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18 Results  for Everything (Includes Articles)

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Discovery of a peroxisome proliferator activated receptor gamma (PPARgamma) modulator with balanced PPARalpha activity for the treatment of type 2 diabetes and dyslipidemia

Liu, Weiguo ; Liu, Kun ; Wood, Harold B ; Mccann, Margaret E ; Doebber, Thomas W ; Chang, Ching H ; Akiyama, Taro E ; Einstein, Monica ; Berger, Joel P ; Meinke, Peter T

Journal of medicinal chemistry, 23 July 2009, Vol.52(14), pp.4443-53 [Peer Reviewed Journal]

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A Genome-Wide siRNA Screen to Identify Modulators of Insulin Sensitivity and Gluconeogenesis (A Novel Approach to Identify Insulin Sensitizers)

Yang, Ruojing ; Lacson, Raul G ; Castriota, Gino ; Zhang, Xiaohua D ; Liu, Yaping ; Zhao, Wenqing ; Einstein, Monica ; Camargo, Luiz Miguel ; Qureshi, Sajjad ; Wong, Kenny K ; Zhang, Bei B ; Ferrer, Marc ; Berger, Joel P Rossi, John J. (Editor)

PLoS ONE, 2012, Vol.7(5), p.e36384 [Peer Reviewed Journal]

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Benzimidazolones: a new class of selective peroxisome proliferator-activated receptor γ (PPARγ) modulators

Liu, Weiguo ; Lau, Fiona ; Liu, Kun ; Wood, Harold B ; Zhou, Gaochao ; Chen, Yuli ; Li, Ying ; Akiyama, Taro E ; Castriota, Gino ; Einstein, Monica ; Wang, Chualin ; Mccann, Margaret E ; Doebber, Thomas W ; Wu, Margaret ; Chang, Ching H ; Mcnamara, Lesley ; Mckeever, Brian ; Mosley, Ralph T ; Berger, Joel P ; Meinke, Peter T

Journal of medicinal chemistry, 22 December 2011, Vol.54(24), pp.8541-54 [Peer Reviewed Journal]

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Correction to Discovery of (2 R )-2-(3-{3-[(4-Methoxyphenyl)carbonyl]-2-methyl-6-(trifluoromethoxy)-1 H -indol-1-yl}phenoxy)butanoic Acid (MK-0533): A Novel Selective Peroxisome Proliferator-Activated Receptor γ Modulator for the Treatment of Type 2 Diabetes Mellitus with a Reduced Potential to Increase Plasma and Extracellular Fluid Volume
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Correction to Discovery of (2 R )-2-(3-{3-[(4-Methoxyphenyl)carbonyl]-2-methyl-6-(trifluoromethoxy)-1 H -indol-1-yl}phenoxy)butanoic Acid (MK-0533): A Novel Selective Peroxisome Proliferator-Activated Receptor γ Modulator for the Treatment of Type 2 Diabetes Mellitus with a Reduced Potential to Increase Plasma and Extracellular Fluid Volume

Acton, John J. ; Akiyama, Taro E. ; Chang, Ching H. ; Colwell, Lawrence ; Debenham, Sheryl ; Doebber, Thomas ; Einstein, Monica ; Liu, Kun ; Mccann, Margaret E. ; Moller, David E. ; Muise, Eric S. ; Tan, Yejun ; Thompson, John R. ; Wong, Kenny K. ; Wu, Margaret ; Xu, Libo ; Meinke, Peter T. ; Berger, Joel P. ; Wood, Harold B.

Journal of Medicinal Chemistry, 11/27/2013, Vol.56(22), pp.9368-9368 [Peer Reviewed Journal]

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Immunohistochemical Analysis of Steroid 5α‐Reductase Type 1 in Human Scalp and Prostate

Patel, Sushma ; Einstein, Monica ; Geissler, Wayne ; Wu, Ling ; Andersson, Stefan

Annals of the New York Academy of Sciences, April 1996, Vol.784(1), pp.27-39 [Peer Reviewed Journal]

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Discovery of 5-aryloxy-2,4-thiazolidinediones as potent GPR40 agonists

Zhou, Changyou ; Tang, Cheng ; Chang, Eric ; Ge, Min ; Lin, Songnian ; Cline, Eric ; Tan, Carina P ; Feng, Yue ; Zhou, Yun-Ping ; Eiermann, George J ; Petrov, Aleksandr ; Salituro, Gino ; Meinke, Peter ; Mosley, Ralph ; Akiyama, Taro E ; Einstein, Monica ; Kumar, Sanjeev ; Berger, Joel ; Howard, Andrew D ; Thornberry, Nancy ; Mills, Sander G ; Yang, Lihu

