [Peer Reviewed Journal]

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Discovery of biaryl anthranilides as full agonists for the high affinity niacin receptor

Shen, Hong C ; Ding, Fa-Xiang ; Luell, Silvi ; Forrest, Michael J ; Carballo-Jane, Ester ; Wu, Kenneth K ; Wu, Tsuei-Ju ; Cheng, Kang ; Wilsie, Larissa C ; Krsmanovic, Mihajlo L ; Taggart, Andrew K ; Ren, Ning ; Cai, Tian-Quan ; Deng, Qiaolin ; Chen, Qing ; Wang, Junying ; Wolff, Michael S ; Tong, Xinchun ; Holt, Tom G ; Waters

Journal of medicinal chemistry, 13 December 2007, Vol.50(25), pp.6303-6 [Peer Reviewed Journal]

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Novel N-arylpyrazolo3,2-c-based ligands for the glucocorticoid receptor: receptor binding and in vivo activity

Ali, Amjad ; Thompson, Christopher F ; Balkovec, James M ; Graham, Donald W ; Hammond, Milton L ; Quraishi, Nazia ; Tata, James R ; Einstein, Monica ; Ge, Lan ; Harris, Georgianna ; Kelly, Terri M ; Mazur, Paul ; Pandit, Shilpa ; Santoro, Joseph ; Sitlani, Ayesha ; Wang, Chuanlin ; Williamson, Joanne ; Miller, Douglas K ; Thompson, Chris M ; Zaller

Journal of medicinal chemistry, 06 May 2004, Vol.47(10), pp.2441-52 [Peer Reviewed Journal]

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Skeletal muscle: a dual system to measure glucocorticoid-dependent transactivation and transrepression of gene regulation

Carballo-Jane, Ester ; Pandit, Shilpa ; Santoro, Joseph C ; Freund, Concetta ; Luell, Silvi ; Harris, Georgianna ; Forrest, Michael J ; Sitlani, Ayesha

Journal of Steroid Biochemistry and Molecular Biology, 2004, Vol.88(2), pp.191-201 [Peer Reviewed Journal]

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14
Discovery of a Potent, Orally Bioavailable β 3 Adrenergic Receptor Agonist, ( R )- N -[4-[2-[[2-Hydroxy-2-(3-pyridinyl)ethyl]amino]ethyl]phenyl]-4-[4-[4-(trifluoromethyl)phenyl]thiazol-2-yl]benzenesulfonamide
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Discovery of a Potent, Orally Bioavailable β 3 Adrenergic Receptor Agonist, ( R )- N -[4-[2-[[2-Hydroxy-2-(3-pyridinyl)ethyl]amino]ethyl]phenyl]-4-[4-[4-(trifluoromethyl)phenyl]thiazol-2-yl]benzenesulfonamide

Mathvink, Robert J. ; Tolman, J. Samuel ; Chitty, Dawn ; Candelore, Mari R. ; Cascieri, Margaret A. ; Colwell, Lawrence F. ; Deng, Liping ; Feeney, William P. ; Forrest, Michael J. ; Hom, Gary J. ; Macintyre, D. Euan ; Miller, Randall R. ; Stearns, Ralph A. ; Tota, Laurie ; Wyvratt, Matthew J. ; Fisher, Michael H. ; Weber, Ann E.

Journal of Medicinal Chemistry, 10/2000, Vol.43(21), pp.3832-3836 [Peer Reviewed Journal]

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15
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Attenuation of Oxygen Free Radical Formation and Tissue Injury During Experimental Inflammation by P‐selectin Blockade

Delano, Frank A. ; Forrest, Michael J. ; Schmid‐Schönbein, Geert W.

