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26 Results  for Everything (Includes Articles)

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1
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Spasmolytic polypeptide-expressing metaplasia (SPEM) in the gastric oxyntic mucosa does not arise from Lgr5-expressing cells

Nam, Ki Taek ; O'Neal, Ryan L ; Coffey, Robert J ; Finke, Paul E ; Barker, Nick ; Goldenring, James R

Gut, December 2012, Vol.61(12), pp.1678-85 [Peer Reviewed Journal]

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Heterogeneity in mouse spasmolytic polypeptide-expressing metaplasia lineages identifies markers of metaplastic progression

Weis, Victoria G ; Sousa, Josane F ; Lafleur, Bonnie J ; Nam, Ki Taek ; Weis, Jared A ; Finke, Paul E ; Ameen, Nadia A ; Fox, James G ; Goldenring, James R

Gut, September 2013, Vol.62(9), pp.1270-9 [Peer Reviewed Journal]

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Expeditious synthesis of tri-substituted cyclopentane derivatives

Desai, Ranjit C ; Cicala, Peter ; Meurer, Laura C ; Finke, Paul E

Tetrahedron Letters, 2002, Vol.43(26), pp.4569-4570 [Peer Reviewed Journal]

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The fibrinogen cleavage product Aα-Val360, a specific marker of neutrophil elastase activity in vivo

Carter, Richard I ; Mumford, Richard A ; Treonze, Kelly M ; Finke, Paul E ; Davies, Phillip ; Si, Qian ; Humes, John L ; Dirksen, Asger ; Piitulainen, Eeva ; Ahmad, Ali ; Stockley, Robert A

Thorax, August 2011, Vol.66(8), pp.686-91 [Peer Reviewed Journal]

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Optimization of Preclinical Metabolism for Somatostatin Receptor Subtype 5-Selective Antagonists

Liu, Weiguo ; Hussain, Zahid ; Zang, Yi ; Sweis, Ramzi F ; Romero, F Anthony ; Finke, Paul E ; Moningka, Remond ; Bao, Jianming ; Plotkin, Michael A ; Shang, Jin ; Dingley, Karen H ; Salituro, Gino ; Murphy, Beth Ann ; Howard, Andrew D ; Ujjainwalla, Feroze ; Wood, Harold B ; Duffy, Joseph L

ACS medicinal chemistry letters, 08 November 2018, Vol.9(11), pp.1088-1093 [Peer Reviewed Journal]

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Binding of 2-aryl-4-(piperidin-1-yl)butanamines and 1,3,4-trisubstituted pyrrolidines to human CCR5: a molecular modeling-guided mutagenesis study of the binding pocket

Castonguay, Laurie A ; Weng, Youmin ; Adolfsen, William ; Di Salvo, Jerry ; Kilburn, Ruth ; Caldwell, Charles G ; Daugherty, Bruce L ; Finke, Paul E ; Hale, Jeffrey J ; Lynch, Christopher L ; Mills, Sander G ; Maccoss, Malcolm ; Springer, Martin S ; Demartino, Julie A

Biochemistry, 18 February 2003, Vol.42(6), pp.1544-50 [Peer Reviewed Journal]

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CCR5 antagonists: 3-(pyrrolidin-1-yl)propionic acid analogues with potent anti-HIV activity

Lynch, Christopher L ; Hale, Jeffrey J ; Budhu, Richard J ; Gentry, Amy L ; Finke, Paul E ; Caldwell, Charles G ; Mills, Sander G ; Maccoss, Malcolm ; Shen, Dong-Ming ; Chapman, Kevin T ; Malkowitz, Lorraine ; Springer, Martin S ; Gould, Sandra L ; Demartino, Julie A ; Siciliano, Salvatore J ; Cascieri, Margaret A ; Carella, Anthony ; Carver, Gwen ; Holmes, Karen ; Schleif, William A ; Danzeisen, Renee ; Hazuda, Daria ; Kessler, Joseph ; Lineberger, Janet ; Miller, Michael ; Emini, Emilio

Organic letters, 10 July 2003, Vol.5(14), pp.2473-5 [Peer Reviewed Journal]

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Characterization of a novel and selective cannabinoid CB 1 receptor inverse agonist, Imidazole 24b, in rodents

Shearman, Lauren P ; Stribling, D. Sloan ; Camacho, Ramon E ; Rosko, Kimberly M ; Wang, Junying ; Tong, Sharon ; Feng, Yue ; Marsh, Donald J ; Yu, Hong ; Guan, Xiaoming ; Spann, Stephanie K ; Macneil, Douglas J ; Fong, Tung M ; Metzger, Joseph M ; Goulet, Mark T ; Hagmann, William K ; Plummer, Christopher W ; Finke, Paul E ; Mills, Sander G ; Shah, Shrenik K ; Truong, Quang ; Van Der Ploeg, L.H.T ; Macintyre, D. Euan ; Strack, Alison M

