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22 Results  for Everything (Includes Articles)

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1
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Crystal structures of MEK1 binary and ternary complexes with nucleotides and inhibitors

Fischmann, Thierry O ; Smith, Catherine K ; Mayhood, Todd W ; Myers, Joseph E ; Reichert, Paul ; Mannarino, Anthony ; Carr, Donna ; Zhu, Hugh ; Wong, Jesse ; Yang, Rong-Sheng ; Le, Hung V ; Madison, Vincent S

Biochemistry, 31 March 2009, Vol.48(12), pp.2661-74 [Peer Reviewed Journal]

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2
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Structural basis of CX-4945 binding to human protein kinase CK2

Ferguson, Andrew D ; Sheth, Payal R ; Basso, Andrea D ; Paliwal, Sunil ; Gray, Kimberly ; Fischmann, Thierry O ; Le, Hung V

FEBS Letters, 03 January 2011, Vol.585(1), pp.104-110 [Peer Reviewed Journal]

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3
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Selective small-molecule inhibition of an RNA structural element

Howe, John A ; Wang, Hao ; Fischmann, Thierry O ; Balibar, Carl J ; Xiao, Li ; Galgoci, Andrew M ; Malinverni, Juliana C ; Mayhood, Todd ; Villafania, Artjohn ; Nahvi, Ali ; Murgolo, Nicholas ; Barbieri, Christopher M ; Mann, Paul A ; Carr, Donna ; Xia, Ellen ; Zuck, Paul ; Riley, Dan ; Painter, Ronald E ; Walker, Scott S ; Sherborne

Nature, 29 October 2015, Vol.526(7575), pp.672-7 [Peer Reviewed Journal]

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4
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Potency switch between CHK1 and MK2: Discovery of imidazo[1,2-a]pyrazine- and imidazo[1,2-c]pyrimidine-based kinase inhibitors

Meng, Zhaoyang ; Ciavarri, Jeffrey P ; Mcriner, Andrew ; Zhao, Yinyan ; Zhao, Lianyun ; Reddy, Panduranga Adulla ; Zhang, Xingmin ; Fischmann, Thierry O ; Whitehurst, Charles ; Arshad Siddiqui, M

Bioorganic & Medicinal Chemistry Letters, 15 May 2013, Vol.23(10), pp.2863-2867 [Peer Reviewed Journal]

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5
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Discovery of pyrazolo[1,5-a]pyrimidine-based Pim inhibitors: A template-based approach

Dwyer, Michael P ; Keertikar, Kartik ; Paruch, Kamil ; Alvarez, Carmen ; Labroli, Marc ; Poker, Cory ; Fischmann, Thierry O ; Mayer-Ezell, Rosemary ; Bond, Richard ; Wang, Yan ; Azevedo, Rita ; Guzi, Timothy J

Bioorganic & Medicinal Chemistry Letters, 15 November 2013, Vol.23(22), pp.6178-6182 [Peer Reviewed Journal]

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6
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Atomic resolution mechanistic studies of ribocil: A highly selective unnatural ligand mimic of the E. coli FMN riboswitch

Howe, John A ; Xiao, Li ; Fischmann, Thierry O ; Wang, Hao ; Tang, Haifeng ; Villafania, Artjohn ; Zhang, Rumin ; Barbieri, Christopher M ; Roemer, Terry

RNA Biology, 02 October 2016, Vol.13(10), pp.946-954 [Peer Reviewed Journal]

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7
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Discovery of a Novel Series of CHK1 Kinase Inhibitors with a Distinctive Hinge Binding Mode

Huang, Xiaohua ; Cheng, Cliff C ; Fischmann, Thierry O ; Duca, José S ; Yang, Xianshu ; Richards, Matthew ; Shipps, Gerald W

ACS medicinal chemistry letters, 09 February 2012, Vol.3(2), pp.123-8 [Peer Reviewed Journal]