Microcirculation, September 1997, Vol.4(3), pp.349-357 [Peer Reviewed Journal]

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16
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L-750355, a human ß3-adrenoceptor agonist; in vitro pharmacology and profile of activity in vivo in the rhesus monkey

Forrest, Michael J ; Hom, Gary ; Bach, Tom ; Candelore, Mari Rios ; Cascieri, Margaret A ; Strader, Catherine ; Tota, Laurie ; Fisher, Michael H ; Szumiloski, John ; Ok, Hyun O ; Weber, Ann E ; Wyvratt, Matthew ; Vicario, Pasquale ; Marko, Olga ; Deng, Liping ; Cioffe, Christine ; Hegarty-Friscino, Bonnie ; Macintyre, Euan

European Journal of Pharmacology, 2000, Vol.407(1), pp.175-181 [Peer Reviewed Journal]

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17
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A novel 3-dimensional micro-ultrasound approach to automated measurement of carotid arterial plaque volume as a biomarker for experimental atherosclerosis

Walker, Matthew ; Campbell, Barry R ; Azer, Karim ; Tong, Christopher ; Fang, Kaijie ; Cook, Jacquelynn J ; Forrest, Michael J ; Kempadoo, Kimberly ; Wright, Samuel D ; Saltzman, Jeffrey S ; Macintyre, Euan ; Hargreaves, Richard

Atherosclerosis, 2009, Vol.204(1), pp.55-65 [Peer Reviewed Journal]

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18
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FK-506 and cyclosporin a: Selective inhibition of calcium ionophore-induced polymorphonuclear leukocyte degranulation

Forrest, Michael J ; Jewell, Marvin E ; Koo, Gloria C ; Sigal, Nolan H

Biochemical Pharmacology, 1991, Vol.42(6), pp.1221-1228 [Peer Reviewed Journal]

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19
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Comparison of rat and dog models of vasodilatation and lipolysis for the calculation of a therapeutic index for GPR109A agonists

Carballo-Jane, Ester ; Gerckens, Lynn S ; Luell, Silvi ; Parlapiano, Allison S ; Wolff, Michael ; Colletti, Steven L ; Tata, James R ; Taggart, Andrew K.P ; Waters, M. Gerard ; Richman, Jeremy G ; Mccann, Margaret E ; Forrest, Michael J

Journal of Pharmacological and Toxicological Methods, 2007, Vol.56(3), pp.308-316 [Peer Reviewed Journal]

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20
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O-Arylmandelic acids as highly selective human PPAR α/γ agonists

Adams, Alan D ; Hu, Zao ; Von Langen, Derek ; Dadiz, Adonis ; Elbrecht, Alex ; Macnaul, Karen L ; Berger, Joel P ; Zhou, Gaochao ; Doebber, Thomas W ; Meurer, Roger ; Forrest, Michael J ; Moller, David E ; Brian Jones, A

Bioorganic & Medicinal Chemistry Letters, 2003, Vol.13(19), pp.3185-3190 [Peer Reviewed Journal]

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21
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3-pyridylethanolamines: Potent and selective human β 3 adrenergic receptor agonists

Naylor, Elizabeth M ; Colandrea, Vincent J ; Candelore, Mari R ; Cascieri, Margaret A ; Colwell, Lawrence F ; Deng, Liping ; Feeney, William P ; Forrest, Michael J ; Hom, Gary J ; Euan Macintyre, D ; Strader, Catherine D ; Tota, Laurie ; Wang, Pei-Ran ; Wyvratt, Matthew J ; Fisher, Michael H ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 1998, Vol.8(21), pp.3087-3092 [Peer Reviewed Journal]

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22
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Discovery of an orally bioavailable alkyl oxadiazole β 3 adrenergic receptor agonist

Feng, Danqing D ; Biftu, Tesfaye ; Candelore, Mari R ; Cascieri, Margaret A ; Colwell, Lawrence F ; Deng, Liping ; Feeney, William P ; Forrest, Michael J ; Hom, Gary J ; Macintyre, D.Euan ; Miller, Randall R ; Stearns, Ralph A ; Strader, Catherine D ; Tota, Laurie ; Wyvratt, Matthew J ; Fisher, Michael H ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 2000, Vol.10(13), pp.1427-1429 [Peer Reviewed Journal]