European Journal of Pharmacology, 2008, Vol.579(1), pp.215-224 [Peer Reviewed Journal]

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Structural Optimization Affording 2-( R )-(1-( R )-3,5-Bis(trifluoromethyl)phenylethoxy)-3-( S )-(4-fluoro)phenyl-4- (3-oxo-1,2,4-triazol-5-yl)methylmorpholine, a Potent, Orally Active, Long-Acting Morpholine Acetal Human NK-1 Receptor Antagonist
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Structural Optimization Affording 2-( R )-(1-( R )-3,5-Bis(trifluoromethyl)phenylethoxy)-3-( S )-(4-fluoro)phenyl-4- (3-oxo-1,2,4-triazol-5-yl)methylmorpholine, a Potent, Orally Active, Long-Acting Morpholine Acetal Human NK-1 Receptor Antagonist

Hale, Jeffrey J. ; Mills, Sander G. ; Maccoss, Malcolm ; Finke, Paul E. ; Cascieri, Margaret A. ; Sadowski, Sharon ; Ber, Elzbieta ; Chicchi, Gary G. ; Kurtz, Marc ; Metzger, Joseph ; Eiermann, George ; Tsou, Nancy N. ; Tattersall, F. David ; Rupniak, Nadia M. J. ; Williams, Angela R. ; Rycroft, Wayne ; Hargreaves, Richard ; Macintyre, D. Euan

Journal of Medicinal Chemistry, 11/1998, Vol.41(23), pp.4607-4614 [Peer Reviewed Journal]

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A facile synthesis of the novel Neurokinin A antagonist SR 48968

Hale, Jeffrey J ; Finke, Paul E ; Maccoss, Malcolm

Bioorganic & Medicinal Chemistry Letters, 1993, Vol.3(2), pp.319-322 [Peer Reviewed Journal]

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Phosphorylated Morpholine Acetal Human Neurokinin-1 Receptor Antagonists as Water-Soluble Prodrugs
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Phosphorylated Morpholine Acetal Human Neurokinin-1 Receptor Antagonists as Water-Soluble Prodrugs

Hale, Jeffrey J. ; Mills, Sander G. ; Maccoss, Malcolm ; Dorn, Conrad P. ; Finke, Paul E. ; Budhu, Richard J. ; Reamer, Robert A. ; Huskey, Su-Er W. ; Luffer-Atlas, Debra ; Dean, Brian J. ; Mcgowan, Erin M. ; Feeney, William P. ; Chiu, Shuet-Hing Lee ; Cascieri, Margaret A. ; Chicchi, Gary G. ; Kurtz, Marc M. ; Sadowski, Sharon ; Ber, Elzbieta ; Tattersall, F. David ; Rupniak, Nadia M. J. ; Williams, Angela R. ; Rycroft, Wayne ; Hargreaves, Richard ; Metzger, Joseph M. ; Macintyre, D. Euan

Journal of Medicinal Chemistry, 03/2000, Vol.43(6), pp.1234-1241 [Peer Reviewed Journal]

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12
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Cyclopentane-based human NK1 antagonists. Part 1: Discovery and initial SAR

Finke, Paul E ; Meurer, Laura C ; Levorse, Dorothy A ; Mills, Sander G ; Maccoss, Malcolm ; Sadowski, Sharon ; Cascieri, Margaret A ; Tsao, Kwei-Lan ; Chicchi, Gary G ; Metzger, Joseph M ; Macintyre, D. Euan

Bioorganic & Medicinal Chemistry Letters, 2006, Vol.16(17), pp.4497-4503 [Peer Reviewed Journal]

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13
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Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 4: synthesis and structure–Activity relationships for 1-[ N-(Methyl)- N-(phenylsulfonyl)amino]-2-(phenyl)-4-(4-( N-(alkyl)- N-(benzyloxycarbonyl)amino)piperidin-1-yl)butanes

Finke, Paul E ; Oates, Bryan ; Mills, Sander G ; Maccoss, Malcolm ; Malkowitz, Lorraine ; Springer, Martin S ; Gould, Sandra L ; Demartino, Julie A ; Carella, Anthony ; Carver, Gwen ; Holmes, Karen ; Danzeisen, Renee ; Hazuda, Daria ; Kessler, Joseph ; Lineberger, Janet ; Miller, Michael ; Schleif, William A ; Emini, Emilio A

Bioorganic & Medicinal Chemistry Letters, 2001, Vol.11(18), pp.2475-2479 [Peer Reviewed Journal]