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8
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Discovery and hit-to-lead optimization of 2,6-diaminopyrimidine inhibitors of interleukin-1 receptor-associated kinase 4

Mcelroy, William T ; Michael Seganish, W ; Jason Herr, R ; Harding, James ; Yang, Jinhai ; Yet, Larry ; Komanduri, Venukrishnan ; Prakash, Koraboina Chandra ; Lavey, Brian ; Tulshian, Deen ; Greenlee, William J ; Sondey, Christopher ; Fischmann, Thierry O ; Niu, Xiaoda

Bioorganic & medicinal chemistry letters, 01 May 2015, Vol.25(9), pp.1836-41 [Peer Reviewed Journal]

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9
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Discovery of novel BTK inhibitors with carboxylic acids

Gao, Xiaolei ; Wang, James ; Liu, Jian ; Guiadeen, Deodial ; Krikorian, Arto ; Boga, Sobhana Babu ; Alhassan, Abdul-Basit ; Selyutin, Oleg ; Yu, Wensheng ; Yu, Younong ; Anand, Rajan ; Liu, Shilan ; Yang, Chundao ; Wu, Hao ; Cai, Jiaqiang ; Cooper, Alan ; Zhu, Hugh ; Maloney, Kevin ; Gao, Ying-Duo ; Fischmann, Thierry O

Bioorganic & Medicinal Chemistry Letters, 15 March 2017, Vol.27(6), pp.1471-1477 [Peer Reviewed Journal]

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10
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Structure-based design and optimization of 2-aminothiazole-4-carboxamide as a new class of CHK1 inhibitors

Huang, Xiaohua ; Cheng, Cliff C ; Fischmann, Thierry O ; Duca, José S ; Richards, Matthew ; Tadikonda, Praveen K ; Reddy, Panduranga Adulla ; Zhao, Lianyun ; Arshad Siddiqui, M ; Parry, David ; Davis, Nicole ; Seghezzi, Wolfgang ; Wiswell, Derek ; Shipps, Gerald W

Bioorganic & Medicinal Chemistry Letters, 01 May 2013, Vol.23(9), pp.2590-2594 [Peer Reviewed Journal]

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11
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Discovery and Structure Enabled Synthesis of 2,6-Diaminopyrimidin-4-one IRAK4 Inhibitors

Seganish, W. Michael ; Fischmann, Thierry O ; Sherborne, Brad ; Matasi, Julius ; Lavey, Brian ; Mcelroy, William T ; Tulshian, Deen ; Tata, James ; Sondey, Christopher ; Garlisi, Charles G ; Devito, Kristine ; Fossetta, James ; Lundell, Daniel ; Niu, Xiaoda Argonne National Lab. (Anl), Argonne, Il (United States). Advanced Photon Source (APS) (Corporate Author)

ACS Medicinal Chemistry Letters, 13 August 2015, Vol.6(8) [Peer Reviewed Journal]

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12
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Discovery of 3-morpholino-imidazole[1,5-a]pyrazine BTK inhibitors for rheumatoid arthritis

Boga, Sobhana Babu ; Alhassan, Abdul-Basit ; Liu, Jian ; Guiadeen, Deodial ; Krikorian, Arto ; Gao, Xiaolei ; Wang, James ; Yu, Younong ; Anand, Rajan ; Liu, Shilan ; Yang, Chundao ; Wu, Hao ; Cai, Jiaqiang ; Zhu, Hugh ; Desai, Jagdish ; Maloney, Kevin ; Gao, Ying-Duo ; Fischmann, Thierry O ; Presland, Jeremy ; Mansueto, My

Bioorganic & Medicinal Chemistry Letters, 15 August 2017, Vol.27(16), pp.3939-3943 [Peer Reviewed Journal]

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13
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Discovery of pyrazolo[1,5-a]pyrimidine-based CHK1 inhibitors: A template-based approach—Part 1