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23
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Potent, selective 3-pyridylethanolamine β 3 adrenergic receptor agonists possessing a thiazole benzenesulfonamide pharmacophore

Mathvink, Robert J ; Tolman, J.Samuel ; Chitty, Dawn ; Candelore, Mari R ; Cascieri, Margaret A ; Colwell, Lawrence F ; Deng, Liping ; Feeney, William P ; Forrest, Michael J ; Hom, Gary J ; Macintyre, D.Euan ; Tota, Laurie ; Wyvratt, Matthew J ; Fisher, Michael H ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 2000, Vol.10(17), pp.1971-1973 [Peer Reviewed Journal]

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24
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Human β 3-adrenergic receptor agonists containing 1,2,3-triazole-substituted benzenesulfonamides

Brockunier, Linda L ; Parmee, Emma R ; Ok, Hyun O ; Candelore, Mari R ; Cascieri, Margaret A ; Colwell, Lawrence F ; Deng, Liping ; Feeney, William P ; Forrest, Michael J ; Hom, Gary J ; Macintyre, D.Euan ; Tota, Laurie ; Wyvratt, Matthew J ; Fisher, Michael H ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 2000, Vol.10(18), pp.2111-2114 [Peer Reviewed Journal]

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25
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Novel glucocorticoids containing a 6,5-bicyclic core fused to a pyrazole ring: Synthesis, in vitro profile, molecular modeling studies, and in vivo experiments

Thompson, Christopher F ; Quraishi, Nazia ; Ali, Amjad ; Mosley, Ralph T ; Tata, James R ; Hammond, Milton L ; Balkovec, James M ; Einstein, Monica ; Ge, Lan ; Harris, Georgianna ; Kelly, Terri M ; Mazur, Paul ; Pandit, Shilpa ; Santoro, Joseph ; Sitlani, Ayesha ; Wang, Chuanlin ; Williamson, Joanne ; Miller, Douglas K ; Yamin, Ting-Ting D ; Thompson, Chris M

Bioorganic & Medicinal Chemistry Letters, 2007, Vol.17(12), pp.3354-3361 [Peer Reviewed Journal]

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26
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Novel heterocyclic glucocorticoids: in vitro profile and in vivo efficacy

Thompson, Christopher F ; Quraishi, Nazia ; Ali, Amjad ; Tata, James R ; Hammond, Milton L ; Balkovec, James M ; Einstein, Monica ; Ge, Lan ; Harris, Georgianna ; Kelly, Theresa M ; Mazur, Paul ; Pandit, Shilpa ; Santoro, Joseph ; Sitlani, Ayesha ; Wang, Chuanlin ; Williamson, Joanne ; Miller, Douglas K ; Yamin, Ting-Ting D ; Thompson, Chris M ; O’neill, Edward A

Bioorganic & Medicinal Chemistry Letters, 2005, Vol.15(8), pp.2163-2167 [Peer Reviewed Journal]

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27
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Novel ketal ligands for the glucocorticoid receptor: in vitro and in vivo activity

Smith, Cameron J ; Ali, Amjad ; Balkovec, James M ; Graham, Donald W ; Hammond, Milton L ; Patel, Gool F ; Rouen, Gregory P ; Smith, Scott K ; Tata, James R ; Einstein, Monica ; Ge, Lan ; Harris, Georgianna S ; Kelly, Theresa M ; Mazur, Paul ; Thompson, Chris M ; Wang, Chuanlin F ; Williamson, Joanne M ; Miller, Douglas K ; Pandit, Shilpa ; Santoro, Joseph C

Bioorganic & Medicinal Chemistry Letters, 2005, Vol.15(11), pp.2926-2931 [Peer Reviewed Journal]