Bioorganic & Medicinal Chemistry Letters, 2010, Vol.20(3), pp.1298-1301 [Peer Reviewed Journal]

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Discovery of (2R)-2-(3-{3-(4-Methoxyphenyl)carbonyl-2-methyl-6-(trifluoromethoxy)-1H-indol-1-yl}phenoxy)butanoic acid (MK-0533): a novel selective peroxisome proliferator-activated receptor gamma modulator for the treatment of type 2 diabetes mellitus with a reduced potential to increase plasma and extracellular fluid volume

Acton, John J ; Akiyama, Taro E ; Chang, Ching H ; Colwell, Lawrence ; Debenham, Sheryl ; Doebber, Thomas ; Einstein, Monica ; Liu, Kun ; Mccann, Margaret E ; Moller, David E ; Muise, Eric S ; Tan, Yejun ; Tan, Yugen ; Thompson, John R ; Wong, Kenny K ; Wu, Margaret ; Xu, Libo ; Meinke, Peter T ; Berger, Joel P ; Wood, Harold B

Journal of medicinal chemistry, 09 July 2009, Vol.52(13), pp.3846-54 [Peer Reviewed Journal]

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Selective small-molecule agonists of G protein-coupled receptor 40 promote glucose-dependent insulin secretion and reduce blood glucose in mice

Tan, Carina P ; Feng, Yue ; Zhou, Yun-Ping ; Eiermann, George J ; Petrov, Aleksandr ; Zhou, Changyou ; Lin, Songnian ; Salituro, Gino ; Meinke, Peter ; Mosley, Ralph ; Akiyama, Taro E ; Einstein, Monica ; Kumar, Sanjeev ; Berger, Joel P ; Mills, Sander G ; Thornberry, Nancy A ; Yang, Lihu ; Howard, Andrew D

Diabetes, August 2008, Vol.57(8), pp.2211-9 [Peer Reviewed Journal]

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Discovery of betamethasone 17α-carbamates as dissociated glucocorticoid receptor modulators in the rat

Ali, Amjad ; Balkovec, James M ; Greenlee, Mark ; Hammond, Milton L ; Rouen, Greg ; Taylor, Gayle ; Einstein, Monica ; Ge, Lan ; Harris, Georgianna ; Kelly, Terri M ; Mazur, Paul ; Pandit, Shilpa ; Santoro, Joseph ; Sitlani, Ayesha ; Wang, Chuanlin ; Williamson, Joann ; Forrest, Michael J ; Carballo-Jane, Ester ; Luell, Silvi ; Lowitz, Karen ; Visco, Denise

Bioorganic & Medicinal Chemistry, 2008, Vol.16(16), pp.7535-7542 [Peer Reviewed Journal]

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Partial Restoration of Lutropin Activity by an Intersubunit Disulfide Bond: Implications for Structure/Function Studies

Einstein, Monica ; Lin, Win ; Macdonald, Gordon J ; Moyle, William R

Experimental Biology and Medicine, June 2001, Vol.226(6), pp.581-590 [Peer Reviewed Journal]

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Novel N-arylpyrazolo3,2-c-based ligands for the glucocorticoid receptor: receptor binding and in vivo activity

Ali, Amjad ; Thompson, Christopher F ; Balkovec, James M ; Graham, Donald W ; Hammond, Milton L ; Quraishi, Nazia ; Tata, James R ; Einstein, Monica ; Ge, Lan ; Harris, Georgianna ; Kelly, Terri M ; Mazur, Paul ; Pandit, Shilpa ; Santoro, Joseph ; Sitlani, Ayesha ; Wang, Chuanlin ; Williamson, Joanne ; Miller, Douglas K ; Thompson, Chris M ; Zaller, Dennis M ; Forrest, Michael J ; Carballo-Jane, Ester ; Luell, Silvi

Journal of medicinal chemistry, 06 May 2004, Vol.47(10), pp.2441-52 [Peer Reviewed Journal]

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Synthesis and biological activities of novel aryl indole-2-carboxylic acid analogs as PPARγ partial agonists

Dropinski, James F ; Akiyama, Taro ; Einstein, Monica ; Habulihaz, Bahanu ; Doebber, Tom ; Berger, Joel P ; Meinke, Peter T ; Shi, Guo Q

Bioorganic & Medicinal Chemistry Letters, 2005, Vol.15(22), pp.5035-5038 [Peer Reviewed Journal]

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The differential interactions of peroxisome proliferator-activated receptor gamma ligands with Tyr473 is a physical basis for their unique biological activities

Einstein, Monica ; Akiyama, Taro E ; Castriota, Gino A ; Wang, Chuanlin F ; Mckeever, Brian ; Mosley, Ralph T ; Becker, Joseph W ; Moller, David E ; Meinke, Peter T ; Wood, Harold B ; Berger, Joel P