Dwyer, Michael P ; Paruch, Kamil ; Labroli, Marc ; Alvarez, Carmen ; Keertikar, Kerry M ; Poker, Cory ; Rossman, Randall ; Fischmann, Thierry O ; Duca, Jose S ; Madison, Vincent ; Parry, David ; Davis, Nicole ; Seghezzi, Wolfgang ; Wiswell, Derek ; Guzi, Timothy J

Bioorganic & Medicinal Chemistry Letters, 01 January 2011, Vol.21(1), pp.467-470 [Peer Reviewed Journal]

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14
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Potent and Selective Amidopyrazole Inhibitors of IRAK4 That Are Efficacious in a Rodent Model of Inflammation

Mcelroy, William T ; Tan, Zheng ; Ho, Ginny ; Paliwal, Sunil ; Li, Guoqing ; Seganish, W. Michael ; Tulshian, Deen ; Tata, James ; Fischmann, Thierry O ; Sondey, Christopher ; Bian, Hong ; Bober, Loretta ; Jackson, James ; Garlisi, Charles G ; Devito, Kristine ; Fossetta, James ; Lundell, Daniel ; Niu, Xiaoda Argonne National Lab. (Anl), Argonne, Il (United States). Advanced Photon Source (APS) (Corporate Author)

ACS Medicinal Chemistry Letters, 11 June 2015, Vol.6(6) [Peer Reviewed Journal]

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15
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Identification of quinazoline based inhibitors of IRAK4 for the treatment of inflammation

Smith, Graham F ; Altman, Michael D ; Andresen, Brian ; Baker, James ; Brubaker, Jason D ; Chen, Hongmin ; Chen, Yiping ; Childers, Matthew ; Donofrio, Anthony ; Ferguson, Heidi ; Fischer, Christian ; Fischmann, Thierry O ; Gibeau, Craig ; Hicks, Alexander ; Jin, Sue ; Kattar, Sam ; Kleinschek, Melanie A ; Leccese, Erica ; Lesburg, Charles ; Li, Chaomin

Bioorganic & Medicinal Chemistry Letters, 15 June 2017, Vol.27(12), pp.2721-2726 [Peer Reviewed Journal]

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16
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Discovery of 8-Amino-imidazo[1,5- a ]pyrazines as Reversible BTK Inhibitors for the Treatment of Rheumatoid Arthritis

Liu, Jian ; Guiadeen, Deodial ; Krikorian, Arto ; Gao, Xiaolei ; Wang, James ; Boga, Sobhana Babu ; Alhassan, Abdul-Basit ; Yu, Younong ; Vaccaro, Henry ; Liu, Shilan ; Yang, Chundao ; Wu, Hao ; Cooper, Alan ; de Man, Jos ; Kaptein, Allard ; Maloney, Kevin ; Hornak, Viktor ; Gao, Ying-Duo ; Fischmann, Thierry O ; Raaijmakers, Hans ; Vu-Pham, Diep ; Presland, Jeremy ; Mansueto, My ; Xu, Zangwei ; Leccese, Erica ; Zhang-Hoover, Jie ; Knemeyer, Ian ; Garlisi, Charles G ; Bays, Nathan ; Stivers, Peter ; Brandish, Philip E ; Hicks, Alexandra ; Kim, Ronald ; Kozlowski, Joseph A Argonne National Lab. (Anl), Argonne, Il (United States). Advanced Photon Source (APS) (Corporate Author)

ACS Medicinal Chemistry Letters, 11 February 2016, Vol.7(2) [Peer Reviewed Journal]

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17
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Modulating the interaction between CDK2 and cyclin A with a quinoline-based inhibitor

Deng, Yongqi ; Shipps, Gerald W ; Zhao, Lianyun ; Siddiqui, M Arshad ; Popovici-Muller, Janeta ; Curran, Patrick J ; Duca, Jose S ; Hruza, Alan W ; Fischmann, Thierry O ; Madison, Vincent S ; Zhang, Rumin ; Mcnemar, Charles W ; Mayhood, Todd W ; Syto, Rosalinda ; Annis, Allen ; Kirschmeier, Paul ; Lees, Emma M ; Parry, David A ; Windsor, William T