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Inhibition of human leukocyte elastase. 6. Inhibition by 6-substituted penicillin esters

Thompson, Kevan R ; Finke, Paul E ; Shah, Shrenik K ; Ashe, Bonnie M ; Dahlgren, Mary E ; Maycock, Alan L ; Doherty, James B

Bioorganic & Medicinal Chemistry Letters, 1993, Vol.3(11), pp.2283-2288 [Peer Reviewed Journal]

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15
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1,2,3-Trisubstituted cyclohexyl substance P antagonists: significance of the ring nitrogen in piperidine-based NK-1 receptor antagonists

Mills, Sander G ; Maccoss, Malcolm ; Underwood, Dennis ; Shah, Shrenik K ; Finke, Paul E ; Miller, Daniel J ; Budhu, Richard J ; Cascieri, Margaret A ; Sadowski, Sharon ; Strader, Catherine D

Bioorganic & Medicinal Chemistry Letters, 1995, Vol.5(13), pp.1345-1350 [Peer Reviewed Journal]

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Synthesis and SAR of 5,6-diarylpyridines as human CB1 inverse agonists

Meurer, Laura C ; Finke, Paul E ; Mills, Sander G ; Walsh, Thomas F ; Toupence, Richard B ; Goulet, Mark T ; Wang, Junying ; Tong, Xinchun ; Fong, Tung M ; Lao, Julie ; Schaeffer, Marie-Therese ; Chen, Jing ; Shen, Chun-Pyn ; Sloan Stribling, D ; Shearman, Lauren P ; Strack, Alison M ; Van Der Ploeg, Lex H.T

Bioorganic & Medicinal Chemistry Letters, 2005, Vol.15(3), pp.645-651 [Peer Reviewed Journal]

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Synthesis and activity of 4,5-diarylimidazoles as human CB1 receptor inverse agonists

Plummer, Christopher W ; Finke, Paul E ; Mills, Sander G ; Wang, Junying ; Tong, Xinchun ; Doss, George A ; Fong, Tung M ; Lao, Julie Z ; Schaeffer, Marie-Therese ; Chen, Jing ; Shen, Chun-Pyn ; Stribling, D. Sloan ; Shearman, Lauren P ; Strack, Alison M ; Van Der Ploeg, Lex H.T

Bioorganic & Medicinal Chemistry Letters, 2005, Vol.15(5), pp.1441-1446 [Peer Reviewed Journal]

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18
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The effect of N-acyl substituents on the stability of monocyclic β-lactam inhibitors of human leukocyte elastase

Hagmann, William K ; Thompson, Kevan R ; Shah, Shrenik K ; Finke, Paul E ; Ashe, Bonnie M ; Weston, Hazel ; Maycock, Alan L ; Doherty, James B

Bioorganic & Medicinal Chemistry Letters, 1992, Vol.2(7), pp.681-684 [Peer Reviewed Journal]

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19
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Cyclopentane-based human NK1 antagonists. Part 2: Development of potent, orally active, water-soluble derivatives

Meurer, Laura C ; Finke, Paul E ; Owens, Karen A ; Tsou, Nancy N ; Ball, Richard G ; Mills, Sander G ; Maccoss, Malcolm ; Sadowski, Sharon ; Cascieri, Margaret A ; Tsao, Kwei-Lan ; Chicchi, Gary G ; Egger, Linda A ; Luell, Silvi ; Metzger, Joseph M ; Macintyre, D. Euan ; Rupniak, Nadia M.J ; Williams, Angela R ; Hargreaves, Richard J

Bioorganic & Medicinal Chemistry Letters, 2006, Vol.16(17), pp.4504-4511 [Peer Reviewed Journal]

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20
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Corrigendum to “Synthesis and SAR of 5,6-diarylpyridines as human CB1 inverse agonists”: [Bioorg. Med. Chem. Lett. 15 (2005) 645]

Meurer, Laura C ; Finke, Paul E ; Mills, Sander G ; Walsh, Thomas F ; Toupence, Richard B ; Debenham, John S ; Goulet, Mark T ; Wang, Junying ; Tong, Xinchun ; Fong, Tung M ; Lao, Julie ; Schaeffer, Marie-Therese ; Chen, Jing ; Shen, Chun-Pyn ; Stribling, D. Sloan ; Shearman, Lauren P ; Strack, Alison M ; Van Der Ploeg, Lex H.T

Bioorganic & Medicinal Chemistry Letters, 2005, Vol.15(6), pp.1755-1755 [Peer Reviewed Journal]

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21
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Syntheses and biological evaluation of 5-(piperidin-1-yl)-3-phenyl-pentylsulfones as CCR5 antagonists