Molecular pharmacology, January 2008, Vol.73(1), pp.62-74 [Peer Reviewed Journal]

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Highly functionalized 7-azaindoles as selective PPARγ modulators

Debenham, Sheryl D ; Chan, Audrey ; Lau, Fiona Waiyu ; Liu, Weiguo ; Wood, Harold B ; Lemme, Karen ; Colwell, Lawrence ; Habulihaz, Bahanu ; Akiyama, Taro E ; Einstein, Monica ; Doebber, Thomas W ; Sharma, Neelam ; Wang, Chaunlin F ; Wu, Margaret ; Berger, Joel P ; Meinke, Peter T

Bioorganic & Medicinal Chemistry Letters, 01 September 2008, Vol.18(17), pp.4798-4801 [Peer Reviewed Journal]

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Selective glucocorticoid receptor nonsteroidal ligands completely antagonize the dexamethasone mediated induction of enzymes involved in gluconeogenesis and glutamine metabolism

Einstein, Monica ; Greenlee, Mark ; Rouen, Greg ; Sitlani, Ayesha ; Santoro, Joe ; Wang, Chuanlin ; Pandit, Shilpa ; Mazur, Paul ; Smalera, Isabella ; Weaver, Alehna Pm ; Zeng, Ying Ying ; Ge, Lan ; Kelly, Theresa ; Paiva, Tony ; Geissler, Wayne ; Mosley, Ralph T ; Williamson, Joanne ; Ali, Amjad ; Balkovec, Jim ; Harris, Georgianna

Journal of Steroid Biochemistry and Molecular Biology, 2004, Vol.92(5), pp.345-356 [Peer Reviewed Journal]

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Novel glucocorticoids containing a 6,5-bicyclic core fused to a pyrazole ring: Synthesis, in vitro profile, molecular modeling studies, and in vivo experiments

Thompson, Christopher F ; Quraishi, Nazia ; Ali, Amjad ; Mosley, Ralph T ; Tata, James R ; Hammond, Milton L ; Balkovec, James M ; Einstein, Monica ; Ge, Lan ; Harris, Georgianna ; Kelly, Terri M ; Mazur, Paul ; Pandit, Shilpa ; Santoro, Joseph ; Sitlani, Ayesha ; Wang, Chuanlin ; Williamson, Joanne ; Miller, Douglas K ; Yamin, Ting-Ting D ; Thompson, Chris M ; O’neill, Edward A ; Zaller, Dennis ; Forrest, Michael J ; Carballo-Jane, Ester ; Luell, Silvi

Bioorganic & Medicinal Chemistry Letters, 2007, Vol.17(12), pp.3354-3361 [Peer Reviewed Journal]

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Novel heterocyclic glucocorticoids: in vitro profile and in vivo efficacy

Thompson, Christopher F ; Quraishi, Nazia ; Ali, Amjad ; Tata, James R ; Hammond, Milton L ; Balkovec, James M ; Einstein, Monica ; Ge, Lan ; Harris, Georgianna ; Kelly, Theresa M ; Mazur, Paul ; Pandit, Shilpa ; Santoro, Joseph ; Sitlani, Ayesha ; Wang, Chuanlin ; Williamson, Joanne ; Miller, Douglas K ; Yamin, Ting-Ting D ; Thompson, Chris M ; O’neill, Edward A ; Zaller, Dennis ; Forrest, Michael J ; Carballo-Jane, Ester ; Luell, Silvi

Bioorganic & Medicinal Chemistry Letters, 2005, Vol.15(8), pp.2163-2167 [Peer Reviewed Journal]

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Novel ketal ligands for the glucocorticoid receptor: in vitro and in vivo activity

Smith, Cameron J ; Ali, Amjad ; Balkovec, James M ; Graham, Donald W ; Hammond, Milton L ; Patel, Gool F ; Rouen, Gregory P ; Smith, Scott K ; Tata, James R ; Einstein, Monica ; Ge, Lan ; Harris, Georgianna S ; Kelly, Theresa M ; Mazur, Paul ; Thompson, Chris M ; Wang, Chuanlin F ; Williamson, Joanne M ; Miller, Douglas K ; Pandit, Shilpa ; Santoro, Joseph C ; Sitlani, Ayesha ; Yamin, Ting-Ting D ; O’neill, Edward A ; Zaller, Dennis M ; Carballo-Jane, Ester ; Forrest, Michael J ; Luell, Silvi

Bioorganic & Medicinal Chemistry Letters, 2005, Vol.15(11), pp.2926-2931 [Peer Reviewed Journal]

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