Bioorganic & medicinal chemistry letters, 01 January 2014, Vol.24(1), pp.199-203 [Peer Reviewed Journal]

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18
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Discovery of Selective RNA-Binding Small Molecules by Affinity-Selection Mass Spectrometry

Rizvi, Noreen F ; Howe, John A ; Nahvi, Ali ; Klein, Daniel J ; Fischmann, Thierry O ; Kim, Hai-Young ; Mccoy, Mark A ; Walker, Scott S ; Hruza, Alan ; Richards, Matthew P ; Chamberlin, Chad ; Saradjian, Peter ; Butko, Margaret T ; Mercado, Gabriel ; Burchard, Julja ; Strickland, Corey ; Dandliker, Peter J ; Smith, Graham F ; Nickbarg, Elliott B

ACS chemical biology, 16 March 2018, Vol.13(3), pp.820-831 [Peer Reviewed Journal]

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19
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Versatile templates for the development of novel kinase inhibitors: Discovery of novel CDK inhibitors

Dwyer, Michael P ; Paruch, Kamil ; Alvarez, Carmen ; Doll, Ronald J ; Keertikar, Kerry ; Duca, Jose ; Fischmann, Thierry O ; Hruza, Alan ; Madison, Vincent ; Lees, Emma ; Parry, David ; Seghezzi, Wolfgang ; Sgambellone, Nicole ; Shanahan, Frances ; Wiswell, Derek ; Guzi, Timothy J

Bioorganic & Medicinal Chemistry Letters, 2007, Vol.17(22), pp.6216-6219 [Peer Reviewed Journal]

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20
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Pembrolizumab microgravity crystallization experimentation

Reichert, Paul ; Prosise, Winifred ; Fischmann, Thierry O ; Scapin, Giovanna ; Narasimhan, Chakravarthy ; Spinale, April ; Polniak, Ray ; Yang, Xiaoyu ; Walsh, Erika ; Patel, Daya ; Benjamin, Wendy ; Welch, Johnathan ; Simmons, Denarra ; Strickland, Corey

NPJ microgravity, 2019, Vol.5, pp.28 [Peer Reviewed Journal]

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21
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Structure‐guided discovery of cyclin‐dependent kinase inhibitors

Fischmann, Thierry O. ; Hruza, Alan ; Duca, José S. ; Ramanathan, Lata ; Mayhood, Todd ; Windsor, William T. ; Le, Hung V. ; Guzi, Timothy J. ; Dwyer, Michael P. ; Paruch, Kamil ; Doll, Ronald J. ; Lees, Emma ; Parry, David ; Seghezzi, Wolfgang ; Madison, Vincent Gierasch, Lila M. ; Deber, Charles M. ; Brodsky, Barbara

Biopolymers, May 2008, Vol.89(5), pp.372-379 [Peer Reviewed Journal]

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22
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Pyrazolo[1,5- a]pyrimidines as orally available inhibitors of cyclin-dependent kinase 2

Paruch, Kamil ; Dwyer, Michael P ; Alvarez, Carmen ; Brown, Courtney ; Chan, Tin-Yau ; Doll, Ronald J ; Keertikar, Kerry ; Knutson, Chad ; Mckittrick, Brian ; Rivera, Jocelyn ; Rossman, Randall ; Tucker, Greg ; Fischmann, Thierry O ; Hruza, Alan ; Madison, Vincent ; Nomeir, Amin A ; Wang, Yaolin ; Lees, Emma ; Parry, David ; Sgambellone, Nicole

Bioorganic & Medicinal Chemistry Letters, 2007, Vol.17(22), pp.6220-6223 [Peer Reviewed Journal]

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