Shankaran, K ; Donnelly, Karla L ; Shah, Shrenik K ; Caldwell, Charles G ; Chen, Ping ; Finke, Paul E ; Oates, Bryan ; Maccoss, Malcolm ; Mills, Sander G ; Demartino, Julie A ; Gould, Sandra L ; Malkowitz, Lorraine ; Siciliano, Salvatore J ; Springer, Martin S ; Kwei, Gloria ; Carella, Anthony ; Carver, Gwen ; Danzeisen, Renee ; Hazuda, Daria ; Holmes, Karen ; Kessler, Joseph ; Lineberger, Janet ; Miller, Michael D ; Emini, Emilio A ; Schleif, William A

Bioorganic & Medicinal Chemistry Letters, 2004, Vol.14(13), pp.3589-3593 [Peer Reviewed Journal]

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22
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Design, synthesis, and SAR of heterocycle-containing antagonists of the human CCR5 receptor for the treatment of HIV-1 infection

Kim, Dooseop ; Wang, Liping ; Caldwell, Charles G ; Chen, Ping ; Finke, Paul E ; Oates, Bryan ; Maccoss, Malcolm ; Mills, Sander G ; Malkowitz, Lorraine ; Gould, Sandra L ; Demartino, Julie A ; Springer, Martin S ; Hazuda, Daria ; Miller, Michael ; Kessler, Joseph ; Danzeisen, Renee ; Carver, Gwen ; Carella, Anthony ; Holmes, Karen ; Lineberger, Janet ; Schleif, William A ; Emini, Emilio A

Bioorganic & Medicinal Chemistry Letters, 2001, Vol.11(24), pp.3103-3106 [Peer Reviewed Journal]

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23
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Discovery of human CCR5 antagonists containing hydantoins for the treatment of HIV-1 infection

Kim, Dooseop ; Wang, Liping ; Caldwell, Charles G ; Chen, Ping ; Finke, Paul E ; Oates, Bryan ; Maccoss, Malcolm ; Mills, Sander G ; Malkowitz, Lorraine ; Gould, Sandra L ; Demartino, Julie A ; Springer, Martin S ; Hazuda, Daria ; Miller, Michael ; Kessler, Joseph ; Danzeisen, Renee ; Carver, Gwen ; Carella, Anthony ; Holmes, Karen ; Lineberger, Janet ; Schleif, William A ; Emini, Emilio A

Bioorganic & Medicinal Chemistry Letters, 2001, Vol.11(24), pp.3099-3102 [Peer Reviewed Journal]

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24
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Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 2: structure–activity relationships for substituted 2-aryl-1-[N-(methyl)-N-(phenylsulfonyl)amino]-4-(piperidin-1-yl)butanes

Finke, Paul E ; Meurer, Laura C ; Oates, Bryan ; Mills, Sander G ; Maccoss, Malcolm ; Malkowitz, Lorraine ; Springer, Martin S ; Daugherty, Bruce L ; Gould, Sandra L ; Demartino, Julie A ; Siciliano, Salvatore J ; Carella, Anthony ; Carver, Gwen ; Holmes, Karen ; Danzeisen, Renee ; Hazuda, Daria ; Kessler, Joseph ; Lineberger, Janet ; Miller, Michael ; Schleif, William A ; Emini, Emilio A

Bioorganic & Medicinal Chemistry Letters, January 2001, Vol.11(2), pp.265-270 [Peer Reviewed Journal]

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25
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1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 2: lead optimization affording selective, orally bioavailable compounds with potent Anti-HIV activity

Hale, Jeffrey J ; Budhu, Richard J ; Holson, Edward B ; Finke, Paul E ; Oates, Bryan ; Mills, Sander G ; Maccoss, Malcolm ; Gould, Sandra L ; Demartino, Julie A ; Springer, Martin S ; Siciliano, Salvatore ; Malkowitz, Lorraine ; Schleif, William A ; Hazuda, Daria ; Miller, Michael ; Kessler, Joseph ; Danzeisen, Renee ; Holmes, Karen ; Lineberger, Janet ; Carella, Anthony ; Carver, Gwen ; Emini, Emilio

Bioorganic & Medicinal Chemistry Letters, 2001, Vol.11(20), pp.2741-2745 [Peer Reviewed Journal]

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26
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Monocyclic β-lactam inhibitors of human leukocyte elastase. Stereospecific synthesis and activity of 3,4-disubstituted-2-azetidinones

Shah, Shrenik K ; Finke, Paul E ; Brause, Karen A ; Chandler, Gilbert O ; Ashe, Bonnie M ; Weston, Hazel ; Maycock, Alan L ; Mumford, Richard A ; Doherty, James B

Bioorganic & Medicinal Chemistry Letters, 1993, Vol.3(11), pp.2295-2298 [Peer Reviewed Journal]

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