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28
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Benzyl vinylogous amide substituted aryldihydropyridazinones and aryldimethylpyrazolones as potent and selective PDE3B inhibitors

Edmondson, Scott D ; Mastracchio, Anthony ; He, Jiafang ; Chung, Christine C ; Forrest, Michael J ; Hofsess, Scott ; Macintyre, Euan ; Metzger, Joseph ; O'Connor, Naphtali ; Patel, Kajal ; Tong, Xinchun ; Tota, Michael R ; Van Der Ploeg, Lex H.T ; Varnerin, Jeff P ; Fisher, Michael H ; Wyvratt, Matthew J ; Weber, Ann E ; Parmee, Emma R

Bioorganic & Medicinal Chemistry Letters, 2003, Vol.13(22), pp.3983-3987 [Peer Reviewed Journal]

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29
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Human β3 adrenergic receptor agonists containing cyclic ureidobenzenesulfonamides

Parmee, Emma R ; Naylor, Elizabeth M ; Perkins, Leroy ; Colandrea, Vincent J ; Ok, Hyun O ; Candelore, Mari R ; Cascieri, Margaret A ; Deng, Liping ; Feeney, William P ; Forrest, Michael J ; Hom, Gary J ; Macintyre, D.Euan ; Miller, Randall R ; Stearns, Ralph A ; Strader, Catherine D ; Tota, Laurie ; Wyvratt, Matthew J ; Fisher, Michael H ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 1999, Vol.9(5), pp.749-754 [Peer Reviewed Journal]

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30
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Synthesis and SAR of benzyl and phenoxymethylene oxadiazole benzenesulfonamides as selective β 3 adrenergic receptor agonist antiobesity agents

Biftu, Tesfaye ; Feng, Dennis D ; Liang, Gui-Bai ; Kuo, Howard ; Qian, Xiaoxia ; Naylor, Elizabeth M ; Colandrea, Vincent J ; Candelore, Mari R ; Cascieri, Margaret A ; Colwell, Lawrence F ; Forrest, Michael J ; Hom, Gary J ; Macintyre, D.Euan ; Stearns, Ralph A ; Strader, Catherine D ; Wyvratt, Matthew J ; Fisher, Michael H ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 2000, Vol.10(13), pp.1431-1434 [Peer Reviewed Journal]

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31
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L-770,644: A potent and selective human β3 adrenergic receptor agonist with improved oral bioavailability

Shih, Thomas L ; Candelore, Mari R ; Cascieri, Margaret A ; Chiu, Shuet-Hing L ; Colwell, Lawrence F ; Deng, Liping ; Feeney, William P ; Forrest, Michael J ; Hom, Gary J ; Macintyre, D.Euan ; Miller, Randall R ; Stearns, Ralph A ; Strader, Catherine D ; Tota, Laurie ; Wyvratt, Matthew J ; Fisher, Michael H ; Weber, Ann E

Bioorganic & Medicinal Chemistry Letters, 1999, Vol.9(9), pp.1251-1254 [Peer Reviewed Journal]

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32
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3-Pyridyloxypropanolamine agonists of the β3 adrenergic receptor with improved pharmacokinetic properties

Weber, Ann E ; Ok, Hyun O ; Alvaro, Raul F ; Candelore, Mari R ; Cascieri, Margaret A ; Chiu, Shuet-Hing L ; Deng, Liping ; Forrest, Michael J ; Hom, Gary J ; Hutchins, Jennifer E ; Kao, John ; Macintyre, D.Euan ; Mathvink, Robert J ; Mcloughlin, Debra ; Miller, Randall R ; Newbold, Ronald C ; Olah, Timothy V ; Parmee, Emma R ; Perkins, Leroy ; Stearns, Ralph A

Bioorganic & Medicinal Chemistry Letters, 1998, Vol.8(16), pp.2111-2116 [Peer Reviewed Journal]

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